Participation of cyclin A in Myc-induced apoptosis.

PubWeight™: 2.34‹?› | Rank: Top 2%

🔗 View Article (PMC 44300)

Published in Proc Natl Acad Sci U S A on July 19, 1994

Authors

A T Hoang1, K J Cohen, J F Barrett, D A Bergstrom, C V Dang

Author Affiliations

1: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

Articles citing this

c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol (1999) 8.17

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol (2001) 8.03

c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc Natl Acad Sci U S A (1997) 5.43

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc Natl Acad Sci U S A (1994) 5.11

AIS is an oncogene amplified in squamous cell carcinoma. Proc Natl Acad Sci U S A (2000) 4.37

Cyclins and cyclin-dependent kinases: a biochemical view. Biochem J (1995) 2.57

c-Myc regulates cyclin D-Cdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent points. Mol Cell Biol (1999) 2.50

A unique glucose-dependent apoptotic pathway induced by c-Myc. Proc Natl Acad Sci U S A (1998) 2.34

Cyclin D1 is an essential mediator of apoptotic neuronal cell death. EMBO J (1996) 2.31

Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle. Proc Natl Acad Sci U S A (1996) 2.24

Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation. Mol Cell Biol (1998) 1.93

Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes. EMBO J (1995) 1.92

Identification of putative c-Myc-responsive genes: characterization of rcl, a novel growth-related gene. Mol Cell Biol (1997) 1.92

Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression. Genes Dev (2000) 1.87

Dual inactivation of RB and p53 pathways in RAS-induced melanomas. Mol Cell Biol (2001) 1.73

HMG-I/Y, a new c-Myc target gene and potential oncogene. Mol Cell Biol (2000) 1.71

Loss of FBP function arrests cellular proliferation and extinguishes c-myc expression. EMBO J (2000) 1.69

Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway. Mol Med (1995) 1.65

Regulation of late G1/S phase transition and APC Cdh1 by reactive oxygen species. Mol Cell Biol (2006) 1.65

Translational control of programmed cell death: eukaryotic translation initiation factor 4E blocks apoptosis in growth-factor-restricted fibroblasts with physiologically expressed or deregulated Myc. Mol Cell Biol (1996) 1.60

A link between increased transforming activity of lymphoma-derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domain. Mol Cell Biol (1995) 1.59

Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis. EMBO J (1996) 1.58

Enhanced RNA polymerase III-dependent transcription is required for oncogenic transformation. J Biol Chem (2008) 1.53

Modulation of apoptosis by the cyclin-dependent kinase inhibitor p27(Kip1). J Clin Invest (1999) 1.46

Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity. Mol Cell Biol (2008) 1.44

Upstream stimulatory factor regulates expression of the cell cycle-dependent cyclin B1 gene promoter. Mol Cell Biol (1995) 1.43

Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis. EMBO J (1996) 1.37

Transformation by the Bmi-1 oncoprotein correlates with its subnuclear localization but not its transcriptional suppression activity. Mol Cell Biol (1996) 1.36

Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues. Mol Cell Biol (2004) 1.35

The latency-related gene of bovine herpesvirus 1 encodes a product which inhibits cell cycle progression. J Virol (1996) 1.33

Human adenovirus type 9 E4 open reading frame 1 encodes a cytoplasmic transforming protein capable of increasing the oncogenicity of CREF cells. J Virol (1996) 1.26

Ionizing radiation induces apoptosis and elevates cyclin A1-Cdk2 activity before but not after the midblastula transition in Xenopus. Mol Biol Cell (1997) 1.23

c-Myc is necessary for DNA damage-induced apoptosis in the G(2) phase of the cell cycle. Mol Cell Biol (2001) 1.19

Exendin-4 stimulation of cyclin A2 in beta-cell proliferation. Diabetes (2008) 1.17

A novel association between the human heat shock transcription factor 1 (HSF1) and prostate adenocarcinoma. Am J Pathol (2000) 1.11

A protein encoded by the latency-related gene of bovine herpesvirus 1 is expressed in trigeminal ganglionic neurons of latently infected cattle and interacts with cyclin-dependent kinase 2 during productive infection. J Virol (1998) 1.10

