Enhanced tumorigenicity of an Epstein-Barr virus-transformed lymphoblastoid cell line is associated with a unique 1:18 chromosomal translocation and decreased expression of lymphocyte function associated antigen-1a (CD11A).

PubWeight™: 0.77‹?›

🔗 View Article (PMC 1887022)

Published in Am J Pathol on August 01, 1993

Authors

G R Picchio1, J I Cohen, E R Wyatt, D E Mosier

Author Affiliations

1: Division of Immunology, Medical Biology Institute, La Jolla, California.

Articles cited by this

Adhesion receptors of the immune system. Nature (1990) 28.86

Identification of a chromosome 18q gene that is altered in colorectal cancers. Science (1990) 8.32

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell (1985) 7.29

Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease. N Engl J Med (1989) 6.66

Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature (1988) 6.38

Differences in B cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt's lymphoma cells. EMBO J (1987) 6.26

Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23. J Virol (1990) 6.23

Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy. Lancet (1984) 5.74

The structure of the termini of the Epstein-Barr virus as a marker of clonal cellular proliferation. Cell (1986) 5.13

Epstein-Barr virus-encoded protein found in plasma membranes of transformed cells. J Virol (1985) 4.76

L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer. Nature (1985) 4.66

Natural killer (NK) cells are present in mice with severe combined immunodeficiency (scid). J Immunol (1985) 3.69

The pathology of posttransplant lymphoproliferative disorders occurring in the setting of cyclosporine A-prednisone immunosuppression. Am J Pathol (1988) 3.24

Epstein-Barr virus nuclear protein 2 mutations define essential domains for transformation and transactivation. J Virol (1991) 3.24

Epstein-Barr virus (EBV) induced polyclonal and monoclonal B-cell lymphoproliferative diseases occurring after renal transplantation. Clinical, pathologic, and virologic findings and implications for therapy. Ann Surg (1983) 3.15

Polymorphic diffuse B-cell hyperplasias and lymphomas in renal transplant recipients. Cancer Res (1981) 2.39

Latent and replicating forms of Epstein-Barr virus DNA in lymphomas and lymphoproliferative diseases. J Infect Dis (1989) 1.99

Epstein-Barr virus-positive Burkitt's lymphoma cells not recognized by virus-specific T-cell surveillance. Nature (1985) 1.86

Tumorigenicity of human hematopoietic cell lines in athymic nude mice. Int J Cancer (1977) 1.84

Epstein-Barr virus associated B cell lymphoproliferative disorders following bone marrow transplantation. Blood (1988) 1.72

Molecular genetic analysis of lymphoid tumors arising after organ transplantation. Am J Pathol (1989) 1.65

Epstein-Barr virus induces aggressive lymphoproliferative disorders of human B cell origin in SCID/hu chimeric mice. J Clin Invest (1990) 1.49

Clonal analysis of transplant-associated lymphoproliferations based on the structure of the genomic termini of the Epstein-Barr virus. Blood (1988) 1.19

Localization of the human JUN protooncogene to chromosome region 1p31-32. Proc Natl Acad Sci U S A (1988) 1.10

Demonstration of a splenic cytotoxic effector cell in mice of genotype SCID/SCID.BG/BG. Cell Immunol (1990) 1.06

Characterization of Epstein-Barr virus-induced lymphoproliferation derived from human peripheral blood mononuclear cells transferred to severe combined immunodeficient mice. Am J Pathol (1990) 0.99

Acquired immunodeficiency syndrome and non-Hodgkin's lymphomas. Cancer Res (1991) 0.98

Heterogeneity among Epstein-Barr virus-seropositive donors in the generation of immunoblastic B-cell lymphomas in SCID mice receiving human peripheral blood leukocyte grafts. Cancer Res (1992) 0.97

Epstein-Barr virus nuclear protein 2 is a critical determinant for tumor growth in SCID mice and for transformation in vitro. J Virol (1992) 0.87

Articles by these authors

(truncated to the top 100)

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science (2003) 19.77

A requirement for two cell types for antibody formation in vitro. Science (1967) 8.91

Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity (1995) 5.96

Extra-intestinal manifestations of salmonella infections. Medicine (Baltimore) (1987) 4.77

Complete nucleotide sequence of wild-type hepatitis A virus: comparison with different strains of hepatitis A virus and other picornaviruses. J Virol (1987) 4.49

