Purification and characterization of the Fas-ligand that induces apoptosis.

PubWeight™: 3.11‹?› | Rank: Top 1%

🔗 View Article (PMC 2191418)

Published in J Exp Med on March 01, 1994

Authors

T Suda1, S Nagata

Author Affiliations

1: Osaka Bioscience Institute, Japan.

Articles citing this

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med (1995) 10.91

Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus In vivo. J Exp Med (1998) 5.33

Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage. J Exp Med (1995) 3.20

Expression of the functional soluble form of human fas ligand in activated lymphocytes. EMBO J (1995) 2.87

Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis. J Clin Invest (1999) 2.43

Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils. J Exp Med (1996) 2.39

Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha. EMBO J (1996) 2.36

Protection against Mycobacterium tuberculosis infection by CD8+ T cells requires the production of gamma interferon. Infect Immun (1998) 2.34

Multiple myeloma: increasing evidence for a multistep transformation process. Blood (1998) 2.29

Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death. Mol Cell Biol (1999) 2.25

Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2. Genes Dev (2004) 2.22

Perforin, a cytotoxic molecule which mediates cell necrosis, is not required for the early control of mycobacterial infection in mice. Infect Immun (1997) 2.19

Fas (CD95) induces alveolar epithelial cell apoptosis in vivo: implications for acute pulmonary inflammation. Am J Pathol (2001) 2.18

Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes. J Virol (1996) 2.07

Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis. J Clin Invest (1998) 1.86

Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody. J Exp Med (1995) 1.57

Differential induction of apoptosis by Fas-Fas ligand interactions in human monocytes and macrophages. J Exp Med (1997) 1.56

Multiple sclerosis: Fas signaling in oligodendrocyte cell death. J Exp Med (1996) 1.53

Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas ligand interactions. J Exp Med (1998) 1.48

Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway. Proc Natl Acad Sci U S A (1997) 1.47

Coxsackievirus B3-induced myocarditis: perforin exacerbates disease, but plays no detectable role in virus clearance. Am J Pathol (1998) 1.46

Anti-Fas/APO-1 antibody-mediated apoptosis of cultured human glioma cells. Induction and modulation of sensitivity by cytokines. J Clin Invest (1994) 1.45

Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain? J Clin Invest (1997) 1.43

TNFalpha regulation of Fas ligand expression on the vascular endothelium modulates leukocyte extravasation. Nat Med (1998) 1.34

The emergence of Beijing family genotypes of Mycobacterium tuberculosis and low-level protection by bacille Calmette-Guérin (BCG) vaccines: is there a link? Clin Exp Immunol (2006) 1.33

Constitutive activation of the Fas ligand gene in mouse lymphoproliferative disorders. EMBO J (1995) 1.33

Differential response of human lung epithelial cells to fas-induced apoptosis. Am J Pathol (2004) 1.27

A new triggering receptor expressed on myeloid cells (Trem) family member, Trem-like 4, binds to dead cells and is a DNAX activation protein 12-linked marker for subsets of mouse macrophages and dendritic cells. J Immunol (2009) 1.26

Peripheral T cells undergoing superantigen-induced apoptosis in vivo express B220 and upregulate Fas and Fas ligand. J Exp Med (1996) 1.25

B cells directly tolerize CD8(+) T cells. J Exp Med (1998) 1.20

The ability of BHRF1 to inhibit apoptosis is dependent on stimulus and cell type. J Virol (1997) 1.19

Interleukin 1 beta-converting enzyme related proteases/caspases are involved in TRAIL-induced apoptosis of myeloma and leukemia cells. J Cell Biol (1997) 1.18

IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation. J Neuroinflammation (2011) 1.17

T cell receptor (TCR)-induced death of immature CD4+CD8+ thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation: implications for negative selection in the thymus. J Exp Med (1997) 1.16

The 55-kD tumor necrosis factor receptor and CD95 independently signal murine hepatocyte apoptosis and subsequent liver failure. Mol Med (1996) 1.16

Receptor-induced death in human natural killer cells: involvement of CD16. J Exp Med (1995) 1.14

The relative role of lymphocyte granule exocytosis versus death receptor-mediated cytotoxicity in viral pathophysiology. J Virol (1998) 1.13

Role of the CD47-SHPS-1 system in regulation of cell migration. EMBO J (2003) 1.10

The expression of Fas Ligand by macrophages and its upregulation by human immunodeficiency virus infection. J Clin Invest (1998) 1.09

Fas antigen expression and its relationship with apoptosis in human hepatocellular carcinoma and noncancerous tissues. Am J Pathol (1996) 1.08

Fas ligand is not only expressed in immune privileged human organs but is also coexpressed with Fas in various epithelial tissues. Mol Pathol (1997) 1.04

Human herpesvirus 6 open reading frame U83 encodes a functional chemokine. J Virol (1999) 1.04

