Published in Cell on December 31, 1993
Transforming growth factor-beta 3 is required for secondary palate fusion. Nat Genet (1995) 4.46
Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev (2004) 3.83
Relations and interactions between cranial mesoderm and neural crest populations. J Anat (2005) 2.26
Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice. J Clin Invest (1998) 2.04
Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development. Development (2012) 2.01
Reassessing the Dlx code: the genetic regulation of branchial arch skeletal pattern and development. J Anat (2005) 1.93
The Sry-related HMG box-containing gene Sox6 is expressed in the adult testis and developing nervous system of the mouse. Nucleic Acids Res (1995) 1.61
Hox11 paralogous genes are essential for metanephric kidney induction. Genes Dev (2002) 1.55
Isolated cleft palate in mice with a targeted mutation of the LIM homeobox gene lhx8. Proc Natl Acad Sci U S A (1999) 1.54
The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity. Development (2008) 1.54
Biomedical discovery acceleration, with applications to craniofacial development. PLoS Comput Biol (2009) 1.49
Gsh-1, an orphan Hox gene, is required for normal pituitary development. EMBO J (1996) 1.49
Prdm16 is required for normal palatogenesis in mice. Hum Mol Genet (2009) 1.46
Hox homeodomain proteins exhibit selective complex stabilities with Pbx and DNA. Nucleic Acids Res (1996) 1.43
Microtia: epidemiology and genetics. Am J Med Genet A (2011) 1.42
A Hox-Eya-Pax complex regulates early kidney developmental gene expression. Mol Cell Biol (2007) 1.42
The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid. Nat Cell Biol (2010) 1.29
Hox genes: choreographers in neural development, architects of circuit organization. Neuron (2013) 1.23
An ultraconserved Hox-Pbx responsive element resides in the coding sequence of Hoxa2 and is active in rhombomere 4. Nucleic Acids Res (2008) 1.22
Jagged-Notch signaling ensures dorsal skeletal identity in the vertebrate face. Development (2010) 1.21
New perspectives on pharyngeal dorsoventral patterning in development and evolution of the vertebrate jaw. Dev Biol (2012) 1.20
Hoxa2 selectively enhances Meis binding to change a branchial arch ground state. Dev Cell (2015) 1.19
A zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for endothelin-1 expression. BMC Dev Biol (2006) 1.13
It's all in your head: new insights into craniofacial development and deformation. J Anat (2005) 1.13
The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005) 1.13
A unique mouse strain expressing Cre recombinase for tissue-specific analysis of gene function in palate and kidney development. Genesis (2007) 1.13
The genesis of cartilage size and shape during development and evolution. Development (2008) 1.12
Evolution of the vertebrate jaw: comparative embryology and molecular developmental biology reveal the factors behind evolutionary novelty. J Anat (2004) 1.08
The development and evolution of the pharyngeal arches. J Anat (2001) 1.07
Complementation mapping of skeletal and central nervous system abnormalities in mice of the piebald deletion complex. Genetics (1996) 1.05
Regulation of facial morphogenesis by endothelin signaling: insights from mice and fish. Am J Med Genet A (2010) 1.04
Rostral and caudal pharyngeal arches share a common neural crest ground pattern. Development (2009) 1.02
Evolution of the mammalian middle ear and jaw: adaptations and novel structures. J Anat (2012) 1.02
Evolution of cis elements in the differential expression of two Hoxa2 coparalogous genes in pufferfish (Takifugu rubripes). Proc Natl Acad Sci U S A (2006) 1.01
A mutation in HOXA2 is responsible for autosomal-recessive microtia in an Iranian family. Am J Hum Genet (2008) 1.01
The conserved role of Krox-20 in directing Hox gene expression during vertebrate hindbrain segmentation. Proc Natl Acad Sci U S A (1996) 0.99
Targeted disruption of the Mn1 oncogene results in severe defects in development of membranous bones of the cranial skeleton. Mol Cell Biol (2005) 0.98
Disruption of teashirt zinc finger homeobox 1 is associated with congenital aural atresia in humans. Am J Hum Genet (2011) 0.97
Hox genes and their candidate downstream targets in the developing central nervous system. Cell Mol Neurobiol (2005) 0.94
Genome-wide occupancy links Hoxa2 to Wnt-β-catenin signaling in mouse embryonic development. Nucleic Acids Res (2012) 0.92
Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis. Development (2013) 0.92
Developmental studies of the lamprey and hierarchical evolutionary steps towards the acquisition of the jaw. J Anat (2005) 0.91
Type 1 fibroblast growth factor receptor in cranial neural crest cell-derived mesenchyme is required for palatogenesis. J Biol Chem (2013) 0.90
