Published in Proc Natl Acad Sci U S A on January 15, 1993
The influence of lysolipids on the spontaneous curvature and bending elasticity of phospholipid membranes. Biophys J (2001) 2.12
Resistance of transgenic mice expressing human group II phospholipase A2 to Escherichia coli infection. Infect Immun (2000) 0.95
Exchange of monooleoylphosphatidylcholine with single egg phosphatidylcholine vesicle membranes. Biophys J (1996) 0.91
Phospholipase A2 from plasma of patients with septic shock is associated with high-density lipoproteins and C3 anaphylatoxin: some implications for its functional role. Biochem J (1995) 0.90
Potential role of phospholipase A2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation. Proc Natl Acad Sci U S A (1993) 0.89
Secreted phospholipase A2 involvement in neurodegeneration: differential testing of prosurvival and anti-inflammatory effects of enzyme inhibition. PLoS One (2012) 0.83
Total direct chemical synthesis and biological activities of human group IIA secretory phospholipase A2. Biochem J (2002) 0.83
Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels. Circ Cardiovasc Genet (2014) 0.78
Identification of a specific region of low molecular weight phospholipases A2 (residues 21-40) as a potential target for structure-based design of inhibitors of these enzymes. Proc Natl Acad Sci U S A (1993) 0.77
A rapid method of total lipid extraction and purification. Can J Biochem Physiol (1959) 173.74
The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature (1984) 28.58
Studies and perspectives of protein kinase C. Science (1986) 14.73
Signaling through phosphatidylcholine breakdown. J Biol Chem (1990) 5.36
The regulation and cellular functions of phosphatidylcholine hydrolysis. Biochem J (1990) 3.44
Role of phospholipase in generating lipid second messengers in signal transduction. FASEB J (1991) 2.56
Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers. Trends Neurosci (1988) 2.14
Synergistic action of diacylglycerol and unsaturated fatty acid for protein kinase C activation: its possible implications. Proc Natl Acad Sci U S A (1991) 1.79
Purification of a cellular (granulocyte) and an extracellular (serum) phospholipase A2 that participate in the destruction of Escherichia coli in a rabbit inflammatory exudate. J Biol Chem (1990) 1.32
Role of lysophosphatidylcholine in T-lymphocyte activation: involvement of phospholipase A2 in signal transduction through protein kinase C. Proc Natl Acad Sci U S A (1992) 1.14
Metabolic rate of membrane-permeant diacylglycerol and its relation to human resting T-lymphocyte activation. Proc Natl Acad Sci U S A (1991) 1.10
Studies on the acyl-chain selectivity of cellular phospholipases A2. Biochim Biophys Acta (1990) 1.03
Approaches to the study of mammalian cellular phospholipases. J Lipid Res (1985) 1.02
Platelet activation by simultaneous actions of diacylglycerol and unsaturated fatty acids. Proc Natl Acad Sci U S A (1992) 1.00
Purification and characterization of phospholipase A2 released from rat platelets. J Biochem (1987) 0.98
Eicosanoid generation from antigen-primed mast cells by extracellular mammalian 14-kDa group II phospholipase A2. FEBS Lett (1991) 0.96
Exacerbation of rat adjuvant arthritis by intradermal injection of purified mammalian 14-kDa group II phospholipase A2. FEBS Lett (1990) 0.91
Immunochemical detection of 'platelet type' phospholipase A2 in the rat. Biochim Biophys Acta (1990) 0.84
Characteristics and pathophysiological roles of extracellular phospholipase A2 in inflamed sites. Dermatologica (1989) 0.82
Monoclonal antibodies against rat platelet phospholipase A2. J Biochem (1988) 0.81
Proposed supplements and amendments to 'A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects', the Rechtschaffen & Kales (1968) standard. Psychiatry Clin Neurosci (2001) 36.50
The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature (1997) 33.47
Functional annotation of a full-length mouse cDNA collection. Nature (2001) 23.61
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry (1984) 10.83
IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest (1999) 7.66
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell (1994) 6.45
Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science (2000) 6.22
The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity (1994) 6.18
A novel integron-like element carrying the metallo-beta-lactamase gene blaIMP. Antimicrob Agents Chemother (1995) 6.00
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet (2000) 5.26
Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. Immunity (2001) 5.14
Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell (1990) 5.06
Clinical application of transvenous mitral commissurotomy by a new balloon catheter. J Thorac Cardiovasc Surg (1984) 4.45
Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell (1995) 4.34
Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts. J Cell Biol (2000) 4.34
Human cerebellar activity reflecting an acquired internal model of a new tool. Nature (2000) 4.29
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat Nanotechnol (2011) 4.22
Molecular evidence for the early evolution of photosynthesis. Science (2000) 4.17
Reciprocal subsidies: dynamic interdependence between terrestrial and aquatic food webs. Proc Natl Acad Sci U S A (2001) 4.13
Real-time detection system for quantification of hepatitis C virus genome. Gastroenterology (1999) 3.83
Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA. Nat Med (2001) 3.81
Perceptual learning without perception. Nature (2001) 3.48
Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan. The Liver Cancer Study Group of Japan. Hepatology (2000) 3.42
Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection. Proc Natl Acad Sci U S A (1990) 3.31
Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2. J Biol Chem (2000) 3.19
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc Natl Acad Sci U S A (1981) 3.04
Relation of mucoid growth of Staphylococcus aureus to clumping factor reaction, morphology in serum-soft agar, and virulence. J Bacteriol (1968) 3.01
Control of doublesex alternative splicing by transformer and transformer-2 in Drosophila. Science (1991) 2.87
Myeloscopy, with special reference to blood flow changes in the cauda equina during Lasègue's test. Int Orthop (1981) 2.82
Experimental investigation of geologically produced antineutrinos with KamLAND. Nature (2005) 2.75
Acquired Chiari I malformation and syringomyelia associated with bilateral chronic subdural hematoma. Case report. J Neurosurg (1995) 2.75
Requirement of CD9 on the egg plasma membrane for fertilization. Science (2000) 2.65
IKKalpha controls formation of the epidermis independently of NF-kappaB. Nature (2001) 2.60
Tumor angiogenesis in human lung adenocarcinoma. Cancer (1994) 2.59
Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. J Neurosci (2001) 2.54
Characteristics of macrolide-resistant Mycoplasma pneumoniae strains isolated from patients and induced with erythromycin in vitro. Microbiol Immunol (2001) 2.52
Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis. J Biol Chem (2000) 2.47
No-mortality liver resection for hepatocellular carcinoma in cirrhotic and noncirrhotic patients: is there a way? A prospective analysis of our approach. Arch Surg (1999) 2.47
Quantitation of hepatitis B virus genomic DNA by real-time detection PCR. J Clin Microbiol (1999) 2.46
Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals. J Immunol (1999) 2.44
Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J Biol Chem (1999) 2.44
Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage. J Biol Chem (2000) 2.44
Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. Cancer Res (1998) 2.42
Increased expression of sialyl Lewisx antigen correlates with poor survival in patients with colorectal carcinoma: clinicopathological and immunohistochemical study. Cancer Res (1993) 2.39
Interferon-alpha-mediated down-regulation of angiogenesis-related genes and therapy of bladder cancer are dependent on optimization of biological dose and schedule. Clin Cancer Res (1999) 2.39
Modification of glial-neuronal cell interactions prevents photoreceptor apoptosis during light-induced retinal degeneration. Neuron (2000) 2.38
DBTBS: a database of Bacillus subtilis promoters and transcription factors. Nucleic Acids Res (2001) 2.35
Chlorophyll a oxygenase (CAO) is involved in chlorophyll b formation from chlorophyll a. Proc Natl Acad Sci U S A (1998) 2.35
Ultrasonically guided percutaneous microwave coagulation therapy for small hepatocellular carcinoma. Cancer (1994) 2.34
Switch circular DNA formed in cytokine-treated mouse splenocytes: evidence for intramolecular DNA deletion in immunoglobulin class switching. Cell (1990) 2.30
Spectral response curves of single cones in the carp. Vision Res (1967) 2.30
Homeostasis of alpha beta TCR+ T cells. Nat Immunol (2000) 2.29
Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clin Cancer Res (1999) 2.26
Downregulation of caffeic acid 3-O-methyltransferase and caffeoyl CoA 3-O-methyltransferase in transgenic alfalfa. impacts on lignin structure and implications for the biosynthesis of G and S lignin. Plant Cell (2001) 2.23
Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase [corrected]. Nature (1994) 2.22
Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling. Immunity (2000) 2.16
Noninvasive assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery by Doppler echocardiography: comparison with invasive technique. J Am Coll Cardiol (1998) 2.14
