Published in Am J Physiol on December 01, 1995
Arginine metabolism: nitric oxide and beyond. Biochem J (1998) 6.44
On the cycle of synthesis of arginine and nitric oxide in the liver. Dokl Biochem Biophys (2005) 0.75
On the cycle of synthesis of arginine and nitric oxide in macrophages. Dokl Biochem Biophys (2006) 0.75
Arginine metabolism: nitric oxide and beyond. Biochem J (1998) 6.44
Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand. Nat Med (2000) 4.40
Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin. J Exp Med (1992) 3.42
Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc Natl Acad Sci U S A (1993) 3.24
Inflammation, immunoregulation, and inducible nitric oxide synthase. J Leukoc Biol (1993) 3.07
Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms. J Biol Chem (1997) 2.89
Place of death: preferences among cancer patients and their carers. Soc Sci Med (2004) 2.87
Surgically induced leukocytic infiltrates within the rat intestinal muscularis mediate postoperative ileus. Gastroenterology (1999) 2.75
Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells. Am J Physiol Endocrinol Metab (2001) 2.50
Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells. J Exp Med (1989) 2.49
Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc Natl Acad Sci U S A (1993) 2.46
Multiple NF-kappaB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene. J Biol Chem (1998) 2.35
Nitrogen oxide levels in patients after trauma and during sepsis. Ann Surg (1991) 2.24
Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression. Cancer Res (1998) 2.15
Bistability in apoptosis: roles of bax, bcl-2, and mitochondrial permeability transition pores. Biophys J (2005) 2.09
The diversion of mentally ill persons from jails to community-based services: a profile of programs. Am J Public Health (1995) 2.08
Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide. J Immunol (1991) 2.07
New insights into the regulation of inducible nitric oxide synthesis. Am J Physiol (1994) 2.06
Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation. J Biol Chem (1992) 2.03
Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock. J Exp Med (1998) 1.96
Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation. Biochem Biophys Res Commun (1997) 1.87
Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Am J Transplant (2008) 1.86
Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer. J Clin Invest (1998) 1.85
Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression. J Biol Chem (1997) 1.83
Essential role for IL-6 in postresuscitation inflammation in hemorrhagic shock. Am J Physiol Cell Physiol (2001) 1.81
Attenuation of myocardial ischemia/reperfusion injury by superinduction of inducible nitric oxide synthase. Circulation (2000) 1.76
Alloantigen-induced activation of rat splenocytes is regulated by the oxidative metabolism of L-arginine. J Immunol (1990) 1.76
Multiple cytokines are required to induce hepatocyte nitric oxide production and inhibit total protein synthesis. Ann Surg (1990) 1.74
Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter. Proc Natl Acad Sci U S A (1996) 1.71
Role of inducible nitric oxide synthase in postoperative intestinal smooth muscle dysfunction in rodents. Gastroenterology (2000) 1.69
Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53. Proc Natl Acad Sci U S A (1996) 1.68
IL-4 and IL-13 upregulate arginase I expression by cAMP and JAK/STAT6 pathways in vascular smooth muscle cells. Am J Physiol Cell Physiol (2000) 1.67
Molecular biology of nitric oxide synthases. Cancer Metastasis Rev (1998) 1.66
Trauma center maturation: quantification of process and outcome. Ann Surg (1999) 1.64
Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene. J Biol Chem (1994) 1.64
Nitric oxide as a bifunctional regulator of apoptosis. Circ Res (1999) 1.63
Generation of a mouse model for arginase II deficiency by targeted disruption of the arginase II gene. Mol Cell Biol (2001) 1.63
Impaired wound healing and angiogenesis in eNOS-deficient mice. Am J Physiol (1999) 1.60
Elevated arginase I expression in rat aortic smooth muscle cells increases cell proliferation. Proc Natl Acad Sci U S A (2001) 1.58
Nitric oxide as a bioregulator of apoptosis. Biochem Biophys Res Commun (2001) 1.57
Regulation of the Wnt signaling pathway by disabled-2 (Dab2). EMBO J (2003) 1.57
Repair of elastase-digested elastic fibers in acellular matrices by replating with neonatal rat-lung lipid interstitial fibroblasts or other elastogenic cell types. Am J Respir Cell Mol Biol (1997) 1.56
Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer. Proc Natl Acad Sci U S A (1995) 1.56
p53 and vascular endothelial growth factor regulate tumor growth of NOS2-expressing human carcinoma cells. Nat Med (1998) 1.55
Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes. Am J Physiol (1991) 1.54
Hemorrhagic shock. Curr Probl Surg (1995) 1.53
Inducible nitric oxide synthase and inflammatory diseases. Mol Med (2000) 1.53
Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry (2001) 1.51
The significant unmet needs of cancer patients: probing psychosocial concerns. Support Care Cancer (2001) 1.51
Maltose absorption as an indicator of small-intestinal allograft rejection. J Surg Res (1984) 1.50
Cytokine-induced changes in chromatin structure and in vivo footprints in the inducible NOS promoter. Am J Physiol Lung Cell Mol Physiol (2001) 1.49
Nitric oxide and nitric oxide-generating compounds inhibit hepatocyte protein synthesis. FASEB J (1991) 1.48
The regulatory role of nitric oxide in apoptosis. Int Immunopharmacol (2001) 1.46
