Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression.

PubWeight™: 1.43‹?› | Rank: Top 5%

🔗 View Article (PMC 50165)

Published in Proc Natl Acad Sci U S A on October 15, 1992

Authors

D Brändle1, C Müller, T Rülicke, H Hengartner, H Pircher

Author Affiliations

1: Institute of Experimental Immunology, University of Zurich, Switzerland.

Articles citing this

Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes. J Exp Med (1993) 1.73

Premature expression of T cell receptor (TCR)alphabeta suppresses TCRgammadelta gene rearrangement but permits development of gammadelta lineage T cells. J Exp Med (2000) 1.55

Two waves of recombinase gene expression in developing thymocytes. J Exp Med (1994) 1.52

Receptor selection in B and T lymphocytes. Annu Rev Immunol (2000) 1.49

Basal immunoglobulin signaling actively maintains developmental stage in immature B cells. PLoS Biol (2005) 1.47

Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness. Proc Natl Acad Sci U S A (1994) 1.43

Thymic involution in aging. J Clin Immunol (2000) 1.37

Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands. J Exp Med (2001) 1.33

Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene. Proc Natl Acad Sci U S A (1994) 1.32

Changes in locus-specific V(D)J recombinase activity induced by immunoglobulin gene products during B cell development. J Exp Med (1997) 1.29

Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor. J Exp Med (1995) 1.24

Downregulation of CD1 marks acquisition of functional maturation of human thymocytes and defines a control point in late stages of human T cell development. J Exp Med (1997) 1.23

Immature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci. J Exp Med (1993) 1.22

Role for rearranged variable gene segments in directing secondary T cell receptor alpha recombination. Proc Natl Acad Sci U S A (2007) 1.11

Restricting Zap70 expression to CD4+CD8+ thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection. J Exp Med (2003) 1.07

c-Myb promotes the survival of CD4+CD8+ double-positive thymocytes through upregulation of Bcl-xL. J Immunol (2010) 1.05

Evidence for a single-niche model of positive selection. Proc Natl Acad Sci U S A (1994) 1.05

The T cell receptor repertoire of CD4-8+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus. J Exp Med (1994) 1.05

Revision of T cell receptor {alpha} chain genes is required for normal T lymphocyte development. Proc Natl Acad Sci U S A (2005) 1.04

The CD3-gammadeltaepsilon and CD3-zeta/eta modules are each essential for allelic exclusion at the T cell receptor beta locus but are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-beta, -gamma, and -delta loci. J Exp Med (1998) 0.99

Small cortical thymocytes are subject to positive selection. J Exp Med (1994) 0.99

ITM2A is induced during thymocyte selection and T cell activation and causes downregulation of CD8 when overexpressed in CD4(+)CD8(+) double positive thymocytes. J Exp Med (1999) 0.97

Reconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancer. J Exp Med (1993) 0.93

Allelic exclusion in pTalpha-deficient mice: no evidence for cell surface expression of two T cell receptor (TCR)-beta chains, but less efficient inhibition of endogeneous Vbeta--> (D)Jbeta rearrangements in the presence of a functional TCR-beta transgene. J Exp Med (1997) 0.89

Precommitment of CD4+CD8+ thymocytes to either CD4 or CD8 lineages. Proc Natl Acad Sci U S A (1993) 0.80

Modulation of TCRβ surface expression during TCR revision. Cell Immunol (2011) 0.79

On defining the rules for interactions between the T cell receptor and its ligand: a critical role for a specific amino acid residue of the T cell receptor beta chain. Proc Natl Acad Sci U S A (1998) 0.78

Expression of 4-1BB and 4-1BBL in thymocytes during thymus regeneration. Exp Mol Med (2009) 0.78

Separation of thymic education from antigen presenting functions of major histocompatibility complex class I molecules. Immunology (1994) 0.77

Developmental regulation of p53-dependent radiation-induced thymocyte apoptosis in mice. Clin Exp Immunol (2015) 0.77

Allelic exclusion of TCR α-chains upon severe restriction of Vα repertoire. PLoS One (2014) 0.75

Articles cited by this

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95

RAG-1-deficient mice have no mature B and T lymphocytes. Cell (1992) 20.97

Ribonucleic acid isolated by cesium chloride centrifugation. Biochemistry (1974) 19.75

