Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3).

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Published in Mol Cell Biol on March 01, 1993

Authors

C S Duckett1, N D Perkins, T F Kowalik, R M Schmid, E S Huang, A S Baldwin, G J Nabel

Author Affiliations

1: Department of Internal Medicine, Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor 48109-0650.

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Congenital cytomegalovirus infection. N Engl J Med (1977) 2.35

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