Published in Genes Dev on December 15, 1995
A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus. Genes Dev (1997) 3.80
Signaling cross-talk between TGF-beta/BMP and other pathways. Cell Res (2009) 3.66
The Spemann organizer gene, Goosecoid, promotes tumor metastasis. Proc Natl Acad Sci U S A (2006) 3.64
Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis. EMBO J (2000) 2.55
The establishment of Spemann's organizer and patterning of the vertebrate embryo. Nat Rev Genet (2000) 2.51
Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif. Genes Dev (2000) 2.13
Endodermal Nodal-related signals and mesoderm induction in Xenopus. Development (2000) 1.97
The Xenopus Brachyury promoter is activated by FGF and low concentrations of activin and suppressed by high concentrations of activin and by paired-type homeodomain proteins. Genes Dev (1997) 1.66
Chromatin immunoprecipitation in early Xenopus laevis embryos. Dev Dyn (2009) 1.58
Siamois is required for formation of Spemann's organizer. Proc Natl Acad Sci U S A (1997) 1.57
Wnt and TGF-beta expression in the sponge Amphimedon queenslandica and the origin of metazoan embryonic patterning. PLoS One (2007) 1.54
Wnt signaling and transcriptional control of Siamois in Xenopus embryos. Proc Natl Acad Sci U S A (1998) 1.41
Xenopus as a model system to study transcriptional regulatory networks. Proc Natl Acad Sci U S A (2005) 1.28
Iroquois transcription factors recognize a unique motif to mediate transcriptional repression in vivo. Proc Natl Acad Sci U S A (2005) 1.22
A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells. Dev Biol (2009) 1.16
Cooperation between the activin and Wnt pathways in the spatial control of organizer gene expression. Proc Natl Acad Sci U S A (1998) 1.11
Geminin cooperates with Polycomb to restrain multi-lineage commitment in the early embryo. Development (2010) 1.08
XSmad2 directly activates the activin-inducible, dorsal mesoderm gene XFKH1 in Xenopus embryos. EMBO J (1997) 1.07
The role of a Williams-Beuren syndrome-associated helix-loop-helix domain-containing transcription factor in activin/nodal signaling. Genes Dev (2002) 1.07
Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins. Nucleic Acids Res (2001) 1.04
Opposing Nodal/Vg1 and BMP signals mediate axial patterning in embryos of the basal chordate amphioxus. Dev Biol (2010) 1.00
Positive and negative regulation of the transforming growth factor beta/activin target gene goosecoid by the TFII-I family of transcription factors. Mol Cell Biol (2005) 1.00
A gene regulatory network controlling hhex transcription in the anterior endoderm of the organizer. Dev Biol (2011) 0.97
Cloning of Mix-related homeodomain proteins using fast retrieval of gel shift activities, (FROGS), a technique for the isolation of DNA-binding proteins. Proc Natl Acad Sci U S A (1998) 0.93
Xvent-1 mediates BMP-4-induced suppression of the dorsal-lip-specific early response gene XFD-1' in Xenopus embryos. EMBO J (1998) 0.91
Siamois and Twin are redundant and essential in formation of the Spemann organizer. Dev Biol (2011) 0.90
Simple, fast, tissue-specific bacterial artificial chromosome transgenesis in Xenopus. Genesis (2011) 0.89
Oct25 represses transcription of nodal/activin target genes by interaction with signal transducers during Xenopus gastrulation. J Biol Chem (2008) 0.87
Bone morphogenetic protein-4-induced activation of Xretpos is mediated by Smads and Olf-1/EBF associated zinc finger (OAZ). Nucleic Acids Res (2002) 0.87
Embryonic lethality of fortilin-null mutant mice by BMP-pathway overactivation. Biochim Biophys Acta (2009) 0.86
Forming and interpreting gradients in the early Xenopus embryo. Cold Spring Harb Perspect Biol (2009) 0.86
Cloning and characterization of a novel MyoD enhancer-binding factor. Mech Dev (2007) 0.86
Transcriptional regulation of the Xlim-1 gene by activin is mediated by an element in intron I. Proc Natl Acad Sci U S A (1997) 0.86
Dynamic in vivo binding of transcription factors to cis-regulatory modules of cer and gsc in the stepwise formation of the Spemann-Mangold organizer. Development (2012) 0.84