Molecular cloning and nucleotide sequence of the cDNA for rat peroxisomal enoyl-CoA: hydratase-3-hydroxyacyl-CoA dehydrogenase bifunctional enzyme. J Biol Chem (1985) 2.12
Reduced myocardial flow reserve in non-insulin-dependent diabetes mellitus. J Am Coll Cardiol (1997) 2.11
Role of human cytochrome P4502A6 in C-oxidation of nicotine. Drug Metab Dispos (1996) 2.11
Identification of a new variable sequence in the P1 cytadhesin gene of Mycoplasma pneumoniae: evidence for the generation of antigenic variation by DNA recombination between repetitive sequences. Infect Immun (1999) 2.11
The elasticity of the MgSiO3 post-perovskite phase in the Earth's lowermost mantle. Nature (2004) 2.10
Phage-conversion of toxigenicity in Clostridium botulinum types C and D. Jpn J Med Sci Biol (1971) 2.09
Site-specific mutagenesis on cloned DNAs: generation of a mutant of Escherichia coli tyrosine suppressor tRNA in which the sequence G-T-T-C corresponding to the universal G-T-pseudouracil-C sequence of tRNAs is changed to G-A-T-C. Proc Natl Acad Sci U S A (1981) 2.09
Fukuyama-type congenital muscular dystrophy and the Walker-Warburg syndrome. Brain Dev (1993) 2.08
Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. EMBO J (1999) 2.08
Myocardial metabolism of fluorodeoxyglucose compared to cell membrane integrity for the potassium analogue rubidium-82 for assessing infarct size in man by PET. J Nucl Med (1991) 2.07
Over-expression of facilitative glucose transporter genes in human cancer. Biochem Biophys Res Commun (1990) 2.06
Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity. Immunity (1996) 2.05
Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice. Proc Natl Acad Sci U S A (1995) 2.05
Mesenchymal to epithelial conversion in rat metanephros is induced by LIF. Cell (1999) 2.04
Room-temperature ferromagnetism in transparent transition metal-doped titanium dioxide. Science (2001) 2.03
Ataxia with isolated vitamin E deficiency is caused by mutations in the alpha-tocopherol transfer protein. Nat Genet (1995) 2.03
Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth. J Biol Chem (1997) 2.03
Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease. Nat Genet (2000) 2.02
Lysenin, a novel sphingomyelin-specific binding protein. J Biol Chem (1998) 2.02
Epidemiological study of Mycoplasma pneumoniae infections in japan based on PCR-restriction fragment length polymorphism of the P1 cytadhesin gene. J Clin Microbiol (1996) 2.02
A cross-validation of the European Organization for Research and Treatment of Cancer QLQ-C30 (EORTC QLQ-C30) for Japanese with lung cancer. Eur J Cancer (1998) 2.01
Postmarketing surveillance of the safety profile of infliximab in 5000 Japanese patients with rheumatoid arthritis. Ann Rheum Dis (2007) 2.01
Autosomal dominant moyamoya disease maps to chromosome 17q25.3. Neurology (2008) 2.00
VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration. Cell Death Differ (2001) 2.00
Cell cycle-dependent expression of the mouse Rad51 gene in proliferating cells. Mol Gen Genet (1996) 2.00
Conversion of toxigenicity in Clostridium botulinum type C. Jpn J Microbiol (1970) 1.98
Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma. Hepatology (1998) 1.97
Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse. Nat Neurosci (2001) 1.96
Did ossification of the posterior longitudinal ligament of the spine evolve in the modern period? A paleopathologic study of ancient human skeletons in Japan. J Rheumatol (2000) 1.96
The class IV semaphorin CD100 plays nonredundant roles in the immune system: defective B and T cell activation in CD100-deficient mice. Immunity (2000) 1.96
A novel capacitative calcium entry channel expressed in excitable cells. EMBO J (1998) 1.95
Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite. J Antibiot (Tokyo) (1994) 1.93
A unique vacuolar processing enzyme responsible for conversion of several proprotein precursors into the mature forms. FEBS Lett (1991) 1.92
Endoscopic neck surgery by the axillary approach. J Am Coll Surg (2000) 1.90
Phytochrome-mediated regulation of two mRNAs, encoded by nuclei and chloroplasts of ribulose-1,5-bisphosphate carboxylase/oxygenase. Eur J Biochem (1983) 1.88
Bacteriophages of Clostridium botulinum. J Virol (1968) 1.88
A transgenic model of autoimmune hemolytic anemia. J Exp Med (1992) 1.87
Monoclonal antibodies to mouse complement receptor type 1 (CR1). Their use in a distribution study showing that mouse erythrocytes and platelets are CR1-negative. J Immunol (1988) 1.86
Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells. J Antibiot (Tokyo) (1991) 1.86
Acute necrotising encephalopathy of childhood: a new syndrome presenting with multifocal, symmetric brain lesions. J Neurol Neurosurg Psychiatry (1995) 1.85
Transition of brain activation from frontal to parietal areas in visuomotor sequence learning. J Neurosci (1998) 1.85