Sequence analysis of peptides bound to MHC class II molecules.

PubWeight™: 5.99‹?› | Rank: Top 1%

🔗 View Article (PMID 1656276)

Published in Nature on October 17, 1991

Authors

Rudensky AYu1, P Preston-Hurlburt, S C Hong, A Barlow, C A Janeway

Author Affiliations

1: Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510.

Articles citing this

(truncated to the top 100)

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles. J Exp Med (1993) 4.99

Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo. J Exp Med (1993) 3.39

Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J Exp Med (2004) 3.30

Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection. Cell (2013) 3.22

CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells. J Exp Med (2009) 2.75

Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation. Proc Natl Acad Sci U S A (1998) 2.75

Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire. J Exp Med (1994) 2.72

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression. J Exp Med (1993) 2.27

Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways. J Exp Med (2000) 2.25

Melanoma-specific CD4+ T cells recognize nonmutated HLA-DR-restricted tyrosinase epitopes. J Exp Med (1996) 2.17

Separation of subcellular compartments containing distinct functional forms of MHC class II. J Cell Biol (1994) 2.09

T cell priming versus T cell tolerance induced by synthetic peptides. J Exp Med (1995) 2.07

Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells. J Cell Biol (2001) 1.87

Identification of a motif for HLA-DR1 binding peptides using M13 display libraries. J Exp Med (1992) 1.78

Cathepsin S activity regulates antigen presentation and immunity. J Clin Invest (1998) 1.76

Major histocompatibility complex class II compartments in human and mouse B lymphoblasts represent conventional endocytic compartments. J Cell Biol (1997) 1.75

High-affinity binding of short peptides to major histocompatibility complex class II molecules by anchor combinations. Proc Natl Acad Sci U S A (1994) 1.69

The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy. J Exp Med (1994) 1.67

Identification of a MHC class II-restricted human gp100 epitope using DR4-IE transgenic mice. J Immunol (2000) 1.66

Public and private V beta T cell receptor repertoires against hen egg white lysozyme (HEL) in nontransgenic versus HEL transgenic mice. J Exp Med (1994) 1.63

T-cell determinants and antibody binding sites on the major mycobacterial secretory protein MPB59 of Mycobacterium bovis. Infect Immun (1994) 1.59

Comparison of peptides bound to spleen and thymus class II. J Exp Med (1993) 1.59

The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules. J Exp Med (1994) 1.59

MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells. J Exp Med (2013) 1.57

Relationship between invariant chain expression and major histocompatibility complex class II transport into early and late endocytic compartments. J Exp Med (1993) 1.56

Identification of the naturally processed form of hen egg white lysozyme bound to the murine major histocompatibility complex class II molecule I-Ak. Proc Natl Acad Sci U S A (1992) 1.55

Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4. J Clin Invest (1999) 1.53

Clonal V alpha 12.1+ T cell expansions in the peripheral blood of rheumatoid arthritis patients. J Exp Med (1993) 1.47

Robustness trade-offs and host-microbial symbiosis in the immune system. Mol Syst Biol (2006) 1.46

Identification of two distinct properties of class II major histocompatibility complex-associated peptides. Proc Natl Acad Sci U S A (1993) 1.46

T cell determinants from autoantibodies to DNA can upregulate autoimmunity in murine systemic lupus erythematosus. J Exp Med (1995) 1.44

Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles. J Exp Med (1995) 1.44

Crystallographic analysis of endogenous peptides associated with HLA-DR1 suggests a common, polyproline II-like conformation for bound peptides. Proc Natl Acad Sci U S A (1996) 1.42

Cytoplasmic processing is a prerequisite for presentation of an endogenous antigen by major histocompatibility complex class II proteins. J Exp Med (2000) 1.40

Identification of novel IGRP epitopes targeted in type 1 diabetes patients. Clin Immunol (2008) 1.38

Supermotifs enable natural invariant chain-derived peptides to interact with many major histocompatibility complex-class II molecules. J Exp Med (1995) 1.37

Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II. J Exp Med (1995) 1.37

Assembly of HLA DR1 molecules translated in vitro: binding of peptide in the endoplasmic reticulum precludes association with invariant chain. EMBO J (1994) 1.37

Multiplicity of virus-encoded helper T-cell epitopes expressed on FBL-3 tumor cells. J Virol (1993) 1.36

A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex. J Exp Med (1999) 1.36

pH dependence and exchange of high and low responder peptides binding to a class II MHC molecule. EMBO J (1992) 1.36

Major histocompatibility complex class II-transfected tumor cells present endogenous antigen and are potent inducers of tumor-specific immunity. Proc Natl Acad Sci U S A (1997) 1.34

Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines. J Cell Biol (1994) 1.34

Mapping functional regions in the lumenal domain of the class II-associated invariant chain. J Exp Med (1994) 1.32

The segment of invariant chain that is critical for association with major histocompatibility complex class II molecules contains the sequence of a peptide eluted from class II polypeptides. Proc Natl Acad Sci U S A (1993) 1.32

Major histocompatibility complex class II-restricted presentation of an internally synthesized antigen displays cell-type variability and segregates from the exogenous class II and endogenous class I presentation pathways. J Exp Med (1993) 1.28

Mapping of the delayed-type hypersensitivity-inducing epitope of secreted protein MPT64 from Mycobacterium tuberculosis. Infect Immun (1995) 1.27

Endogenous human cytomegalovirus gB is presented efficiently by MHC class II molecules to CD4+ CTL. J Exp Med (2005) 1.26

Arthritis induced in rats with adjuvant oil is a genetically restricted, alpha beta T-cell dependent autoimmune disease. Immunology (1992) 1.24

Kinetics of antigen expression and epitope presentation during virus infection. PLoS Pathog (2013) 1.21

The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function. Immunol Rev (2012) 1.20

T cell responses affected by aminopeptidase N (CD13)-mediated trimming of major histocompatibility complex class II-bound peptides. J Exp Med (1996) 1.19

Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease. J Exp Med (1993) 1.19

Amino acid residues that flank core peptide epitopes and the extracellular domains of CD4 modulate differential signaling through the T cell receptor. J Exp Med (1994) 1.19

Minimum structural requirements for peptide presentation by major histocompatibility complex class II molecules: implications in induction of autoimmunity. Proc Natl Acad Sci U S A (1994) 1.18

Francisella tularensis--a model for studies of the immune response to intracellular bacteria in man. Immunology (1992) 1.18

Amino-terminal trimming of peptides for presentation on major histocompatibility complex class II molecules. Proc Natl Acad Sci U S A (1997) 1.17

Expression of endogenous peptide-major histocompatibility complex class II complexes derived from invariant chain-antigen fusion proteins. Proc Natl Acad Sci U S A (1995) 1.17

Allele specificity of structural requirement for peptides bound to HLA-DRB1*0405 and -DRB1*0406 complexes: implication for the HLA-associated susceptibility to methimazole-induced insulin autoimmune syndrome. J Exp Med (1994) 1.16

Negative selection imparts peptide specificity to the mature T cell repertoire. Proc Natl Acad Sci U S A (2003) 1.16

Rejection of skin allografts by indirect allorecognition of donor class I major histocompatibility complex peptides. J Exp Med (1992) 1.16

Analysis of the primary T-cell response to Sendai virus infection in C57BL/6 mice: CD4+ T-cell recognition is directed predominantly to the hemagglutinin-neuraminidase glycoprotein. J Virol (1994) 1.15

How Do CD4(+) T Cells Detect and Eliminate Tumor Cells That Either Lack or Express MHC Class II Molecules? Front Immunol (2014) 1.14

Identification of a CD4+ T cell-stimulating antigen of pathogenic bacteria by expression cloning. J Exp Med (1995) 1.14

Induction of a major histocompatibility complex class I-restricted cytotoxic T-lymphocyte response to a highly conserved region of human immunodeficiency virus type 1 (HIV-1) gp120 in seronegative humans immunized with a candidate HIV-1 vaccine. J Virol (1994) 1.14

