Published in J Infect Dis on September 01, 1976
Turbidimetric studies of growth inhibition of yeasts with three drugs: inquiry into inoculum-dependent susceptibility testing, time of onset of drug effect, and implications for current and newer methods. Antimicrob Agents Chemother (1978) 5.94
Microbicidal cationic proteins in rabbit alveolar macrophages: a potential host defense mechanism. Infect Immun (1980) 3.13
Sensitive high-pressure liquid chromatographic assay for amphotericin B which incorporates an internal standard. Antimicrob Agents Chemother (1986) 1.77
Microbicidal cationic proteins of rabbit alveolar macrophages: amino acid composition and functional attributes. Infect Immun (1981) 1.61
Risk factors of ventricular fibrillation during rapid amphotericin B infusion. Antimicrob Agents Chemother (1985) 1.34
Inhibition of specific amino acid uptake in Candida albicans by lysosomal extracts from rabbit alveolar macrophages. Infect Immun (1978) 1.30
Antagonistic effects of fluconazole and 5-fluorocytosine on candidacidal action of amphotericin B in human serum. Antimicrob Agents Chemother (1994) 1.23
Interaction of chemotherapy and immune defenses in experimental murine cryptococcosis. Antimicrob Agents Chemother (1978) 0.96
Radiometric determination of the concentration of amphotericin B in body fluids. Antimicrob Agents Chemother (1977) 0.81
Interaction of Candida albicans with human leukocytes and serum. J Bacteriol (1969) 9.19
Defensins. Natural peptide antibiotics of human neutrophils. J Clin Invest (1985) 8.63
Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection. J Clin Invest (1969) 7.61
Purification and antibacterial activity of antimicrobial peptides of rabbit granulocytes. Infect Immun (1984) 5.30
Severe candidal infections: clinical perspective, immune defense mechanisms, and current concepts of therapy. Ann Intern Med (1978) 4.15
Phagocytosis by human monocytes. Blood (1968) 3.96
Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. Proc Natl Acad Sci U S A (1990) 3.90
Primary structures of three human neutrophil defensins. J Clin Invest (1985) 3.70
Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils. J Biol Chem (1985) 3.58
Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils. Antimicrob Agents Chemother (1998) 3.45
Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett (1996) 3.39
Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins. FEBS Lett (1993) 3.30
Antifungal effects of peroxidase systems. J Bacteriol (1969) 3.24
Microbicidal cationic proteins in rabbit alveolar macrophages: a potential host defense mechanism. Infect Immun (1980) 3.13
Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family. Proc Natl Acad Sci U S A (1998) 3.02
Primary structures of MCP-1 and MCP-2, natural peptide antibiotics of rabbit lung macrophages. J Biol Chem (1983) 3.00
Direct inactivation of viruses by human granulocyte defensins. J Virol (1986) 3.00
Defensins. Eur J Haematol (1990) 2.88
Nonoxidative fungicidal mechanisms of mammalian granulocytes: demonstration of components with candidacidal activity in human, rabbit, and guinea pig leukocytes. Infect Immun (1975) 2.68
NADPH oxidase deficiency in X-linked chronic granulomatous disease. J Clin Invest (1975) 2.62
Defensins. Curr Opin Immunol (1994) 2.55
Defensins. Pharmacol Ther (1995) 2.52
Crystallization of antimicrobial pores in membranes: magainin and protegrin. Biophys J (2000) 2.41
Cryptdins: antimicrobial defensins of the murine small intestine. Infect Immun (1992) 2.39
Cyclic 3',5'-adenosine monophosphate in the human lukocyte: synthesis, degradation, andeffects n neutrophil candidacidal activity. J Clin Invest (1971) 2.35
Antibacterial activity of microbicidal cationic proteins 1 and 2, natural peptide antibiotics of rabbit lung macrophages. Infect Immun (1983) 2.33
Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics from rabbit leukocytes. J Virol (1985) 2.31
