D B Clewell

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Supercoiled circular DNA-protein complex in Escherichia coli: purification and induced conversion to an opern circular DNA form. Proc Natl Acad Sci U S A 1969 71.62
2 Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. J Bacteriol 1972 46.61
3 Properties of a supercoiled deoxyribonucleic acid-protein relaxation complex and strand specificity of the relaxation event. Biochemistry 1970 26.22
4 Characterization of three plasmid deoxyribonucleic acid molecules in a strain of Streptococcus faecalis: identification of a plasmid determining erythromycin resistance. J Bacteriol 1974 12.44
5 Evidence for a chromosome-borne resistance transposon (Tn916) in Streptococcus faecalis that is capable of "conjugal" transfer in the absence of a conjugative plasmid. J Bacteriol 1981 11.15
6 Circular DNA. Annu Rev Biochem 1971 9.75
7 Induced cell aggregation and mating in Streptococcus faecalis: evidence for a bacterial sex pheromone. Proc Natl Acad Sci U S A 1978 9.67
8 Effect of growth conditions on the formation of the relaxation complex of supercoiled ColE1 deoxyribonucleic acid and protein in Escherichia coli. J Bacteriol 1972 9.50
9 Transmissible toxin (hemolysin) plasmid in Streptococcus faecalis and its mobilization of a noninfectious drug resistance plasmid. J Bacteriol 1975 8.65
10 Plasmids, drug resistance, and gene transfer in the genus Streptococcus. Microbiol Rev 1981 7.86
11 Plasmid transfer in Streptococcus faecalis: production of multiple sex pheromones by recipients. Plasmid 1979 7.20
12 Mapping of Streptococcus faecalis plasmids pAD1 and pAD2 and studies relating to transposition of Tn917. J Bacteriol 1982 7.03
13 Complete nucleotide sequence of macrolide-lincosamide-streptogramin B-resistance transposon Tn917 in Streptococcus faecalis. J Bacteriol 1985 7.00
14 Regeneration of insertionally inactivated streptococcal DNA fragments after excision of transposon Tn916 in Escherichia coli: strategy for targeting and cloning of genes from gram-positive bacteria. J Bacteriol 1984 6.82
15 Properties of erythromycin-inducible transposon Tn917 in Streptococcus faecalis. J Bacteriol 1980 6.06
16 A transposon in Streptococcus faecalis with fertility properties. Nature 1982 5.65
17 Highly efficient protoplast transformation system for Streptococcus faecalis and a new Escherichia coli-S. faecalis shuttle vector. J Bacteriol 1986 5.35
18 Novel shuttle plasmid vehicles for Escherichia-Streptococcus transgeneric cloning. Gene 1983 5.30
19 Plasmid-related transmissibility and multiple drug resistance in Streptococcus faecalis subsp. zymogenes strain DS16. Antimicrob Agents Chemother 1979 5.28
20 Modification of Streptococcus faecalis sex pheromones after acquisition of plasmid DNA. Proc Natl Acad Sci U S A 1983 5.27
21 A cloning vector able to replicate in Escherichia coli and Streptococcus sanguis. Gene 1982 5.13
22 Conjugative transposons and the dissemination of antibiotic resistance in streptococci. Annu Rev Microbiol 1986 5.08
23 Strand-specific supercoiled DNA-protein relaxation complexes: comparison of the complexes of bacterial plasmids ColE1 and ColE2. Proc Natl Acad Sci U S A 1971 4.76
24 Recombination-deficient mutant of Streptococcus faecalis. J Bacteriol 1980 4.60
25 Isolation and characterization of plasmid deoxyribonucleic acid from Streptococcus mutans. J Bacteriol 1973 4.59
26 Characterization of a plasmid determining resistance to erythromycin, lincomycin, and vernamycin Balpha in a strain Streptococcus pyogenes. Antimicrob Agents Chemother 1974 4.47
27 Isolation of supercoiled colicinogenic factor E 1 DNA sensitive to ribonuclease and alkali. Proc Natl Acad Sci U S A 1972 4.46