Death receptor-ligand systems in cancer, cell death, and inflammation. Cold Spring Harb Perspect Biol (2013) 1.03

Factors that influence activated CD8+ T-cell apoptosis in patients with acute herpesvirus infections: loss of costimulatory molecules CD28, CD5 and CD6 but relative maintenance of Bax and Bcl-X expression. Immunology (1996) 1.02

High-dose factor VIII inhibits factor VIII-specific memory B cells in hemophilia A with factor VIII inhibitors. Blood (2005) 1.02

The apoptosis of neutrophils is accelerated in respiratory syncytial virus (RSV)-induced bronchiolitis. Clin Exp Immunol (1998) 1.02

Differential expression of human Fas mRNA species upon peripheral blood mononuclear cell activation. Biochem J (1995) 1.02

Apoptosis in the heart: when and why? Mol Cell Biochem (1997) 1.00

Alterations of Fas (Apo-1/CD95) gene in cutaneous malignant melanoma. Am J Pathol (1999) 0.98

Expression of FAP-1 by human colon adenocarcinoma: implication for resistance against Fas-mediated apoptosis in cancer. Br J Cancer (2004) 0.95

The status of Fas and Fas ligand expression can predict recurrence of hepatocellular carcinoma. Br J Cancer (2000) 0.95

Fas/FasL interaction of nucleus pulposus and cancer cells with the activation of caspases. Int Orthop (2007) 0.94

Exosomes: novel organelles implicated in immunomodulation and apoptosis. Yale J Biol Med (2002) 0.92

Differential effects of staphylococcal toxic shock syndrome toxin-1 on B cell apoptosis. Proc Natl Acad Sci U S A (1996) 0.91

Release of preformed Fas ligand in soluble form is the major factor for activation-induced death of Jurkat T cells. Immunology (1996) 0.91

Characterization of the interleukin-1beta-converting enzyme/ced-3-family protease, caspase-3/CPP32, in Hodgkin's disease: lack of caspase-3 expression in nodular lymphocyte predominance Hodgkin's disease. Am J Pathol (1999) 0.90

Apoptosis in labial salivary glands from Sjögren's syndrome (SS) patients: comparison with human T lymphotropic virus-I (HTLV-I)-seronegative and -seropositive SS patients. Clin Exp Immunol (1998) 0.89

T helper cell activation and human retroviral pathogenesis. Microbiol Rev (1996) 0.88

Fas induces apoptosis in human coronary artery endothelial cells in vitro. BMC Cell Biol (2004) 0.87

Antioxidant c-FLIP inhibits Fas ligand-induced NF-kappaB activation in a phosphatidylinositol 3-kinase/Akt-dependent manner. J Immunol (2011) 0.87

Prognostic significance of RCAS1 expression in relation to the infiltration of dendritic cells and lymphocytes in patients with esophageal carcinoma. Dig Dis Sci (2007) 0.86

Increased spontaneous apoptosis in T lymphocytes in DiGeorge anomaly. Clin Exp Immunol (1998) 0.86

Involvement of CD27/CD70 interactions in antigen-specific cytotoxic T-lymphocyte (CTL) activity by perforin-mediated cytotoxicity. Clin Exp Immunol (2002) 0.85

A biochemical mechanism for resistance of intervertebral discs to metastatic cancer: Fas ligand produced by disc cells induces apoptotic cell death of cancer cells. Eur Spine J (2007) 0.83

Silencing Fas-associated phosphatase 1 expression enhances efficiency of chemotherapy for colon carcinoma with oxaliplatin. World J Gastroenterol (2010) 0.83

Studies of the mechanism of cytolysis by tumour-infiltrating lymphocytes. Clin Exp Immunol (1999) 0.82

Tolerance induction ameliorates allograft vasculopathy in rat aortic transplants. Influence of Fas-mediated apoptosis. J Clin Invest (1998) 0.81

Cross-linking of Fas by antibodies to a peculiar domain of gp120 V3 loop can enhance T cell apoptosis in HIV-1-infected patients. J Exp Med (1996) 0.81

Fas and Fas ligand expression in cystic fibrosis airway epithelium. Thorax (1999) 0.81

Systemic FasL neutralization increases eosinophilic inflammation in a mouse model of asthma. Allergy (2011) 0.80

CD95 (Fas) may control the expansion of activated T cells after elimination of bacteria in murine listeriosis. Infect Immun (1997) 0.80

Participation of the Fas and Fas ligand systems in apoptosis during atrophy of the rat submandibular glands. Int J Exp Pathol (2007) 0.80

Soluble Fas and Fas ligand in HIV/HCV coinfected patients and impact of HCV therapy. Eur J Clin Microbiol Infect Dis (2011) 0.79

