Published in Nat Med on March 01, 1996
Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner. J Biol Chem (1999) 3.76
Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity. J Exp Med (1998) 3.72
The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand. J Exp Med (1996) 3.56
Lymphopenia as a prognostic factor for overall survival in advanced carcinomas, sarcomas, and lymphomas. Cancer Res (2009) 2.51
A list of candidate cancer biomarkers for targeted proteomics. Biomark Insights (2007) 2.39
Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils. J Exp Med (1996) 2.39
Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome. Am J Pathol (2002) 2.30
Fas (CD95) induces alveolar epithelial cell apoptosis in vivo: implications for acute pulmonary inflammation. Am J Pathol (2001) 2.18
In vitro suppression of programmed cell death of B cells by tissue inhibitor of metalloproteinases-1. J Clin Invest (1998) 1.95
High Fas ligand expression on lymphocytes in lesions of ulcerative colitis. Gut (1998) 1.88
WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. Genes Dev (2002) 1.80
Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing. J Exp Med (1997) 1.80
Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L. J Cell Biol (1998) 1.75
Gene transfer of Fas ligand induces tumor regression in vivo. Proc Natl Acad Sci U S A (1997) 1.69
Expression of Fas ligand in liver metastases of human colonic adenocarcinomas. Proc Natl Acad Sci U S A (1997) 1.68
Necrotic death pathway in Fas receptor signaling. J Cell Biol (2000) 1.68
Shared reactivity of V{delta}2(neg) {gamma}{delta} T cells against cytomegalovirus-infected cells and tumor intestinal epithelial cells. J Exp Med (2005) 1.67
Interleukin-10 promotes activation-induced cell death of SLE lymphocytes mediated by Fas ligand. J Clin Invest (1997) 1.58
Opposing effects of transmembrane and soluble Fas ligand expression on inflammation and tumor cell survival. J Exp Med (2000) 1.56
Evasion of cytotoxic T lymphocyte (CTL) responses by nef-dependent induction of Fas ligand (CD95L) expression on simian immunodeficiency virus-infected cells. J Exp Med (1997) 1.52
Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice. J Exp Med (1997) 1.51
Involvement of TWEAK in interferon gamma-stimulated monocyte cytotoxicity. J Exp Med (2000) 1.40
TNFalpha regulation of Fas ligand expression on the vascular endothelium modulates leukocyte extravasation. Nat Med (1998) 1.34
Involvement of the CD95 (APO-1/Fas) receptor/ligand system in multiple sclerosis brain. J Exp Med (1996) 1.34
Primary and secondary autoimmune neutropenia. Arthritis Res Ther (2005) 1.25
Oxidized LDL activates fas-mediated endothelial cell apoptosis. J Clin Invest (1998) 1.23
Identification of patients at risk for early death after conventional chemotherapy in solid tumours and lymphomas. Br J Cancer (2001) 1.21
Toxic epidermal necrolysis and Stevens-Johnson syndrome are induced by soluble Fas ligand. Am J Pathol (2003) 1.14
Bcl-2-mediated drug resistance: inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas ligand transcription. J Exp Med (1999) 1.10
Development of inflammatory angiogenesis by local stimulation of Fas in vivo. J Exp Med (1997) 1.09
The expression of Fas Ligand by macrophages and its upregulation by human immunodeficiency virus infection. J Clin Invest (1998) 1.09
Targeting of the tumor necrosis factor receptor superfamily for cancer immunotherapy. ISRN Oncol (2013) 1.04
Serum levels of soluble Fas ligand in patients with silicosis. Clin Exp Immunol (1999) 1.01
The Fas counterattack: a molecular mechanism of tumor immune privilege. Mol Med (1997) 0.99
Effects of α-mangostin on apoptosis induction of human colon cancer. World J Gastroenterol (2011) 0.99
Expressions of Fas ligand and other apoptosis-related genes and their prognostic significance in epithelial ovarian neoplasms. Br J Cancer (2000) 0.96
Soluble Fas ligand released by colon adenocarcinoma cells induces host lymphocyte apoptosis: an active mode of immune evasion in colon cancer. Br J Cancer (2001) 0.95
Soluble Fas might serve as a diagnostic tool for gastric adenocarcinoma. BMC Cancer (2010) 0.93
Large granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets. Future Oncol (2012) 0.93
Programmed cell death (apoptosis) in cord blood lymphocytes. J Clin Immunol (1997) 0.92