28 Plasmid-determined tetracycline resistance in Streptococcus faecalis: evidence for gene amplification during growth in presence of tetracycline. Proc Natl Acad Sci U S A 1975 4.21
29 Streptococcus faecalis sex pheromone (cAM373) also produced by Staphylococcus aureus and identification of a conjugative transposon (Tn918). J Bacteriol 1985 3.84
30 Hemolysin of Streptococcus faecalis subspecies zymogenes contributes to virulence in mice. Infect Immun 1984 3.83
31 Plasmid content of Streptococcus faecalis strain 39-5 and identification of a pheromone (cPD1)-induced surface antigen. J Gen Microbiol 1983 3.80
32 Genetic analysis of the pAD1 pheromone response in Streptococcus faecalis, using transposon Tn917 as an insertional mutagen. J Bacteriol 1984 3.69
33 Plasmid-associated hemolysin and aggregation substance production contribute to virulence in experimental enterococcal endocarditis. Antimicrob Agents Chemother 1993 3.35
34 Genetic organization of the bacterial conjugative transposon Tn916. J Bacteriol 1988 3.18
35 Direct inhibition of Col E 1 plasmid DNA replication in Escherichia coli by rifampicin. Nat New Biol 1972 3.05
36 Nucleotide sequence of the 18-kb conjugative transposon Tn916 from Enterococcus faecalis. Plasmid 1994 3.01
37 Plasmid-determined resistance to erythromycin: comparison of strains of streptococcus faecalis and streptococcus pyogenes with regard to plasmid hmology and resistance inducibility. Antimicrob Agents Chemother 1975 2.91
38 Transfer functions of the Streptococcus faecalis plasmid pAD1: organization of plasmid DNA encoding response to sex pheromone. J Bacteriol 1987 2.87
39 Conjugative transfer of R-plasmids from Streptococcus faecalis to Staphylococcus aureus. Antimicrob Agents Chemother 1982 2.85
40 Evidence for conjugal transfer of a Streptococcus faecalis transposon (Tn916) from a chromosomal site in the absence of plasmid DNA. Cold Spring Harb Symp Quant Biol 1981 2.80
41 Plasmid-determined tetracycline resistance in Streptococcus faecalis: tandemly repeated resistance determinants in amplified forms of pAMalpha1 DNA. J Mol Biol 1976 2.79
42 A transposon (Tn917) in Streptococcus faecalis that exhibits enhanced transposition during induction of drug resistance. Cold Spring Harb Symp Quant Biol 1979 2.64
43 Simple and reliable multiplex PCR assay for surveillance isolates of vancomycin-resistant enterococci. J Clin Microbiol 2000 2.62
44 High incidence of hemolysin production by Enterococcus (Streptococcus) faecalis strains associated with human parenteral infections. J Clin Microbiol 1987 2.42
45 A conjugative transposon (Tn919) in Streptococcus sanguis. Infect Immun 1985 2.41
46 Nucleotide sequence of the gelatinase gene (gelE) from Enterococcus faecalis subsp. liquefaciens. Infect Immun 1991 2.41
47 Sex pheromone cAD1 in Streptococcus faecalis: induction of a function related to plasmid transfer. J Bacteriol 1980 2.37
48 Plasmids and pheromone response of the beta-lactamase producer Streptococcus (Enterococcus) faecalis HH22. Antimicrob Agents Chemother 1988 2.27
49 Existence of the colicinogenic factor-sex factor ColI-b-P9 as a supercoiled circular DNA-protein relaxation complex. Biochem Biophys Res Commun 1970 2.22
50 Genetic analysis of the pAD1 hemolysin/bacteriocin determinant in Enterococcus faecalis: Tn917 insertional mutagenesis and cloning. J Bacteriol 1990 2.20
51 Characterization of plasmids determining hemolysin and bacteriocin production in Streptococcus faecalis 5952. J Bacteriol 1977 2.16
52 Identification and characterization of a small sequence located at two sites on the amplifiable tetracycline resistance plasmid pAMalpha1 in Streptococcus faecalis. J Bacteriol 1977 2.16