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell (1992) 17.50

T-cell antigen receptor genes and T-cell recognition. Nature (1988) 16.77

The V(D)J recombination activating gene, RAG-1. Cell (1989) 9.79

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science (1990) 9.33

The nucleotide sequence of the human beta-globin gene. Cell (1980) 8.11

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature (1989) 7.52

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature (1989) 6.70

The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition. Annu Rev Immunol (1986) 6.23

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo. Nature (1990) 5.41

Developmental biology of T cells in T cell-receptor transgenic mice. Annu Rev Immunol (1990) 5.27

The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype. J Exp Med (1984) 4.29

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice. Cell (1991) 3.66

In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes. Cell (1988) 3.34

Exclusion and inclusion of alpha and beta T cell receptor alleles. Cell (1992) 3.34

T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire. J Exp Med (1991) 3.08

Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking. Science (1991) 2.65

A rat antibody against a structure functionally related to the mouse T-cell receptor/T3 complex. Immunogenetics (1988) 2.13

T-cell-specific deletion of T-cell receptor transgenes allows functional rearrangement of endogenous alpha- and beta-genes. Nature (1988) 2.06

T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice. EMBO J (1989) 1.94

The thymus has two functionally distinct populations of immature alpha beta + T cells: one population is deleted by ligation of alpha beta TCR. Cell (1989) 1.91

A T cell clone expresses two T cell receptor alpha genes but uses one alpha beta heterodimer for allorecognition and self MHC-restricted antigen recognition. Cell (1988) 1.85

Preferential usage of V alpha 4 and V beta 10 T cell receptor genes by lymphocytic choriomeningitis virus glycoprotein-specific H-2Db-restricted cytotoxic T cells. Eur J Immunol (1990) 1.74

Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities. Nature (1990) 1.61

Preferential positive selection of V alpha 2+ CD8+ T cells in mouse strains expressing both H-2k and T cell receptor V alpha a haplotypes: determination with a V alpha 2-specific monoclonal antibody. Eur J Immunol (1992) 1.58

Involvement of both T cell receptor V alpha and V beta variable region domains and alpha chain junctional region in viral antigen recognition. Eur J Immunol (1991) 1.47

Isotypic exclusion of gamma delta T cell receptors in transgenic mice bearing a rearranged beta-chain gene. Science (1988) 1.32

Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus. Eur J Immunol (1989) 1.24

Each of the two productive T cell receptor alpha-gene rearrangements found in both the A10 and BM 3.3 T cell clones give rise to an alpha chain which can contribute to the constitution of a surface-expressed alpha beta dimer. Int Immunol (1991) 1.10

A novel type of aberrant T cell receptor alpha-chain gene rearrangement. Implications for allelic exclusion and the V-J recombination process. J Immunol (1990) 0.98

Post-transcriptional allelic exclusion of two functionally rearranged T cell receptor alpha genes. Int Immunol (1989) 0.93

Analysis of immature (CD4-CD8-) thymic subsets in T-cell receptor alpha beta transgenic mice. Dev Immunol (1992) 0.87

T cell receptor (TcR) beta chain transgenic mice: studies on allelic exclusion and on the TcR+ gamma/delta population. Eur J Immunol (1990) 0.87

Specific deletion of the J-C delta locus in murine alpha/beta T cell clones and studies using transgenic mice. Eur J Immunol (1990) 0.86

Nonrandom rearrangement of T cell receptor J alpha genes in bone marrow T cell differentiation cultures. J Immunol (1990) 0.83

Articles by these authors

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature (1994) 11.22

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature (1993) 9.81

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature (1989) 7.52

Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science (1994) 7.34

Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. EMBO J (1996) 6.66

Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell (1991) 6.49

A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science (2000) 5.78

Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes. J Exp Med (1998) 5.78

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo. Nature (1990) 5.41

Molecular and neuronal substrate for the selective attenuation of anxiety. Science (2000) 5.07

Control of early viral and bacterial distribution and disease by natural antibodies. Science (1999) 4.73

Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice. J Virol (1994) 4.34

Translational control of C/EBPalpha and C/EBPbeta isoform expression. Genes Dev (2000) 4.06