Increased expression of TATA-binding protein, the central transcription factor, can contribute to oncogenesis. Mol Cell Biol (2003) 1.09

Extracellular matrix remodeling and the regulation of epithelial-stromal interactions during differentiation and involution. Kidney Int Suppl (1996) 1.07

A link between c-Myc-mediated transcriptional repression and neoplastic transformation. J Clin Invest (1996) 1.06

Walleye dermal sarcoma virus: OrfA N-terminal end inhibits the activity of a reporter gene directed by eukaryotic promoters and has a negative effect on the growth of fish and mammalian cells. J Virol (1999) 0.98

Tumor necrosis factor-alpha-induced apoptosis in hepatocytes in long-term culture. Am J Pathol (1996) 0.96

Cyclin D3 sensitizes tumor cells to tumor necrosis factor-induced, c-Myc-dependent apoptosis. Mol Cell Biol (1996) 0.92

Knocking-down cyclin A(2) by siRNA suppresses apoptosis and switches differentiation pathways in K562 cells upon administration with doxorubicin. PLoS One (2009) 0.90

Bax-mediated cell death by the Gax homeoprotein requires mitogen activation but is independent of cell cycle activity. EMBO J (1998) 0.90

Tumor necrosis factor-alpha acts as a complete mitogen for primary rat hepatocytes. Am J Pathol (2003) 0.89

Commitment and effector phases of the physiological cell death pathway elucidated with respect to Bcl-2 caspase, and cyclin-dependent kinase activities. Mol Cell Biol (1998) 0.86

Cdk2-dependent phosphorylation of p21 regulates the role of Cdk2 in cisplatin cytotoxicity. Am J Physiol Renal Physiol (2011) 0.85

DeltaRaf-1:ER* bypasses the cyclic AMP block of extracellular signal-regulated kinase 1 and 2 activation but not CDK2 activation or cell cycle reentry. Mol Cell Biol (2003) 0.84

Comparative pathogenesis of epsilonretroviruses. J Virol (2003) 0.83

Transgenic expression of walleye dermal sarcoma virus rv-cyclin gene in zebrafish and its suppressive effect on liver tumor development after carcinogen treatment. Mar Biotechnol (NY) (2010) 0.82

Mitochondrial uncoupling protein 2 induces cell cycle arrest and necrotic cell death. Metab Syndr Relat Disord (2013) 0.79

Colocalization of somatic and meiotic double strand breaks near the Myc oncogene on mouse chromosome 15. Genes Chromosomes Cancer (2009) 0.79

Apoptosis induced by tumor necrosis factor-alpha in rat hepatocyte cell lines expressing hepatitis B virus. Am J Pathol (1996) 0.79

Repression of cyclin D1 expression does not contribute to initiation or maintenance of cell transformation by adenovirus type 5 E1. J Virol (1996) 0.77

Rewiring of the apoptotic TGF-β-SMAD/NFκB pathway through an oncogenic function of p27 in human papillary thyroid cancer. Oncogene (2016) 0.76

Theabrownin Inhibits Cell Cycle Progression and Tumor Growth of Lung Carcinoma through c-myc-Related Mechanism. Front Pharmacol (2017) 0.75

Novel rapid tissue lysis method to evaluate cancer proteins: correlation between elevated Bcl-X(L) expression and colorectal cancer cell proliferation. World J Gastroenterol (2005) 0.75

Elevated cyclin A associated kinase activity promotes sensitivity of metastatic human cancer cells to DNA antimetabolite drug. Int J Oncol (2015) 0.75

Articles cited by this

Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65

Induction of apoptosis in fibroblasts by c-myc protein. Cell (1992) 16.95

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature (1988) 14.66

Social controls on cell survival and cell death. Nature (1992) 9.81

Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B. Nature (1990) 7.34

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J Immunol (1984) 6.82

Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis. J Pathol (1984) 6.67

Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell (1991) 6.65

Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature (1992) 5.50

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene (1991) 5.32

Programmed cell death: apoptosis and oncogenesis. Cell (1991) 4.78

Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature (1992) 4.75

Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase. Cell (1993) 4.37

Premature p34cdc2 activation required for apoptosis. Science (1994) 4.15

Cyclins and cancer. Cell (1991) 3.65

Cell cycle regulation in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe. Annu Rev Cell Biol (1991) 3.14