53 Analysis of plasmid deoxyribonucleic acid in a cariogenic strain of Streptococcus faecalis: an approach to identifying genetic determinants on cryptic plasmids. J Bacteriol 1977 2.06
54 Broad geographical distribution of a cytotoxin gene mediating beta-hemolysis and bacteriocin activity among Streptococcus faecalis strains. Infect Immun 1983 2.02
55 Regulation of the pAD1 sex pheromone response in Enterococcus faecalis: construction and characterization of lacZ transcriptional fusions in a key control region of the plasmid. J Bacteriol 1988 1.94
56 Isolation and structure of bacterial sex pheromone, cPD1. Science 1984 1.92
57 Identification of pheromone-induced surface proteins in Streptococcus faecalis and evidence of a role for lipoteichoic acid in formation of mating aggregates. J Bacteriol 1986 1.90
58 Characterization of the tet(M) determinant of Tn916: evidence for regulation by transcription attenuation. Antimicrob Agents Chemother 1992 1.89
59 Characterization of a small plasmid determining resistance to erythromycin, lincomycin, and vernamycin Balpha in a strain of Streptococcus sanguis isolated from dental plaque. Antimicrob Agents Chemother 1978 1.89
60 Identification of a gene, rgg, which regulates expression of glucosyltransferase and influences the Spp phenotype of Streptococcus gordonii Challis. J Bacteriol 1992 1.89
61 Genetic structure of the Enterococcus faecalis plasmid pAD1-encoded cytolytic toxin system and its relationship to lantibiotic determinants. J Bacteriol 1994 1.87
62 Characterization of the traC determinant of the Enterococcus faecalis hemolysin-bacteriocin plasmid pAD1: binding of sex pheromone. J Bacteriol 1993 1.80
63 Identification and characterization of a determinant (eep) on the Enterococcus faecalis chromosome that is involved in production of the peptide sex pheromone cAD1. J Bacteriol 1999 1.75
64 Isolation and structure of the bacterial sex pheromone, cAD1, that induces plasmid transfer in Streptococcus faecalis. FEBS Lett 1984 1.73
65 A functional origin of transfer (oriT) on the conjugative transposon Tn916. J Bacteriol 1995 1.69
66 Evidence for the existence of the colicinogenic factors E2 and E3 as supercoiled circular DNA-protein relaxation complexes. Biochem Biophys Res Commun 1970 1.68
67 Purification and substrate specificity of a strongly hydrophobic extracellular metalloendopeptidase ("gelatinase") from Streptococcus faecalis (strain 0G1-10). J Biol Chem 1989 1.65
68 Molecular analysis of glycopeptide-resistant Enterococcus faecium isolates collected from Michigan hospitals over a 6-year period. J Clin Microbiol 1998 1.63
69 A novel gentamicin resistance gene in Enterococcus. Antimicrob Agents Chemother 1997 1.63
70 Spontaneous switching of the sucrose-promoted colony phenotype in Streptococcus sanguis. Infect Immun 1989 1.60
71 A new high-level gentamicin resistance gene, aph(2'')-Id, in Enterococcus spp. Antimicrob Agents Chemother 1998 1.60
72 Electron microscopic mapping of deletions on a streptococcal plasmid carrying extraordinarily long inverted repeats. Plasmid 1980 1.59
73 Regulation of the pAD1-encoded sex pheromone response in Enterococcus faecalis: expression of the positive regulator TraE1. J Bacteriol 1993 1.59
74 Detection of the high-level aminoglycoside resistance gene aph(2")-Ib in Enterococcus faecium. Antimicrob Agents Chemother 2000 1.57
75 Characterization of the left 4 kb of conjugative transposon Tn916: determinants involved in excision. Plasmid 1993 1.57
76 Conjugative transfer of Tn916 in Enterococcus faecalis: trans activation of homologous transposons. J Bacteriol 1991 1.55