Release of preformed Fas ligand in soluble form is the major factor for activation-induced death of Jurkat T cells. Immunology (1996) 0.91
Fas ligand is present in tumors of the Ewing's sarcoma family and is cleaved into a soluble form by a metalloproteinase. Am J Pathol (1998) 0.89
The role of CD95 and CD95 ligand in cancer. Cell Death Differ (2015) 0.88
Dual treatment with COX-2 inhibitor and sodium arsenite leads to induction of surface Fas Ligand expression and Fas-Ligand-mediated apoptosis in human melanoma cells. Exp Cell Res (2006) 0.87
Immature and neurally differentiated mouse embryonic stem cells do not express a functional Fas/Fas ligand system. Stem Cells (2007) 0.87
CD95 ligand expression as a mechanism of immune escape in breast cancer. Immunology (2000) 0.86
The strength of the Fas ligand signal determines whether hepatocytes act as type 1 or type 2 cells in murine livers. Hepatology (2009) 0.86
Increased spontaneous apoptosis in T lymphocytes in DiGeorge anomaly. Clin Exp Immunol (1998) 0.86
Amplification of Fas-mediated apoptosis in type II cells via microdomain recruitment. Mol Cell Biol (2005) 0.85
Herpesvirus saimiri transforms human T-cell clones to stable growth without inducing resistance to apoptosis. J Virol (1998) 0.85
Molecular steps of cell suicide: an insight into immune senescence. J Clin Immunol (2000) 0.85
Interferon-alpha (IFN-alpha) enhances cytotoxicity in healthy volunteers and chronic hepatitis C infection mainly by the perforin pathway. Clin Exp Immunol (1999) 0.85
Apoptosis and the airway epithelium. J Allergy (Cairo) (2011) 0.85
Regression of basal cell carcinoma by intralesional interferon-alpha treatment is mediated by CD95 (Apo-1/Fas)-CD95 ligand-induced suicide. J Clin Invest (1997) 0.84
Soluble Fas ligand and soluble Fas in ocular fluid of patients with uveitis. Br J Ophthalmol (2000) 0.83
EBV-negative Aggressive NK-cell Leukemia/Lymphoma: Clinical, Pathologic, and Genetic Features. Am J Surg Pathol (2017) 0.82
Fas and Fas ligand expression in cystic fibrosis airway epithelium. Thorax (1999) 0.81
Never say die: survival signaling in large granular lymphocyte leukemia. Clin Lymphoma Myeloma (2009) 0.81
Fas/Fas ligand (FasL)-deregulated apoptosis and IL-6 insensitivity in highly malignant myeloma cells. Clin Exp Immunol (1998) 0.80
Significance of Fas and Fas ligand in tuberculous lymphadenitis. Immunology (2005) 0.79
Increased serum concentrations of soluble CD95/Fas and caspase 1/ICE in patients with acute angina. Heart (2004) 0.77
Frequent deletion of Fas gene sequences encoding death and transmembrane domains in nasal natural killer/T-cell lymphoma. Am J Pathol (2002) 0.76
Cell death and the immune response: a lesson from the privileged. J Clin Immunol (1997) 0.76
Keynote lecture in the 13th Japanese Society of Immunotoxicology (JSIT 2006) : -Pathophysiological Development and Immunotoxicology: what we have found from research related to silica and silicate such as asbestos-. Environ Health Prev Med (2007) 0.76
Apoptosis induction in Jurkat cells and sCD95 levels in women's sera are related with the risk of developing cervical cancer. BMC Cancer (2008) 0.75
Dual Role of Fas/FasL-Mediated Signal in Peripheral Immune Tolerance. Front Immunol (2017) 0.75
Soluble Fas and Fas ligand in human tear fluid after photorefractive keratectomy. Br J Ophthalmol (1999) 0.75
Correlation of CD95 and soluble CD95 expression with acute rejection status of liver transplantation. World J Gastroenterol (2005) 0.75
Declining Physical Performance Associates with Serum FasL, miR-21, and miR-146a in Aging Sprinters. Biomed Res Int (2017) 0.75
Atorvastatin does not alter serum levels of sCD95 and sCD95L in multiple sclerosis. Clin Exp Immunol (2008) 0.75
STAT3 mutation impacts biological and clinical features of T-LGL leukemia. Oncotarget (2017) 0.75
Activation-induced apoptosis of peripheral lymphocytes treated with 7-hydroxystaurosporine, UCN-01. Invest New Drugs (1999) 0.75
CD95/Fas, Non-Apoptotic Signaling Pathways, and Kinases. Front Immunol (2017) 0.75
KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res (1999) 40.62
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79
Functional annotation of a full-length mouse cDNA collection. Nature (2001) 23.61
