Published in Am J Respir Cell Mol Biol on March 01, 1995
Susceptibility of Chlamydia trachomatis to protegrins and defensins. Infect Immun (1996) 2.16
Antimicrobial peptides: natural effectors of the innate immune system. Semin Immunopathol (2007) 1.43
ADP ribosylation of human neutrophil peptide-1 regulates its biological properties. Proc Natl Acad Sci U S A (2002) 1.34
Dying and necrotic neutrophils are anti-inflammatory secondary to the release of alpha-defensins. J Immunol (2009) 1.21
Neutrophil alpha-defensins cause lung injury by disrupting the capillary-epithelial barrier. Am J Respir Crit Care Med (2010) 1.10
Porcine epithelial beta-defensin 1 is expressed in the dorsal tongue at antimicrobial concentrations. Infect Immun (1999) 1.06
Ocular surface expression and in vitro activity of antimicrobial peptides. Curr Eye Res (2007) 1.06
Association of defensin beta-1 gene polymorphisms with asthma. J Allergy Clin Immunol (2005) 1.03
Defensins and other antimicrobial peptides at the ocular surface. Ocul Surf (2004) 1.00
Human neutrophil peptides: a novel potential mediator of inflammatory cardiovascular diseases. Am J Physiol Heart Circ Physiol (2008) 0.99
Modular determinants of antimicrobial activity in platelet factor-4 family kinocidins. Biochim Biophys Acta (2006) 0.94
Small, anionic, and charge-neutralizing propeptide fragments of zymogens are antimicrobial. Antimicrob Agents Chemother (1997) 0.91
The role of protegrins and other elastase-activated polypeptides in the bactericidal properties of porcine inflammatory fluids. Infect Immun (1998) 0.90
In vitro activity of human beta-defensin 2 against Pseudomonas aeruginosa in the presence of tear fluid. Antimicrob Agents Chemother (2007) 0.88
alpha1-antitrypsin and its C-terminal fragment attenuate effects of degranulated neutrophil-conditioned medium on lung cancer HCC cells, in vitro. Cancer Cell Int (2004) 0.87
alpha1-Antitrypsin deficiency . 6: new and emerging treatments for alpha1-antitrypsin deficiency. Thorax (2004) 0.86
Human neutrophil peptides and phagocytic deficiency in bronchiectatic lungs. Am J Respir Crit Care Med (2009) 0.86
Role of defensins in the pathogenesis of chronic lung allograft rejection. Hum Immunol (2013) 0.84
Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study. Respir Res (2006) 0.83
Krüppel-like zinc finger proteins in end-stage COPD lungs with and without severe alpha1-antitrypsin deficiency. Orphanet J Rare Dis (2012) 0.80
Biomaterials selectively modulate interactions between human blood-derived polymorphonuclear leukocytes and monocytes. Am J Pathol (2013) 0.78
Two-dimensional gel electrophoresis analysis in simultaneous influenza pneumonia and bacterial infection in mice. Clin Exp Immunol (2008) 0.78
In vitro studies on the antimicrobial peptide human beta-defensin 9 (HBD9): signalling pathways and pathogen-related response (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc (2014) 0.75
The Role and Function of Fcγ Receptors on Myeloid Cells. Microbiol Spectr (2016) 0.75
Poly(ethylene glycol)-containing hydrogels promote the release of primary granules from human blood-derived polymorphonuclear leukocytes. J Biomed Mater Res A (2014) 0.75
Targeting and inactivation of bacterial toxins by human defensins. Biol Chem (2017) 0.75
Defensins. Natural peptide antibiotics of human neutrophils. J Clin Invest (1985) 8.63
Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem (2000) 8.39
Defensins: antimicrobial and cytotoxic peptides of mammalian cells. Annu Rev Immunol (1993) 5.36
Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. J Clin Invest (1989) 5.21
An antimicrobial activity of cytolytic T cells mediated by granulysin. Science (1998) 5.02
Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. Proc Natl Acad Sci U S A (1990) 3.90
Production of beta-defensins by human airway epithelia. Proc Natl Acad Sci U S A (1998) 3.85
Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. J Clin Invest (1998) 3.78
Primary structures of three human neutrophil defensins. J Clin Invest (1985) 3.70
Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3. Blood (2001) 3.49
Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium. J Immunol (1999) 3.39
The multifaceted Paneth cell. Cell Mol Life Sci (2002) 3.11
Antimicrobial peptides in mammalian and insect host defence. Curr Opin Immunol (1999) 3.05
A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease. J Allergy Clin Immunol (1990) 2.98
IFN-gamma-induced L-arginine-dependent toxoplasmastatic activity in murine peritoneal macrophages is mediated by endogenous tumor necrosis factor-alpha. J Immunol (1992) 2.73
Innate immunity in the lung: how epithelial cells fight against respiratory pathogens. Eur Respir J (2004) 2.70