77 Regulation of the pAD1 sex pheromone response in Enterococcus faecalis: effects of host strain and traA, traB, and C region mutants on expression of an E region pheromone-inducible lacZ fusion. J Bacteriol 1990 1.43
78 Conjugative transfer of Enterococcus faecalis plasmid pAD1: nucleotide sequence and transcriptional fusion analysis of a region involved in positive regulation. J Bacteriol 1992 1.41
79 Identification, characterization, and nucleotide sequence of a region of Enterococcus faecalis pheromone-responsive plasmid pAD1 capable of autonomous replication. J Bacteriol 1993 1.40
80 Molecular characterization of highly gentamicin-resistant Enterococcus faecalis isolates lacking high-level streptomycin resistance. Antimicrob Agents Chemother 1993 1.40
81 Enterococcal sex pheromone precursors are part of signal sequences for surface lipoproteins. Mol Microbiol 2000 1.37
82 Hyperhemolytic phenomena associated with insertions of Tn916 into the hemolysin determinant of Enterococcus faecalis plasmid pAD1. J Bacteriol 1992 1.35
83 Evidence that the hemolysin/bacteriocin phenotype of Enterococcus faecalis subsp. zymogenes can be determined by plasmids in different incompatibility groups as well as by the chromosome. J Bacteriol 1992 1.34
84 Buoyant densities of DNA from various strains of Streptococcus mutans. Arch Oral Biol 1972 1.34
85 Degenerate oligonucleotide primers for enzymatic amplification of recA sequences from gram-positive bacteria and mycoplasmas. J Bacteriol 1992 1.32
86 Regulation of the pAD1-encoded sex pheromone response in Enterococcus faecalis: nucleotide sequence analysis of traA. J Bacteriol 1992 1.31
87 Isolation and structure of the Streptococcus faecalis sex pheromone, cAM373. FEBS Lett 1986 1.31
88 Rgg is a positive transcriptional regulator of the Streptococcus gordonii gtfG gene. J Bacteriol 1996 1.30
89 Generation of Tn5 insertions in streptococcal conjugative transposon Tn916. Appl Environ Microbiol 1987 1.29
90 Characterization of the determinant (traB) encoding sex pheromone shutdown by the hemolysin/bacteriocin plasmid pAD1 in Enterococcus faecalis. Plasmid 1994 1.27
91 Return of Streptococcus faecalis DNA cloned in Escherichia coli to its original host via transformation of Streptococcus sanguis followed by conjugative mobilization. J Bacteriol 1984 1.25
92 Characterization of a class of nonformylated Enterococcus faecalis-derived neutrophil chemotactic peptides: the sex pheromones. Proc Natl Acad Sci U S A 1990 1.22
93 Construction of Enterococcus faecalis pAD1 miniplasmids: identification of a minimal pheromone response regulatory region and evaluation of a novel pheromone-dependent growth inhibition. Plasmid 1989 1.20
94 Prevalence, phenotype and genotype of oral enterococci. Oral Microbiol Immunol 2004 1.18
95 Amplification of the tetracycline resistance determinant of plasmid pAM alpha 1 in Streptococcus faecalis: dependence on host recombination machinery. J Bacteriol 1980 1.17
96 Sucrose-promoted accumulation of growing glucosyltransferase variants of Streptococcus gordonii on hydroxyapatite surfaces. Infect Immun 1991 1.15
97 Changes in the carboxyl-terminal repeat region affect extracellular activity and glucan products of Streptococcus gordonii glucosyltransferase. Infect Immun 1996 1.12
98 Enterococcus faecalis conjugative plasmid pAM373: complete nucleotide sequence and genetic analyses of sex pheromone response. Mol Microbiol 2000 1.12
99 Evidence that coupling sequences play a frequency-determining role in conjugative transposition of Tn916 in Enterococcus faecalis. J Bacteriol 1994 1.11
100 Regulation of the pAD1 sex pheromone response of Enterococcus faecalis by direct interaction between the cAD1 peptide mating signal and the negatively regulating, DNA-binding TraA protein. Proc Natl Acad Sci U S A 1998 1.10