The function of heterodimeric AP-1 comprised of c-Jun and c-Fos in activin mediated Spemann organizer gene expression. PLoS One (2011) 0.82
Anteroposterior neural tissue specification by activin-induced mesoderm. Proc Natl Acad Sci U S A (1997) 0.82
Antagonistic actions of activin A and BMP-2/4 control dorsal lip-specific activation of the early response gene XFD-1' in Xenopus laevis embryos. EMBO J (1996) 0.82
Transcriptional integration of Wnt and Nodal pathways in establishment of the Spemann organizer. Dev Biol (2012) 0.81
Developmental enhancers are marked independently of zygotic Nodal signals in Xenopus. Dev Biol (2014) 0.81
Transcriptional activation by the Mixl1 homeodomain protein in differentiating mouse embryonic stem cells. Stem Cells (2009) 0.81
Epithelial-Mesenchymal Transition (EMT) and Regulation of EMT Factors by Steroid Nuclear Receptors in Breast Cancer: A Review and in Silico Investigation. J Clin Med (2016) 0.81
XIC is required for Siamois activity and dorsoanterior development. Mol Cell Biol (2005) 0.80
The Spemann organizer-expressed zinc finger gene Xegr-1 responds to the MAP kinase/Ets-SRF signal transduction pathway. EMBO J (1998) 0.80
Specificity in transforming growth factor-beta signaling pathways. Am J Hum Genet (1999) 0.80
Jak1 kinase is required for cell migrations and anterior specification in zebrafish embryos. Proc Natl Acad Sci U S A (1997) 0.79
Enhancers. Wiley Interdiscip Rev Dev Biol (2012) 0.75
Identification of a novel negative regulator of activin/nodal signaling in mesendodermal formation of Xenopus embryos. J Biol Chem (2009) 0.75
Proposed supplements and amendments to 'A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects', the Rechtschaffen & Kales (1968) standard. Psychiatry Clin Neurosci (2001) 36.50
Genome cross-referencing and XREFdb: implications for the identification and analysis of genes mutated in human disease. Nat Genet (1997) 10.14
Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med (1995) 8.51
IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest (1999) 7.66
The genome of the natural genetic engineer Agrobacterium tumefaciens C58. Science (2001) 6.90
REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell (1995) 6.43
In vivo visualization of gene expression using magnetic resonance imaging. Nat Biotechnol (2000) 5.49
Radiation hybrid mapping: a somatic cell genetic method for constructing high-resolution maps of mammalian chromosomes. Science (1990) 5.35
Dishevelled controls cell polarity during Xenopus gastrulation. Nature (2000) 4.91
Clinical application of transvenous mitral commissurotomy by a new balloon catheter. J Thorac Cardiovasc Surg (1984) 4.45
HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene (2012) 4.30
Molecular evidence for the early evolution of photosynthesis. Science (2000) 4.17
A trial of shortened zidovudine regimens to prevent mother-to-child transmission of human immunodeficiency virus type 1. Perinatal HIV Prevention Trial (Thailand) Investigators. N Engl J Med (2000) 4.14
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med (1997) 4.10
Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A (2000) 4.08
Specific and nonspecific NK cell activation during virus infection. Nat Immunol (2001) 4.02
Real-time detection system for quantification of hepatitis C virus genome. Gastroenterology (1999) 3.83
Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA. Nat Med (2001) 3.81
Imaging membrane protein helical wheels. J Magn Reson (2000) 3.80
Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J Biol Chem (2000) 3.74
U4 and U6 RNAs coexist in a single small nuclear ribonucleoprotein particle. Nucleic Acids Res (1984) 3.61
"Fluorescent timer": protein that changes color with time. Science (2000) 3.42
Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan. The Liver Cancer Study Group of Japan. Hepatology (2000) 3.42
Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer. Nature (2000) 3.35