Epstein-Barr virus nuclear antigen 2 transactivates latent membrane protein LMP1. J Virol (1990) 4.24

Cell interactions in the primary immune response in vitro: a requirement for specific cell clusters. J Exp Med (1969) 3.38

Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors. Science (1999) 3.10

Retroviral induction of acute lymphoproliferative disease and profound immunosuppression in adult C57BL/6 mice. J Exp Med (1985) 2.87

Activation of mouse lymphocytes by anti-immunoglobulin. I. Parameters of the proliferative response. J Exp Med (1978) 2.86

Hepatitis A virus cDNA and its RNA transcripts are infectious in cell culture. J Virol (1987) 2.83

The Epstein-Barr virus nuclear protein encoded by the leader of the EBNA RNAs is important in B-lymphocyte transformation. J Virol (1991) 2.81

Neutralizing antibodies have limited effects on the control of established HIV-1 infection in vivo. Immunity (1999) 2.67

Complete nucleotide sequence of an attenuated hepatitis A virus: comparison with wild-type virus. Proc Natl Acad Sci U S A (1987) 2.56

Surface immunoglobulin D as a functional receptor for a subclass of B lymphocytes. Immunol Rev (1977) 2.50

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis. Proc Natl Acad Sci U S A (1997) 2.50

Ontogeny of mouse lymphocyte function. II. Development of the ability to produce antibody is modulated by T lymphocytes. J Exp Med (1975) 2.49

Cytomegalovirus infection in the normal host. Medicine (Baltimore) (1985) 2.34

BHRF1, the Epstein-Barr virus gene with homology to Bc12, is dispensable for B-lymphocyte transformation and virus replication. J Virol (1991) 2.28

The ORF47 and ORF66 putative protein kinases of varicella-zoster virus determine tropism for human T cells and skin in the SCID-hu mouse. Proc Natl Acad Sci U S A (1998) 2.22

Inability of mice with a defect in B-lymphocyte maturation to respond to phosphorycholine on immunogenic carriers. J Exp Med (1977) 2.18

Protection against HIV-1 infection in hu-PBL-SCID mice by passive immunization with a neutralizing human monoclonal antibody against the gp120 CD4-binding site. AIDS (1995) 2.15

T-independent responses in B cell-defective CBA/N mice to Brucella abortus and to trinitrophenyl (TNP) conjugates of Brucella abortus. Eur J Immunol (1978) 2.13

The rate of division of antibody-forming cells during the early primary immune response. J Exp Med (1968) 2.10

Cellular requirements for the primary in vitro antibody response to DNP-ficoll. J Exp Med (1974) 2.10

Varicella-zoster virus open reading frame 61 protein is functionally homologous to herpes simplex virus type 1 ICP0. J Virol (1992) 2.09

CD4+ T cells are required for development of a murine retrovirus-induced immunodeficiency syndrome (MAIDS). J Exp Med (1988) 2.06

The ontogeny of thymic independent antibody responses in vitro in normal mice and mice with an X-linked B cell defect. J Immunol (1977) 2.03

Human immunodeficiency virus type 1 coreceptor switching: V1/V2 gain-of-fitness mutations compensate for V3 loss-of-fitness mutations. J Virol (2006) 2.00

Functional T lymphocytes are required for a murine retrovirus-induced immunodeficiency disease (MAIDS). J Exp Med (1987) 2.00

The extracellular domain of the Epstein-Barr virus BZLF2 protein binds the HLA-DR beta chain and inhibits antigen presentation. J Virol (1996) 1.93

NIH conference. Epstein-Barr virus infections: biology, pathogenesis, and management. Ann Intern Med (1993) 1.92

Anti-idiotype induced regulation of helper cell function for the response to phosphorylcholine in adult BALB/c mice. J Exp Med (1978) 1.89

Collaboration: a concept analysis. J Adv Nurs (1995) 1.89

Mice whose B cells cannot produce the T15 idiotype also lack an antigen-specific helper T cell required for T15 expression. J Exp Med (1979) 1.86

In vitro responses of CBA/N mice: spleen cells of mice with an X-linked defect that precludes immune responses to several thymus-independent antigens can respond to TNP-lipopolysaccharide. J Immunol (1976) 1.86

Functional maturation of thymic lymphocyte populations in vitro. J Exp Med (1972) 1.76

