Published in EMBO J on June 01, 1994
Hepatitis B virus biology. Microbiol Mol Biol Rev (2000) 7.58
Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas. Gut (2005) 1.66
Molecular biology of hepatitis B virus infection. Virology (2015) 1.47
A new hepadnavirus endemic in arctic ground squirrels in Alaska. J Virol (1996) 1.26
Clonal expansion of hepatocytes during chronic woodchuck hepatitis virus infection. Proc Natl Acad Sci U S A (2005) 1.17
Combination of DNA prime--adenovirus boost immunization with entecavir elicits sustained control of chronic hepatitis B in the woodchuck model. PLoS Pathog (2013) 1.16
The HNF1/HNF4-dependent We2 element of woodchuck hepatitis virus controls viral replication and can activate the N-myc2 promoter. J Virol (1996) 1.10
Apoptosis is induced by N-myc expression in hepatocytes, a frequent event in hepadnavirus oncogenesis, and is blocked by insulin-like growth factor II. J Virol (1996) 1.06
Virus associated malignancies: the role of viral hepatitis in hepatocellular carcinoma. Semin Cancer Biol (2014) 1.04
Double-stranded linear duck hepatitis B virus (DHBV) stably integrates at a higher frequency than wild-type DHBV in LMH chicken hepatoma cells. J Virol (1999) 1.03
Increase in the frequency of hepadnavirus DNA integrations by oxidative DNA damage and inhibition of DNA repair. J Virol (1997) 1.01
Detection of clonally expanded hepatocytes in chimpanzees with chronic hepatitis B virus infection. J Virol (2009) 1.00
Pathogenesis of occult chronic hepatitis B virus infection. World J Gastroenterol (2011) 0.97
Cellular factors controlling the activity of woodchuck hepatitis virus enhancer II. J Virol (1996) 0.96
The liver of woodchucks chronically infected with the woodchuck hepatitis virus contains foci of virus core antigen-negative hepatocytes with both altered and normal morphology. Virology (2006) 0.91
Hepatocellular carcinoma. Cold Spring Harb Perspect Med (2015) 0.88
Woodchuck hepatitis virus enhancer I and enhancer II are both involved in N-myc2 activation in woodchuck liver tumors. J Virol (1998) 0.87
Distinct Viral Lineages from Fish and Amphibians Reveal the Complex Evolutionary History of Hepadnaviruses. J Virol (2016) 0.85
Early mesozoic coexistence of amniotes and hepadnaviridae. PLoS Genet (2014) 0.84
Animal models and the molecular biology of hepadnavirus infection. Cold Spring Harb Perspect Med (2015) 0.79
Antisense downregulation of N-myc1 in woodchuck hepatoma cells reverses the malignant phenotype. J Virol (1998) 0.78
Liver cell transformation in chronic HBV infection. Viruses (2009) 0.76
Functional analysis of ground squirrel hepatitis virus enhancer II. J Virol (1998) 0.75
Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan. Lancet (1981) 13.54
The molecular biology of the hepatitis B viruses. Annu Rev Biochem (1987) 12.32
Origin and evolution of retroelements based upon their reverse transcriptase sequences. EMBO J (1990) 9.93
A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks. Proc Natl Acad Sci U S A (1978) 8.92
The hepatitis B virus. Nature (1985) 8.71
Sequence homology between retroviral reverse transcriptase and putative polymerases of hepatitis B virus and cauliflower mosaic virus. Nature (1983) 6.96
Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma. Nature (1990) 4.10
Variant (6;15) translocations in murine plasmacytomas involve a chromosome 15 locus at least 72 kb from the c-myc oncogene. EMBO J (1985) 3.68
Eukaryotic activators function during multiple steps of preinitiation complex assembly. Nature (1993) 3.16
Transcription of T cell receptor beta-chain genes is controlled by a downstream regulatory element. EMBO J (1988) 2.93
The matrix attachment regions of the chicken lysozyme gene co-map with the boundaries of the chromatin domain. EMBO J (1988) 2.66
A novel, inducible and T cell-specific enhancer located at the 3' end of the T cell receptor alpha locus. EMBO J (1989) 2.64
Frequent activation of N-myc genes by hepadnavirus insertion in woodchuck liver tumours. Nature (1990) 2.61
Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma. Nature (1986) 2.21
Common evolutionary origin of hepatitis B virus and retroviruses. Proc Natl Acad Sci U S A (1986) 2.20
The enhancer of the immunoglobulin heavy chain locus is flanked by presumptive chromosomal loop anchorage elements. J Biol Chem (1987) 2.15
Transcriptional regulation of multigene loci: multilevel control. Trends Genet (1993) 2.12
Hepatocarcinogenicity of the woodchuck hepatitis virus. Proc Natl Acad Sci U S A (1987) 1.93