T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens. Nature (1988) 4.04

Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction. Nature (2001) 3.99

Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates. J Virol Methods (1991) 3.78

Localization and capacity of proton pumps in roots of intact sunflower plants. Plant Physiol (1984) 3.60

Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. Cell (1998) 3.59

Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection. Eur J Immunol (1998) 3.52

Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc Natl Acad Sci U S A (1998) 3.46

Photosynthetic O2 formation tracked by time-resolved x-ray experiments. Science (2005) 3.35

The influence of antigen organization on B cell responsiveness. Science (1993) 3.32

Immune responses in interleukin-2-deficient mice. Science (1993) 3.29

On immunity against infections and vaccines: credo 2004. Scand J Immunol (2004) 3.29

Fine specificity of a continuously growing killer cell clone specific for H-Y antigen. Eur J Immunol (1979) 3.27

IgA production without mu or delta chain expression in developing B cells. Nat Immunol (2001) 3.26

Visualization, characterization, and turnover of CD8+ memory T cells in virus-infected hosts. J Exp Med (1996) 3.26

On immunological memory. Annu Rev Immunol (1996) 3.21

Gender differences in long-term survival of patients with colorectal cancer. Br J Surg (2001) 3.18

Viral infections induce abundant numbers of senescent CD8 T cells. J Immunol (2001) 3.04

Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides. J Exp Med (1998) 3.03

Decreased tumor surveillance in perforin-deficient mice. J Exp Med (1996) 3.00

Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu Rev Immunol (1996) 2.96

Measles virus spread and pathogenesis in genetically modified mice. J Virol (1998) 2.84

Major histocompatibility complex--dependent T cell epitopes of lymphocytic choriomeningitis virus nucleoprotein and their protective capacity against viral disease. Eur J Immunol (1989) 2.71

Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. Blood (2000) 2.70

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function. Nature (1991) 2.66

Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity. Immunol Rev (1997) 2.58

Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide. J Exp Med (1990) 2.58

A non-retroviral RNA virus persists in DNA form. Nature (1997) 2.57

On the role of antigen in maintaining cytotoxic T-cell memory. Proc Natl Acad Sci U S A (1996) 2.55

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. J Neurosci (2000) 2.54

The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses. Eur J Immunol (1995) 2.47

Structure and function of human perforin. Nature (1988) 2.47

The role of antibody concentration and avidity in antiviral protection. Science (1997) 2.45

Methylene blue improves the hepatopulmonary syndrome. Ann Intern Med (2000) 2.43

Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure. Proc Natl Acad Sci U S A (1991) 2.41

Assignment of genes for immunoglobulin kappa and heavy chains to chromosomes 6 and 12 in mouse. Proc Natl Acad Sci U S A (1978) 2.38

Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity. Cell (1986) 2.38

The NF-M transcription factor is related to C/EBP beta and plays a role in signal transduction, differentiation and leukemogenesis of avian myelomonocytic cells. EMBO J (1993) 2.33

Influence of sex, age, body mass index, and smoking on alcohol intake and mortality. BMJ (1994) 2.31

Intrathymic deletion of self-reactive cells prevented by neonatal anti-CD4 antibody treatment. Nature (1988) 2.28

Specific cytotoxic T cells eliminate B cells producing virus-neutralizing antibodies [corrected]. Nature (1996) 2.25

T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides. Eur J Immunol (1993) 2.25

T cell-mediated hepatitis in mice infected with lymphocytic choriomeningitis virus. Liver cell destruction by H-2 class I-restricted virus-specific cytotoxic T cells as a physiological correlate of the 51Cr-release assay? J Exp Med (1986) 2.24

Interleukin 1 activity in the synovial fluid of patients with rheumatoid arthritis. Rheumatol Int (1982) 2.24

Altered circadian activity rhythms and sleep in mice devoid of prion protein. Nature (1996) 2.24

Protection against immunopathological consequences of a viral infection by activated but not resting cytotoxic T cells: T cell memory without "memory T cells"? Proc Natl Acad Sci U S A (1997) 2.23

Antivirally protective cytotoxic T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen. J Exp Med (1992) 2.22