Varicella-zoster virus open reading frame 10 protein, the herpes simplex virus VP16 homolog, transactivates herpesvirus immediate-early gene promoters. J Virol (1993) 1.71

Varicella-zoster virus (VZV) virion-associated transactivator open reading frame 62 protein enhances the infectivity of VZV DNA. Virology (1994) 1.70

Absence of an antigen-specific helper T cell required for the expression of the T 15 idiotype in mice treated with anti-mu antibody. Eur J Immunol (1980) 1.62

The varicella-zoster virus (VZV) open reading frame 47 (ORF47) protein kinase is dispensable for viral replication and is not required for phosphorylation of ORF63 protein, the VZV homolog of herpes simplex virus ICP22. J Virol (1995) 1.61

Primary in vitro antibody responses by purified murine B lymphocytes in serum-free defined medium. J Immunol (1981) 1.61

Cellular deficit in thymectomized mice. Nature (1970) 1.57

Pneumococcal polysaccharides induce antibody formation by human B lymphocytes in vitro. J Immunol (1985) 1.55

Varicella-zoster virus open reading frame 4 protein is functionally distinct from and does not complement its herpes simplex virus type 1 homolog, ICP27. J Virol (1994) 1.52

A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR. Immunity (1998) 1.52

Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family. J Immunol (2001) 1.51

Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands. Proc Natl Acad Sci U S A (1998) 1.50

In vitro studies of the genetically determined unresponsiveness to thymus-independent antigens in CBA/N mice. J Immunol (1976) 1.50

The role of surface IgD in the response to thymic-independent antigens. J Exp Med (1977) 1.46

The Epstein-Barr virus BARF1 gene encodes a novel, soluble colony-stimulating factor-1 receptor. J Virol (1998) 1.46

Infection of human T lymphocytes with varicella-zoster virus: an analysis with viral mutants and clinical isolates. J Virol (2000) 1.46

Varicella-zoster virus (VZV) open reading frame 61 protein transactivates VZV gene promoters and enhances the infectivity of VZV DNA. J Virol (1993) 1.45

Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family. Clin Immunol (2001) 1.44

The rat ventral island flap: a comparison of the effects of reduction in arterial inflow and venous outflow. Plast Reconstr Surg (1996) 1.44

Lyb-7, a new B cell alloantigen controlled by genes linked to the IgCH locus. J Immunol (1979) 1.43

Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity. Eur J Immunol (2000) 1.42

Nucleotide sequences that distinguish Oka vaccine from parental Oka and other varicella-zoster virus isolates. J Infect Dis (2000) 1.40

Ontogeny of mouse lymphocyte function. I. Paradoxical elevation of reactivity to allogeneic cells and phytohemagglutinin in BALB-c fetal thymocytes. J Immunol (1974) 1.39

Activation of mouse lymphocytes by anti-immunoglobulin. II. A thymus-independent response by a mature subset of B lymphocytes. J Exp Med (1978) 1.37

Unilateral parathyroid exploration. Arch Otolaryngol Head Neck Surg (1998) 1.37

Proteins and cis-acting elements associated with transactivation of the varicella-zoster virus (VZV) immediate-early gene 62 promoter by VZV open reading frame 10 protein. J Virol (1995) 1.36

Animal models for retrovirus-induced immunodeficiency disease. Immunol Invest (1986) 1.34

Ly phenotype and mechanism of action of mouse neonatal suppressor T cells. J Exp Med (1977) 1.33

Disruption of the varicella-zoster virus dUTPase and the adjacent ORF9A gene results in impaired growth and reduced syncytia formation in vitro. Virology (1997) 1.32

CD40 ligand/trimer DNA enhances both humoral and cellular immune responses and induces protective immunity to infectious and tumor challenge. J Immunol (1998) 1.32

Tumor angiogenesis, the p53 antigen, and cervical metastasis in squamous carcinoma of the tongue. Otolaryngol Head Neck Surg (1994) 1.31

hu-PBL-SCID mice: a model for human immune function, AIDS, and lymphomagenesis. Immunol Rev (1991) 1.29

The varicella-zoster virus ORF66 protein induces kinase activity and is dispensable for viral replication. J Virol (1996) 1.29