Molecular basis of human B cell neoplasia. Blood (1985) 1.85
Transcriptional activation of Drosophila homeotic genes from distant regulatory elements. Trends Genet (1993) 1.83
Interaction between transcription regulatory regions of prolactin chromatin. Science (1993) 1.75
The size of chromatin loops in HeLa cells. EMBO J (1990) 1.75
Long-range restriction map of the terminal part of the short arm of the human X chromosome. Proc Natl Acad Sci U S A (1990) 1.75
Tumorigenesis by slow-transforming retroviruses--an update. Biochim Biophys Acta (1990) 1.71
A simple method for simultaneous R- or G-banding and fluorescence in situ hybridization of small single-copy genes. Cytogenet Cell Genet (1992) 1.64
Long-distance activation of the Myc protooncogene by provirus insertion in Mlvi-1 or Mlvi-4 in rat T-cell lymphomas. Proc Natl Acad Sci U S A (1990) 1.63
Retroviral insertions 90 kilobases proximal to the Evi-1 myeloid transforming gene activate transcription from the normal promoter. Mol Cell Biol (1991) 1.61
Physical mapping of the human pseudo-autosomal region; comparison with genetic linkage map. EMBO J (1988) 1.60
Activation of c-myc by woodchuck hepatitis virus insertion in hepatocellular carcinoma. Cell (1988) 1.58
Threshold phenomena and long-distance activation of transcription by RNA polymerase II. Science (1992) 1.52
Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc. Mol Cell Biol (1989) 1.52
Tight clustering of human hepatitis B virus integration sites in hepatomas near a triple-stranded region. J Virol (1987) 1.42
Complete nucleotide sequence of a molecular clone of woodchuck hepatitis virus that is infectious in the natural host. Proc Natl Acad Sci U S A (1989) 1.41
Differential activation of myc gene family members in hepatic carcinogenesis by closely related hepatitis B viruses. Mol Cell Biol (1993) 1.38
Hepadnavirus integration: mechanisms of activation of the N-myc2 retrotransposon in woodchuck liver tumors. J Virol (1992) 1.34
Chromatin dynamics and the modulation of genetic activity. Trends Biochem Sci (1992) 1.25
Effects of translocations on transcription from PVT. Mol Cell Biol (1990) 1.25
Topoisomerase I-mediated integration of hepadnavirus DNA in vitro. J Virol (1991) 1.19
Hepatocellular carcinoma in ground squirrels persistently infected with ground squirrel hepatitis virus. Proc Natl Acad Sci U S A (1986) 1.17
The Mlvi-1 locus involved in the induction of rat T-cell lymphomas and the pvt-1/Mis-1 locus are identical. J Virol (1989) 1.10
Frequent amplification of c-myc in ground squirrel liver tumors associated with past or ongoing infection with a hepadnavirus. Proc Natl Acad Sci U S A (1992) 0.99
Regulatory elements in the immunoglobulin kappa locus induce c-myc activation and the promoter shift in Burkitt's lymphoma cells. EMBO J (1993) 0.93
Chromosomal sites for hepatitis B virus integration in human hepatocellular carcinoma. J Virol (1991) 0.90
Expression of the woodchuck N-myc2 retroposon in brain and in liver tumors is driven by a cryptic N-myc promoter. Mol Cell Biol (1992) 0.85
Nucleotide sequence of the woodchuck N-myc gene (WN-myc1). Nucleic Acids Res (1990) 0.82
[Great degree of homology between the ancestral karyotype of squirrels (rodents) and that of primates and carnivores]. Ann Genet (1984) 0.80
The genome of black cottonwood, Populus trichocarpa (Torr. & Gray). Science (2006) 21.03
Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli. Nature (1979) 15.42
Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma (1997) 11.04
The hepatitis B virus. Nature (1985) 8.71
Sequence of simian immunodeficiency virus from macaque and its relationship to other human and simian retroviruses. Nature (1987) 7.96
Nucleotide sequence of the visna lentivirus: relationship to the AIDS virus. Cell (1985) 7.86
Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene. Nature (1990) 5.50
Identification of a second human retinoic acid receptor. Nature (1988) 5.11
Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas. Proc Natl Acad Sci U S A (1998) 4.99
Biology of hepatitis B virus. Science (1981) 4.93
Cloning in Escherichia coli and physical structure of hepatitis B virion DNA. Proc Natl Acad Sci U S A (1979) 4.71
Bacteriophage lambda having EcoRI endonuclease sites only in the nonessential region of the genome. Proc Natl Acad Sci U S A (1974) 4.35
Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial. Neurology (2006) 4.11
Excretion of hepatitis B surface antigen particles from mouse cells transformed with cloned viral DNA. Proc Natl Acad Sci U S A (1980) 3.97
