Published in N Engl J Med on June 16, 1994
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med (2007) 8.33
The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis. Crit Care Med (2008) 3.73
Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. Intensive Care Med (2014) 3.37
Multicenter implementation of a severe sepsis and septic shock treatment bundle. Am J Respir Crit Care Med (2013) 2.52
Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome. J Intensive Care Med (2006) 2.47
Bench-to-bedside review: Cytopathic hypoxia. Crit Care (2002) 2.29
Hemodynamic parameters to guide fluid therapy. Ann Intensive Care (2011) 2.19
Swan song for the Swan-Ganz catheter? BMJ (1996) 1.93
Association of arterial blood pressure and vasopressor load with septic shock mortality: a post hoc analysis of a multicenter trial. Crit Care (2009) 1.87
The incidence of low venous oxygen saturation on admission to the intensive care unit: a multi-center observational study in The Netherlands. Crit Care (2008) 1.81
The incidence and outcome of septic shock patients in the absence of early-goal directed therapy. Crit Care (2006) 1.77
Renal hypoxia and dysoxia after reperfusion of the ischemic kidney. Mol Med (2008) 1.72
Bench-to-bedside review: sepsis is a disease of the microcirculation. Crit Care (2004) 1.66
Reducing mortality in sepsis: new directions. Crit Care (2002) 1.52
High-altitude physiology and pathophysiology: implications and relevance for intensive care medicine. Crit Care (2007) 1.48
The apoptotic pathway as a therapeutic target in sepsis. Curr Drug Targets (2007) 1.47
Effects of intra-aortic balloon counterpulsation in a model of septic shock. Crit Care Med (2009) 1.44
Endothelial and Microcirculatory Function and Dysfunction in Sepsis. Clin Chest Med (2016) 1.42
Evidence-based review of the use of the pulmonary artery catheter: impact data and complications. Crit Care (2006) 1.36
The effect of goal-directed therapy on mortality in patients with sepsis - earlier is better: a meta-analysis of randomized controlled trials. Crit Care (2014) 1.35
Clinical review: Goal-directed therapy-what is the evidence in surgical patients? The effect on different risk groups. Crit Care (2013) 1.35
Clinicians' abilities to estimate cardiac index in ventilated children and infants. Arch Dis Child (1997) 1.33
Sympathetic modulation of immunity: relevance to disease. Cell Immunol (2008) 1.33
Bench-to-bedside review: potential strategies to protect or reverse mitochondrial dysfunction in sepsis-induced organ failure. Crit Care (2006) 1.30
Clinical review: Volume of fluid resuscitation and the incidence of acute kidney injury - a systematic review. Crit Care (2012) 1.28
Regulation of mitochondrial respiration and apoptosis through cell signaling: cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation. Biochim Biophys Acta (2011) 1.27
Lactate as a marker of energy failure in critically ill patients: hypothesis. Crit Care (2005) 1.24
Clinical relevance of data from the pulmonary artery catheter. Crit Care (2006) 1.24
Severe sepsis: variation in resource and therapeutic modality use among academic centers. Crit Care (2003) 1.24
Goal-directed haemodynamic therapy during elective total hip arthroplasty under regional anaesthesia. Crit Care (2011) 1.22
Meta-analysis of hemodynamic optimization: relationship to methodological quality. Crit Care (2005) 1.21
A critique of fluid bolus resuscitation in severe sepsis. Crit Care (2012) 1.19
Bench-to-bedside review: Beta-adrenergic modulation in sepsis. Crit Care (2009) 1.18
Sepsis-associated hyperlactatemia. Crit Care (2014) 1.17
The evolution of evidence hierarchies: what can Bradford Hill's 'guidelines for causation' contribute? J R Soc Med (2009) 1.14
The role of nitrogen oxides in human adaptation to hypoxia. Sci Rep (2011) 1.14
Clinical review: Goal-directed therapy in high risk surgical patients. Crit Care (2009) 1.13
Stress-related cardiomyopathies. Ann Intensive Care (2011) 1.12
Gastric tonometry versus cardiac index as resuscitation goals in septic shock: a multicenter, randomized, controlled trial. Crit Care (2009) 1.11
Sepsis-associated microvascular dysfunction measured by peripheral arterial tonometry: an observational study. Crit Care (2009) 1.10