A link between cyclin A expression and adhesion-dependent cell cycle progression. Science (1993) 2.96

Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E. Mol Cell Biol (1993) 2.75

Differential modulation of cyclin gene expression by MYC. Proc Natl Acad Sci U S A (1993) 2.31

Activation of cyclin A-dependent protein kinases during apoptosis. Proc Natl Acad Sci U S A (1994) 2.29

IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: demonstration of a novel role for c-myc. Cell (1992) 2.25

Myc and Max function as a nucleoprotein complex. Curr Opin Genet Dev (1992) 1.76

Function of the c-Myc oncoprotein. FASEB J (1992) 1.34

Cell cycle control in normal and neoplastic cells. Curr Opin Genet Dev (1992) 1.25

Inducible transformation of fibroblasts using a metallothionein-v-myc gene construct. Oncogene (1991) 0.92

Articles by these authors

c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc Natl Acad Sci U S A (1997) 5.43

An amino-terminal c-myc domain required for neoplastic transformation activates transcription. Mol Cell Biol (1990) 4.24

In vitro and in vivo antibacterial activities of levofloxacin (l-ofloxacin), an optically active ofloxacin. Antimicrob Agents Chemother (1992) 3.88

Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J Biol Chem (2000) 3.74

Identification of CDK4 as a target of c-MYC. Proc Natl Acad Sci U S A (2000) 3.38

Translocations involving c-myc and c-myc function. Oncogene (2001) 3.21

Effect of epidural vs parenteral opioid analgesia on the progress of labor: a meta-analysis. JAMA (1999) 3.08

Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression. Mol Cell Biol (1999) 3.08

Max: functional domains and interaction with c-Myc. Genes Dev (1992) 2.88

Hypoxia inhibits G1/S transition through regulation of p27 expression. J Biol Chem (2000) 2.70

Identification of c-myc responsive genes using rat cDNA microarray. Cancer Res (2000) 2.62

c-Myc is glycosylated at threonine 58, a known phosphorylation site and a mutational hot spot in lymphomas. J Biol Chem (1995) 2.47

Two domains of MyoD mediate transcriptional activation of genes in repressive chromatin: a mechanism for lineage determination in myogenesis. Genes Dev (1997) 2.40

A unique glucose-dependent apoptotic pathway induced by c-Myc. Proc Natl Acad Sci U S A (1998) 2.34

In vivo repackaging of recombinant cosmid molecules for analyses of Salmonella typhimurium, Streptococcus mutans, and mycobacterial genomic libraries. Infect Immun (1986) 2.31

A potential transcriptional activation element in the p53 protein. Oncogene (1990) 2.07

Transformation of Streptococcus mutans with chromosomal and shuttle plasmid (pYA629) DNAs. Infect Immun (1986) 2.00

Isolation and properties of porcine thyrotropin-releasing hormone. J Biol Chem (1969) 1.97

Identification of putative c-Myc-responsive genes: characterization of rcl, a novel growth-related gene. Mol Cell Biol (1997) 1.92

Characterization of nucleophosmin (B23) as a Myc target by scanning chromatin immunoprecipitation. J Biol Chem (2001) 1.89

Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo. Proc Natl Acad Sci U S A (2000) 1.89

Binding and suppression of the Myc transcriptional activation domain by p107. Science (1994) 1.84

Structure, function, and assembly of cell walls of gram-positive bacteria. Annu Rev Microbiol (1983) 1.80

The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1. Oncogene (1996) 1.65

A link between increased transforming activity of lymphoma-derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domain. Mol Cell Biol (1995) 1.59

Glycosylation of the c-Myc transactivation domain. Proc Natl Acad Sci U S A (1995) 1.58

Biochemical characteristics and physiological significance of major DNA topoisomerases. Antimicrob Agents Chemother (1989) 1.55

Frequent detection of tumor cells in hematopoietic grafts in neuroblastoma and Ewing's sarcoma. Bone Marrow Transplant (1998) 1.51

Immunoablative high-dose cyclophosphamide without stem-cell rescue for refractory, severe autoimmune disease. Ann Intern Med (1998) 1.51

D1 dopamine receptor activation required for postsynaptic expression of D2 agonist effects. Science (1987) 1.49

