Published in J Exp Med on June 01, 1975
Cellular basis of regulation of expression of idiotype. II. Immunity to anti-MOPC-460 idiotype antibodies increases the level of anti-trinitrophenyl antibodies bearing 460 idiotypes. J Exp Med (1979) 1.76
Enhancing antibody: a novel component of the immune response. Proc Natl Acad Sci U S A (1982) 1.36
Vaccination with syngeneic, lymphoma-derived immunoglobulin idiotype combined with granulocyte/macrophage colony-stimulating factor primes mice for a protective T-cell response. Proc Natl Acad Sci U S A (1996) 1.27
The natural abundance of lambda2-light chains in inbred mice. J Exp Med (1978) 1.23
Precipitable immune complexes in healthy homosexual men, acquired immune deficiency syndrome and the related lymphadenopathy syndrome. Clin Exp Immunol (1985) 1.04
Immunoglobulin isotype influences affinity and specificity. Proc Natl Acad Sci U S A (2012) 1.03
Immunoglobulin heavy chain constant regions regulate immunity and tolerance to idiotypes of antibody variable regions. Proc Natl Acad Sci U S A (2002) 1.02
Detection and partial characterization of Crohn's disease tissue specific proteins recognized by Crohn's disease sera. Clin Exp Immunol (1984) 1.02
Induction of idiotype-specific suppressor T cells with antigen/antibody complexes. J Exp Med (1983) 0.96
Suppression of a "recurrent" idiotype results in profound alterations of the whole B-cell compartment. Proc Natl Acad Sci U S A (1981) 0.95
Vaccination with syngeneic monoclonal anti-idiotype protects against a tumour challenge. Immunology (1987) 0.94
A small hypervariable segment in the variable domain of an immunoglobulin light chain stimulates formation of anti-idiotypic suppressor T cells. Proc Natl Acad Sci U S A (1982) 0.93
Novel strategies for immunotherapy in multiple myeloma: previous experience and future directions. Clin Dev Immunol (2012) 0.88
Immune networks. Frequencies of antibody- and idiotype-producing B cell clones in various steady states. J Exp Med (1981) 0.86
Targeted DNA vaccines for enhanced induction of idiotype-specific B and T cells. Front Oncol (2012) 0.84
Effect of passively administered isologous anti-idiotypes directed against anti-carrier (ovalbumin) antibodies on the anti-hapten IgE and IgG antibody responses in BALB/c mice. Immunology (1983) 0.83
Autologous anti-idiotypic antibody response is regulated by the level of circulating complementary idiotype. Immunology (1996) 0.80
Idiotypic analysis of antibodies to hen egg-white lysozyme (HEL). II. Distribution and frequency of occurrence of idiotypes shared by A/J anti-HEL antibody. Immunology (1981) 0.80
The antibody response to specific immune complexes is under genetic control and correlates with the expression of a recurrent idiotype. J Exp Med (1986) 0.80
T-cell dependent response to immune complexes abrogates B-cell unresponsiveness to pneumococcal cell wall polysaccharide. Immunology (1995) 0.78
Cross-reactive idiotypes in immunoglobulin A-deficient sera. J Clin Invest (1985) 0.77
Immunotherapy strategies for multiple myeloma: the present and the future. Immunotherapy (2013) 0.76
Monoclonal anti-VH141 antibodies that specifically recognize the heavy chain variable region of, and are closely related to, MOPC141 myeloma protein whose VH gene belongs to VHQ52 family. Immunology (1991) 0.75
Genetic control of specific immune responses. Adv Immunol (1969) 8.81
A theory of self-nonself discrimination. Science (1970) 7.99
Individual Antigenic Specificity of Isolated Antibodies. Science (1963) 7.27
Mouse myeloma proteins with antihapten antibody acitivity. The protein produced by plasma cell tumor MOPC-315. Biochemistry (1968) 4.83
Immunoglobulin-producing tumors and myeloma proteins of mice. Physiol Rev (1972) 4.63
Affinity labeling of a phosphorylcholine binding mouse myeloma protein. Biochemistry (1972) 4.26