Thymus epithelium induces tissue-specific tolerance. J Exp Med (1993) 1.13

T cell positive selection by a high density, low affinity ligand. Proc Natl Acad Sci U S A (1998) 1.12

CD1c presentation of synthetic glycolipid antigens with foreign alkyl branching motifs. Chem Biol (2007) 1.11

Induction of immunity and oral tolerance with polymorphic class II major histocompatibility complex allopeptides in the rat. Proc Natl Acad Sci U S A (1992) 1.10

Analysis of virus-specific CD4(+) t cells during long-term gammaherpesvirus infection. J Virol (2001) 1.10

A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition. Proc Natl Acad Sci U S A (2004) 1.09

Expression of myosin-class II major histocompatibility complexes in the normal myocardium occurs before induction of autoimmune myocarditis. Proc Natl Acad Sci U S A (1992) 1.09

Evaluating the immunogenicity of protein drugs by applying in vitro MHC binding data and the immune epitope database and analysis resource. Clin Dev Immunol (2013) 1.09

Definition of an HLA-DPw2-restricted epitope on NS3, recognized by a dengue virus serotype-cross-reactive human CD4+ CD8- cytotoxic T-cell clone. J Virol (1993) 1.08

Self-peptide released from class II HLA-DR1 exhibits a hydrophobic two-residue contact motif. J Exp Med (1992) 1.08

Role of lipid trimming and CD1 groove size in cellular antigen presentation. EMBO J (2006) 1.08

T cell recognition of self-human histocompatibility leukocyte antigens (HLA)-DR peptides in context of syngeneic HLA-DR molecules. J Exp Med (1992) 1.06

Identification of T cell epitopes occurring in a meningococcal class 1 outer membrane protein using overlapping peptides assembled with simultaneous multiple peptide synthesis. J Exp Med (1992) 1.06

Immune tolerance to autoantibody-derived peptides delays development of autoimmunity in murine lupus. J Clin Invest (1995) 1.06

Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens. Diabetes (2008) 1.06

Antigen compartmentation and T helper cell tolerance induction. J Exp Med (1996) 1.06

Protective mechanisms by cystatin C in neurodegenerative diseases. Front Biosci (Schol Ed) (2011) 1.05

Comparative analysis of B- and T-cell epitopes of Mycobacterium leprae and Mycobacterium tuberculosis culture filtrate protein 10. Infect Immun (2004) 1.04

Cloning and expression of a Leishmania donovani gene instructed by a peptide isolated from major histocompatibility complex class II molecules of infected macrophages. J Exp Med (1995) 1.04

A mutant human histocompatibility leukocyte antigen DR molecule associated with invariant chain peptides. J Exp Med (1994) 1.02

Endogenous altered peptide ligands can affect peripheral T cell responses. J Exp Med (1996) 1.01

Alum increases antigen uptake, reduces antigen degradation and sustains antigen presentation by DCs in vitro. Immunol Lett (2012) 1.01

CD4⁺CD25⁺Foxp3⁺ regulatory T cell formation requires more specific recognition of a self-peptide than thymocyte deletion. Proc Natl Acad Sci U S A (2011) 1.01

Monocyte-derived dendritic cells exhibit increased levels of lysosomal proteolysis as compared to other human dendritic cell populations. PLoS One (2010) 1.00

Human HLA class I- and HLA class II-restricted cloned cytotoxic T lymphocytes identify a cluster of epitopes on the measles virus fusion protein. J Virol (1993) 0.99

Autoimmune myocarditis induced in mice by cardiac C-protein. Cloning of complementary DNA encoding murine cardiac C-protein and partial characterization of the antigenic peptides. J Clin Invest (1994) 0.99

Age-related oxidative stress compromises endosomal proteostasis. Cell Rep (2012) 0.98

Comparative quantitative mass spectrometry analysis of MHC class II-associated peptides reveals a role of GILT in formation of self-peptide repertoire. PLoS One (2010) 0.98

