Published in Mol Cell Biol on April 01, 1995
The V protein of simian virus 5 inhibits interferon signalling by targeting STAT1 for proteasome-mediated degradation. J Virol (1999) 4.99
Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination. Proc Natl Acad Sci U S A (1995) 4.16
Identification, analysis, and prediction of protein ubiquitination sites. Proteins (2010) 2.53
N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity. Mol Cell Biol (1995) 2.12
Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability. Mol Cell Biol (1996) 1.90
Both amino- and carboxyl-terminal sequences within I kappa B alpha regulate its inducible degradation. Mol Cell Biol (1996) 1.73
Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factors. Microbiol Rev (1995) 1.63
Basal phosphorylation of the PEST domain in the I(kappa)B(beta) regulates its functional interaction with the c-rel proto-oncogene product. Mol Cell Biol (1996) 1.33
I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain. Mol Cell Biol (1997) 1.31
Inhibition of I kappa B-alpha phosphorylation and degradation and subsequent NF-kappa B activation by glutathione peroxidase overexpression. J Cell Biol (1996) 1.26
Brush border myosin-I truncated in the motor domain impairs the distribution and the function of endocytic compartments in an hepatoma cell line. Proc Natl Acad Sci U S A (1996) 1.19
Signal-induced degradation of I(kappa)B(alpha): association with NF-kappaB and the PEST sequence in I(kappa)B(alpha) are not required. Mol Cell Biol (1996) 1.17
Transdominant mutants of I kappa B alpha block Tat-tumor necrosis factor synergistic activation of human immunodeficiency virus type 1 gene expression and virus multiplication. J Virol (1996) 1.11
IkappaB-mediated inhibition of virus-induced beta interferon transcription. J Virol (1999) 1.09
Potentiation of tumor necrosis factor-induced NF-kappa B activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of I kappa B alpha. Mol Cell Biol (2003) 1.04
Control of NF-kappa B transcriptional activation by signal induced proteolysis of I kappa B alpha. Philos Trans R Soc Lond B Biol Sci (1999) 1.02
Identification by in vivo genomic footprinting of a transcriptional switch containing NF-kappaB and Sp1 that regulates the IkappaBalpha promoter. Mol Cell Biol (1999) 1.00
A structural guide to proteins of the NF-kappaB signaling module. Cold Spring Harb Perspect Biol (2009) 0.99
Domain organization of the adenovirus preterminal protein. J Virol (1997) 0.99
Caspase-3-mediated cleavage of p65/RelA results in a carboxy-terminal fragment that inhibits IkappaBalpha and enhances HIV-1 replication in human T lymphocytes. Retrovirology (2008) 0.96
Interaction between hnRNPA1 and IkappaBalpha is required for maximal activation of NF-kappaB-dependent transcription. Mol Cell Biol (2001) 0.92
Role of preterminal protein processing in adenovirus replication. J Virol (1997) 0.90
The signal response of IkappaB alpha is regulated by transferable N- and C-terminal domains. Mol Cell Biol (1997) 0.90
Distinct domains of IkappaBalpha regulate c-Rel in the cytoplasm and in the nucleus. Mol Cell Biol (1998) 0.89
A multimeric complex and the nuclear targeting of the Drosophila Rel protein Dorsal. Proc Natl Acad Sci U S A (1997) 0.87
Nuclear magnetic resonance assignment and secondary structure of an ankyrin-like repeat-bearing protein: myotrophin. Protein Sci (1997) 0.82
The ORF61 Protein Encoded by Simian Varicella Virus and Varicella-Zoster Virus Inhibits NF-κB Signaling by Interfering with IκBα Degradation. J Virol (2015) 0.80
I(kappa)B(gamma) inhibits DNA binding of NF-kappaB p50 homodimers by interacting with residues that contact DNA. Mol Cell Biol (1996) 0.78
Structural modeling of the N-terminal signal-receiving domain of IκBα. Front Mol Biosci (2015) 0.75
Regulation and function of nuclear IκBα in inflammation and cancer. Am J Clin Exp Immunol (2012) 0.75
Dynamic phosphorylation of RelA on Ser42 and Ser45 in response to TNFα stimulation regulates DNA binding and transcription. Open Biol (2016) 0.75