Transcription of the hepatitis B surface antigen gene in mouse cells transformed with cloned viral DNA. J Virol (1982) 3.51
Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma. Nature (1980) 3.16
Detection of hepatitis B virus DNA in serum by a simple spot hybridization technique: comparison with results for other viral markers. Hepatology (1983) 3.11
Biosynthesis of hepatitis B virus surface antigen in Escherichia coli. Nature (1980) 3.00
PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase. J Biol Chem (1999) 2.92
Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription. Genes Dev (2000) 2.90
Two interferon mRNAs in human fibroblasts: in vitro translation and Escherichia coli cloning studies. Proc Natl Acad Sci U S A (1980) 2.88
Detection of hepatitis B virus DNA in liver and serum: a direct appraisal of the chronic carrier state. Lancet (1981) 2.80
Nucleotide sequence and expression of the diphtheria tox228 gene in Escherichia coli. Science (1983) 2.65
Frequent activation of N-myc genes by hepadnavirus insertion in woodchuck liver tumours. Nature (1990) 2.61
Transcription of woodchuck hepatitis virus in the chronically infected liver. EMBO J (1985) 2.49
The cytoplasmic domain of simian immunodeficiency virus transmembrane protein modulates infectivity. J Virol (1989) 2.46
Localization on the viral genome and nucleotide sequence of the gene coding for the two major polypeptides of the hepatitis B surface antigen (HBs Ag). Nucleic Acids Res (1979) 2.42
Differential expression and ligand regulation of the retinoic acid receptor alpha and beta genes. EMBO J (1989) 2.41
Three novel mammalian toll-like receptors: gene structure, expression, and evolution. Eur Cytokine Netw (2000) 2.40
Structure of two adenovirus type 12 transforming polypeptides and their evolutionary implications. Nature (1980) 2.38
State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and -negative liver diseases. Proc Natl Acad Sci U S A (1981) 2.37
Seed-specific over-expression of an Arabidopsis cDNA encoding a diacylglycerol acyltransferase enhances seed oil content and seed weight. Plant Physiol (2001) 2.31
The Arabidopsis thaliana TAG1 mutant has a mutation in a diacylglycerol acyltransferase gene. Plant J (1999) 2.30
Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice. Cancer Res (1999) 2.23
Molecular cloning of lymphadenopathy-associated virus. Nature (1985) 2.22
Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma. Nature (1986) 2.21
In vitro and in vivo synthesis of the hepatitis B virus surface antigen and of the receptor for polymerized human serum albumin from recombinant human adenoviruses. EMBO J (1985) 2.18
Enhanced immunogenicity of the pre-S region of hepatitis B surface antigen. Science (1985) 2.18
Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptors. J Exp Med (1996) 2.08
[Trisomy 21 and superoxide dismutase-1 (IPO-A). Tentative localization of sub-band 21Q22.1]. Exp Cell Res (1976) 2.07
Maternal inhibition of hepatitis B surface antigen gene expression in transgenic mice correlates with de novo methylation. Nature (1987) 2.00
Synthesis in animal cells of hepatitis B surface antigen particles carrying a receptor for polymerized human serum albumin. Proc Natl Acad Sci U S A (1984) 2.00
A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma. Nature (1988) 1.96
Transmission of hepatitis B from hepatitis-B-seronegative subjects. Lancet (1988) 1.95
Quality assessment of genetic markers used for therapy stratification. J Clin Oncol (2003) 1.92
[Staining of human chromosomes with acridine orange after treatment with 5 bromodeoxyuridine]. C R Acad Sci Hebd Seances Acad Sci D (1973) 1.89
Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation. Am J Pathol (1999) 1.87
NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines. Genomics (2001) 1.85
The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice. Oncogene (1997) 1.81
A new member of the ETS family fused to EWS in Ewing tumors. Oncogene (1997) 1.79
Oxygen-mediated regulation of skeletal muscle satellite cell proliferation and adipogenesis in culture. J Cell Physiol (2001) 1.76
The use of synthetic tandem repeats to isolate new VNTR loci: cloning of a human hypermutable sequence. Genomics (1991) 1.76
Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer (1997) 1.74
A genomic approach of the hepatitis C virus generates a protein interaction map. Gene (2000) 1.72
Specific hepatitis B virus integration in hepatocellular carcinoma DNA through a viral 11-base-pair direct repeat. Proc Natl Acad Sci U S A (1984) 1.71