Inversion of aerotactic response in Escherichia coli deficient in cheB protein methylesterase. J Bacteriol (1986) 1.47

SAR studies of diaryltriazoles against bacterial two-component regulatory systems and their antibacterial activities. Bioorg Med Chem Lett (1998) 1.42

c-Myc overexpression uncouples DNA replication from mitosis. Mol Cell Biol (1999) 1.42

Comparison of the postantibiotic and postantibiotic sub-MIC effects of levofloxacin and ciprofloxacin on Staphylococcus aureus and Streptococcus pneumoniae. Antimicrob Agents Chemother (1997) 1.40

Activation domains of L-Myc and c-Myc determine their transforming potencies in rat embryo cells. Mol Cell Biol (1992) 1.39

Astroblastoma: clinicopathologic features and chromosomal abnormalities defined by comparative genomic hybridization. Brain Pathol (2000) 1.38

Transformation by the Bmi-1 oncoprotein correlates with its subnuclear localization but not its transcriptional suppression activity. Mol Cell Biol (1996) 1.36

Identification of a large Myc-binding protein that contains RCC1-like repeats. Proc Natl Acad Sci U S A (1998) 1.34

Function of the c-Myc oncoprotein. FASEB J (1992) 1.34

Oxygen as attractant and repellent in bacterial chemotaxis. J Bacteriol (1987) 1.34

Tumor growth inhibition induced in a murine model of human Burkitt's lymphoma by a proteasome inhibitor. Cancer Res (1998) 1.33

Pediatric neuroblastic brain tumors containing abundant neuropil and true rosettes. Pediatr Dev Pathol (2000) 1.32

A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1. Nucleic Acids Res (1999) 1.32

The hepatitis B virus X protein increases the cellular level of TATA-binding protein, which mediates transactivation of RNA polymerase III genes. Mol Cell Biol (1995) 1.32

Substituted salicylanilides as inhibitors of two-component regulatory systems in bacteria. J Med Chem (1998) 1.31

Severe liver trauma in the face of coagulopathy. A case for temporary packing and early reexploration. Am J Surg (1982) 1.30

Selection and genetic characterization of Streptococcus pneumoniae mutants resistant to the des-F(6) quinolone BMS-284756. Antimicrob Agents Chemother (2001) 1.30

Tumor induction by the c-Myc target genes rcl and lactate dehydrogenase A. Cancer Res (2000) 1.29

Opposite orientations of DNA bending by c-Myc and Max. Proc Natl Acad Sci U S A (1992) 1.27

Myc target transcriptomes. Curr Top Microbiol Immunol (2006) 1.23

Differential binding of c-Myc and Max to nucleosomal DNA. Mol Cell Biol (1994) 1.19

Phase relationships support a role for coordinated activity in the indirect pathway in organizing slow oscillations in basal ganglia output after loss of dopamine. Neuroscience (2006) 1.19

Disorganization of cultured vascular endothelial cell monolayers by fibrinogen fragment D. Science (1985) 1.19

Association of methionyl-tRNA synthetase with detergent-insoluble components of the rough endoplasmic reticulum. J Cell Biol (1983) 1.17

The upstream stimulatory factor binds to and activates the promoter of the rat class I alcohol dehydrogenase gene. J Biol Chem (1991) 1.17

Localization of a fibrinogen calcium binding site between gamma-subunit positions 311 and 336 by terbium fluorescence. J Biol Chem (1985) 1.16

Structure of porcine thyrotropin releasing hormone. Biochemistry (1970) 1.15

Max and inhibitory c-Myc mutants induce erythroid differentiation and resistance to apoptosis in human myeloid leukemia cells. Oncogene (1997) 1.15

MXI1, a putative tumor suppressor gene, suppresses growth of human glioblastoma cells. Cancer Res (1997) 1.15

Multisecond oscillations in firing rate in the basal ganglia: robust modulation by dopamine receptor activation and anesthesia. J Neurophysiol (1999) 1.15

Drugs used in the treatment of attention-deficit/hyperactivity disorder affect postsynaptic firing rate and oscillation without preferential dopamine autoreceptor action. Biol Psychiatry (2001) 1.15