Phytochemicals as potential antidotes for targeting NF-κB in rheumatoid arthritis. 3 Biotech (2017) 0.75
I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science (1988) 16.40
Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J (1991) 11.86
The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B. Cell (1994) 11.62
The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product. Cell (1990) 9.37
Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal. Cell (1990) 9.24
NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway. Science (1993) 9.03
Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation. Mol Cell Biol (1993) 6.79
Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B. Nature (1993) 6.75
DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide. Cell (1991) 6.63
Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity. Cell (1991) 6.49
The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B. EMBO J (1991) 6.08
I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention. Genes Dev (1992) 5.67
Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B. Science (1991) 5.52
Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65. Nature (1991) 5.07
Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha. Proc Natl Acad Sci U S A (1993) 4.99
Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins. Nature (1990) 4.59
Regulation of the NF-kappa B/rel transcription factor and I kappa B inhibitor system. Curr Opin Cell Biol (1993) 4.29
Nucleic acid sequences of the oncogene v-rel in reticuloendotheliosis virus strain T and its cellular homolog, the proto-oncogene c-rel. J Virol (1984) 4.17
RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B. Mol Cell Biol (1992) 4.03
B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa B p50. Cell (1991) 3.84
Rel-associated pp40: an inhibitor of the rel family of transcription factors. Science (1991) 3.76
Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa B subunit. Cell (1992) 3.73
A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site. Mol Cell Biol (1992) 3.63
Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappa B. Genes Dev (1992) 3.47
I kappa B gamma, a 70 kd protein identical to the C-terminal half of p110 NF-kappa B: a new member of the I kappa B family. Cell (1992) 3.25
Autoregulation of I kappa B alpha activity. Proc Natl Acad Sci U S A (1994) 3.24
In vivo control of NF-kappa B activation by I kappa B alpha. EMBO J (1993) 3.11
Cytokine-inducible expression in endothelial cells of an I kappa B alpha-like gene is regulated by NF kappa B. EMBO J (1993) 2.75
Promoter analysis of the gene encoding the I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B family. EMBO J (1993) 2.71
Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells. J Biol Chem (1993) 2.70
Cytoplasmic retention, DNA binding and processing of the NF-kappa B p50 precursor are controlled by a small region in its C-terminus. EMBO J (1991) 2.39
Direct association of pp40/I kappa B beta with rel/NF-kappa B transcription factors: role of ankyrin repeats in the inhibition of DNA binding activity. Proc Natl Acad Sci U S A (1992) 2.29
Rapid induction in regenerating liver of RL/IF-1 (an I kappa B that inhibits NF-kappa B, RelB-p50, and c-Rel-p50) and PHF, a novel kappa B site-binding complex. Mol Cell Biol (1992) 2.27
Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins. Cell (1992) 2.21
The NF-kappa B p50 precursor, p105, contains an internal I kappa B-like inhibitor that preferentially inhibits p50. EMBO J (1992) 2.19
Proteolytic degradation of MAD3 (I kappa B alpha) and enhanced processing of the NF-kappa B precursor p105 are obligatory steps in the activation of NF-kappa B. Nucleic Acids Res (1993) 2.08
The I kappa B proteins: members of a multifunctional family. Trends Genet (1993) 1.96
Common structural constituents confer I kappa B activity to NF-kappa B p105 and I kappa B/MAD-3. EMBO J (1993) 1.77
Construction of solid matrix-antibody-antigen complexes containing simian immunodeficiency virus p27 using tag-specific monoclonal antibody and tag-linked antigen. J Gen Virol (1992) 1.57
