Published in Proc Natl Acad Sci U S A on June 01, 1993
The influence of lysolipids on the spontaneous curvature and bending elasticity of phospholipid membranes. Biophys J (2001) 2.12
Activation of protein kinase C by lysophosphatidic acid: dependence on composition of phospholipid vesicles. Biochem J (1996) 0.95
Regulation of phospholipase A2 in human leukemia cell lines: its implication for intracellular signaling. Proc Natl Acad Sci U S A (1994) 0.95
Secreted phospholipase A2 involvement in neurodegeneration: differential testing of prosurvival and anti-inflammatory effects of enzyme inhibition. PLoS One (2012) 0.83
Carcinogenic potential of duodenal reflux juice from patients with long-standing postgastrectomy. World J Gastroenterol (2001) 0.83
Detergent properties influence the stability of the glycophorin A transmembrane helix dimer in lysophosphatidylcholine micelles. Biophys J (2012) 0.80
Exposure to p,p'-DDE Induces Morphological Changes and Activation of the PKCα-p38-C/EBPβ Pathway in Human Promyelocytic HL-60 Cells. Biomed Res Int (2016) 0.75
A synaptic model of memory: long-term potentiation in the hippocampus. Nature (1993) 29.13
Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science (1992) 12.18
Signaling through phosphatidylcholine breakdown. J Biol Chem (1990) 5.36
The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. Blood (1987) 3.90
The regulation and cellular functions of phosphatidylcholine hydrolysis. Biochem J (1990) 3.44
Role of phospholipase in generating lipid second messengers in signal transduction. FASEB J (1991) 2.56
Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid. Proc Natl Acad Sci U S A (1992) 2.55
Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C. J Biol Chem (1993) 2.55
Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers. Trends Neurosci (1988) 2.14
Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation. Nature (1992) 1.82
Synergistic action of diacylglycerol and unsaturated fatty acid for protein kinase C activation: its possible implications. Proc Natl Acad Sci U S A (1991) 1.79
Protein kinase C, calcium and phospholipid degradation. Trends Biochem Sci (1992) 1.50
Dissociation of protein kinase C activation from phorbol ester-induced maturation of HL-60 leukemia cells. J Biol Chem (1985) 1.41
Regulation of protein kinase C by lysophospholipids. Potential role in signal transduction. J Biol Chem (1988) 1.38
Crosstalk among multiple signal-activated phospholipases. Trends Biochem Sci (1992) 1.36
Inflammatory factors stimulate expression of group II phospholipase A2 in rat cultured astrocytes. Two distinct pathways of the gene expression. J Biol Chem (1991) 1.32
Isolation and characterization of delta-subspecies of protein kinase C from rat brain. Proc Natl Acad Sci U S A (1992) 1.18
Role of lysophosphatidylcholine in T-lymphocyte activation: involvement of phospholipase A2 in signal transduction through protein kinase C. Proc Natl Acad Sci U S A (1992) 1.14
Failure of 1-oleoyl-2-acetylglycerol to mimic the cell-differentiating action of 12-O-tetradecanoylphorbol 13-acetate in HL-60 cells. J Biol Chem (1985) 1.10
Sustained activation of protein kinase C is essential to HL-60 cell differentiation to macrophage. Proc Natl Acad Sci U S A (1991) 1.08
Platelet activation by simultaneous actions of diacylglycerol and unsaturated fatty acids. Proc Natl Acad Sci U S A (1992) 1.00
Possible role of mammalian secretory group II phospholipase A2 in T-lymphocyte activation: implication in propagation of inflammatory reaction. Proc Natl Acad Sci U S A (1993) 0.98
Potentiation of diacylglycerol-induced activation of protein kinase C by lysophospholipids. Subspecies difference. FEBS Lett (1993) 0.95
Enhancement of long-term potentiation by cis-unsaturated fatty acid: relation to protein kinase C and phospholipase A2. J Neurosci (1987) 0.95
Protein kinase C during differentiation of human promyelocytic leukemia cell line, HL-60. FEBS Lett (1990) 0.92
IL-1 increases phospholipase A2 activity, expression of phospholipase A2-activating protein, and release of linoleic acid from the murine T helper cell line EL-4. J Immunol (1992) 0.91
Disparate effects of activators of protein kinase C on HL-60 promyelocytic leukemia cell differentiation. J Biol Chem (1987) 0.89
Differentiation of HL-60 promyelocytic leukemia cells: simultaneous determination of phagocytic activity and cell cycle distribution by flow cytometry. Cytometry (1986) 0.87
Evidence for the possible involvement of protein kinase C in the activation of non-specific phospholipase A2 in human neutrophils. J Lipid Mediat (1992) 0.79
The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature (1997) 33.47
The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature (1984) 28.58
Functional annotation of a full-length mouse cDNA collection. Nature (2001) 23.61
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J Biol Chem (1982) 16.71
Studies and perspectives of protein kinase C. Science (1986) 14.73
Essential Bacillus subtilis genes. Proc Natl Acad Sci U S A (2003) 14.01
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry (1984) 10.83