Herpesvirus saimiri open reading frame 14, a protein encoded by T lymphotropic herpesvirus, binds to MHC class II molecules and stimulates T cell proliferation. J Immunol (1996) 1.25

Adoptive transfer of neonatal T lymphocytes rescues immunoglobulin production in mice with severe combined immune deficiency. J Exp Med (1991) 1.23

The murine gammaherpesvirus-68 M11 protein inhibits Fas- and TNF-induced apoptosis. J Gen Virol (1999) 1.21

Role of a nonimmunoglobulin cell surface determinant in the activation of B lymphocytes by thymus-independent antigens. J Exp Med (1979) 1.19

Macrophage requirement for the in vitro response to TNP Ficoll: a thymic independent antigen. J Immunol (1976) 1.19

HIV results in the frame. CD4+ cell turnover. Nature (1995) 1.19

Identification of an immunodominant antigenic site involving the capsid protein VP3 of hepatitis A virus. Proc Natl Acad Sci U S A (1988) 1.18

Deletion of the varicella-zoster virus large subunit of ribonucleotide reductase impairs growth of virus in vitro. J Virol (1994) 1.17

The cell tropism of human immunodeficiency virus type 1 determines the kinetics of plasma viremia in SCID mice reconstituted with human peripheral blood leukocytes. J Virol (1998) 1.15

Donor- and ligand-dependent differences in C-C chemokine receptor 5 reexpression. J Virol (2001) 1.15

Autoantibody production by severe combined immunodeficient mice reconstituted with synovial cells from rheumatoid arthritis patients. Eur J Immunol (1990) 1.14

Induction of B lymphocyte proliferation by monoclonal anti-Lyb 2 antibody. J Immunol (1983) 1.11

Varicella-zoster virus ORF57, unlike its pseudorabies virus UL3.5 homolog, is dispensable for viral replication in cell culture. Virology (1998) 1.10

Recombinant varicella-zoster virus glycoproteins E and I: immunologic responses and clearance of virus in a guinea pig model of chronic uveitis. J Infect Dis (1998) 1.10

The RING finger domain of the varicella-zoster virus open reading frame 61 protein is required for its transregulatory functions. Virology (1994) 1.09

Varicella-zoster virus (VZV) ORF32 encodes a phosphoprotein that is posttranslationally modified by the VZV ORF47 protein kinase. J Virol (1998) 1.08

The immunoglobulin allotype contributed by peritoneal cavity B cells dominates in SCID mice reconstituted with allotype-disparate mixtures of splenic and peritoneal cavity B cells. J Exp Med (1990) 1.07

Activation of B lymphocytes by monovalent anti-Lyb-2 antibodies. J Exp Med (1984) 1.04

Molecular mechanisms of antiviral resistance. Antiviral Res (1995) 1.03

Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses. J Virol (1997) 1.02

Virus entry via the alternative coreceptors CCR3 and FPRL1 differs by human immunodeficiency virus type 1 subtype. J Virol (2009) 1.02

Specific H chain junctional diversity may be required for non-T15 antibodies to bind phosphorylcholine. J Immunol (1988) 1.01

Common and idiosyncratic patterns of cytokine gene expression by Epstein-Barr virus transformed human B cell lines. Viral Immunol (1997) 1.01

Studies of HIV infection and the development of Epstein-Barr virus-related B cell lymphomas following transfer of human lymphocytes to mice with severe combined immunodeficiency. Curr Top Microbiol Immunol (1989) 1.01

Formation of antibody in the newborn mouse: study of T-cell-independent antibody response. J Infect Dis (1977) 1.00

Immunologic effects of neonatal infection with mouse thymic virus. J Immunol (1975) 1.00

Lyb antigens and their role in B lymphocyte activation. Immunol Rev (1982) 0.99

Ex situ conservation of plant genetic resources: global development and environmental concerns. Science (1991) 0.99

The acidic amino-terminal region of varicella-zoster virus open reading frame 4 protein is required for transactivation and can functionally replace the corresponding region of herpes simplex virus ICP27. Virology (1995) 0.98

The antiviral activity of HIV-specific CD8+ CTL clones is limited by elimination due to encounter with HIV-infected targets. J Immunol (1999) 0.98

Expression of a uracil DNA glycosylase (UNG) inhibitor in mammalian cells: varicella-zoster virus can replicate in vitro in the absence of detectable UNG activity. Virology (1998) 0.98