Role of cysteine62 in DNA recognition by the P50 subunit of NF-kappa B. Nucleic Acids Res (1993) 1.43
Sequence requirement for specific interaction of an enhancer binding protein (EBP1) with DNA. Nucleic Acids Res (1989) 1.29
Enhancer binding protein (EBP1) makes base and backbone contacts over one complete turn of the DNA double helix. J Mol Biol (1989) 1.19
Interaction of the C-terminal region of p105 with the nuclear localisation signal of p50 is required for inhibition of NF-kappa B DNA binding activity. Nucleic Acids Res (1993) 1.07
GAL4-I kappa B alpha and GAL4-I kappa B gamma activate transcription by different mechanisms. Nucleic Acids Res (1993) 0.83
Control of nuclear factor-kappa B DNA-binding activity by inhibitory proteins containing ankyrin repeats. Biochem Soc Trans (1993) 0.81
SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation. Mol Cell (1998) 6.62
Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. J Biol Chem (2001) 5.04
SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting. J Biol Chem (2000) 4.96
Initiation of SV40 DNA replication in vivo: location and structure of 5' ends of DNA synthesized in the ori region. Cell (1982) 4.50
SUMO-1 modification activates the transcriptional response of p53. EMBO J (1999) 4.19
Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62. Nucleic Acids Res (1992) 3.22
Ubch9 conjugates SUMO but not ubiquitin. FEBS Lett (1997) 2.73
Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation. Mol Cell Biol (2000) 2.72
Inducible nuclear expression of newly synthesized I kappa B alpha negatively regulates DNA-binding and transcriptional activities of NF-kappa B. Mol Cell Biol (1995) 2.69
SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation. J Cell Sci (1999) 2.46
Nuclear localization of I kappa B alpha promotes active transport of NF-kappa B from the nucleus to the cytoplasm. J Cell Sci (1997) 2.44
An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo. Oncogene (2000) 2.36
Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. J Biol Chem (1999) 2.18
Absolute dependence on kappa B responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes. EMBO J (1995) 2.10
Proteolytic degradation of MAD3 (I kappa B alpha) and enhanced processing of the NF-kappa B precursor p105 are obligatory steps in the activation of NF-kappa B. Nucleic Acids Res (1993) 2.08
Nuclear retention of IkappaBalpha protects it from signal-induced degradation and inhibits nuclear factor kappaB transcriptional activation. J Biol Chem (1999) 2.05
zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro. EMBO J (1994) 1.95
Calpain 3 deficiency is associated with myonuclear apoptosis and profound perturbation of the IkappaB alpha/NF-kappaB pathway in limb-girdle muscular dystrophy type 2A. Nat Med (1999) 1.94
Inhibition of NF-kappaB DNA binding by nitric oxide. Nucleic Acids Res (1996) 1.94
Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha. Oncogene (1999) 1.93
The origin of adenovirus DNA replication: minimal DNA sequence requirement in vivo. EMBO J (1985) 1.89
The adenovirus protease is activated by a virus-coded disulphide-linked peptide. Cell (1993) 1.86
Role of IkappaBalpha ubiquitination in signal-induced activation of NFkappaB in vivo. J Biol Chem (1996) 1.82
Properties of herpesvirus-induced "immediate early" polypeptides. Virology (1980) 1.75
Replication of adenovirus mini-chromosomes. J Mol Biol (1984) 1.62
Antipeptide antisera define neutralizing epitopes on the adenovirus hexon. J Gen Virol (1992) 1.57
Recognition of the adenovirus type 2 origin of DNA replication by the virally encoded DNA polymerase and preterminal proteins. EMBO J (1992) 1.52
Role of cysteine62 in DNA recognition by the P50 subunit of NF-kappa B. Nucleic Acids Res (1993) 1.43
Posttransplant lymphoproliferative disorder presenting as multiple cystic lesions in a renal transplant recipient. Am J Transplant (2012) 1.40
The adenovirus type 40 hexon: sequence, predicted structure and relationship to other adenovirus hexons. J Gen Virol (1989) 1.39