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell (1994) 6.45
The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity (1994) 6.18
Turnover of inositol phospholipids and signal transduction. Science (1984) 5.76
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet (2000) 5.26
Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. Immunity (2001) 5.14
Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover. J Biol Chem (1980) 5.08
Comparison of guanosine triphosphate split and polypeptide synthesis with a purified E. coli system. Proc Natl Acad Sci U S A (1966) 4.72
Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell (1995) 4.34
Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts. J Cell Biol (2000) 4.34
Human cerebellar activity reflecting an acquired internal model of a new tool. Nature (2000) 4.29
The structure, expression, and properties of additional members of the protein kinase C family. J Biol Chem (1988) 4.15
Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids. J Biol Chem (1979) 4.12
Diphtheria toxin-dependent adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis. J Biol Chem (1968) 3.81
Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation. J Biol Chem (1983) 3.69
Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties. J Biol Chem (1982) 3.64
Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters. J Biol Chem (1983) 3.60
Perceptual learning without perception. Nature (2001) 3.48
Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection. Proc Natl Acad Sci U S A (1990) 3.31
Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties. Proc Natl Acad Sci U S A (1989) 3.21
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc Natl Acad Sci U S A (1981) 3.04
Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain. J Biol Chem (1977) 3.02
Relation of mucoid growth of Staphylococcus aureus to clumping factor reaction, morphology in serum-soft agar, and virulence. J Bacteriol (1968) 3.01
Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system. Biochem Biophys Res Commun (1979) 2.96
Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin. Cell (2001) 2.81
Acquired Chiari I malformation and syringomyelia associated with bilateral chronic subdural hematoma. Case report. J Neurosurg (1995) 2.75
Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence. Proc Natl Acad Sci U S A (1989) 2.72
The protein kinase C family: heterogeneity and its implications. Annu Rev Biochem (1989) 2.70
The interrelationship between guanosine triphosphatase and amino acid polymerization. Arch Biochem Biophys (1966) 2.64
IKKalpha controls formation of the epidermis independently of NF-kappaB. Nature (2001) 2.60
Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3':5'-monophosphate-dependent protein kinase. J Biol Chem (1985) 2.55
Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. J Neurosci (2001) 2.54
Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis. J Exp Med (1982) 2.52
Characteristics of macrolide-resistant Mycoplasma pneumoniae strains isolated from patients and induced with erythromycin in vitro. Microbiol Immunol (2001) 2.52
Thymus and reproduction: sex-linked dysgenesia of the gonad after neonatal thymectomy in mice. Science (1969) 2.48
Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals. J Immunol (1999) 2.44
Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage. J Biol Chem (2000) 2.44
Activation of protein kinase C by tyrosine phosphorylation in response to H2O2. Proc Natl Acad Sci U S A (1997) 2.42
Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. Cancer Res (1998) 2.42
Increased expression of sialyl Lewisx antigen correlates with poor survival in patients with colorectal carcinoma: clinicopathological and immunohistochemical study. Cancer Res (1993) 2.39
Modification of glial-neuronal cell interactions prevents photoreceptor apoptosis during light-induced retinal degeneration. Neuron (2000) 2.38
DBTBS: a database of Bacillus subtilis promoters and transcription factors. Nucleic Acids Res (2001) 2.35
Chlorophyll a oxygenase (CAO) is involved in chlorophyll b formation from chlorophyll a. Proc Natl Acad Sci U S A (1998) 2.35
Switch circular DNA formed in cytokine-treated mouse splenocytes: evidence for intramolecular DNA deletion in immunoglobulin class switching. Cell (1990) 2.30
The role of protein kinase C in transmembrane signalling. Annu Rev Cell Biol (1986) 2.29
Adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis by diphtheria toxin. J Biol Chem (1971) 2.23
Proteolytic activation of calcium-activated, phospholipid-dependent protein kinase by calcium-dependent neutral protease. J Biol Chem (1983) 2.20
Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling. Immunity (2000) 2.16
Inhibitory action of chlorpromazine, dibucaine, and other phospholipid-interacting drugs on calcium-activated, phospholipid-dependent protein kinase. J Biol Chem (1980) 2.15
Noninvasive assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery by Doppler echocardiography: comparison with invasive technique. J Am Coll Cardiol (1998) 2.14
