Enhanced I kappa B alpha degradation is responsible for constitutive NF-kappa B activity in mature murine B-cell lines.

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Published in Mol Cell Biol on May 01, 1994

Authors

S Miyamoto1, P J Chiao, I M Verma

Author Affiliations

1: Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92186-5800.

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Both the basic region and the 'leucine zipper' domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation. EMBO J (1990) 2.11

Molecular cloning of unintegrated and a portion of integrated moloney murine leukemia viral DNA in bacteriophage lambda. J Virol (1980) 2.10

Role of Rel/NF-kappaB transcription factors during the outgrowth of the vertebrate limb. Nature (1998) 2.08

Expression of c-onc genes: c-fos transcripts accumulate to high levels during development of mouse placenta, yolk sac and amnion. EMBO J (1983) 2.08

Fos-Jun interaction: mutational analysis of the leucine zipper domain of both proteins. Genes Dev (1989) 2.06

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BRCA1 is a cell cycle-regulated nuclear phosphoprotein. Proc Natl Acad Sci U S A (1997) 2.02

Identification and molecular cloning of Moloney mouse sarcoma virus-specific sequences from uninfected mouse cells. Proc Natl Acad Sci U S A (1980) 1.98

Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation. Genes Dev (2000) 1.96

Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-kappa B. Nature (1993) 1.94

Sustained correction of bleeding disorder in hemophilia B mice by gene therapy. Proc Natl Acad Sci U S A (1999) 1.90

Size analysis and relationship of murine leukemia virus-specific mRNA's: evidence for transposition of sequences during synthesis and processing of subgenomic mRNA. J Virol (1978) 1.90

DNA polymerase activity from two temperature-sensitive mutants of Rous sarcoma virus is thermolabile. Nature (1974) 1.90

Qualitative changes in the subunit composition of kappa B-binding complexes during murine B-cell differentiation. Proc Natl Acad Sci U S A (1994) 1.89

c-fos expression is neither sufficient nor obligatory for differentiation of monomyelocytes to macrophages. Cell (1986) 1.87

Thermolabile reverse transcriptase of a mammalian leukemia virus mutant temperature sensitive in its replication and sarcoma virus helper functions. J Virol (1975) 1.87

Studies on reverse transcriptase of RNA tumor viruses. I. Localization of thermolabile DNA polymerase and RNase H activities on one polypeptide. J Virol (1975) 1.84

Inhibition of TNF-induced apoptosis by NF-kappa B. Trends Cell Biol (1998) 1.84

Rel/NF-kappa B/I kappa B story. Adv Cancer Res (1995) 1.83

Modulation of c-fos gene transcription by negative and positive cellular factors. Nature (1987) 1.83