From macrohemodynamic to the microcirculation. Crit Care Res Pract (2013) 1.09
Why are clinicians not embracing the results from pivotal clinical trials in severe sepsis? A bayesian analysis. PLoS One (2008) 1.08
Pulse high-volume haemofiltration for treatment of severe sepsis: effects on hemodynamics and survival. Crit Care (2005) 1.08
Cardiovascular response to dobutamine stress predicts outcome in severe sepsis and septic shock. Crit Care (2008) 1.07
Endpoints of resuscitation of critically injured patients: normal or supranormal? A prospective randomized trial. Ann Surg (2000) 1.06
Phosphorylation of mammalian cytochrome c and cytochrome c oxidase in the regulation of cell destiny: respiration, apoptosis, and human disease. Adv Exp Med Biol (2012) 1.05
Monitoring cardiac function in intensive care. Arch Dis Child (2003) 1.04
Pharmacologic agents for acute hemodynamic instability: Recent advances in the management of perioperative shock- A systematic review. Ann Card Anaesth (2015) 1.01
Utility of the Surgical Apgar Score in a district general hospital. World J Surg (2012) 1.00
Red blood cell transfusion and outcomes in patients with acute lung injury, sepsis and shock. Crit Care (2011) 1.00
Effect of processing and storage on red blood cell function in vivo. Semin Perinatol (2012) 1.00
Mitochondrial mechanisms of sepsis-induced organ failure. Front Biosci (2008) 0.98
Longitudinal increases in mitochondrial DNA levels in blood cells are associated with survival in critically ill patients. Crit Care (2007) 0.98
Clinical review: how to optimize management of high-risk surgical patients. Crit Care (2004) 0.97
Peri-operative hemodynamic therapy: only large clinical trials can resolve our uncertainty. Crit Care (2011) 0.97
Detecting volume responsiveness and unresponsiveness in intensive care unit patients: two different problems, only one solution. Crit Care (2009) 0.97
Oxygen uptake-to-delivery relationship: a way to assess adequate flow. Crit Care (2006) 0.97
Early goal-directed therapy in the management of severe sepsis or septic shock in adults: a meta-analysis of randomized controlled trials. BMC Med (2015) 0.97
Effects of volume resuscitation on splanchnic perfusion in canine model of severe sepsis induced by live Escherichia coli infusion. Crit Care (2004) 0.96
Clinical review: use of venous oxygen saturations as a goal - a yet unfinished puzzle. Crit Care (2011) 0.96
When to stop septic shock resuscitation: clues from a dynamic perfusion monitoring. Ann Intensive Care (2014) 0.96
Towards integrative physiological monitoring of the critically ill: from cardiovascular to microcirculatory and cellular function monitoring at the bedside. Crit Care (2013) 0.95
Hemodynamic coherence and the rationale for monitoring the microcirculation. Crit Care (2015) 0.94
Treating critical illness: the importance of first doing no harm. PLoS Med (2005) 0.94
Use of inotropes and vasopressor agents in critically ill patients. Br J Pharmacol (2012) 0.93
Variation in sepsis care: a wake-up call. Crit Care (2003) 0.93
Microhemodynamic aberrations created by transfusion of stored blood. Transfusion (2013) 0.92
Obituary: pulmonary artery catheter 1970 to 2013. Ann Intensive Care (2013) 0.92
Sepsis: from bench to bedside. Clinics (Sao Paulo) (2008) 0.91
Early non-invasive cardiac output monitoring in hemodynamically unstable intensive care patients: a multi-center randomized controlled trial. Crit Care (2011) 0.90
Hemodynamic variables and mortality in cardiogenic shock: a retrospective cohort study. Crit Care (2009) 0.90
Oxygen delivery is an important predictor of outcome in patients with ruptured abdominal aortic aneurysms. Ann Surg (1998) 0.90
Energy crisis: the role of oxidative phosphorylation in acute inflammation and sepsis. Biochim Biophys Acta (2014) 0.89
Early goal-directed therapy: a UK perspective. Emerg Med J (2006) 0.89
Can peripheral blood mononuclear cells be used as a proxy for mitochondrial dysfunction in vital organs during hemorrhagic shock and resuscitation? Shock (2013) 0.89
Equipment review: the success of early goal-directed therapy for septic shock prompts evaluation of current approaches for monitoring the adequacy of resuscitation. Crit Care (2005) 0.88
Hemodynamic optimization of sepsis-induced tissue hypoperfusion. Crit Care (2006) 0.88