Evidence that rat Kupffer cells stimulate and inhibit hepatocyte protein synthesis in vitro by different mechanisms. Gastroenterology (1989) 1.45
Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-alpha-induced apoptosis and toxicity in the liver. J Med Chem (1997) 1.44
Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: oxyradical overload diseases. Proc Natl Acad Sci U S A (2000) 1.44
Prostanoid production via COX-2 as a causative mechanism of rodent postoperative ileus. Gastroenterology (2001) 1.44
Microvascular pedal bypass for salvage of the severely ischemic limb. Mayo Clin Proc (1991) 1.42
Nitric oxide prevents IL-1beta and IFN-gamma-inducing factor (IL-18) release from macrophages by inhibiting caspase-1 (IL-1beta-converting enzyme). J Immunol (1998) 1.42
The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes: evidence for up-regulated neuronal nitric oxide synthase. J Exp Med (1995) 1.41
Endogenous nitric oxide inhibits the synthesis of cyclooxygenase products and interleukin-6 by rat Kupffer cells. J Leukoc Biol (1993) 1.40
Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes. Gastroenterology (2001) 1.40
Efficacy of inhaled nitric oxide in oleic acid-induced acute lung injury. Crit Care Med (1997) 1.39
The therapeutic use of L-arginine to increase nitric oxide production. Nutrition (1992) 1.38
Efficient inhibition of intimal hyperplasia by adenovirus-mediated inducible nitric oxide synthase gene transfer to rats and pigs in vivo. J Am Coll Surg (1998) 1.38
A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis. J Biol Chem (1999) 1.38
Metallothionein protects against the cytotoxic and DNA-damaging effects of nitric oxide. Proc Natl Acad Sci U S A (1995) 1.37
Molecular mechanisms in the early phase of hemorrhagic shock. Langenbecks Arch Surg (2001) 1.37
High-mobility group box-1 in sterile inflammation. J Intern Med (2014) 1.37
Nitric oxide down-regulates hepatocyte-inducible nitric oxide synthase gene expression. Arch Surg (1997) 1.34
A central role for IL-1 beta in the in vitro and in vivo regulation of hepatic inducible nitric oxide synthase. IL-1 beta induces hepatic nitric oxide synthesis. J Immunol (1995) 1.33
LPS-induced muscularis macrophage nitric oxide suppresses rat jejunal circular muscle activity. Am J Physiol (1999) 1.32
Nitric oxide-mediated antiplasmodial activity in human and murine hepatocytes induced by gamma interferon and the parasite itself: enhancement by exogenous tetrahydrobiopterin. Infect Immun (1994) 1.32
Improved methods to measure end products of nitric oxide in biological fluids: nitrite, nitrate, and S-nitrosothiols. Nitric Oxide (1997) 1.31
Lipopolysaccharide activates the muscularis macrophage network and suppresses circular smooth muscle activity. Am J Physiol (1997) 1.29
Nitric Oxide. IV. Determinants of nitric oxide protection and toxicity in liver. Am J Physiol (1999) 1.29
Nitric oxide prevents tumor necrosis factor alpha-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylation of caspase-8. Hepatology (2000) 1.29
Inducible nitric oxide synthase in the liver: regulation and function. Biochemistry (Mosc) (1998) 1.28
The roles of iNOS in liver ischemia-reperfusion injury. Shock (2001) 1.28
Correlation between specific DNA-methylation products and mutation induction at the HGPRT locus in Chinese hamster ovary cells. Mutat Res (1983) 1.27
TLR4/MyD88-induced CD11b+Gr-1 int F4/80+ non-migratory myeloid cells suppress Th2 effector function in the lung. Mucosal Immunol (2010) 1.27
Cellular non-heme iron content is a determinant of nitric oxide-mediated apoptosis, necrosis, and caspase inhibition. J Biol Chem (2000) 1.25
Inhibition of nitric oxide synthesis during endotoxemia promotes intrahepatic thrombosis and an oxygen radical-mediated hepatic injury. J Leukoc Biol (1992) 1.25
Sphingosine 1-phosphate protects human umbilical vein endothelial cells from serum-deprived apoptosis by nitric oxide production. J Biol Chem (2000) 1.24
Mutually dependent localization of megalin and Dab2 in the renal proximal tubule. Am J Physiol Renal Physiol (2005) 1.23
Informal carers of cancer patients: what are their unmet psychosocial needs? Health Soc Care Community (2001) 1.23
Cholinergic-adrenergic interactions on intestinal ion transport. Am J Physiol (1978) 1.23
Signaling events triggered by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL): caspase-8 is required for TRAIL-induced apoptosis. Cancer Res (2001) 1.22
Inducible nitric oxide synthase is an endogenous neuroprotectant after traumatic brain injury in rats and mice. J Clin Invest (1999) 1.21
Adenovirus-mediated gene transfer of human inducible nitric oxide synthase in porcine vein grafts inhibits intimal hyperplasia. J Vasc Surg (2001) 1.20
Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes. J Biol Chem (1999) 1.20
Nitric oxide suppression of apoptosis occurs in association with an inhibition of Bcl-2 cleavage and cytochrome c release. J Biol Chem (1998) 1.20
Increased circulating nitrogen oxides after human tumor immunotherapy: correlation with toxic hemodynamic changes. J Natl Cancer Inst (1992) 1.20
Complement-mediated solubilization in patients with systemic lupus erythematosus, nephritis or vasculitis. Clin Exp Immunol (1981) 1.19
Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury. Am J Physiol (1998) 1.17
Regulation of mRNA levels for five urea cycle enzymes in rat liver by diet, cyclic AMP, and glucocorticoids. Arch Biochem Biophys (1987) 1.16
Neutrophil deactivation by influenza A viruses: mechanisms of protection after viral opsonization with collectins and hemagglutination-inhibiting antibodies. Blood (1996) 1.16