The fungicidal mechanisms of human monocytes. I. Evidence for myeloperoxidase-linked and myeloperoxidase-independent candidacidal mechanisms. J Clin Invest (1975) 2.26
Functional aspects of a second mechanism of candidacidal activity by human neutrophils. J Clin Invest (1972) 2.25
Defensins and other endogenous peptide antibiotics of vertebrates. J Leukoc Biol (1995) 2.25
Bactericidal activity of mammalian cathelicidin-derived peptides. Infect Immun (2000) 2.24
Susceptibility of Chlamydia trachomatis to protegrins and defensins. Infect Immun (1996) 2.16
Effects of cholera enterotoxin on adenosine 3',5'-monophosphate and neutrophil function. Comparison with other compounds which stimulate leukocyte adenyl cyclase. J Clin Invest (1973) 2.16
Assessment of chlorination by human neutrophils. Nature (1983) 2.12
Activity of rabbit leukocyte peptides against Candida albicans. Infect Immun (1985) 2.05
Development of amphotericin B-resistant Candida tropicalis in a patient with defective leukocyte function. Am J Med Sci (1979) 2.02
Mouse neutrophils lack defensins. Infect Immun (1992) 2.01
In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes. Blood (1986) 2.01
Antimicrobial peptides of vertebrates. Curr Opin Immunol (1998) 1.94
Correlation of binding of rabbit granulocyte peptides to Candida albicans with candidacidal activity. Infect Immun (1985) 1.89
Neutrophil defensins: purification, characterization, and antimicrobial testing. Methods Enzymol (1994) 1.88
Solution structure of protegrin-1, a broad-spectrum antimicrobial peptide from porcine leukocytes. Chem Biol (1996) 1.87
In vitro killing of spores and hyphae of Aspergillus fumigatus and Rhizopus oryzae by rabbit neutrophil cationic peptides and bronchoalveolar macrophages. J Infect Dis (1986) 1.84
Designer assays for antimicrobial peptides. Disputing the "one-size-fits-all" theory. Methods Mol Biol (1997) 1.79
Fungicidal activity of rabbit alveolar and peritoneal macrophages against Candida albicans. Infect Immun (1980) 1.79
Bactericidal properties of murine intestinal phospholipase A2. J Clin Invest (1995) 1.75
Phagolysosomal pH of human neutrophils. Blood (1984) 1.75
Effects of pH and salinity on the antimicrobial properties of clavanins. Infect Immun (1997) 1.75
Amino-acid sequence of fragment A, an enzymically active fragment from diphtheria toxin. Proc Natl Acad Sci U S A (1976) 1.74
Susceptibility of Neisseria gonorrhoeae to protegrins. Infect Immun (1996) 1.65
Membrane thinning effect of the beta-sheet antimicrobial protegrin. Biochemistry (2000) 1.64
Mechanism of target cytolysis by peptide defensins. Target cell metabolic activities, possibly involving endocytosis, are crucial for expression of cytotoxicity. J Immunol (1988) 1.64
Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency. J Clin Invest (1988) 1.63
Microbicidal cationic proteins of rabbit alveolar macrophages: amino acid composition and functional attributes. Infect Immun (1981) 1.61
Fungicidal properties of a chymotrypsin-like cationic protein from human neutrophils: adsorption to Candida parapsilosis. Infect Immun (1977) 1.61
Isolation and characterization of human defensin cDNA clones. Proc Natl Acad Sci U S A (1988) 1.61
Defensin-rich dense granules of human neutrophils. Blood (1987) 1.59
Arginine-rich cationic proteins of human eosinophil granules: comparison of the constituents of eosinophilic and neutrophilic leukocytes. Lab Invest (1977) 1.57
Defensins: a family of antimicrobial and cytotoxic peptides. Toxicology (1994) 1.53
Increased content of microbicidal cationic peptides in rabbit alveolar macrophages elicited by complete Freund adjuvant. Infect Immun (1981) 1.52
Antimicrobial proteins of murine macrophages. Infect Immun (1993) 1.50
Antimicrobial activity of phagocyte granule proteins. Semin Respir Infect (1986) 1.49
Purification and antimicrobial properties of three defensins from rat neutrophils. Infect Immun (1989) 1.46