A review of sepsis-induced cardiomyopathy. J Intensive Care (2015) 0.88
Meta-analysis of protocolized goal-directed hemodynamic optimization for the management of severe sepsis and septic shock in the Emergency Department. West J Emerg Med (2014) 0.87
Current practice in hemodynamic monitoring and management in high-risk surgery patients: a national survey of Korean anesthesiologists. Korean J Anesthesiol (2013) 0.87
Hemodynamic monitoring over the past 10 years. Crit Care (2006) 0.86
Why is early goal-directed therapy successful - is it the technology? Crit Care (2005) 0.86
Why measure cardiac output? Crit Care (2003) 0.86
Impact of early haemodynamic goal-directed therapy in patients undergoing emergency surgery: an open prospective, randomised trial. J Clin Monit Comput (2015) 0.85
The key advance in the treatment of sepsis in the last 10 years...doing less. Crit Care (2006) 0.85
Searching for non-invasive markers of tissue hypoxia. Crit Care (2007) 0.85
The Surviving Sepsis Campaign's Revised Sepsis Bundles. Curr Infect Dis Rep (2013) 0.84
Dobutamine reverses the vasopressin-associated impairment in cardiac index and systemic oxygen supply in ovine endotoxemia. Crit Care (2006) 0.84
β2-agonists and acute respiratory distress syndrome. Am J Respir Crit Care Med (2014) 0.83
Examining and mitigating acellular hemoglobin vasoactivity. Antioxid Redox Signal (2012) 0.83
Should we use central venous saturation to guide management in high-risk surgical patients? Crit Care (2006) 0.83
The fluid management of adults with severe malaria. Crit Care (2014) 0.82
Therapeutic strategies for high-dose vasopressor-dependent shock. Crit Care Res Pract (2013) 0.82
The International Sepsis Forum's frontiers in sepsis: High cardiac output should not be maintained in severe sepsis. Crit Care (2003) 0.82
Another nail in the hammer's coffin? Crit Care (2011) 0.82
Clinical review: Outreach - a strategy for improving the care of the acutely ill hospitalized patient. Crit Care (2003) 0.82
Surfactant medication for acute respiratory distress syndrome. Thorax (1997) 0.82
Sepsis: frontiers in diagnosis, resuscitation and antibiotic therapy. Intensive Care Med (2016) 0.82
Basic concepts of fluid responsiveness. Neth Heart J (2013) 0.81
Central venous oxygen saturation in septic shock--a marker of cardiac output, microvascular shunting and/or dysoxia? Crit Care (2011) 0.81
Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications. J Abnorm Psychol (1991) 11.09
Organ donation from intensive care units in England. BMJ (1989) 7.90
Negative affectivity: the disposition to experience aversive emotional states. Psychol Bull (1984) 5.93
Toward a consensual structure of mood. Psychol Bull (1985) 5.58
Health complaints, stress, and distress: exploring the central role of negative affectivity. Psychol Rev (1989) 4.72
Comorbidity of anxiety and unipolar mood disorders. Annu Rev Psychol (1998) 4.71
Temperament, personality, and the mood and anxiety disorders. J Abnorm Psychol (1994) 4.70
Increased mortality associated with growth hormone treatment in critically ill adults. N Engl J Med (1999) 4.63
Serum IgM and IgG responses in postnatally acquired rubella. Lancet (1969) 4.16
Public confidence and cardiac surgical outcome. Cardiac surgery: the fall guy in medical quality assurance. BMJ (1998) 3.77
Measurement of social-evaluative anxiety. J Consult Clin Psychol (1969) 3.72
A gamma-ray burst at a redshift of z approximately 8.2. Nature (2009) 3.29
Positive and negative affectivity and their relation to anxiety and depressive disorders. J Abnorm Psychol (1988) 3.19
Stimulation of insulin secretion by gastric inhibitory polypeptide in man. J Clin Endocrinol Metab (1973) 2.77
Intra-abdominal and gastrointestinal tuberculosis. Colorectal Dis (2007) 2.70
Measurement of Pseudomonas aeruginosa phenazine pigments in sputum and assessment of their contribution to sputum sol toxicity for respiratory epithelium. Infect Immun (1988) 2.56
Mortality and utilisation of critical care resources amongst high-risk surgical patients in a large NHS trust. Anaesthesia (2008) 2.42
Pyocyanin and 1-hydroxyphenazine produced by Pseudomonas aeruginosa inhibit the beating of human respiratory cilia in vitro. J Clin Invest (1987) 2.40