Studies of 125I trace labeling of immunoglobulin G by chloramine-T. Immunochemistry (1970) 3.71
Genetics of a new IgVH (T15 idiotype) marker in the mouse regulating natural antibody to phosphorylcholine. J Exp Med (1974) 3.64
Genetics of immunoglobulins in the mouse. Adv Immunol (1967) 3.14
Quantitative investigations of idiotypic antibodies. I. Analysis of precipitating antibody populations. J Exp Med (1969) 3.10
Inheritance of an idiotype associated with the immune response of inbred mice to phosphorylcholine. Eur J Immunol (1972) 3.04
Immunological specificity, unique combinations of selected natural globulins provide an alternative to the classical concept. Science (1959) 2.82
The genetic control of immunoglobulin synthesis. Proc R Soc Lond B Biol Sci (1966) 2.61
Specificity for phosphorylcholine of six murine myeloma proteins reactive with Pneumococcus C polysaccharide and beta-lipoprotein. Biochemistry (1971) 2.55
Idiotypic identity of antibodies to streptococcal carbohydrate in inbred mice. Eur J Immunol (1972) 2.52
Autoimmune-like antibodies to the ligand-binding sites of myeloma proteins. Proc Natl Acad Sci U S A (1971) 2.17
Experimental approaches tohomogenous antibody populations. iIndividual antigenic specificity, cross specificity and diversity of human antibodies. Fed Proc (1970) 2.10
Association of H-2 types with genetic control of immune responsiveness to IgA allotypes in the mouse. Proc Natl Acad Sci U S A (1971) 2.07
Regulation of immune response by autogenous antibody against receptor. Proc Natl Acad Sci U S A (1974) 2.05
Clonal nature of the immune response to phosphorylcholine. IV. Idiotypic uniformity of binding site-associated antigenic determinants among mouse antiphosphorylcholine antibodies. J Exp Med (1974) 2.02
Immunoglobulin structure: amino terminal sequences of mouse myeloma proteins that bind phosphorylcholine. Science (1974) 1.94
Studies of idiotypic antibodies. Production and characterization of autoantiidiotypic antisera. J Exp Med (1974) 1.92
Neonatal tolerance induced by antibody against antigen-specific receptor. Science (1974) 1.61
Mouse myelomas producing precipitating antibody to nucleic acid bases and-or nitrophenyl derivatives. Nature (1968) 1.56
Experimental approaches to homogenous antibody populations. Myeloma proteins with antihapten antibody activity. Fed Proc (1970) 1.51
Ability of CBA mice to produce anti-idiotypic sera to 5563 myeloma protein. Nature (1970) 1.46
Hapten-specific augmentation of the anti-idiotype antibody response to hapten-myeloma protein conjugates in mice. Eur J Immunol (1973) 1.37
Specificity and structure of the myeloma protein produced by mouse plasmacytoma MOPC-460. Biochemistry (1971) 1.32
Speculations. How specific are antibodies? Immunochemistry (1973) 1.29
Antibodies with multiple binding functions. Induction of single immunoglobin species by structurally dissimilar haptens. Proc Natl Acad Sci U S A (1973) 1.19
The strange cross-reaction of menadione (vitamin K3) and 2,4-dinitrophenyl ligands with a myeloma protein and some conventional antibodies. J Exp Med (1974) 1.13
Cross-reactions between 2,4-dinitrophenyl and 5-acetouracil groups. J Immunol (1971) 0.94
Detection of serum-hepatitis antigen by charcoal particle agglutination-inhibition. J Immunol (1972) 0.93
Immunological paralysis induced by an idiotypic antigen. Nature (1970) 0.86
Enhancement of immunogenicity of a BALB-c myeloma protein in BALB-c mice. J Immunol (1974) 0.83
Binding of monomeric immunoglobulins to Fc receptors of mouse macrophages. J Exp Med (1975) 5.19
Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences. Nature (1984) 5.19
Mouse myeloma proteins with antihapten antibody acitivity. The protein produced by plasma cell tumor MOPC-315. Biochemistry (1968) 4.83
Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response. Immunity (1996) 4.68
Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells. J Exp Med (2000) 4.54
EXCITATION ENERGY TRANSFER AND THE QUANTITATIVE STUDY OF THE ANTIBODY HAPTEN REACTION. Proc Natl Acad Sci U S A (1960) 4.43
Structure, organization, and somatic rearrangement of T cell gamma genes. Cell (1985) 3.49
A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes. Nature (1984) 3.46
Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1. J Exp Med (1994) 2.81
Origins of MIT inquiry. Nature (1991) 2.81
Characterization and use of monoclonal antibodies for isolation of phosphotyrosyl proteins from retrovirus-transformed cells and growth factor-stimulated cells. Mol Cell Biol (1983) 2.70
Limited diversity of the rearranged T-cell gamma gene. Nature (1985) 2.58
Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera. Proc Natl Acad Sci U S A (1984) 2.54
A novel serine esterase expressed by cytotoxic T lymphocytes. Nature (1985) 2.43
Kinetic and affinity limits on antibodies produced during immune responses. Proc Natl Acad Sci U S A (1995) 2.41
Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes. Immunity (1994) 2.39
A naturally occurring peptide recognized by alloreactive CD8+ cytotoxic T lymphocytes in association with a class I MHC protein. Cell (1992) 2.34
The relative affinity of antibodies synthesized in the secondary response. J Exp Med (1967) 2.33
Attachment of an anti-receptor antibody to non-target cells renders them susceptible to lysis by a clone of cytotoxic T lymphocytes. Proc Natl Acad Sci U S A (1984) 2.32
Amino acid sequence of the light chain of a mouse myeloma protein (MOPC-315). Biochemistry (1973) 2.30
An optimal viral peptide recognized by CD8+ T cells binds very tightly to the restricting class I major histocompatibility complex protein on intact cells but not to the purified class I protein. Proc Natl Acad Sci U S A (1991) 2.26
Preparation and characterization of antibodies specific for the 2,4,6-trinitrophenyl group. Biochemistry (1966) 2.20
Autoimmune-like antibodies to the ligand-binding sites of myeloma proteins. Proc Natl Acad Sci U S A (1971) 2.17
A DEMONSTRATION OF ANTIBODY ACTIVITY ON MICROSOMES. Proc Natl Acad Sci U S A (1959) 2.12
Myeloma proteins as tumor-specific transplantation antigens. Proc Natl Acad Sci U S A (1972) 2.09
High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins. Proc Natl Acad Sci U S A (1994) 2.09
Phosphotyrosine-containing proteins isolated by affinity chromatography with antibodies to a synthetic hapten. Nature (1981) 2.08
Functional differences between memory and naive CD8 T cells. Proc Natl Acad Sci U S A (1999) 1.94
Variations in the number of peptide-MHC class I complexes required to activate cytotoxic T cell responses. J Immunol (1995) 1.91
Vesicular stomatitis virus glycoprotein is necessary for H-2-restricted lysis of infected cells by cytotoxic T lymphocytes. Proc Natl Acad Sci U S A (1978) 1.88
Serine esterase in cytolytic T lymphocytes. Nature (1986) 1.85
Secondary, tertiary, and quaternary structure of T-cell-specific immunoglobulin-like polypeptide chains. Proc Natl Acad Sci U S A (1986) 1.81
Sequential changes in the relative affinity of antibodies synthesized during the immune response. J Exp Med (1967) 1.80
Subunit structure and number of combining sites of the immunoglobulin A myeloma protein produced by mouse plasmacytoma MOPC-315. Biochemistry (1971) 1.68
Symposium on in vitro studies of the immune response. I. Variations in the immune response to a simple determinant. Bacteriol Rev (1966) 1.65
A ubiquitous protein is the source of naturally occurring peptides that are recognized by a CD8+ T-cell clone. Proc Natl Acad Sci U S A (1993) 1.63