FMD control strategies. Vet Rec (2001) 1.39
Activation of NF-kappaB by PM(10) occurs via an iron-mediated mechanism in the absence of IkappaB degradation. Toxicol Appl Pharmacol (2000) 1.36
DNA sequence of the adenovirus type 41 hexon gene and predicted structure of the protein. J Gen Virol (1988) 1.36
p75-mediated NF-kappaB activation enhances the survival response of developing sensory neurons to nerve growth factor. Mol Cell Neurosci (1999) 1.34
Interactions between the adenovirus type 2 DNA polymerase and the DNA binding domain of nuclear factor I. New Biol (1990) 1.33
The degradation of intravenously injected chondroitin 4-sulphate in the rat. Biochem J (1973) 1.33
Identification of lysine residues required for signal-induced ubiquitination and degradation of I kappa B-alpha in vivo. Oncogene (1996) 1.30
Common properties of nuclear body protein SP100 and TIF1alpha chromatin factor: role of SUMO modification. Mol Cell Biol (2001) 1.29
Sequence requirement for specific interaction of an enhancer binding protein (EBP1) with DNA. Nucleic Acids Res (1989) 1.29
Co-operative interactions between NFI and the adenovirus DNA binding protein at the adenovirus origin of replication. EMBO J (1989) 1.28
Identification and purification of EBP1: a HeLa cell protein that binds to a region overlapping the 'core' of the SV40 enhancer. Genes Dev (1988) 1.27
Expression of a foreign epitope on the surface of the adenovirus hexon. J Gen Virol (1994) 1.25
NF-kappaB inhibits apoptosis in murine mammary epithelia. J Biol Chem (2000) 1.25
Inducible degradation of I kappa B alpha in vitro and in vivo requires the acidic C-terminal domain of the protein. Mol Cell Biol (1995) 1.24
Interaction of enhancer-binding protein EBP1 (NF-kappa B) with the human immunodeficiency virus type 1 enhancer. J Virol (1990) 1.22
Sequence specificity for the initiation of RNA-primed simian virus 40 DNA synthesis in vivo. J Mol Biol (1984) 1.22
Origin of adenovirus DNA replication. Role of the nuclear factor I binding site in vivo. J Mol Biol (1985) 1.21
Characterization of IkappaBalpha nuclear import pathway. J Biol Chem (1999) 1.20
Enhancer binding protein (EBP1) makes base and backbone contacts over one complete turn of the DNA double helix. J Mol Biol (1989) 1.19
NF-kappa B-dependent induction of the NF-kappa B p50 subunit gene promoter underlies self-perpetuation of human immunodeficiency virus transcription in monocytic cells. Proc Natl Acad Sci U S A (1992) 1.18
Regulation of transcription factors by protein degradation. Cell Mol Life Sci (2000) 1.15
Nuclear factor I is specifically targeted to discrete subnuclear sites in adenovirus type 2-infected cells. J Virol (1992) 1.15
SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1. Oncogene (2007) 1.14
Defective IkappaBalpha in Hodgkin cell lines with constitutively active NF-kappaB. Oncogene (1998) 1.14
Cytokine-induced nuclear factor kappa B activation promotes the survival of developing neurons. J Cell Biol (2000) 1.10
Interaction of the C-terminal region of p105 with the nuclear localisation signal of p50 is required for inhibition of NF-kappa B DNA binding activity. Nucleic Acids Res (1993) 1.07
The use of phenol as a neurolytic agent: a review. Pain (1978) 1.07
Expression of the genome of potato leafroll virus: readthrough of the coat protein termination codon in vivo. J Gen Virol (1990) 1.06
Adenovirus DNA replication. Curr Top Microbiol Immunol (2003) 1.06
DNA sequences required for the initiation of adenovirus type 4 DNA replication in vitro. J Mol Biol (1988) 1.05
A cellular protein binds to a conserved sequence in the adenovirus type 2 enhancer. Nucleic Acids Res (1987) 1.04
Adenovirus DNA binding protein: helix destabilising properties. Nucleic Acids Res (1994) 1.03
Histological profile of tumours from MYCN transgenic mice. J Clin Pathol (2008) 1.01
Viable viruses with deletions in the left inverted terminal repeat define the adenovirus origin of DNA replication. J Gen Virol (1986) 1.01
Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies. Oncogene (2006) 0.99
Domain organization of the adenovirus preterminal protein. J Virol (1997) 0.99
Activation of adenovirus-coded protease and processing of preterminal protein. J Virol (1994) 0.98
The carboxy-terminus of I kappaB alpha determines susceptibility to degradation by the catalytic core of the proteasome. Oncogene (1997) 0.96
Adenovirus subviral particles and cores can support limited DNA replication. J Gen Virol (1989) 0.95
The metabolic fate of intravenously injected peptide-bound chondroitin sulphate in the rat. Biochem J (1976) 0.95
Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) interacts with Lys-tRNA synthetase: implications for priming of HIV-1 reverse transcription. J Virol (1998) 0.94
Regulation of the DNA binding activity of NF-kappa B. Int J Biochem Cell Biol (1995) 0.93
Interaction between hnRNPA1 and IkappaBalpha is required for maximal activation of NF-kappaB-dependent transcription. Mol Cell Biol (2001) 0.92
Loss of nuclear expression of the p33(ING1b) inhibitor of growth protein in childhood acute lymphoblastic leukaemia. J Clin Pathol (2002) 0.91
Aphid Acquisition and Cellular Transport of Potato leafroll virus-like Particles Lacking P5 Readthrough Protein. Phytopathology (2000) 0.91
Role of preterminal protein processing in adenovirus replication. J Virol (1997) 0.90
Identification of conserved residues contributing to the activities of adenovirus DNA polymerase. J Virol (2000) 0.90
Replication of adenovirus type 4 DNA by a purified fraction from infected cells. Nucleic Acids Res (1991) 0.89
Transcription of the mouse ribosomal spacer region. Mol Cell Biol (1984) 0.89
Intercostobrachial nerve entrapment syndrome. South Med J (1978) 0.87
A complex containing betaTrCP recruits Cdc34 to catalyse ubiquitination of IkappaBalpha. FEBS Lett (1999) 0.87
Ribozymes that cleave potato leafroll virus RNA within the coat protein and polymerase genes. J Gen Virol (1990) 0.87
The metabolic fate of chondroitin (35S)sulphate proteoglycan in the rat. Biochem Soc Trans (1975) 0.86
Characterisation of the adenovirus preterminal protein and its interaction with the POU homeodomain of NFIII (Oct-1). Nucleic Acids Res (1999) 0.86
Identification of two distinct regions within the adenovirus minimal origin of replication that are required for adenovirus type 4 DNA replication in vitro. J Virol (1991) 0.85
Acute renal failure due to mantle cell lymphoma--a case report and discussion of the literature. Clin Nephrol (2007) 0.85
Expression of adenovirus type 2 DNA polymerase in insect cells infected with a recombinant baculovirus. Nucleic Acids Res (1990) 0.85
Repression of SOX6 transcriptional activity by SUMO modification. FEBS Lett (2006) 0.84
T-cell lymphoma presenting as acute mastoiditis with a facial palsy. Int J Pediatr Otorhinolaryngol (2004) 0.83
Conformational changes induced by DNA binding of NF-kappa B. Nucleic Acids Res (1995) 0.83
Adenovirus DNA polymerase: domain organisation and interaction with preterminal protein. Nucleic Acids Res (1998) 0.82
The relationship between the activity of DNA-dependent RNA polymerase I and the rate of synthesis of rRNA in hepatoma cells in culture. Biochem J (1981) 0.82
The DNA-binding domain of nuclear factor I is sufficient to cooperate with the adenovirus type 2 DNA-binding protein in viral DNA replication. J Gen Virol (1991) 0.82
New approaches to treatment of back pain. West J Med (1979) 0.81
Assembly of virus-like particles in insect cells infected with a baculovirus containing a modified coat protein gene of potato leafroll luteovirus. J Gen Virol (1996) 0.81
Inflammatory myofibroblastic tumours of the respiratory tract: paediatric case series with varying clinical presentations. J Laryngol Otol (2011) 0.81
Detection of Z DNA binding proteins in tissue culture cells. Nucleic Acids Res (1988) 0.81
Binding of [3H]imipramine to human platelet membranes with compensation for saturable binding to filters and its implication for binding studies with brain membranes. J Neurochem (1984) 0.81