101 A phase variation event that activates conjugation functions encoded by the Enterococcus faecalis plasmid pAD1. Plasmid 1991 1.09
102 Tn924, a chromosome-borne transposon encoding high-level gentamicin resistance in Enterococcus faecalis. Antimicrob Agents Chemother 1994 1.09
103 Virulence, phenotype and genotype characteristics of endodontic Enterococcus spp. Oral Microbiol Immunol 2005 1.09
104 Effects of rifampicin, streptolydigin and actinomycin D on the replication of Col E1 plasmid DNA in Escherichia coli. J Mol Biol 1973 1.09
105 Control of Enterococcus faecalis sex pheromone cAD1 elaboration: effects of culture aeration and pAD1 plasmid-encoded determinants. Plasmid 1991 1.08
106 Aminoglycoside resistance genes aph(2")-Ib and aac(6')-Im detected together in strains of both Escherichia coli and Enterococcus faecium. Antimicrob Agents Chemother 2001 1.07
107 Cloning and characterization of a region of Enterococcus faecalis plasmid pPD1 encoding pheromone inhibitor (ipd), pheromone sensitivity (traC), and pheromone shutdown (traB) genes. J Bacteriol 1995 1.07
108 Completion of the nucleotide sequence of the Enterococcus faecalis conjugative virulence plasmid pAD1 and identification of a second transfer origin. Plasmid 2001 1.07
109 Nucleotide sequence analysis of the Streptococcus gordonii glucosyltransferase gene, gtfG. DNA Seq 1997 1.06
110 Vancomycin resistance plasmid in Enterococcus faecalis that encodes sensitivity to a sex pheromone also produced by Staphylococcus aureus. Antimicrob Agents Chemother 2001 1.06
111 Quantitative analysis for pheromone inhibitor and pheromone shutdown in Enterococcus faecalis. Dev Biol Stand 1995 1.04
112 Streptococcus faecalis sex pheromone (cAD1) response: evidence that the peptide inhibitor excreted by pAD1-containing cells may be plasmid determined. Plasmid 1987 1.01
113 Quantitative real-time PCR detection of oral Enterococcus faecalis in humans. Arch Oral Biol 2004 1.00
114 Infectivity of a glucan synthesis-defective mutant of Streptococcus gordonii (Challis) in a rat endocarditis model. FEMS Microbiol Lett 1993 0.99
115 Isolation and structure of the sex pheromone inhibitor, iPD1, excreted by Streptococcus faecalis donor strains harboring plasmid pPD1. J Bacteriol 1987 0.99
116 Tn917 transposase. Sequence correction reveals a single open reading frame corresponding to the tnpA determinant of Tn3-family elements. Plasmid 1991 0.98
117 PCR fragment length polymorphism analysis of vancomycin-resistant Enterococcus faecium. J Clin Microbiol 2000 0.97
118 The origin of transfer (oriT) of the enterococcal, pheromone-responding, cytolysin plasmid pAD1 is located within the repA determinant. Plasmid 1997 0.96
119 A pAD1-encoded small RNA molecule, mD, negatively regulates Enterococcus faecalis pheromone response by enhancing transcription termination. J Bacteriol 2000 0.94
120 Oral streptococci with genetic determinants similar to the glucosyltransferase regulatory gene, rgg. Infect Immun 1995 0.93
121 Phase variation of Enterococcus faecalis pAD1 conjugation functions relates to changes in iteron sequence region. J Bacteriol 1995 0.92
122 Ecological implications of glucosyltransferase phase variation in Streptococcus gordonii. Appl Environ Microbiol 1991 0.92
123 Regulation of transfer of the Enterococcus faecalis pheromone-responding plasmid pAD1: temperature-sensitive transfer mutants and identification of a new regulatory determinant, traD. J Bacteriol 1997 0.90
124 In vitro susceptibility and molecular analysis of gentamicin-resistant enterococci. Diagn Microbiol Infect Dis 1998 0.89