Cognate peptides induce self-destruction of CD8+ cytolytic T lymphocytes. Proc Natl Acad Sci U S A (1990) 1.63
Dependence of lymphopenia-induced T cell proliferation on the abundance of peptide/ MHC epitopes and strength of their interaction with T cell receptors. Proc Natl Acad Sci U S A (2001) 1.61
Amino acid sequence of the light chain from a mouse myeloma protein with anti-hapten activity: evidence for a third type of light chain. Proc Natl Acad Sci U S A (1971) 1.52
Experimental approaches to homogenous antibody populations. Myeloma proteins with antihapten antibody activity. Fed Proc (1970) 1.51
Myeloma proteins with anti-hapten antibody activity: epsilon-2,4-dinitrophenyl lysine binding by the protein produced by mouse plasmacytoma MOPC-460. J Immunol (1969) 1.51
Calcium ion concentrations and DNA fragmentation in target cell destruction by murine cloned cytotoxic T lymphocytes. J Exp Med (1988) 1.49
The immune response to a simple antigenic determinant. Harvey Lect (1966) 1.47
Peptide antagonism and T cell receptor interactions with peptide-MHC complexes. Immunity (1998) 1.46
Heat shock fusion proteins as vehicles for antigen delivery into the major histocompatibility complex class I presentation pathway. Proc Natl Acad Sci U S A (1997) 1.46
Specificity of the immune response to the 2,4-dinitrophenyl and 2,4,6-trinitrophenyl groups. Ligand binding and fluorescence properties of cross-reacting antibodies. J Exp Med (1969) 1.44
The law of mass action governs antigen-stimulated cytolytic activity of CD8+ cytotoxic T lymphocytes. Proc Natl Acad Sci U S A (1995) 1.43
Cytotoxic T lymphocytes recognize a reconstituted class I histocompatibility antigen (HLA-A2) as an allogeneic target molecule. Proc Natl Acad Sci U S A (1990) 1.41
Effects of N alpha-tosyl-L-lysyl-chloromethylketone on the activity of cytotoxic T lymphocytes. J Immunol (1980) 1.39
Amino-acid sequence of the variable region of the heavy (alpha) chain of a mouse myeloma protein with anti-hapten activity. Proc Natl Acad Sci U S A (1974) 1.36
Adenomatoid Transformation of the Glomerular Capsular Epithelium. Am J Pathol (1946) 1.33
Recognition of immunoglobulin idiotypes by thymus-derived lymphocytes. Proc Natl Acad Sci U S A (1975) 1.33
Specificity and structure of the myeloma protein produced by mouse plasmacytoma MOPC-460. Biochemistry (1971) 1.32
Synthetic phospholipid vesicles containing a purified viral antigen and cell membrane proteins stimulate the development of cytotoxic T lymphocytes. J Exp Med (1979) 1.31
Identification of a third type of lambda light chain in mouse immunoglobulins. Proc Natl Acad Sci U S A (1981) 1.31
Differences in antigen recognition and cytolytic activity of CD8(+) and CD8(-) T cells that express the same antigen-specific receptor. Proc Natl Acad Sci U S A (2001) 1.30
Resistance of cytotoxic T lymphocytes to lysis by a clone of cytotoxic T lymphocytes. Proc Natl Acad Sci U S A (1987) 1.30
Expression of the T-cell-specific gamma gene is unnecessary in T cells recognizing class II MHC determinants. Nature (1985) 1.29
Degeneracy in the secondary immune response: stimulation of antibody formation by cross-reacting antigens. Isr J Med Sci (1969) 1.27
In vivo cytotoxic T lymphocyte elicitation by mycobacterial heat shock protein 70 fusion proteins maps to a discrete domain and is CD4(+) T cell independent. J Exp Med (2000) 1.26
The natural abundance of lambda2-light chains in inbred mice. J Exp Med (1978) 1.23
Crawling movements of lymphocytes on and beneath fibroblasts in culture. Proc Natl Acad Sci U S A (1979) 1.21
Cell-bound myeloma proteins on the surface of myeloma cells: potential targets for the immune system. Proc Natl Acad Sci U S A (1972) 1.20
Affinity labeling of the heavy and light chains of a myeloma protein with anti-2,4-dinitrophenyl activity. Proc Natl Acad Sci U S A (1970) 1.20