Transient activation of meox1 is an early component of the gene regulatory network downstream of hoxa2. Mol Cell Biol (2011) 0.90
Pbx homeodomain proteins: TALEnted regulators of limb patterning and outgrowth. Dev Dyn (2011) 0.89
Relationship between spatially restricted Krox-20 gene expression in branchial neural crest and segmentation in the chick embryo hindbrain. EMBO J (1995) 0.87
Molecular signaling along the anterior-posterior axis of early palate development. Front Physiol (2013) 0.86
Can you hear me now? Understanding vertebrate middle ear development. Front Biosci (Landmark Ed) (2011) 0.86
Cochleovestibular nerve development is integrated with migratory neural crest cells. Dev Biol (2013) 0.86
Segmental identity and cerebellar granule cell induction in rhombomere 1. BMC Biol (2004) 0.83
Temporal and spatial expression of Hoxa-2 during murine palatogenesis. Cell Mol Neurobiol (2000) 0.82
The etiology of cleft palate formation in BMP7-deficient mice. PLoS One (2013) 0.82
HOXA2 haploinsufficiency in dominant bilateral microtia and hearing loss. Hum Mutat (2013) 0.81
Hox genes in the lung. Am J Respir Cell Mol Biol (1996) 0.81
The road to embryologically based dose-response models. Environ Health Perspect (1996) 0.81
Conditional Tet-regulated over-expression of Hoxa2 in CG4 cells increases their proliferation and delays their differentiation into oligodendrocyte-like cells expressing myelin basic protein. Cell Mol Neurobiol (2011) 0.79
The homeodomain transcription factor Hoxa2 interacts with and promotes the proteasomal degradation of the E3 ubiquitin protein ligase RCHY1. PLoS One (2013) 0.79
Development and evolution of the pharyngeal apparatus. Wiley Interdiscip Rev Dev Biol (2014) 0.79
Molecular basis of cleft palates in mice. World J Biol Chem (2015) 0.78
An Efficient Approach to Screening Epigenome-Wide Data. Biomed Res Int (2016) 0.78
Head segmentation in vertebrates. Integr Comp Biol (2008) 0.78
Competition between Jagged-Notch and Endothelin1 Signaling Selectively Restricts Cartilage Formation in the Zebrafish Upper Face. PLoS Genet (2016) 0.77
Differential distribution of the Ca (2+) regulator Pcp4 in the branchial arches is regulated by Hoxa2. PLoS One (2013) 0.77
Ascorbic acid reverses valproic acid-induced inhibition of hoxa2 and maintains glutathione homeostasis in mouse embryos in culture. Cell Mol Neurobiol (2009) 0.77
Late gestation modulation of fetal glucocorticoid effects requires the receptor for leukemia inhibitory factor: an observational study. Reprod Biol Endocrinol (2003) 0.75
G-Protein α-Subunit Gsα Is Required for Craniofacial Morphogenesis. PLoS One (2016) 0.75
Genetic Advances in the Understanding of Microtia. J Pediatr Genet (2016) 0.75
Cellular and Molecular Underpinnings of Neuronal Assembly in the Central Auditory System during Mouse Development. Front Neural Circuits (2017) 0.75
Developmental basis of phenotypic integration in two Lake Malawi cichlids. Evodevo (2016) 0.75
Ablation of the Sox11 Gene Results in Clefting of the Secondary Palate Resembling the Pierre Robin Sequence. J Biol Chem (2016) 0.75
A distal 594 bp ECR specifies Hmx1 expression in pinna and lateral facial morphogenesis and is regulated by the Hox-Pbx-Meis complex. Development (2016) 0.75
Transferrin receptor facilitates TGF-β and BMP signaling activation to control craniofacial morphogenesis. Cell Death Dis (2016) 0.75
Applications of Mesenchymal Stem Cells and Neural Crest Cells in Craniofacial Skeletal Research. Stem Cells Int (2016) 0.75
HMG-1 as a late mediator of endotoxin lethality in mice. Science (1999) 17.72
FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex. Cell (1996) 12.07
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature (2000) 11.49
Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature (1995) 8.12
Properties and applications of monoclonal antibodies directed against determinants of they Thy-1 locus. J Immunol (1979) 7.79
High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med (2000) 7.38
Notch signaling is essential for vascular morphogenesis in mice. Genes Dev (2000) 6.88
Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature (1998) 6.49
RSC, an essential, abundant chromatin-remodeling complex. Cell (1996) 6.17
Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins. Genes Dev (1998) 5.79
IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages. J Immunol (1998) 5.79
The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition. Mol Cell Biol (2001) 4.80
Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. Hum Mol Genet (1999) 4.55
Roles for Nkx3.1 in prostate development and cancer. Genes Dev (1999) 4.30
Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption. Neoplasia (2001) 4.22