Clones of alloreactive T cells. Nature (1978) 2.21

T cell-specific gamma genes in C57BL/10 mice. Sequence and expression of new constant and variable region genes. J Exp Med (1986) 2.20

A critical role for neutralizing-antibody-producing B cells, CD4(+) T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: implications for adoptive immunotherapy of virus carriers. Proc Natl Acad Sci U S A (1997) 2.20

Immune surveillance against a solid tumor fails because of immunological ignorance. Proc Natl Acad Sci U S A (1999) 2.19

Partial impairment of cytokine responses in Tyk2-deficient mice. Immunity (2000) 2.17

Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern. J Immunol (1998) 2.17

Lysis of human melanoma cells by autologous cytolytic T cell clones. Identification of human histocompatibility leukocyte antigen A2 as a restriction element for three different antigens. J Exp Med (1989) 2.15

Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover. J Cell Biol (1996) 2.14

FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory. J Immunol (2000) 2.13

Bystander activation of cytotoxic T cells: studies on the mechanism and evaluation of in vivo significance in a transgenic mouse model. J Exp Med (1997) 2.13

Kinetics of the response of naive and memory CD8 T cells to antigen: similarities and differences. Eur J Immunol (1999) 2.12

Different roles for cytotoxic T cells in the control of infections with cytopathic versus noncytopathic viruses. Curr Opin Immunol (1996) 2.11

Impairment and delay of neutralizing antiviral antibody responses by virus-specific cytotoxic T cells. J Immunol (1993) 2.10

A central role of perforin in cytolysis? Annu Rev Immunol (1991) 2.08

T cell priming versus T cell tolerance induced by synthetic peptides. J Exp Med (1995) 2.07

Induction or prevention of immunopathological disease by cloned cytotoxic T cell lines specific for lymphocytic choriomeningitis virus. Eur J Immunol (1986) 2.06

13C-urea versus 14C-urea breath test: is there still a need for 14C-urea? Nucl Med Commun (1998) 2.06

Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis. EMBO J (2000) 2.05

Anti-viral protection and prevention of lymphocytic choriomeningitis or of the local footpad swelling reaction in mice by immunization with vaccinia-recombinant virus expressing LCMV-WE nucleoprotein or glycoprotein. Eur J Immunol (1989) 2.05

Fibroblasts as efficient antigen-presenting cells in lymphoid organs. Science (1995) 2.01

CD8+ T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity. Eur J Immunol (1994) 2.00

Scandinavian Sarcoma Group Osteosarcoma Study SSG VIII: prognostic factors for outcome and the role of replacement salvage chemotherapy for poor histological responders. Eur J Cancer (2003) 1.99

Susceptibility to lymphocytic choriomeningitis virus isolates correlates directly with early and high cytotoxic T cell activity, as well as with footpad swelling reaction, and all three are regulated by H-2D. J Exp Med (1985) 1.98

Vaccination for disease. Science (1991) 1.97

T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice. EMBO J (1989) 1.94

Virus-induced transient bone marrow aplasia: major role of interferon-alpha/beta during acute infection with the noncytopathic lymphocytic choriomeningitis virus. J Exp Med (1997) 1.93

Peptide-induced antiviral protection by cytotoxic T cells. Proc Natl Acad Sci U S A (1991) 1.89

Positive selection of CD4+ thymocytes controlled by MHC class II gene products. Nature (1988) 1.86

Prognostic factors in patients with advanced hepatocellular carcinoma treated with sorafenib. Aliment Pharmacol Ther (2011) 1.85

Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain. EMBO J (2001) 1.85

Intensive care unit stay is prolonged in chronic alcoholic men following tumor resection of the upper digestive tract. Acta Anaesthesiol Scand (1996) 1.85

Regulation of the immune response by antigen. Science (2001) 1.84

Comparison of activation versus induction of unresponsiveness of virus-specific CD4+ and CD8+ T cells upon acute versus persistent viral infection. Immunity (1998) 1.83

Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies. Science (2001) 1.82

T-cell-mediated immunopathology versus direct cytolysis by virus: implications for HIV and AIDS. Immunol Today (1994) 1.81

Ectopic expression of prion protein (PrP) in T lymphocytes or hepatocytes of PrP knockout mice is insufficient to sustain prion replication. Proc Natl Acad Sci U S A (1999) 1.81