Neutrophil serine proteinases and defensins in chronic obstructive pulmonary disease: effects on pulmonary epithelium. Eur Respir J (1998) 2.51
Monocyte-chemotactic activity of defensins from human neutrophils. J Clin Invest (1989) 2.50
Defensins: endogenous antibiotic peptides of animal cells. Cell (1991) 2.45
Cutting edge: IFN-inducible ELR- CXC chemokines display defensin-like antimicrobial activity. J Immunol (2001) 2.38
Concurrent assessment of inner and outer membrane permeabilization and bacteriolysis in E. coli by multiple-wavelength spectrophotometry. J Immunol Methods (1988) 2.31
Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics from rabbit leukocytes. J Virol (1985) 2.31
Defensins and other endogenous peptide antibiotics of vertebrates. J Leukoc Biol (1995) 2.25
Broad-spectrum antimicrobial activity of human intestinal defensin 5. Infect Immun (1997) 2.22
Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations. J Clin Invest (1988) 2.18
Innate antimicrobial activity of nasal secretions. Infect Immun (1999) 2.13
Discovery of new human beta-defensins using a genomics-based approach. Gene (2001) 2.08
Extracellular release of antimicrobial defensins by human polymorphonuclear leukocytes. Infect Immun (1987) 2.07
Activity of rabbit leukocyte peptides against Candida albicans. Infect Immun (1985) 2.05
Repeatability of cellular and soluble markers of inflammation in induced sputum from patients with asthma. Eur Respir J (1996) 2.05
In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes. Blood (1986) 2.01
Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation. Gene (1998) 1.99
Antimicrobial polypeptides of human neutrophils. Blood (1990) 1.98
Neutrophils and host defense. Ann Intern Med (1988) 1.92
Correlation of binding of rabbit granulocyte peptides to Candida albicans with candidacidal activity. Infect Immun (1985) 1.89
Neutrophil defensins: purification, characterization, and antimicrobial testing. Methods Enzymol (1994) 1.88
The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry. Genomics (1997) 1.86
Localization of human intestinal defensin 5 in Paneth cell granules. Infect Immun (1997) 1.84
In vitro killing of spores and hyphae of Aspergillus fumigatus and Rhizopus oryzae by rabbit neutrophil cationic peptides and bronchoalveolar macrophages. J Infect Dis (1986) 1.84
Determinants of Staphylococcus aureus nasal carriage. Clin Diagn Lab Immunol (2001) 1.80
Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin-8 in nasal lavage in asthmatic subjects in vivo. Clin Exp Allergy (1997) 1.76
Posttranslational processing of defensins in immature human myeloid cells. Blood (1992) 1.68
Antibacterial properties of eosinophil major basic protein and eosinophil cationic protein. J Immunol (1989) 1.64
Mechanism of target cytolysis by peptide defensins. Target cell metabolic activities, possibly involving endocytosis, are crucial for expression of cytotoxicity. J Immunol (1988) 1.64
Interleukin-8 stimulates cell proliferation in non-small cell lung cancer through epidermal growth factor receptor transactivation. Lung Cancer (2006) 1.61
Isolation and characterization of human defensin cDNA clones. Proc Natl Acad Sci U S A (1988) 1.61
Relation between duration of smoking cessation and bronchial inflammation in COPD. Thorax (2005) 1.60
Defensin-rich dense granules of human neutrophils. Blood (1987) 1.59
Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD. Eur Respir J (2008) 1.59
Transforming growth factor beta1 and recruitment of macrophages and mast cells in airways in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (1998) 1.59
Localized antimicrobial peptide expression in human gingiva. J Periodontal Res (2001) 1.58
Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis. J Lab Clin Med (1993) 1.57
Imaging of bacterial infections with 99mTc-labeled human neutrophil peptide-1. J Nucl Med (1999) 1.57
CD24(hi)CD27(+) B cells from patients with allergic asthma have impaired regulatory activity in response to lipopolysaccharide. Clin Exp Allergy (2014) 1.56
Experimental rhinovirus 16 infection. Effects on cell differentials and soluble markers in sputum in asthmatic subjects. Am J Respir Crit Care Med (1997) 1.55
Monocyte chemoattractant protein 1, interleukin 8, and chronic airways inflammation in COPD. J Pathol (2000) 1.54
Defensins: a family of antimicrobial and cytotoxic peptides. Toxicology (1994) 1.53
Purification and antimicrobial properties of three defensins from rat neutrophils. Infect Immun (1989) 1.46
Variation in the tumour necrosis factor gene is not associated with susceptibility to COPD. Eur Respir J (2007) 1.45
Defensins and innate host defence of the gastrointestinal tract. Gut (1999) 1.41
Porcine polymorphonuclear leukocytes generate extracellular microbicidal activity by elastase-mediated activation of secreted proprotegrins. Infect Immun (1997) 1.40
Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from wounds. Blood (2001) 1.39
Granulysin, a T cell product, kills bacteria by altering membrane permeability. J Immunol (2000) 1.39
Antileukoprotease: an endogenous protein in the innate mucosal defense against fungi. J Infect Dis (1997) 1.39
Activation of the alternative pathway of complement by human serum IgA. Eur J Immunol (1987) 1.38
Effect of defensins on interleukin-8 synthesis in airway epithelial cells. Am J Physiol (1997) 1.34
Regulation of human beta-defensins by gastric epithelial cells in response to infection with Helicobacter pylori or stimulation with interleukin-1. Infect Immun (2000) 1.33
In human epidermis, beta-defensin 2 is packaged in lamellar bodies. Exp Mol Pathol (2003) 1.33
Intramolecular inhibition of human defensin HNP-1 by its propiece. J Clin Invest (1996) 1.32
Activity of defensins from human neutrophilic granulocytes against Mycobacterium avium-Mycobacterium intracellulare. Infect Immun (1992) 1.32
Impaired innate immunity in the newborn: newborn neutrophils are deficient in bactericidal/permeability-increasing protein. Pediatrics (1999) 1.31
Activated alpha 2-macroglobulin is a principal defensin-binding protein. Am J Respir Cell Mol Biol (1991) 1.30
IgA- and secretory IgA-opsonized S. aureus induce a respiratory burst and phagocytosis by polymorphonuclear leucocytes. Immunology (1987) 1.30
Defensins mediate the microbicidal activity of human neutrophil granule extract against Acinetobacter calcoaceticus. Infect Immun (1987) 1.27
Regulation of secretory leukocyte proteinase inhibitor (SLPI) production by human bronchial epithelial cells: increase of cell-associated SLPI by neutrophil elastase. J Investig Med (2000) 1.26
Isolation of human intestinal defensins from ileal neobladder urine. FEBS Lett (1998) 1.26
Chronic obstructive pulmonary disease: role of bronchiolar mast cells and macrophages. Am J Pathol (1997) 1.25
Antibacterial activity of human neutrophil defensins in experimental infections in mice is accompanied by increased leukocyte accumulation. J Clin Invest (1998) 1.25
Induction of SLPI (ALP/HUSI-I) in epidermal keratinocytes. J Invest Dermatol (1998) 1.24
Endogenous vertebrate antibiotics. Defensins, protegrins, and other cysteine-rich antimicrobial peptides. Ann N Y Acad Sci (1996) 1.22
Proteases from Aspergillus fumigatus induce release of proinflammatory cytokines and cell detachment in airway epithelial cell lines. J Infect Dis (1997) 1.21
Defensins: key players or bystanders in infection, injury, and repair in the lung? J Allergy Clin Immunol (1999) 1.21
Direct cytotoxicity of polymorphonuclear leukocyte granule proteins to human lung-derived cells and endothelial cells. Am Rev Respir Dis (1990) 1.21
Oxygen-independent bactericidal systems. Mechanisms and disorders. Hematol Oncol Clin North Am (1988) 1.21
The structure of porcine protegrin genes. FEBS Lett (1995) 1.19
Molecular cloning of the rat metallothionein 1 (MT-1) mRNA sequence. DNA (1983) 1.17
Newborn rabbit alveolar macrophages are deficient in two microbicidal cationic peptides, MCP-1 and MCP-2. Am Rev Respir Dis (1985) 1.17
Analysis of neutrophil-derived antimicrobial peptides in gingival crevicular fluid suggests importance of cathelicidin LL-37 in the innate immune response against periodontogenic bacteria. Oral Microbiol Immunol (2008) 1.17
Anti-endothelial cell antibodies in patients with rheumatoid arthritis complicated by vasculitis. Clin Exp Immunol (1989) 1.17
The opsonizing ligand on Salmonella typhimurium influences incorporation of specific, but not azurophil, granule constituents into neutrophil phagosomes. J Cell Biol (1989) 1.16
Cationic defensins arise from charge-neutralized propeptides: a mechanism for avoiding leukocyte autocytotoxicity? J Leukoc Biol (1992) 1.16
Protegrins: new antibiotics of mammalian origin. Expert Opin Investig Drugs (2000) 1.15
Effect of neutrophil serine proteinases and defensins on lung epithelial cells: modulation of cytotoxicity and IL-8 production. J Leukoc Biol (1997) 1.14
Proteinase 3, the major autoantigen of Wegener's granulomatosis, enhances IL-8 production by endothelial cells in vitro. J Am Soc Nephrol (1996) 1.14
Purification and characterization of a major phosphatidylserine-binding phosphoprotein from human platelets. Biochem J (1990) 1.14
In vitro sensitivity of oral, gram-negative, facultative bacteria to the bactericidal activity of human neutrophil defensins. Infect Immun (1990) 1.13
Initiation of apoptosis by actin cytoskeletal derangement in human airway epithelial cells. Am J Respir Cell Mol Biol (2001) 1.13
A 450-kb contig of defensin genes on human chromosome 8p23. Gene (1999) 1.12
An enzyme immunoassay for human defensins. J Immunol Methods (1991) 1.12