An open-label dose escalation study of the nitric oxide synthase inhibitor, N(G)-methyl-L-arginine hydrochloride (546C88), in patients with septic shock. Glaxo Wellcome International Septic Shock Study Group. Crit Care Med (1999) 2.33
Hyaluronic acid in synovial fluid. I. Molecular parameters of hyaluronic acid in normal and arthritis human fluids. Arthritis Rheum (1967) 2.23
Is there a Persian Gulf War syndrome? Evidence from a large population-based survey of veterans and nondeployed controls. Am J Med (2000) 2.23
Preliminary observations on the neuromuscular abnormalities in patients with organ failure and sepsis. Intensive Care Med (1993) 2.20
Drotrecogin alfa (activated): diffusion from clinical trials to clinical practice. Eur J Anaesthesiol (2007) 2.19
Diagnosis and classification of psychopathology: challenges to the current system and future directions. Annu Rev Psychol (1995) 2.11
In situ bioreduction of technetium and uranium in a nitrate-contaminated aquifer. Environ Sci Technol (2004) 2.11
Response of critically ill patients to treatment aimed at achieving supranormal oxygen delivery and consumption. Relationship to outcome. Chest (1993) 2.01
Isolation and characterization of antigenic components of a new heptavalent Pseudomonas vaccine. Nat New Biol (1971) 1.98
Manipulating hemodynamics and oxygen transport in critically ill patients. N Engl J Med (1995) 1.91
Safety and efficacy of postoperative epidural analgesia. Br J Anaesth (2001) 1.90
Serum Copper Levels in Pregnancy and Pre-Eclampsia. J Clin Pathol (1949) 1.85
Biochemical quantification of DNA in human articular and septal cartilage using PicoGreen and Hoechst 33258. Osteoarthritis Cartilage (2002) 1.84
Initial construction of a maladaptive personality trait model and inventory for DSM-5. Psychol Med (2011) 1.78
Colchicine myopathy and neuropathy. N Engl J Med (1987) 1.77
The clinical course and management of thoracic empyema. QJM (1996) 1.76
A prospective randomised concurrent comparison of the COBE Spectra Version 4.7, COBE Spectra Version 6 (auto PBSC) and Haemonetics MCS+ cell separators for leucapheresis in patients with haematological and non-haematological malignancies. Transfus Apher Sci (2001) 1.68
Plastic bronchitis occurring late after the Fontan procedure: treatment with aerosolized urokinase. Crit Care Med (2000) 1.66
Oxygen transport patterns in patients with sepsis syndrome or septic shock: influence of treatment and relationship to outcome. Crit Care Med (1997) 1.66
Mood and the mundane: relations between daily life events and self-reported mood. J Pers Soc Psychol (1988) 1.56
Texture analysis of aggressive and nonaggressive lung tumor CE CT images. IEEE Trans Biomed Eng (2008) 1.52
Patients with faecal peritonitis admitted to European intensive care units: an epidemiological survey of the GenOSept cohort. Intensive Care Med (2013) 1.52
Incidence and outcome of critical illness amongst hospitalised patients with haematological malignancy: a prospective observational study of ward and intensive care unit based care. Anaesthesia (2005) 1.50
Sustained cognitive improvement following treatment of Alzheimer's disease with donepezil. Int J Geriatr Psychiatry (2000) 1.48
Testing of Streptococcus pneumoniae for resistance to penicillin. J Clin Microbiol (1993) 1.46
Managing chronic headaches in the clinic. Int J Clin Pract (2004) 1.45
Preparation, characterization, and immunogenicity of conjugates composed of the O-specific polysaccharide of Shigella dysenteriae type 1 (Shiga's bacillus) bound to tetanus toxoid. Infect Immun (1991) 1.44
Purification and structural analysis of pyocyanin and 1-hydroxyphenazine. Eur J Biochem (1986) 1.43
Inverting papilloma of the head and neck: the UCLA update. Otolaryngol Head Neck Surg (1993) 1.43
Symmetrical peripheral gangrene: association with noradrenaline administration. Intensive Care Med (1992) 1.42
Is being Aboriginal or Torres Strait Islander a risk factor for poor neonatal outcome in a tertiary referral unit in north Queensland? J Paediatr Child Health (2002) 1.40
Improving outpatient diabetes management through a collaboration of six competing, capitated Medicare managed care plans. Am J Med Qual (2000) 1.37
Variations in the incidence of lipodystrophy using different insulins. Med J Aust (1973) 1.36
