Published in Biochemistry on March 14, 1995
The struggle by Caenorhabditis elegans to maintain proteostasis during aging and disease. Biol Direct (2016) 0.80
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell (1994) 9.73
All ras proteins are polyisoprenylated but only some are palmitoylated. Cell (1989) 9.68
Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature (1994) 6.16
A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane. Cell (1990) 6.08
Activation of the MAP kinase pathway by the protein kinase raf. Cell (1992) 5.95
The mechanism of Z alpha 1-antitrypsin accumulation in the liver. Nature (1992) 5.71
The relationship of depression to cardiovascular disease: epidemiology, biology, and treatment. Arch Gen Psychiatry (1998) 4.83
The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature. J Biol Chem (2001) 4.81
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1. EMBO J (1994) 4.37
The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product. Nature (1988) 4.33
Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation. EMBO J (1995) 4.17
Structure and variation of human alpha 1-antitrypsin. Nature (1982) 4.13
Structure of a serpin-protease complex shows inhibition by deformation. Nature (2000) 4.02
Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein. EMBO J (1992) 4.00
Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1. Nature (1983) 3.86
Involvement of p21ras in activation of extracellular signal-regulated kinase 2. Nature (1992) 3.78
Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1. Nature (1998) 3.67
A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins. EMBO J (1991) 3.64
Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Mol Cell Biol (1998) 3.58
Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis. EMBO J (1989) 3.51
Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production. Nature (1986) 3.41
Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins. Biochemistry (1989) 3.18
The anticoagulant activation of antithrombin by heparin. Proc Natl Acad Sci U S A (1997) 3.09
EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Curr Biol (1994) 3.06
Dynamic fatty acylation of p21N-ras. EMBO J (1987) 2.99
Analysis of RAS gene mutations in acute myeloid leukemia by polymerase chain reaction and oligonucleotide probes. Proc Natl Acad Sci U S A (1988) 2.99
Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia. Nature (1985) 2.90
Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf. Methods Enzymol (1995) 2.82
Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation. EMBO J (1999) 2.79
The estimation of red cell superoxide dismutase activity. J Lab Clin Med (1975) 2.75
Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility. EMBO J (2001) 2.66
Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2. EMBO J (1995) 2.51
Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases. J Biol Chem (1997) 2.47
Impact of stressful life events, depression, social support, coping, and cortisol on progression to AIDS. Am J Psychiatry (2000) 2.40
Mutation of antitrypsin to antithrombin. alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorder. N Engl J Med (1983) 2.36
Progression to AIDS: the effects of stress, depressive symptoms, and social support. Psychosom Med (1999) 2.36
Progression to AIDS, a clinical AIDS condition and mortality: psychosocial and physiological predictors. Psychol Med (2002) 2.34
Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2. Curr Biol (1998) 2.33
Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry. Biochim Biophys Acta (1992) 2.33
rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivo. EMBO J (1993) 2.31
Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique. Cancer Res (1991) 2.30
What do dysfunctional serpins tell us about molecular mobility and disease? Nat Struct Biol (1995) 2.30
DNA in medicine. Oncogenes. Lancet (1984) 2.28
Post-translational modifications of p21rho proteins. J Biol Chem (1992) 2.17
Methylation and proteolysis are essential for efficient membrane binding of prenylated p21K-ras(B). EMBO J (1991) 2.09
Markers of neoplastic transformation in epithelial cell lines derived from human carcinomas. J Natl Cancer Inst (1977) 2.07
Variations in the structure of human haemoglobin. With particular reference to the unstable haemoglobins. Br Med Bull (1969) 2.07
Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C. Science (1998) 2.06
Smoking, lung function, and alpha 1-antitrypsin deficiency. Lancet (1985) 1.99
Familial dementia caused by polymerization of mutant neuroserpin. Nature (1999) 1.88
A simple method for the detection of unstable haemoglobins. Br J Haematol (1972) 1.87