125 Regulation of the Enterococcus faecalis pAD1-related sex pheromone response: analyses of traD expression and its role in controlling conjugation functions. Mol Microbiol 1998 0.88
126 Indication of transposition of a mobile DNA element containing the vat(D) and erm(B) genes in Enterococcus faecium. Antimicrob Agents Chemother 2001 0.88
127 Construction of recombination-deficient strains of Streptococcus gordonii by disruption of the recA gene. J Bacteriol 1993 0.87
128 Analyses of traA, int-Tn, and xis-Tn mutations in the conjugative transposon Tn916 in Enterococcus faecalis. Plasmid 1996 0.87
129 A genetic determinant in Streptococcus gordonii Challis encodes a peptide with activity similar to that of enterococcal sex pheromone cAM373, which facilitates intergeneric DNA transfer. J Bacteriol 2010 0.87
130 The Enterococcus faecalis pheromone-responsive plasmid pAM373 does not encode an entry exclusion function. Plasmid 2001 0.86
131 Amino acid sequence of pheromone-inducible surface protein in Enterococcus faecalis, that is encoded on the conjugative plasmid pPD1. FEBS Lett 1990 0.85
132 Glucosyltransferase phase variation in Streptococcus gordonii modifies adhesion to saliva-coated hydroxyapatite surfaces in a sucrose-independent manner. Oral Microbiol Immunol 1992 0.85
133 Deletions in the carboxyl-terminal region of Streptococcus gordonii glucosyltransferase affect cell-associated enzyme activity and sucrose-associated accumulation of growing cells. Appl Environ Microbiol 1997 0.82
134 Sex pheromones and plasmid transfer in Streptococcus faecalis: a pheromone, cAM373, which is also excreted by Staphylococcus aureus. Basic Life Sci 1985 0.81
135 Multiple phase variation in haemolytic, adhesive and antigenic properties of Streptococcus gordonii. Microbiology 1996 0.80
136 Enterococcus faecalis pheromone-responding plasmid pAD1 gives rise to an aggregation (clumping) response when cells are exposed to subinhibitory concentrations of chloramphenicol, erythromycin, or tetracycline. Plasmid 1999 0.79
137 Fractionation of spleen and serum in attempts to isolate the radiation-leukemia protection factor. Cancer Res 1969 0.79
138 Prevention of x-ray-induced leukemia in mice. I. Action of a radiation leukemia protection factor in several mouse strains following leukemogenic or sublethal doses of x-ray. Cancer Res 1966 0.78
139 Targeted disruption of the PD78 gene (traF) reduces pheromone-inducible conjugal transfer of the bacteriocin plasmid pPD1 in Enterococcus faecalis. FEMS Microbiol Lett 1995 0.77
140 Molecular analysis of Streptococcus gordonii glucosyltransferase phase variants. Dev Biol Stand 1995 0.77
141 Regulation of Streptococcus gordonii glucosyltransferase. Adv Exp Med Biol 1997 0.76
142 Molecular analysis of representative Streptococcus gordonii Spp phase variants reveals no differences in the glucosyltransferase structural gene, gtfG. Oral Microbiol Immunol 1997 0.76
143 Amino acid sequence of pheromone-inducible surface protein in Enterococcus faecalis, that is encoded on the conjugative plasmid pPD1. FEBS Lett 1990 0.75
144 [Sex pheromones and plasmid transfer in Streptococcus faecalis]. Tanpakushitsu Kakusan Koso 1985 0.75
145 The pAD1 sex pheromone response in Enterococcus faecalis. Adv Exp Med Biol 1997 0.75
146 Isolation and structure of staph-cAM373 produced by Staphylococcus aureus that induces conjugal transfer of Enterococcus faecalis plasmid pAM373. Biosci Biotechnol Biochem 1996 0.75
147 C-terminal identification of AD74, a proteolytic product of Enterococcus faecalis aggregation substance: application of liquid chromatography/mass spectrometry. Biosci Biotechnol Biochem 1992 0.75
148 Identification and partial purification of a dipeptidyl aminopeptidase from Streptococcus faecalis. J Gen Microbiol 1986 0.75