Published in Science on October 30, 1987
Genome-wide analysis of clustered Dorsal binding sites identifies putative target genes in the Drosophila embryo. Proc Natl Acad Sci U S A (2001) 6.39
Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha. Proc Natl Acad Sci U S A (1993) 4.99
RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B. Mol Cell Biol (1992) 4.03
Cloning of the DNA-binding subunit of human nuclear factor kappa B: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha. Proc Natl Acad Sci U S A (1991) 3.80
Sequence of the twist gene and nuclear localization of its protein in endomesodermal cells of early Drosophila embryos. EMBO J (1988) 3.66
A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site. Mol Cell Biol (1992) 3.63
The history of Toll-like receptors - redefining innate immunity. Nat Rev Immunol (2013) 3.59
Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction. Mol Cell Biol (1993) 3.51
NF-kappa B subunit-specific regulation of the interleukin-8 promoter. Mol Cell Biol (1993) 3.27
Autoregulation of I kappa B alpha activity. Proc Natl Acad Sci U S A (1994) 3.24
Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62. Nucleic Acids Res (1992) 3.22
Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. Genes Dev (1997) 3.01
Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila. Proc Natl Acad Sci U S A (1996) 2.99
Functional characterization of the NF-kappa B p65 transcriptional activator and an alternatively spliced derivative. Mol Cell Biol (1992) 2.67
c-rel activates but v-rel suppresses transcription from kappa B sites. Proc Natl Acad Sci U S A (1991) 2.65
Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappaB factor. Genes Dev (1999) 2.64
Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila. EMBO J (1995) 2.48
The mouse c-rel protein has an N-terminal regulatory domain and a C-terminal transcriptional transactivation domain. Mol Cell Biol (1990) 2.47
Rapid induction in regenerating liver of RL/IF-1 (an I kappa B that inhibits NF-kappa B, RelB-p50, and c-Rel-p50) and PHF, a novel kappa B site-binding complex. Mol Cell Biol (1992) 2.27
Oncogenic transformation by vrel requires an amino-terminal activation domain. Mol Cell Biol (1990) 2.15
Proteolytic degradation of MAD3 (I kappa B alpha) and enhanced processing of the NF-kappa B precursor p105 are obligatory steps in the activation of NF-kappa B. Nucleic Acids Res (1993) 2.08
vRel is an inactive member of the Rel family of transcriptional activating proteins. J Virol (1991) 2.04
Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3). Mol Cell Biol (1993) 2.00
A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF. EMBO J (1999) 1.99
Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability. Mol Cell Biol (1996) 1.90
The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B. EMBO J (1993) 1.90
Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene. Mol Cell Biol (1994) 1.89
Transactivation of gene expression by nuclear and cytoplasmic rel proteins. Mol Cell Biol (1989) 1.87
An ancient defense system eliminates unfit cells from developing tissues during cell competition. Science (2014) 1.74
Dissociation of the dorsal-cactus complex and phosphorylation of the dorsal protein correlate with the nuclear localization of dorsal. J Cell Biol (1993) 1.70
Enhanced I kappa B alpha degradation is responsible for constitutive NF-kappa B activity in mature murine B-cell lines. Mol Cell Biol (1994) 1.67
Identification of the rel family members required for virus induction of the human beta interferon gene. Mol Cell Biol (1995) 1.66
Individual dorsal morphogen binding sites mediate activation and repression in the Drosophila embryo. EMBO J (1992) 1.65
Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity. Proc Natl Acad Sci U S A (1991) 1.63
The oncoprotein Bcl-3 can facilitate NF-kappa B-mediated transactivation by removing inhibiting p50 homodimers from select kappa B sites. EMBO J (1993) 1.61
Proneural gene self-stimulation in neural precursors: an essential mechanism for sense organ development that is regulated by Notch signaling. Genes Dev (1998) 1.59