In vitro and in vivo activity of DL-8280, a new oxazine derivative. Antimicrob Agents Chemother (1982) 21.31
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature (1992) 12.92
pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res (1990) 12.75
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A (1998) 12.61
Transient left ventricular apical ballooning without coronary artery stenosis: a novel heart syndrome mimicking acute myocardial infarction. Angina Pectoris-Myocardial Infarction Investigations in Japan. J Am Coll Cardiol (2001) 12.56
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell (1991) 10.96
Lethal effect of the anti-Fas antibody in mice. Nature (1993) 9.20
Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell (1993) 9.06
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature (1998) 8.93
Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor. Nature (1986) 7.73
IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest (1999) 7.66
Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science (1994) 7.34
Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell (1994) 7.23
T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature (2000) 6.49
Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature (1998) 6.47
Delineating developmental and metabolic pathways in vivo by expression profiling using the RIKEN set of 18,816 full-length enriched mouse cDNA arrays. Proc Natl Acad Sci U S A (2001) 6.07
Typing hepatitis C virus by polymerase chain reaction with type-specific primers: application to clinical surveys and tracing infectious sources. J Gen Virol (1992) 5.93
Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol (1994) 5.93
Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science (1997) 5.80
ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol Cell Biol (2000) 5.73
Intrathecal methylprednisolone for intractable postherpetic neuralgia. N Engl J Med (2000) 5.64
Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol (2000) 5.22
Isolation and characterization of the human chromosomal gene for polypeptide chain elongation factor-1 alpha. J Biol Chem (1989) 5.09
Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. J Exp Med (2000) 5.02
Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature (1996) 4.92
The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha. Nature (1980) 4.82
Processing of tumour necrosis factor-alpha precursor by metalloproteinases. Nature (1994) 4.78
Fas and Fas ligand: lpr and gld mutations. Immunol Today (1995) 4.69
A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J Immunol (1993) 4.44
Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acad Sci U S A (1990) 4.40
Osteoblastic cells are involved in osteoclast formation. Endocrinology (1988) 4.37
Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur J Immunol (1988) 4.20
Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature (1995) 4.20
Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci U S A (1999) 4.19
Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3. Proc Natl Acad Sci U S A (1981) 4.12
In vitro activity of DR-3355, an optically active ofloxacin. Antimicrob Agents Chemother (1988) 4.03
Downregulation of Fas ligand by shedding. Nat Med (1998) 3.83
Isolation of human rotavirus in cell cultures: brief report. Arch Virol (1981) 3.83
A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. J Biol Chem (1993) 3.81
Synthesis in E. coli of a polypeptide with human leukocyte interferon activity. Nature (1980) 3.78
Purification and properties of DNA gyrase from a fluoroquinolone-resistant strain of Escherichia coli. Antimicrob Agents Chemother (1986) 3.69
The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. J Immunol (1992) 3.66
Biochemical properties of beta-lactamase produced by Flavobacterium odoratum. Antimicrob Agents Chemother (1985) 3.62
Chromospheric alfvenic waves strong enough to power the solar wind. Science (2007) 3.58
Human leukocyte and fibroblast interferons are structurally related. Nature (1980) 3.57
Defining the functions of trans-SNARE pairs. Nature (1998) 3.52
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44
A protective role of gamma/delta T cells in primary infection with Listeria monocytogenes in mice. J Exp Med (1992) 3.37