T-cell co-stimulation through B7RP-1 and ICOS. Nature (1999) 4.20
Notch1 is essential for postimplantation development in mice. Genes Dev (1994) 4.06
Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20. Genes Dev (1993) 3.93
Terminal differentiation of human breast cancer through PPAR gamma. Mol Cell (1998) 3.71
The homeobox gene GLABRA2 is required for position-dependent cell differentiation in the root epidermis of Arabidopsis thaliana. Development (1996) 3.59
Notch signalling pathway mediates hair cell development in mammalian cochlea. Nat Genet (1999) 3.37
Murine macrophages secrete interferon gamma upon combined stimulation with interleukin (IL)-12 and IL-18: A novel pathway of autocrine macrophage activation. J Exp Med (1998) 2.89
Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Genes Dev (1998) 2.70
Survival, integration, and differentiation of cardiomyocyte grafts: a study in normal and injured rat hearts. Circulation (1999) 2.68
U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction. Genes Dev (1997) 2.67
Notch activity influences the alphabeta versus gammadelta T cell lineage decision. Cell (1997) 2.66
Opioid modulation of taste hedonics within the ventral striatum. Physiol Behav (2002) 2.62
Histone octamer transfer by a chromatin-remodeling complex. Cell (1999) 2.54
Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis (2013) 2.52
Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes. Surgery (1999) 2.44
Metabolic Engineering of a Pentose Metabolism Pathway in Ethanologenic Zymomonas mobilis. Science (1995) 2.40
Activated RSC-nucleosome complex and persistently altered form of the nucleosome. Cell (1998) 2.38
Defects in somite formation in lunatic fringe-deficient mice. Nature (1998) 2.37
Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation. Development (2001) 2.37
Cellular localization and trafficking of the human ABCA1 transporter. J Biol Chem (2001) 2.26
A peripheral blood diagnostic test for acute rejection in renal transplantation. Am J Transplant (2012) 2.25
Saccadic dysmetria and adaptation after lesions of the cerebellar cortex. J Neurosci (1999) 2.24
Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety. Leukemia (2010) 2.22
Self-perceived health and 5-year mortality risks among the elderly in Shanghai, China. Am J Epidemiol (1998) 2.14
The Slug gene is not essential for mesoderm or neural crest development in mice. Dev Biol (1998) 2.13
Power output and columbic efficiencies from biofilms of Geobacter sulfurreducens comparable to mixed community microbial fuel cells. Environ Microbiol (2008) 2.06
Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation. Auton Neurosci (2000) 2.06
Leisure activity and risk of cognitive impairment: the Chongqing aging study. Neurology (2005) 2.00
Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development. Development (1992) 1.99
Translocation of jellyfish green fluorescent protein via the Tat system of Escherichia coli and change of its periplasmic localization in response to osmotic up-shock. J Biol Chem (2000) 1.99
Solution structure of the extended neuronal nitric oxide synthase PDZ domain complexed with an associated peptide. Nat Struct Biol (1999) 1.95
Cellular response to modulated radiation fields. Phys Med Biol (2007) 1.88
Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate. Oncogene (2010) 1.87
Interleukin-10 downregulates Mycobacterium tuberculosis-induced Th1 responses and CTLA-4 expression. Infect Immun (1996) 1.85
Improved serodiagnosis of hepatitis C virus infection with synthetic peptide antigen from capsid protein. Proc Natl Acad Sci U S A (1991) 1.81
Aclarubicin treatment restores SMN levels to cells derived from type I spinal muscular atrophy patients. Hum Mol Genet (2001) 1.80
Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease. Neurology (2011) 1.77
Deacetylation of cortactin by SIRT1 promotes cell migration. Oncogene (2008) 1.76
The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif. J Biol Chem (2001) 1.75
Endoscopic vein harvest for coronary artery bypass grafting: technique and outcomes. J Thorac Cardiovasc Surg (1998) 1.74
Persistently poor outcomes of undetected major depression in primary care. Gen Hosp Psychiatry (1998) 1.69
A common position-dependent mechanism controls cell-type patterning and GLABRA2 regulation in the root and hypocotyl epidermis of Arabidopsis. Plant Physiol (1998) 1.67
Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth. Proc Natl Acad Sci U S A (1996) 1.67
Antitumor activity of the novel human breast cancer growth inhibitor, mammary-derived growth inhibitor-related gene, MRG. Cancer Res (1997) 1.66
A three-dimensional model of lanosterol 14alpha-demethylase of Candida albicans and its interaction with azole antifungals. J Med Chem (2000) 1.62
