Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.

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Published in Proc Natl Acad Sci U S A on January 15, 1993

Authors

Z Eshhar1, T Waks, G Gross, D G Schindler

Author Affiliations

1: Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.

Associated clinical trials:

CAR-T Cell Immunotherapy for Advanced Lung Cancer | NCT03330834

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