Self tolerance and localized autoimmunity. Mouse models of autoimmune disease that suggest tissue-specific suppressor T cells are involved in self tolerance. J Exp Med (1987) 2.14
Reduced myocardial flow reserve in non-insulin-dependent diabetes mellitus. J Am Coll Cardiol (1997) 2.11
Study on cellular events in postthymectomy autoimmune oophoritis in mice. I. Requirement of Lyt-1 effector cells for oocytes damage after adoptive transfer. J Exp Med (1982) 2.11
Identification of a new variable sequence in the P1 cytadhesin gene of Mycoplasma pneumoniae: evidence for the generation of antigenic variation by DNA recombination between repetitive sequences. Infect Immun (1999) 2.11
Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum. J Biol Chem (1977) 2.10
Mesenchyme-dependent morphogenesis and epithelium-specific cytodifferentiation in mouse mammary gland. Science (1976) 2.08
Studies on the polymer of adenosine diphosphate ribose. I. Enzymic formation from nicotinamide adenine dinuclotide in mammalian nuclei. J Biol Chem (1967) 2.08
Fukuyama-type congenital muscular dystrophy and the Walker-Warburg syndrome. Brain Dev (1993) 2.08
Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. EMBO J (1999) 2.08
Myocardial metabolism of fluorodeoxyglucose compared to cell membrane integrity for the potassium analogue rubidium-82 for assessing infarct size in man by PET. J Nucl Med (1991) 2.07
Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity. Immunity (1996) 2.05
Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice. Proc Natl Acad Sci U S A (1995) 2.05
Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B. Proc Natl Acad Sci U S A (1999) 2.04
Mesenchymal to epithelial conversion in rat metanephros is induced by LIF. Cell (1999) 2.04
Synergistic functions of phorbol ester and calcium in serotonin release from human platelets. Biochem Biophys Res Commun (1983) 2.03
Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth. J Biol Chem (1997) 2.03
Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease. Nat Genet (2000) 2.02
A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions. J Biol Chem (1983) 2.02
Epidemiological study of Mycoplasma pneumoniae infections in japan based on PCR-restriction fragment length polymorphism of the P1 cytadhesin gene. J Clin Microbiol (1996) 2.02
A cross-validation of the European Organization for Research and Treatment of Cancer QLQ-C30 (EORTC QLQ-C30) for Japanese with lung cancer. Eur J Cancer (1998) 2.01
Spontaneous development of autoimmune thyroiditis in neonatally thymectomized mice. Lab Invest (1976) 2.00
Cell cycle-dependent expression of the mouse Rad51 gene in proliferating cells. Mol Gen Genet (1996) 2.00
Autoimmune oophoritis in thymectomized mice: detection of circulating antibodies against oocytes. Clin Exp Immunol (1980) 1.98
Taxonomy and function of C1 protein kinase C homology domains. Protein Sci (1997) 1.98
Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma. Hepatology (1998) 1.97
Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse. Nat Neurosci (2001) 1.96
The class IV semaphorin CD100 plays nonredundant roles in the immune system: defective B and T cell activation in CD100-deficient mice. Immunity (2000) 1.96
The protein kinase C family for neuronal signaling. Annu Rev Neurosci (1994) 1.95
Comprehensive DNA microarray analysis of Bacillus subtilis two-component regulatory systems. J Bacteriol (2001) 1.94
Experimental autoimmune orchitis after neonatal thymectomy in the mouse. Clin Exp Immunol (1981) 1.94
Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-delta subspecies. Proc Natl Acad Sci U S A (1992) 1.91
Endoscopic neck surgery by the axillary approach. J Am Coll Surg (2000) 1.90
Phytochrome-mediated regulation of two mRNAs, encoded by nuclei and chloroplasts of ribulose-1,5-bisphosphate carboxylase/oxygenase. Eur J Biochem (1983) 1.88
Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells. J Antibiot (Tokyo) (1991) 1.86
Acute necrotising encephalopathy of childhood: a new syndrome presenting with multifocal, symmetric brain lesions. J Neurol Neurosurg Psychiatry (1995) 1.85
Transition of brain activation from frontal to parietal areas in visuomotor sequence learning. J Neurosci (1998) 1.85
Changes in distribution of hepatic blood flow induced by intra-arterial infusion of angiotensin II in human hepatic cancer. Cancer (1985) 1.84
Domain structure of heparan sulfates from bovine organs. J Biol Chem (1996) 1.84
Acetyl-CoA carboxylase in higher plants: most plants other than gramineae have both the prokaryotic and the eukaryotic forms of this enzyme. Plant Cell Physiol (1996) 1.83
Enhanced myosin light chain phosphorylations as a central mechanism for coronary artery spasm in a swine model with interleukin-1beta. Circulation (1997) 1.83
Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis. Proc Natl Acad Sci U S A (1997) 1.82
Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. Oncogene (2007) 1.81
Pseudocompact-type growth and conversion of growth types of strains of Staphylococcus aureus in vitro and in vivo. J Bacteriol (1969) 1.81
Effect of captopril on heavy proteinuria in azotemic diabetics. N Engl J Med (1985) 1.81