Transport function and regulation of mitochondrial uncoupling proteins 2 and 3. J Biol Chem (1999) 1.61
Relationship between serum urate and plasma oxypurinol in the management of gout: determination of minimum plasma oxypurinol concentration to achieve a target serum urate level. Clin Pharmacol Ther (2011) 1.60
Chemokine production by a human alveolar epithelial cell line in response to Mycobacterium tuberculosis. Infect Immun (1998) 1.58
The impact of geographic accessibility on the intensity and quality of depression treatment. Med Care (1999) 1.57
The Nrarp gene encodes an ankyrin-repeat protein that is transcriptionally regulated by the notch signaling pathway. Dev Biol (2001) 1.54
Recombinant hepatitis E virus genomes infectious for primates: importance of capping and discovery of a cis-reactive element. Proc Natl Acad Sci U S A (2001) 1.54
Molecular characteristics of non-small cell lung cancer. Proc Natl Acad Sci U S A (2001) 1.53
Three-dimensional gait analysis of obese adults. Clin Biomech (Bristol, Avon) (2008) 1.52
The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice. Dev Biol (1999) 1.51
Absence of a prominent Th2 cytokine response in human tuberculosis. Infect Immun (1996) 1.51
An autoinhibitory mechanism for nonsyntaxin SNARE proteins revealed by the structure of Ykt6p. Science (2001) 1.51
Krox-20 controls SCIP expression, cell cycle exit and susceptibility to apoptosis in developing myelinating Schwann cells. Development (1999) 1.50
RSC unravels the nucleosome. Mol Cell (2001) 1.50
Structure of Tctex-1 and its interaction with cytoplasmic dynein intermediate chain. J Biol Chem (2001) 1.50
Normal aging in the basal ganglia evaluated by eigenvalues of diffusion tensor imaging. AJNR Am J Neuroradiol (2009) 1.49
Goosecoid is not an essential component of the mouse gastrula organizer but is required for craniofacial and rib development. Development (1995) 1.49
Fibroblast growth factor receptor 2 mutations in Beare-Stevenson cutis gyrata syndrome. Nat Genet (1996) 1.49
CD4(+) v(alpha)14 NKT cells play a crucial role in an early stage of protective immunity against infection with Leishmania major. Int Immunol (2000) 1.49
Restricted daily consumption of a highly palatable food (chocolate Ensure(R)) alters striatal enkephalin gene expression. Eur J Neurosci (2003) 1.48
High TPMT enzyme activity does not explain drug resistance due to preferential 6-methylmercaptopurine production in patients on thiopurine treatment. Aliment Pharmacol Ther (2012) 1.46
The role of complement in inflammation and adaptive immunity. Immunol Rev (2001) 1.45
Synthesis and characterization of macroporous chitosan/calcium phosphate composite scaffolds for tissue engineering. J Biomed Mater Res (2001) 1.45
A non-isotopic method for the detection of telomerase activity in tumour tissues: TRAP-silver staining assay. Mol Pathol (1998) 1.44
Determination of benflumetol in human plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection. J Chromatogr B Biomed Appl (1996) 1.44
Association of adiponectin multimers with Barrett's oesophagus. Gut (2009) 1.43
Formation of nNOS/PSD-95 PDZ dimer requires a preformed beta-finger structure from the nNOS PDZ domain. J Mol Biol (2000) 1.43
Fetuin (alpha2-HS-glycoprotein) opsonizes cationic macrophagedeactivating molecules. Proc Natl Acad Sci U S A (1998) 1.42
Local phase decomposition as a cause of polarization fatigue in ferroelectric thin films. Phys Rev Lett (2006) 1.42
Targeting of SNAP-23 and SNAP-25 in polarized epithelial cells. J Biol Chem (1998) 1.42
Cloning, analysis, and chromosomal localization of Notch-1, a mouse homolog of Drosophila Notch. Genomics (1993) 1.42
Isolation of Sna, a mouse gene homologous to the Drosophila genes snail and escargot: its expression pattern suggests multiple roles during postimplantation development. Development (1992) 1.42
Catalytically critical nucleotide in domain 5 of a group II intron. Proc Natl Acad Sci U S A (1995) 1.41
Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription. Proc Natl Acad Sci U S A (1990) 1.41
The effects of La(III) on the peroxidation of membrane lipids in wheat seedling leaves under osmotic stress. Biol Trace Elem Res (1999) 1.40
Genomic deletion marking an emerging subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula. Appl Environ Microbiol (2007) 1.39
Msx1 is required for the induction of Patched by Sonic hedgehog in the mammalian tooth germ. Dev Dyn (1999) 1.38
Expression of Math1 and HES5 in the cochleae of wildtype and Jag2 mutant mice. J Assoc Res Otolaryngol (2000) 1.38
Randomised placebo-controlled trial of use of topical recombinant bovine basic fibroblast growth factor for second-degree burns. Lancet (1998) 1.32
Neural tube defects and neuroepithelial cell death in Tulp3 knockout mice. Hum Mol Genet (2001) 1.32