Inhibitory effects of quinolone antibacterial agents on eucaryotic topoisomerases and related test systems. Antimicrob Agents Chemother (1990) 1.14

Definition of the activities and properties of c-myc required to inhibit cell differentiation. Cell Growth Differ (1990) 1.14

Elevated extracellular calcium can prevent apoptosis via the calcium-sensing receptor. Biochem Biophys Res Commun (1998) 1.13

Nuclear punctate distribution of ALL-1 is conferred by distinct elements at the N terminus of the protein. Proc Natl Acad Sci U S A (1997) 1.12

Detection and modulation in vivo of helix-loop-helix protein-protein interactions. J Biol Chem (1993) 1.11

A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation. J Biol Chem (2001) 1.08

Purification and partial characterization of the multicomponent dextranase complex of Streptococcus sobrinus and cloning of the dextranase gene. Infect Immun (1987) 1.07

Hydrolysis of soluble, linear, un-cross-linked peptidoglycans by endogenous bacterial N-acetylmuramoylhydrolases. J Bacteriol (1984) 1.07

A link between c-Myc-mediated transcriptional repression and neoplastic transformation. J Clin Invest (1996) 1.06

Efflux in bacteria: what do we really know about it? Expert Opin Investig Drugs (2001) 1.06

Staphylococcus aureus mutants selected by BMS-284756. Antimicrob Agents Chemother (2001) 1.05

The mechanism of soluble peptidoglycan hydrolysis by an autolytic muramidase. A processive exodisaccharidase. J Biol Chem (1984) 1.05

Cyclin A links c-Myc to adhesion-independent cell proliferation. J Biol Chem (1995) 1.05

The basic helix-loop-helix protein upstream stimulating factor regulates the cardiac ventricular myosin light-chain 2 gene via independent cis regulatory elements. Mol Cell Biol (1994) 1.04

Acute pancreatitis: a complication of Foley catheter gastrostomy. J Natl Med Assoc (1986) 1.04

Arsenic inhibition of telomerase transcription leads to genetic instability. J Clin Invest (2001) 1.03

Isolation of thyrotropin releasing factor (TRF) from porcine hypothalamus. Biochem Biophys Res Commun (1966) 1.02

Cancer genetics: tumor suppressor meets oncogene. Curr Biol (1999) 1.02

Effect of electroconvulsive shock on monoaminergic receptor binding sites in rat brain. Nature (1979) 1.02

Correlated multisecond oscillations in firing rate in the basal ganglia: modulation by dopamine and the subthalamic nucleus. Neuroscience (2003) 1.01

B-myc inhibits neoplastic transformation and transcriptional activation by c-myc. Mol Cell Biol (1993) 1.01

Second surgery for recurrent pilocytic astrocytoma in children. Pediatr Neurosurg (2001) 0.96

Isolation and characterization of soluble peptidoglycan from several strains of Streptococcus faecium. J Bacteriol (1984) 0.93

Multienzyme complex of aminoacyl-tRNA synthetases: an essence of being eukaryotic. Biochem J (1986) 0.92

Importance of antifungal drug-resistance: clinical significance and need for novel therapy. Expert Opin Investig Drugs (1998) 0.92

Pancytopenia secondary to oxalosis in a 23-year-old woman. Blood (1998) 0.92

In vivo characterization of two cell types in the rat globus pallidus which have opposite responses to dopamine receptor stimulation: comparison of electrophysiological properties and responses to apomorphine, dizocilpine, and ketamine anesthesia. Synapse (1995) 0.91

Renaturation of dextranase activity from culture supernatant fluids of Streptococcus sobrinus after sodium dodecylsulfate polyacrylamide gel electrophoresis. Anal Biochem (1986) 0.91

Localization of the human Mxi1 transcription factor gene (MXI1) to chromosome 10q24-q25. Genomics (1994) 0.91

Pre- and postsynaptic aspects of dopamine-mediated transmission. Trends Neurosci (2000) 0.91

Clustered mutations in the transcriptional activation domain of Myc in 8q24 translocated lymphomas and their functional consequences. Curr Top Microbiol Immunol (1995) 0.90

Rat liver histidyl-tRNA synthetase. Purification and inhibition by the myositis-specific anti-Jo-1 autoantibody. Biochem Biophys Res Commun (1984) 0.90