Intramolecular disulfide bonds enhance the antimicrobial and lytic activities of protegrins at physiological sodium chloride concentrations. Eur J Biochem (1996) 1.45
Antibiotic peptides from higher eukaryotes: biology and applications. Mol Med Today (1999) 1.44
D-amino acid oxidase in leukocytes: a possible D-amino-acid-linked antimicrobial system. Proc Natl Acad Sci U S A (1969) 1.43
Phagocytosis by human eosinophils. Blood (1968) 1.42
Myeloperoxidase deficiency. Immunologic study of a genetic leukocyte defect. N Engl J Med (1970) 1.41
Uteroglobin/Clara cell 10-kDa family of proteins: nomenclature committee report. Ann N Y Acad Sci (2000) 1.41
Effects of colchicine and chloramphenicol on the oxidative metabolism and phagocytic activity of human neutrophils. J Infect Dis (1973) 1.40
UCLA Conference. Monocytes and macrophages: functions and diseases. Ann Intern Med (1978) 1.38
In vitro activity of the antimicrobial peptides human and rabbit defensins and porcine leukocyte protegrin against Mycobacterium tuberculosis. Infect Immun (1996) 1.37
In vitro candidastatic properties of the human neutrophil calprotectin complex. J Immunol (1993) 1.37
Membrane channel formation by antimicrobial protegrins. Biochim Biophys Acta (1999) 1.36
Multiple states of beta-sheet peptide protegrin in lipid bilayers. Biochemistry (1998) 1.36
Individual and synergistic effects of rabbit granulocyte proteins on Escherichia coli. J Clin Invest (1994) 1.34
Gallinacins: cysteine-rich antimicrobial peptides of chicken leukocytes. FEBS Lett (1994) 1.33
Antimicrobial peptides of leukocytes. Curr Opin Hematol (1997) 1.32
Activity of defensins from human neutrophilic granulocytes against Mycobacterium avium-Mycobacterium intracellulare. Infect Immun (1992) 1.32
Secretory phospholipase A2 is the principal bactericide for staphylococci and other gram-positive bacteria in human tears. Infect Immun (1998) 1.31
Inhibition by sulfonamides of the candidacidal activity of human neutrophils. J Clin Invest (1971) 1.30
Defective bactericidal activity in myeloperoxidase-deficient human neutrophils. Nature (1969) 1.29
Human neutrophil antimicrobial activity. Rev Infect Dis (1988) 1.28
Orientation and dynamics of an antimicrobial peptide in the lipid bilayer by solid-state NMR spectroscopy. Biophys J (2001) 1.27
Leukocyte candidacidal activity and resistance to systemic candidiasis in patients with cancer. Cancer (1971) 1.26
NAD(P)H oxidase activity in human neutrophils stimulated by phorbol myristate acetate. J Clin Invest (1980) 1.26
Protegrin structure and activity against Neisseria gonorrhoeae. Infect Immun (1997) 1.25
Evaluation of the inactivation of infectious Herpes simplex virus by host-defense peptides. Eur J Clin Microbiol Infect Dis (2000) 1.24
Identification of a new member of the protegrin family by cDNA cloning. FEBS Lett (1994) 1.22
Purification of cysteine-rich bioactive peptides from leukocytes by continuous acid-urea-polyacrylamide gel electrophoresis. Anal Biochem (1993) 1.21
The structure of porcine protegrin genes. FEBS Lett (1995) 1.19
Newborn rabbit alveolar macrophages are deficient in two microbicidal cationic peptides, MCP-1 and MCP-2. Am Rev Respir Dis (1985) 1.17
Protegrins: new antibiotics of mammalian origin. Expert Opin Investig Drugs (2000) 1.15
In vitro sensitivity of oral, gram-negative, facultative bacteria to the bactericidal activity of human neutrophil defensins. Infect Immun (1990) 1.13
Circular minidefensins and posttranslational generation of molecular diversity. J Leukoc Biol (2001) 1.12
An enzyme immunoassay for human defensins. J Immunol Methods (1991) 1.12
Characterization of defensin precursors in mature human neutrophils. Blood (1992) 1.12
Receptor-mediated regulation of superoxide production in human neutrophils stimulated by phorbol myristate acetate. J Clin Invest (1981) 1.10