Attenuated Yersinia pseudotuberculosis carrier vaccine for simultaneous antigen-specific CD4 and CD8 T-cell induction. Infect Immun (2003) 0.98

Physiological functions of endosomal proteolysis. Biochem J (1995) 0.97

B cells induce tolerance by presenting endogenous peptide-IgG on MHC class II molecules via an IFN-gamma-inducible lysosomal thiol reductase-dependent pathway. J Immunol (2008) 0.97

Human CD4-CD8- alpha beta + T-cell receptor T cells recognize different mycobacteria strains in the context of CD1b. Immunology (1995) 0.97

Motifs and supermotifs for MHC class II binding peptides. J Exp Med (1995) 0.96

Negative selection by an endogenous retrovirus promotes a higher-avidity CD4+ T cell response to retroviral infection. PLoS Pathog (2012) 0.95

State of the art and challenges in sequence based T-cell epitope prediction. Immunome Res (2010) 0.95

Articles by these authors

MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics (1987) 54.39

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature (1997) 23.92

Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease. Proc Natl Acad Sci U S A (1981) 10.72

CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XII. THE USE OF CONCENTRATED NORMAL HUMAN SERUM GAMMA GLOBULIN (HUMAN IMMUNE SERUM GLOBULIN) IN THE PREVENTION AND ATTENUATION OF MEASLES. J Clin Invest (1944) 10.24

Innate immunity: the virtues of a nonclonal system of recognition. Cell (1997) 9.42

Phylogenetic perspectives in innate immunity. Science (1999) 9.42

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell (1998) 8.73

STUDIES ON THE PLASMA PROTEINS. V. THE EFFECT OF CONCENTRATED SOLUTIONS OF HUMAN AND BOVINE SERUM ALBUMIN ON BLOOD VOLUME AFTER ACUTE BLOOD LOSS IN MAN. J Clin Invest (1943) 8.26

Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells. J Exp Med (1983) 6.23

Innate immunity: impact on the adaptive immune response. Curr Opin Immunol (1997) 5.62

Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2. J Immunol (1984) 5.51

HISTOLOGICAL AND SEROLOGICAL SEQUENCES IN EXPERIMENTAL HYPERSENSITIVITY. J Exp Med (1947) 5.11

Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma. J Exp Med (1993) 4.99

Characterization of herpes simplex virus-induced deoxyribonucleic acid polymerase. J Biol Chem (1973) 4.30

Specificity and function of T cells bearing gamma delta receptors. Immunol Today (1988) 3.93

Monoclonal antibody against an Ir gene product? J Exp Med (1980) 3.88

Interferon gamma plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance. J Exp Med (1990) 3.45

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library. Nat Med (1999) 3.45

On the complexity of self. Nature (1991) 3.43

Immunoglobulin determinants on the lymphocytes of normal rabbits. I. Demonstration by the mixed antiglobulin reaction of determinants recognized by anti-gamma, anti-mu, anti-Fab and anti-allotype sera, anti-As4 and anti-As6. Immunology (1970) 3.36

Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice. J Exp Med (1996) 3.36

Two different VH gene products make up the T-cell receptors. Scand J Immunol (1976) 3.32

Selective modulation of protein kinase C-theta during T-cell activation. Nature (1997) 3.22

The gamma globulins. 3. The antibody deficiency syndromes. N Engl J Med (1966) 3.03

Designing and maintaining the mature TCR repertoire: the continuum of self-peptide:self-MHC complex recognition. Immunity (1999) 2.89

Intestinal intraepithelial lymphocytes are a distinct set of gamma delta T cells. Nature (1988) 2.89

Cooperative interaction of B lymphocytes with antigen-specific helper T lymphocytes is MHC restricted. Nature (1981) 2.85

Evidence for an immunoglobulin-dependent antigen-specific helper T cell. Proc Natl Acad Sci U S A (1977) 2.72

Induction of autoreactive B cells allows priming of autoreactive T cells. J Exp Med (1991) 2.60