Insect immunity. Two 17 bp repeats nesting a kappa B-related sequence confer inducibility to the diptericin gene and bind a polypeptide in bacteria-challenged Drosophila. EMBO J (1993) 1.57
Immune factor Gambif1, a new rel family member from the human malaria vector, Anopheles gambiae. EMBO J (1996) 1.56
The bZIP transactivator of Epstein-Barr virus, BZLF1, functionally and physically interacts with the p65 subunit of NF-kappa B. Mol Cell Biol (1994) 1.54
Kappa B site-dependent activation of the interleukin-2 receptor alpha-chain gene promoter by human c-Rel. Mol Cell Biol (1992) 1.52
Viral induction of the human beta interferon promoter: modulation of transcription by NF-kappa B/rel proteins and interferon regulatory factors. J Virol (1994) 1.51
Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif. Mol Cell Biol (1993) 1.46
NF-κB/Rel proteins and the humoral immune responses of Drosophila melanogaster. Curr Top Microbiol Immunol (2011) 1.45
Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-kappa B2 p100 gene product: implications for viral latency. Mol Cell Biol (1994) 1.45
Evolutionary relationships among Rel domains indicate functional diversification by recombination. Proc Natl Acad Sci U S A (2001) 1.45
The dorsal-related immunity factor, Dif, is a sequence-specific trans-activator of Drosophila Cecropin gene expression. EMBO J (1995) 1.43
Role of cysteine62 in DNA recognition by the P50 subunit of NF-kappa B. Nucleic Acids Res (1993) 1.43
NF-kappaB in the immune response of Drosophila. Cold Spring Harb Perspect Biol (2009) 1.41
Novel Jun- and Fos-related proteins in Drosophila are functionally homologous to enhancer factor AP-1. EMBO J (1988) 1.29
Structural and functional characterization of the promoter regions of the NFKB2 gene. Nucleic Acids Res (1995) 1.28
Dorsal, a Drosophila Rel-like protein, is phosphorylated upon activation of the transmembrane protein Toll. Mol Cell Biol (1994) 1.28
Conservation of transcriptional activation functions of the NF-kappa B p50 and p65 subunits in mammalian cells and Saccharomyces cerevisiae. Mol Cell Biol (1993) 1.26
Drosophila immunity: a comparative analysis of the Rel proteins dorsal and Dif in the induction of the genes encoding diptericin and cecropin. Nucleic Acids Res (1996) 1.23
Cloning and functional characterization of mouse IkappaBepsilon. Proc Natl Acad Sci U S A (1997) 1.22
Differential regulation of NF-kappaB2(p100) processing and control by amino-terminal sequences. Mol Cell Biol (1996) 1.21
The same dorsal binding site mediates both activation and repression in a context-dependent manner. EMBO J (1992) 1.19
A conserved signal transduction pathway regulating the activity of the rel-like proteins dorsal and NF-kappa B. Mol Biol Cell (1993) 1.18
Endocytic pathway is required for Drosophila Toll innate immune signaling. Proc Natl Acad Sci U S A (2010) 1.18
The swi4+ gene of Schizosaccharomyces pombe encodes a homologue of mismatch repair enzymes. Nucleic Acids Res (1992) 1.18
Length variation of CAG/CAA trinucleotide repeats in natural populations of Drosophila melanogaster and its relation to the recombination rate. Genetics (1996) 1.18
The Drosophila membrane receptor Toll can function to promote cellular adhesion. EMBO J (1990) 1.18
Signal-induced degradation of I(kappa)B(alpha): association with NF-kappaB and the PEST sequence in I(kappa)B(alpha) are not required. Mol Cell Biol (1996) 1.17
In vivo self-association of the Drosophila rel-protein dorsal. Proc Natl Acad Sci U S A (1992) 1.16
The v-rel oncogene: insights into the mechanism of transcriptional activation, repression, and transformation. J Virol (1992) 1.16
A direct contact between the dorsal rel homology domain and Twist may mediate transcriptional synergy. Mol Cell Biol (1997) 1.11
Characterization of three alternatively spliced isoforms of the Rel/NF-kappa B transcription factor Relish from the mosquito Aedes aegypti. Proc Natl Acad Sci U S A (2002) 1.10
Negative regulation of transcription in eukaryotes. Biochem J (1993) 1.10
Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression. J Virol (1994) 1.08
Conserved DNA binding and self-association domains of the Drosophila zeste protein. Mol Cell Biol (1992) 1.08
Structural studies of NF-κB signaling. Cell Res (2010) 1.07
Interaction of the C-terminal region of p105 with the nuclear localisation signal of p50 is required for inhibition of NF-kappa B DNA binding activity. Nucleic Acids Res (1993) 1.07
Expression of cellular protooncogenes in the mouse male germ line: a distinctive 2.4-kilobase pim-1 transcript is expressed in haploid postmeiotic cells. Proc Natl Acad Sci U S A (1988) 1.07
Expression of a mRNA related to c-rel and dorsal in early Xenopus laevis embryos. Proc Natl Acad Sci U S A (1991) 1.07
Evidence for a non-alpha-helical DNA-binding motif in the Rel homology region. Proc Natl Acad Sci U S A (1994) 1.05
Conventional and non-conventional Drosophila Toll signaling. Dev Comp Immunol (2013) 1.05
Mutational analysis of the Drosophila snake protease: an essential role for domains within the proenzyme polypeptide chain. Genetics (1994) 1.04
Interaction of the v-rel protein with an NF-kappa B DNA binding site. Proc Natl Acad Sci U S A (1991) 1.04
A role for CKII phosphorylation of the cactus PEST domain in dorsoventral patterning of the Drosophila embryo. Genes Dev (1997) 1.03
The ets multigene family is conserved throughout the Metazoa. Nucleic Acids Res (1993) 1.02
v-rel induces expression of three avian immunoregulatory surface receptors more efficiently than c-rel. J Virol (1994) 0.99
A genomewide survey of developmentally relevant genes in Ciona intestinalis. III. Genes for Fox, ETS, nuclear receptors and NFkappaB. Dev Genes Evol (2003) 0.98
The transcription factor NF-kappaB in the demosponge Amphimedon queenslandica: insights on the evolutionary origin of the Rel homology domain. Dev Genes Evol (2008) 0.96
HMG boxes of DSP1 protein interact with the rel homology domain of transcription factors. Nucleic Acids Res (2000) 0.96
Identification of a C/EBP-Rel complex in avian lymphoid cells. Mol Cell Biol (1994) 0.96
Functional characterization of a novel promoter element required for an innate immune response in Drosophila. Mol Cell Biol (2003) 0.95
Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products. J Virol (1992) 0.95
Regulated nuclear import of the Drosophila rel protein dorsal: structure-function analysis. Mol Cell Biol (1996) 0.95
The Drosophila dorsal morphogen represses the tolloid gene by interacting with a silencer element. Mol Cell Biol (1994) 0.94
Domain mapping of tube, a protein essential for dorsoventral patterning of the Drosophila embryo. EMBO J (1993) 0.92
Evolution of the oncogenic potential of v-rel: rel-induced expression of immunoregulatory receptors correlates with tumor development and in vitro transformation. J Virol (1994) 0.91
Acquisition of NFKB1-selective DNA binding by substitution of four amino acid residues from NFKB1 into RelA. Mol Cell Biol (1993) 0.90
Stage-specific phosphorylation of the fushi tarazu protein during Drosophila development. EMBO J (1989) 0.87
A multimeric complex and the nuclear targeting of the Drosophila Rel protein Dorsal. Proc Natl Acad Sci U S A (1997) 0.87
Rice stripe virus affects the viability of its vector offspring by changing developmental gene expression in embryos. Sci Rep (2015) 0.87
Transformation of avian fibroblasts overexpressing the c-rel proto-oncogene and a variant of c-rel lacking 40 C-terminal amino acids. J Virol (1994) 0.86
Conformational changes induced by DNA binding of NF-kappa B. Nucleic Acids Res (1995) 0.83
DNA binding alters the protease susceptibility of the p50 subunit of NF-kappa B. Nucleic Acids Res (1993) 0.82
Identification of a rel-related protein in the nucleus during the S phase of the cell cycle. Mol Cell Biol (1993) 0.80
Distribution of Xrel in the early Xenopus embryo: a cytoplasmic and nuclear gradient. Eur J Cell Biol (1994) 0.79
Maternal control of the Drosophila dorsal-ventral body axis. Wiley Interdiscip Rev Dev Biol (2014) 0.78