Structural basis of the redox switch in the OxyR transcription factor. Cell (2001) 3.32
Inhibition of human immunodeficiency virus gene amplification by heparin. J Clin Microbiol (1991) 3.32
Structure of the transmembrane region of the M2 protein H(+) channel. Protein Sci (2001) 3.31
Identification of sequences in a yeast histone promoter involved in periodic transcription. Cell (1986) 3.22
Weighted-ensemble Brownian dynamics simulations for protein association reactions. Biophys J (1996) 2.87
Control of doublesex alternative splicing by transformer and transformer-2 in Drosophila. Science (1991) 2.87
Predicting protein diffusion coefficients. Proc Natl Acad Sci U S A (1993) 2.87
Myeloscopy, with special reference to blood flow changes in the cauda equina during Lasègue's test. Int Orthop (1981) 2.82
Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes. Proc Natl Acad Sci U S A (1991) 2.81
Experimental investigation of geologically produced antineutrinos with KamLAND. Nature (2005) 2.75
Genomic organization of Borna disease virus. Proc Natl Acad Sci U S A (1994) 2.74
Monoclonal antibodies to the extracellular domain of prostate-specific membrane antigen also react with tumor vascular endothelium. Cancer Res (1997) 2.72
Programmable matter by folding. Proc Natl Acad Sci U S A (2010) 2.65
Requirement of CD9 on the egg plasma membrane for fertilization. Science (2000) 2.65
Efficient expression of the Saccharomyces cerevisiae PGK gene depends on an upstream activation sequence but does not require TATA sequences. Mol Cell Biol (1986) 2.63
Identification of c-myc responsive genes using rat cDNA microarray. Cancer Res (2000) 2.62
AN APPROXIMATE CELL MODEL FOR LIQUID HYDROGEN, I. Proc Natl Acad Sci U S A (1962) 2.59
Tumor angiogenesis in human lung adenocarcinoma. Cancer (1994) 2.59
Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis. EMBO J (2000) 2.55
Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production. FASEB J (2001) 2.55
Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature (1996) 2.54
Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. J Neurosci (2001) 2.54
A small nuclear ribonucleoprotein associates with the AAUAAA polyadenylation signal in vitro. Cell (1986) 2.51
Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae. Genetics (1999) 2.50
No-mortality liver resection for hepatocellular carcinoma in cirrhotic and noncirrhotic patients: is there a way? A prospective analysis of our approach. Arch Surg (1999) 2.47
Quantitation of hepatitis B virus genomic DNA by real-time detection PCR. J Clin Microbiol (1999) 2.46
Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J Biol Chem (1999) 2.44
Pharmacologic doses of granulocyte colony-stimulating factor affect cytokine production by lymphocytes in vitro and in vivo. Blood (2000) 2.42
Interferon-alpha-mediated down-regulation of angiogenesis-related genes and therapy of bladder cancer are dependent on optimization of biological dose and schedule. Clin Cancer Res (1999) 2.39
Constitutive and antibody-induced internalization of prostate-specific membrane antigen. Cancer Res (1998) 2.38
DNA looping generated by DNA bending protein IHF and the two domains of lambda integrase. Science (1989) 2.34
Ultrasonically guided percutaneous microwave coagulation therapy for small hepatocellular carcinoma. Cancer (1994) 2.34
Trends in diet, nutritional status, and diet-related noncommunicable diseases in China and India: the economic costs of the nutrition transition. Nutr Rev (2001) 2.33
Regulation of the mating pheromone and invasive growth responses in yeast by two MAP kinase substrates. Curr Biol (1997) 2.32
PRMT1 is the predominant type I protein arginine methyltransferase in mammalian cells. J Biol Chem (2000) 2.26
Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clin Cancer Res (1999) 2.26
Estrogen inhibits the vascular injury response in estrogen receptor alpha-deficient mice. Nat Med (1997) 2.24
Downregulation of caffeic acid 3-O-methyltransferase and caffeoyl CoA 3-O-methyltransferase in transgenic alfalfa. impacts on lignin structure and implications for the biosynthesis of G and S lignin. Plant Cell (2001) 2.23
Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase [corrected]. Nature (1994) 2.22
WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra. Nature (2000) 2.21
Induction of gamma interferon production in human alveolar macrophages by Mycobacterium tuberculosis. Infect Immun (1997) 2.16
Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity. EMBO J (2000) 2.15
Molecular cloning and nucleotide sequence of the cDNA for rat peroxisomal enoyl-CoA: hydratase-3-hydroxyacyl-CoA dehydrogenase bifunctional enzyme. J Biol Chem (1985) 2.12
Function of the c-Myc oncogenic transcription factor. Exp Cell Res (1999) 2.11
Role of human cytochrome P4502A6 in C-oxidation of nicotine. Drug Metab Dispos (1996) 2.11
Phage-conversion of toxigenicity in Clostridium botulinum types C and D. Jpn J Med Sci Biol (1971) 2.09
Intracellular BMP signaling regulation in vertebrates: pathway or network? Dev Biol (2001) 2.09
Hydrodynamic steering effects in protein association. Proc Natl Acad Sci U S A (1994) 2.09
Cycloplegic refractions in healthy children aged 1 through 48 months. Arch Ophthalmol (2001) 2.07
Over-expression of facilitative glucose transporter genes in human cancer. Biochem Biophys Res Commun (1990) 2.06
Structure and expression of a smooth muscle cell-specific gene, SM22 alpha. J Biol Chem (1995) 2.05
Ataxia with isolated vitamin E deficiency is caused by mutations in the alpha-tocopherol transfer protein. Nat Genet (1995) 2.03
Lysenin, a novel sphingomyelin-specific binding protein. J Biol Chem (1998) 2.02
Production of a DPP activity gradient in the early Drosophila embryo through the opposing actions of the SOG and TLD proteins. Cell (1997) 2.01
Cinnamon zeylanicum bark extract and powder mediated green synthesis of nano-crystalline silver particles and its bactericidal activity. Colloids Surf B Biointerfaces (2009) 2.01
Postmarketing surveillance of the safety profile of infliximab in 5000 Japanese patients with rheumatoid arthritis. Ann Rheum Dis (2007) 2.01
Autosomal dominant moyamoya disease maps to chromosome 17q25.3. Neurology (2008) 2.00
VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration. Cell Death Differ (2001) 2.00
Conversion of toxigenicity in Clostridium botulinum type C. Jpn J Microbiol (1970) 1.98
Generation of neutralizing human monoclonal antibodies against parvovirus B19 proteins. J Virol (1999) 1.97
Transport of solar wind into Earth's magnetosphere through rolled-up Kelvin-Helmholtz vortices. Nature (2004) 1.97
Did ossification of the posterior longitudinal ligament of the spine evolve in the modern period? A paleopathologic study of ancient human skeletons in Japan. J Rheumatol (2000) 1.96
Protein methylation. Science (1971) 1.95
Sequential association of nucleolar 7-2 RNA with two different autoantigens. J Biol Chem (1983) 1.95
Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism. Clin Pharmacol Ther (1999) 1.94
Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite. J Antibiot (Tokyo) (1994) 1.93
A unique vacuolar processing enzyme responsible for conversion of several proprotein precursors into the mature forms. FEBS Lett (1991) 1.92
Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads. Development (1997) 1.91
Organizer-specific homeobox genes in Xenopus laevis embryos. Science (1991) 1.90
Bacteriophages of Clostridium botulinum. J Virol (1968) 1.88
Monoclonal antibodies to mouse complement receptor type 1 (CR1). Their use in a distribution study showing that mouse erythrocytes and platelets are CR1-negative. J Immunol (1988) 1.86
The prevalence of and risk factors for erosive oesophagitis and non-erosive reflux disease: a nationwide multicentre prospective study in Korea. Aliment Pharmacol Ther (2007) 1.85
Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling. Nature (2001) 1.85
Molecular cloning of translocations involving chromosome 15 and the immunoglobulin C alpha gene from chromosome 12 in two murine plasmacytomas. Proc Natl Acad Sci U S A (1982) 1.84