The B cell is the initiating antigen-presenting cell in peripheral lymph nodes. J Immunol (1987) 2.55

TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective. Cell (1993) 2.43

Heat-stable antigen is a costimulatory molecule for CD4 T cell growth. J Exp Med (1992) 2.42

CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells. J Exp Med (1996) 2.42

Receptor-directed focusing of lymphokine release by helper T cells. Nature (1988) 2.41

Implantation of a foetal thymus, restoring immunological competence in a patient with thymic aplasia (Digeorge's syndrome). Lancet (1968) 2.40

Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis. Science (1996) 2.36

Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells: possible role of T cellbound Ia antigens as targets of immunoregulatory T cells. J Immunol (1984) 2.35

Do B cells drive the diversification of immune responses? Immunol Today (1993) 2.31

The role of Fas in autoimmune diabetes. Cell (1997) 2.30

Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression. Immunity (1996) 2.28

Monoclonal antibodies to murine CD3 epsilon define distinct epitopes, one of which may interact with CD4 during T cell activation. J Immunol (1989) 2.24

Differential adhesion molecule requirements for immune surveillance and inflammatory recruitment. Brain (2000) 2.23

ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes Dev (1999) 2.17

Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells. Proc Natl Acad Sci U S A (1996) 2.06

A novel MHC class II epitope expressed in thymic medulla but not cortex. Nature (1989) 2.06

Coclustering of CD4 (L3T4) molecule with the T-cell receptor is induced by specific direct interaction of helper T cells and antigen-presenting cells. Proc Natl Acad Sci U S A (1987) 2.04

Evidence for a physical association of CD4 and the CD3:alpha:beta T-cell receptor. Nature (1987) 2.01

The specific direct interaction of helper T cells and antigen-presenting B cells. Proc Natl Acad Sci U S A (1986) 1.98

An explanation for the protective effect of the MHC class II I-E molecule in murine diabetes. Nature (1989) 1.97

Monoclonal antibody detection of a major self peptide. MHC class II complex. J Immunol (1992) 1.94

Innate immune recognition and control of adaptive immune responses. Semin Immunol (1998) 1.92

Breaking T cell tolerance with foreign and self co-immunogens. A study of autoimmune B and T cell epitopes of cytochrome c. J Immunol (1992) 1.89

Blood and Blood Derivatives-A New Public Health Field. Am J Public Health Nations Health (1946) 1.86

Recognition of a self major histocompatibility complex TL region product by gamma delta T-cell receptors. Proc Natl Acad Sci U S A (1989) 1.84

Cellular cooperation during in vivo anti-hapten antibody responses. I. The effect of cell number on the response. J Immunol (1975) 1.81

IgG anti-DNA autoantibodies within an individual autoimmune mouse are the products of clonal selection. J Immunol (1989) 1.81

Signalling interactions during facial development. Mech Dev (1998) 1.74

Screening for inherited diseases. N Engl J Med (1971) 1.73

An ancient system of host defense. Curr Opin Immunol (1998) 1.73

Mapping of functional organization in human visual cortex: electrical cortical stimulation. Neurology (2000) 1.72

Co-stimulation of murine CD4 T cell growth: cooperation between B7 and heat-stable antigen. Eur J Immunol (1992) 1.72

Frontiers of the immune system. Nature (1988) 1.70

The response in vitro of human lymphocytes to phytohemagglutinin and to antigens after fractionation on discontinuous density gradients of albumin. Cell Immunol (1970) 1.70

The Fab fragment of a directly activating monoclonal antibody that precipitates a disulfide-linked heterodimer from a helper T cell clone blocks activation by either allogeneic Ia or antigen and self-Ia. J Exp Med (1984) 1.69

Activity of migration inhibitory factor in the absence of antigen. J Immunol (1972) 1.68

Cloned helper T cells can kill B lymphoma cells in the presence of specific antigen: Ia restriction and cognate vs. noncognate interactions in cytolysis. Eur J Immunol (1984) 1.66

Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs. Nature (1992) 1.65

Absence of an antigen-specific helper T cell required for the expression of the T 15 idiotype in mice treated with anti-mu antibody. Eur J Immunol (1980) 1.62

CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XXXVI. INACTIVATION OF THE VIRUS OF HOMOLOGOUS SERUM HEPATITIS IN SOLUTIONS OF NORMAL HUMAN SERUM ALBUMIN BY MEANS OF HEAT. J Clin Invest (1948) 1.60

Induction of receptors for interleukin 2 requires T cell Ag:Ia receptor crosslinking and interleukin 1. Lymphokine Res (1984) 1.57

T-cell development. Accessories or coreceptors? Nature (1988) 1.56

Anterior distribution of human olfactory epithelium. Laryngoscope (2000) 1.55

Bacterial proteins that mediate the association of a defined subset of T cell receptor:CD4 complexes with class II MHC. J Immunol (1990) 1.54

Microbial induction of co-stimulatory activity for CD4 T-cell growth. Int Immunol (1991) 1.54

Immunoglobulin determinants on the lymphocytes of normal rabbits. 3. As4 and As6 determinants on individual lymphocytes and the concept of allelic exclusion. Immunology (1971) 1.54

Immune response gene function correlates with the expression of an Ia antigen. I. Preferential association of certain Ae and E alpha chains results in a quantitative deficiency in expression of an Ae:E alpha complex. J Exp Med (1982) 1.53

Autocrine growth inhibition of a cloned line of helper T cells. Proc Natl Acad Sci U S A (1986) 1.51

Seroprevalence of toxoplasmosis in the residents of Cheju island, Korea. Korean J Parasitol (2000) 1.51

Two distinct antigen-specific suppressor factors induced by the oral administration of antigen. J Exp Med (1980) 1.50

Functional heterogeneity among the T-derived lymphocytes of the mouse. IV. Nature of spontaneously induced suppressor cells. J Immunol (1975) 1.49

The expression of I-Ed molecules in F1 hybrid mice detected with antigen-specific, I-Ed-restricted cloned T-cell lines. Immunogenetics (1984) 1.48

Immune response gene function correlates with the expression of an Ia antigen. II. A quantitative deficiency in Ae:E alpha complex expression causes a corresponding defect in antigen-presenting cell function. J Exp Med (1982) 1.47

Synthetic antigens composed exclusively of L- or D-amino acids. I. Effect of optical configuration on the immunogenicity of synthetic polypeptides in mice. Immunology (1967) 1.47

Diversity in T-cell receptor gamma gene usage in intestinal epithelium. Proc Natl Acad Sci U S A (1989) 1.46

Transgenic mice demonstrate that epithelial homing of gamma/delta T cells is determined by cell lineages independent of T cell receptor specificity. J Exp Med (1990) 1.45

The role of L3T4 in T cell activation: L3T4 may be both an Ia-binding protein and a receptor that transduces a negative signal. J Mol Cell Immunol (1986) 1.45

An analysis of the defective response of CBA/N mice to T-dependent antigens. J Immunol (1975) 1.45

Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells. Proc Natl Acad Sci U S A (1992) 1.44

Treatment of l(2)mbn Drosophila tumorous blood cells with the steroid hormone ecdysone amplifies the inducibility of antimicrobial peptide gene expression. Insect Biochem Mol Biol (1997) 1.43

Histological observations of bovine tuberculosis in lung and lymph node tissues from British deer. Vet J (2007) 1.42

Single-stage operation for bilateral middle cerebral artery aneurysms. Acta Neurochir (Wien) (2005) 1.42

A B-cell receptor-specific selection step governs immature to mature B cell differentiation. Proc Natl Acad Sci U S A (2000) 1.42

T cells with two functional antigen-specific receptors. Proc Natl Acad Sci U S A (1995) 1.41

The gamma globulins. 3. The antibody deficiency syndromes. N Engl J Med (1966) 1.40

Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells. J Exp Med (1996) 1.39