IMPAIRMENT OF ANTIBODY RESPONSE IN PYRIDOXINE-DEFICIENT RATS. J Exp Med (1947) 1.19
Localization of affinity-labeled residues on the heavy and light chain of two myeloma proteins with anti-hapten activity. Biochemistry (1972) 1.17
Inhibition of cytotoxic T lymphocyte activity by concanavalin A. J Immunol (1982) 1.17
A proposed mechanism for the induction of cytotoxic T lymphocyte production by heat shock fusion proteins. Immunity (2000) 1.16
Learning and memory in the immune response. Cancer Res (1966) 1.16
A functional gamma gene formed from known gamma-gene segments is not necessary for antigen-specific responses of murine cytotoxic T lymphocytes. Nature (1986) 1.15
Evidence for tryptophan in the active sites of antibodies to polynitrobenzenes. Biochemistry (1967) 1.14
Resistance of cytotoxic T lymphocytes to the lytic effects of their toxic granules. J Exp Med (1987) 1.14
The strange cross-reaction of menadione (vitamin K3) and 2,4-dinitrophenyl ligands with a myeloma protein and some conventional antibodies. J Exp Med (1974) 1.13
Breaking the affinity ceiling for antibodies and T cell receptors. Proc Natl Acad Sci U S A (2000) 1.12
Quantitation of reversible binding by particle counting: hapten-antibody interaction as a model system. Proc Natl Acad Sci U S A (1992) 1.12
The site of action of N-alpha-tosyl-L-lysyl-chloromethyl-ketone (TLCK) on cloned cytotoxic T lymphocytes. J Immunol (1983) 1.11
Chromosomal locations of the murine T-cell receptor alpha-chain gene and the T-cell gamma gene. Science (1985) 1.10
Lambda chains and genes in inbred mice. Annu Rev Immunol (1985) 1.10
Heteroantibody duplexes target cells for lysis by cytotoxic T lymphocytes. Proc Natl Acad Sci U S A (1985) 1.08
Distribution of allelic allotypes among gamma-G-immunoglobulins and purified anti-hapten antibodies from the same rabbit. J Immunol (1965) 1.06
Glycosylation of the T-cell antigen-specific receptor and its potential role in lectin-mediated cytotoxicity. Proc Natl Acad Sci U S A (1986) 1.04
Lambda2 light chains in normal mouse immunoglobulins. Proc Natl Acad Sci U S A (1978) 1.03
Allorecognition of purified major histocompatibility complex glycoproteins by cytotoxic T lymphocytes. Proc Natl Acad Sci U S A (1988) 1.03
Isolation and partial characterization of concanavalin A receptors on cloned cytotoxic T lymphocytes. Proc Natl Acad Sci U S A (1984) 1.02
Selective use of the VHQ52 family in functional VH to DJH rearrangements in a B precursor cell line. J Exp Med (1987) 1.02
Perforin mRNA in primary peritoneal exudate cytotoxic T lymphocytes. J Immunol (1989) 1.02
T-cell antigens in cancer. Proc Natl Acad Sci U S A (1994) 1.01
Myeloma proteins as tumor-specific antigens. Transplant Proc (1975) 1.00
Tissue-specific expression of functionally rearranged lambda 1 Ig gene through a retrovirus vector. Science (1987) 1.00
Resistance of primary CD8+ cytotoxic T lymphocytes to lysis by cytotoxic granules from cloned T cell lines. J Immunol (1988) 0.99
Affinity labeling and cross-linking of the heavy and light chains of a myeloma protein with anti-2,4-dinitrophenyl activity. Biochemistry (1971) 0.99
Periodic loss of reactivity of a myeloma tumor with cytotoxic thymus-derived lymphocytes. Proc Natl Acad Sci U S A (1978) 0.98
Restricted association of V and J-C gene segments for mouse lambda chains. Proc Natl Acad Sci U S A (1984) 0.98
Effect of variation in antibody-hapten association constant upon the biologic activity of the antibody. J Immunol (1965) 0.97
Unusual association of V, J and C regions in a mouse immunoglobulin lambda chain. Nature (1982) 0.97
Cognate peptide-induced destruction of CD8+ cytotoxic T lymphocytes is due to fratricide. J Immunol (1993) 0.95
Lymphomas with cytotoxic activity. Nature (1979) 0.95