Mesoderm induction in Xenopus caused by activation of MAP kinase. Nature (1995) 1.86
Factors influencing the epidemiology of Helicobacter pylori infection in children. Pediatrics (1991) 1.82
Lysophosphatidic acid stimulates mitogen-activated protein kinase activation via a G-protein-coupled pathway requiring p21ras and p74raf-1. J Biol Chem (1993) 1.79
Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals. Mol Cell Biol (1999) 1.77
Control of the ERK MAP kinase cascade by Ras and Raf. Cancer Surv (1996) 1.74
A dominant-negative mutant of raf blocks mitogen-activated protein kinase activation by growth factors and oncogenic p21ras. J Biol Chem (1993) 1.74
Loss of heterozygosity in familial tumors from three BRCA1-linked kindreds. Cancer Res (1994) 1.71
A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway. EMBO J (1994) 1.68
A transforming gene present in human sarcoma cell lines. Nature (1982) 1.67
Reactions involving superoxide and normal and unstable haemoglobins. Biochem J (1976) 1.66
Inhibitory conformation of the reactive loop of alpha 1-antitrypsin. Nat Struct Biol (1996) 1.66
Biochemical and biological properties of the human N-ras p21 protein. Mol Cell Biol (1987) 1.65
alpha 1-Antitrypsin: molecular pathology, leukocytes, and tissue damage. J Clin Invest (1986) 1.61
Mechanism of activation of an N-ras gene in the human fibrosarcoma cell line HT1080. EMBO J (1984) 1.56
Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease. Proc Natl Acad Sci U S A (2000) 1.54
Personality disorder in patients infected with HIV: a controlled study with implications for clinical care. Am J Psychiatry (1993) 1.53
A circulating variant of human proalbumin. Nature (1978) 1.52
Crystal structure of uncleaved ovalbumin at 1.95 A resolution. J Mol Biol (1991) 1.52
Scrape-loading of Swiss 3T3 cells with ras protein rapidly activates protein kinase C in the absence of phosphoinositide hydrolysis. Oncogene (1989) 1.50
Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin. Biochemistry (1993) 1.49
Hormone binding globulins undergo serpin conformational change in inflammation. Nature (1988) 1.47
The sevenmaker gain-of-function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action. FEBS Lett (1994) 1.47
Transformation and stimulation of DNA synthesis in NIH-3T3 cells are a titratable function of normal p21N-ras expression. EMBO J (1986) 1.46
Abnormal haem binding and globin SH group blockade in unstable haemoglobins. Nature (1968) 1.44
Plakalbumin, alpha 1-antitrypsin, antithrombin and the mechanism of inflammatory thrombosis. Nature (1985) 1.44
The influence of the MAPK pathway on T cell lineage commitment. Immunity (1997) 1.43
Behavioral stimulation associated with risperidone initiation. Am J Psychiatry (1995) 1.43
Crystal structure of ovalbumin as a model for the reactive centre of serpins. Nature (1990) 1.42
Alpha 1-antitrypsin Siiyama (Ser53-->Phe). Further evidence for intracellular loop-sheet polymerization. J Biol Chem (1993) 1.41
Activated oxygen and haemolysis. Br J Haematol (1975) 1.41
Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein. Curr Biol (1997) 1.41
Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells. Oncogene (1999) 1.41
CLINICAL EXPERIENCES WITH PERCAIN, A NEW LOCAL ANAESTHETIC. Br Med J (1930) 1.40
The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion. Structure (1999) 1.40
A new hemoglobin variant resembling hemoglobin E. Hemoglobin E Saskatoon: beta-22 Glu replaced by Lys. Can J Biochem (1967) 1.40
Activation of c-Ha-ras-1 proto-oncogene by in vitro modification with a chemical carcinogen, benzo(a)pyrene diol-epoxide. Nature (1984) 1.40
Cost savings controversy. J Ophthalmic Nurs Technol (1991) 1.39
Psychopharmacological screening criteria. APA Committee on Research on Psychiatric Treatments. J Clin Psychiatry (1992) 1.39
Studies of hemoglobin denaturation and Heinz body formation in the unstable hemoglobins. J Clin Invest (1974) 1.39
The urease ELISA for H-Y antibody. A cautionary tale. J Immunol Methods (1990) 1.38
Maintenance of long-term potentiation in rat dentate gyrus requires protein synthesis but not messenger RNA synthesis immediately post-tetanization. Neuroscience (1989) 1.37
Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling. Mol Cell Biol (2001) 1.37
Mutant but not normal p21 ras elevates inositol phospholipid breakdown in two different cell systems. Oncogene (1988) 1.37
Activated MEK stimulates expression of AP-1 components independently of phosphatidylinositol 3-kinase (PI3-kinase) but requires a PI3-kinase signal To stimulate DNA synthesis. Mol Cell Biol (1999) 1.37