Characterization of integrated hepatitis B viral DNA cloned from a human hepatoma and the hepatoma-derived cell line PLC/PRF/5. Proc Natl Acad Sci U S A (1983) 1.69
Replication and gene expression of hepatitis B virus in a transgenic mouse that contains the complete viral genome. J Virol (1988) 1.68
Targeted agents in metastatic Xp11 translocation/TFE3 gene fusion renal cell carcinoma (RCC): a report from the Juvenile RCC Network. Ann Oncol (2010) 1.65
[Cloning of the hepatitis B virus genome in Escherichia coli]. C R Acad Sci Hebd Seances Acad Sci D (1978) 1.62
Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia. Leukemia (2008) 1.61
DNA-mediated immunization to the hepatitis B surface antigen in mice: aspects of the humoral response mimic hepatitis B viral infection in humans. Proc Natl Acad Sci U S A (1995) 1.60
Activation of c-myc by woodchuck hepatitis virus insertion in hepatocellular carcinoma. Cell (1988) 1.58
Transmission of hepatitis B by transplantation of livers from donors positive for antibody to hepatitis B core antigen. The National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database. Gastroenterology (1997) 1.54
Comprehensive allelotyping of human hepatocellular carcinoma. Oncogene (1997) 1.52
Comprehensive screening for constitutional RB1 mutations by DHPLC and QMPSF. Hum Mutat (2004) 1.52
Mac-1 (CD11b/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells. Blood (1996) 1.52
Interregional migration in socialist countries: the case of China. GeoJournal (1997) 1.49
Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin. J Clin Invest (1997) 1.49
Detection of hepatitis B virus DNA in mononuclear blood cells. Br Med J (Clin Res Ed) (1984) 1.49
Akt is essential for insulin modulation of amphetamine-induced human dopamine transporter cell-surface redistribution. Mol Pharmacol (2005) 1.47
Hepatitis G virus infection before and after liver transplantation. Liver Transplantation Database. Liver Transpl Surg (1997) 1.44
Nucleotide sequence and evolution of ETn elements. Proc Natl Acad Sci U S A (1987) 1.42
Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer. Nature (1997) 1.42
Crystal structure of RhoA-GDP and its functional implications. Nat Struct Biol (1997) 1.42
A mutational epitope for cytochrome C binding to the apoptosis protease activation factor-1. J Biol Chem (2000) 1.41
Synthesis of human interferon beta 1 in Escherichia coli infected by a lambda phage recombinant containing a human genomic fragment. Eur J Biochem (1981) 1.41
Bilateral renal oncocytosis with renal failure. Arch Pathol Lab Med (2001) 1.41
Crystal structure, at 2.6-A resolution, of the Streptomyces lividans xylanase A, a member of the F family of beta-1,4-D-glycanases. J Biol Chem (1994) 1.41
Assessing HER2 gene amplification as a potential target for therapy in invasive urothelial bladder cancer with a standardized methodology: results in 1005 patients. Ann Oncol (2009) 1.40
Secretory clusterin is upregulated in rats with pulmonary arterial hypertension induced by systemic-to-pulmonary shunts and exerts important roles in pulmonary artery smooth muscle cells. Acta Physiol (Oxf) (2014) 1.39
Chromosomal CGH identifies patients with a higher risk of relapse in neuroblastoma without MYCN amplification. Br J Cancer (2007) 1.39
hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer. Proc Natl Acad Sci U S A (1998) 1.38
Constitutional balanced translocations in patients with solid tumors. Cancer Genet Cytogenet (1992) 1.38
Evidence that hepatitis B virus has a role in liver-cell carcinoma in alcoholic liver disease. N Engl J Med (1982) 1.37
Endothelin-induced conversion of embryonic heart muscle cells into impulse-conducting Purkinje fibers. Proc Natl Acad Sci U S A (1998) 1.37
Sequence of DNA replication in 277 R- and Q-bands of human chromosomes using a BrdU treatment. Chromosoma (1976) 1.36
Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family. Genes Chromosomes Cancer (1994) 1.36
Hepadnavirus integration: mechanisms of activation of the N-myc2 retrotransposon in woodchuck liver tumors. J Virol (1992) 1.34
[Mosaic 14 trisomy in a female child with multiple abnormalities]. Ann Genet (1975) 1.34
Fused transcripts of c-myc and a new cellular locus, hcr in a primary liver tumor. Oncogene (1989) 1.33
Detection of hepatitis B virus DNA in pancreas, kidney and skin of two human carriers of the virus. J Gen Virol (1984) 1.32
Comparison of the effects of sucrose and fructose on insulin action and glucose tolerance. Am J Physiol Regul Integr Comp Physiol (2000) 1.31