ABC of major trauma. Management of the upper airway. BMJ (1990) 1.32
Antibody to capsular polysaccharides of Streptococcus pneumoniae after vaccination of human immunodeficiency virus-infected subjects with 23-valent pneumococcal vaccine. J Infect Dis (1992) 1.32
Monoclonal antibodies in sepsis and septic shock. BMJ (1992) 1.31
Glutamyl-tRNA synthetases of Bacillus subtilis 168T and of Bacillus stearothermophilus. Cloning and sequencing of the gltX genes and comparison with other aminoacyl-tRNA synthetases. J Biol Chem (1990) 1.25
A three-factor model of trait anger: dimensions of affect, behavior, and cognition. J Pers (2000) 1.25
Tumour gene expression predicts response to cetuximab in patients with KRAS wild-type metastatic colorectal cancer. Br J Cancer (2011) 1.24
Nocodazole action on tubulin assembly, axonal ultrastructure and fast axoplasmic transport. J Pharmacol Exp Ther (1979) 1.24
The association of rhinoviruses with lower respiratory tract disease in hospitalized patients. J Med Virol (1986) 1.23
Serum antibody response in adult volunteers elicited by injection of Streptococcus pneumoniae type 12F polysaccharide alone or conjugated to diphtheria toxoid. Infect Immun (1990) 1.20
Recombinant human growth hormone, insulin-like growth factor 1, and combination therapy in AIDS-associated wasting. A randomized, double-blind, placebo-controlled trial. Ann Intern Med (1996) 1.16
Nucleotide sequence of two overlapping myc-related genes in avian carcinoma virus OK10 and their relation to the myc genes of other viruses and the cell. Proc Natl Acad Sci U S A (1985) 1.16
Towards a method for automated classification of 1H MRS spectra from brain tumours. NMR Biomed (1998) 1.14
Horner's syndrome and vocal cord paralysis as a complication of percutaneous internal jugular vein catheterisation in adults. Anaesthesia (1982) 1.14
Prognosis of patients receiving intensive care for lifethreatening medical complications of haematological malignancy. Br Med J (Clin Res Ed) (1988) 1.14
Physiological scoring systems and audit. Lancet (1993) 1.09
The afterglow of GRB 050709 and the nature of the short-hard gamma-ray bursts. Nature (2005) 1.09
Utilization of microbial biofilms as monitors of bioremediation. Microb Ecol (2004) 1.09
Expression of ets family of genes in systemic lupus erythematosus and Sjogren's syndrome. Int J Oncol (1996) 1.08
New guidelines for the management of migraine in primary care. Curr Med Res Opin (2002) 1.08
Serum triiodothyronine determination in clinical use. J Clin Pathol (1976) 1.08
TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study. Genes Immun (2004) 1.06
Emergency and prolonged use of intravenous etomidate to control hypercortisolemia in a patient with Cushing's syndrome and peritonitis. J Clin Endocrinol Metab (1998) 1.05
Exertional heat stroke induced by amphetamine analogues. Does dantrolene have a place? Anaesthesia (1993) 1.04
Stimulant medication use by primary care physicians in the treatment of attention deficit hyperactivity disorder. Pediatrics (1990) 1.04
Effect of pyocyanin and 1-hydroxyphenazine on in vivo tracheal mucus velocity. J Appl Physiol (1985) (1989) 1.04
A review of the results of laparoscopic versus open appendectomy. Surg Gynecol Obstet (1993) 1.03
Patterns of neurophysiological abnormality in prolonged critical illness. Intensive Care Med (1998) 1.02
The preparation and biological activity of novel amino acid analogs of butirosin. Carbohydr Res (1973) 1.02
Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration. Hepatology (1991) 1.02
Analytical investigations closer to the patient. Br Med J (1980) 1.01
The specificity of inhibition of debrisoquine 4-hydroxylase activity by quinidine and quinine in the rat is the inverse of that in man. Biochem Pharmacol (1989) 1.00
The structure of common and uncommon mental disorders. Psychol Med (2012) 0.99
Incidence and pathogenesis of acute megaloblastic bone-marrow change in patients receiving intensive care. Lancet (1982) 0.98
Fat embolism syndrome. Br J Hosp Med (1989) 0.97
Adrenaline administered via a nebulizer in adult patients with upper airway obstruction. Anaesthesia (1995) 0.96
Selection of mutant Chinese hamster ovary cells altered glycoproteins by means of tritiated fucose suicide. Mol Cell Biol (1981) 0.96