Cdc2 kinase directly phosphorylates the cis-Golgi matrix protein GM130 and is required for Golgi fragmentation in mitosis. Cell (1998) 3.36
Breast cancer after exposure to the atomic bombings of Hiroshima and Nagasaki. N Engl J Med (1968) 3.29
Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J Biol Chem (2001) 3.27
A role for hematopoietic stem cells in promoting angiogenesis. Cell (2000) 3.25
Calcium movements, distribution, and functions in smooth muscle. Pharmacol Rev (1997) 3.23
Dentatorubral and pallidoluysian atrophy expansion of an unstable CAG trinucleotide on chromosome 12p. Nat Genet (1994) 3.17
In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells. Blood (1992) 3.15
Purification and characterization of the Fas-ligand that induces apoptosis. J Exp Med (1994) 3.11
Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors. J Exp Med (1999) 3.07
Essential roles of the Fas ligand in the development of hepatitis. Nat Med (1997) 3.05
Some properties of subunits of DNA gyrase from Pseudomonas aeruginosa PAO1 and its nalidixic acid-resistant mutant. J Bacteriol (1987) 3.04
Elevated levels of oxidized low density lipoprotein show a positive relationship with the severity of acute coronary syndromes. Circulation (2001) 3.03
IL-10, a novel growth cofactor for mature and immature T cells. J Immunol (1990) 3.02
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death. Cell Death Differ (2005) 2.91
Expression of the functional soluble form of human fas ligand in activated lymphocytes. EMBO J (1995) 2.87
Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J Bone Miner Res (1996) 2.86
Biological activity of 25-hydroxyergocalciferol in rats. J Nutr (1970) 2.85
The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells. Endocrinology (1989) 2.83
The nucleotide sequence of the yeast PHO5 gene: a putative precursor of repressible acid phosphatase contains a signal peptide. Nucleic Acids Res (1983) 2.83
Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain. Proc Natl Acad Sci U S A (1986) 2.83
Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice. Proc Natl Acad Sci U S A (1993) 2.81
Polypeptide chain elongation factor 1 alpha (EF-1 alpha) from yeast: nucleotide sequence of one of the two genes for EF-1 alpha from Saccharomyces cerevisiae. EMBO J (1984) 2.77
Activity of beta-lactamase produced by Bacteroides fragilis against newly introduced cephalosporins. Antimicrob Agents Chemother (1980) 2.76
Comparison of inhibition of Escherichia coli topoisomerase IV by quinolones with DNA gyrase inhibition. Antimicrob Agents Chemother (1994) 2.76
Expression cloning of a receptor for murine granulocyte colony-stimulating factor. Cell (1990) 2.74
Human Fas ligand: gene structure, chromosomal location and species specificity. Int Immunol (1994) 2.74
Identification of various serovar strains of Mycobacterium avium complex by using DNA probes specific for Mycobacterium avium and Mycobacterium intracellulare. J Clin Microbiol (1990) 2.73
A simple fluorimetric microassay for adenine compounds in platelets and plasma and its application to studies on the platelet release reaction. Biochem J (1974) 2.73
Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors. J Exp Med (1988) 2.71
Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction. Biochemistry (1993) 2.70
Change in receptor-binding specificity of recent human influenza A viruses (H3N2): a single amino acid change in hemagglutinin altered its recognition of sialyloligosaccharides. Virology (2000) 2.70
Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res (1991) 2.70
Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1. Endocr Rev (2000) 2.68
Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver. Nat Genet (1995) 2.65
Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinology (1988) 2.60
Mapping the interaction between GRASP65 and GM130, components of a protein complex involved in the stacking of Golgi cisternae. EMBO J (1998) 2.57
Expression of the Fas ligand in cells of T cell lineage. J Immunol (1995) 2.54
Effect of N-formimidoyl thienamycin (MK0787) on beta-lactamases and activity against beta-lactamase-producing strains. Antimicrob Agents Chemother (1980) 2.53
Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis. Science (1997) 2.52
Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors. J Clin Invest (1993) 2.52