Cartilage-hair hypoplasia syndrome: increased apoptosis of T lymphocytes is associated with altered expression of Fas (CD95), FasL (CD95L), IAP, Bax, and Bcl2. J Clin Immunol (1999) 0.79

Anti-Fas gene therapy prevents doxorubicin-induced acute cardiotoxicity through mechanisms independent of apoptosis. Am J Pathol (2009) 0.79

Inhibition of intracellular peroxides and apoptosis of lymphocytes in lupus-prone B/W mice by dietary n-6 and n-3 lipids with calorie restriction. J Clin Immunol (2002) 0.78

Linomide prevents the lethal effect of anti-Fas antibody and reduces Fas-mediated ceramide production in mouse hepatocytes. J Clin Invest (1996) 0.77

Protective potential of SCF for mice preimplantation embryos cultured in vitro in suboptimal conditions. J Assist Reprod Genet (2008) 0.77

Marked mitigation of transplant vascular sclerosis in FasLgld (CD95L) mutant recipients. The role of alloantibodies in the development of chronic rejection. Transplantation (1999) 0.77

T cells of lupus and molecular targets for immunotherapy. J Clin Immunol (1997) 0.76

Induction of antiviral antibodies by DNA immunization requires neither perforin-mediated nor CD8(+)-T-cell-mediated lysis of antigen-expressing cells. J Virol (1999) 0.76

Long noncoding RNA Saf and splicing factor 45 increase soluble Fas and resistance to apoptosis. Oncotarget (2016) 0.76

Apoptosis of CD4+ T cells occurs in experimental autoimmune anterior uveitis (EAAU). Clin Exp Immunol (1999) 0.76

Lack of activation induced cell death in human T blasts despite CD95L up-regulation: protection from apoptosis by MEK signalling. Immunology (1999) 0.76

Anaplastic and atypical meningiomas express high levels of Fas and undergo apoptosis in response to Fas ligation. Am J Pathol (2001) 0.75

Fas-670A>G polymorphism is not associated with an increased risk of acute myeloid leukemia development. Biomed Rep (2015) 0.75

FAS and FASL gene polymorphisms are not associated with hepatitis B virus infection based on a case-control study in a Brazilian population. Dis Markers (2013) 0.75

A Fas(hi) Lymphoproliferative Phenotype Reveals Non-Apoptotic Fas Signaling in HTLV-1-Associated Neuroinflammation. Front Immunol (2017) 0.75

Use of Lentiviral Particles As a Cell Membrane-Based mFasL Delivery System for In Vivo Treatment of Inflammatory Arthritis. Front Immunol (2017) 0.75

Articles cited by this

Cell death: the significance of apoptosis. Int Rev Cytol (1980) 24.88

Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation. Proc Natl Acad Sci U S A (1984) 17.51

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature (1992) 12.92

pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res (1990) 12.75

CD44 is the principal cell surface receptor for hyaluronate. Cell (1990) 11.01

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell (1991) 10.96

Lethal effect of the anti-Fas antibody in mice. Nature (1993) 9.20

Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell (1993) 9.06

Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science (1989) 7.76

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor. J Exp Med (1989) 7.07

Human tumor necrosis factor. Production, purification, and characterization. J Biol Chem (1985) 6.28

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF. Cell (1988) 5.42

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity. J Exp Med (1993) 4.53

Apoptosis and programmed cell death in immunity. Annu Rev Immunol (1992) 4.47

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. J Immunol (1992) 3.66

Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice. Science (1990) 3.26

Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide. Proc Natl Acad Sci U S A (1993) 2.79

Expression cloning of a receptor for murine granulocyte colony-stimulating factor. Cell (1990) 2.74

DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement. Cell Immunol (1992) 2.37

Anti-Fas monoclonal antibody is cytocidal to human immunodeficiency virus-infected cells without augmenting viral replication. Proc Natl Acad Sci U S A (1990) 1.68

Recombinant 55-kDa tumor necrosis factor (TNF) receptor. Stoichiometry of binding to TNF alpha and TNF beta and inhibition of TNF activity. J Biol Chem (1991) 1.57

Identification of a source of biologically active CD40 ligand. Eur J Immunol (1992) 1.30

Cell-mediated cytotoxicity: contact and secreted factors. Curr Opin Immunol (1993) 1.27

Immunodetection of biotinylated lymphocyte-surface proteins by enhanced chemiluminescence: a nonradioactive method for cell-surface protein analysis. Anal Biochem (1992) 1.25

Recombinant human-mouse chimeric monoclonal antibody specific for common acute lymphocytic leukemia antigen. Cancer Res (1987) 1.11

Lymphotoxin is expressed as a heteromeric complex with a distinct 33-kDa glycoprotein on the surface of an activated human T cell hybridoma. J Biol Chem (1992) 1.10

Articles by these authors

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature (1992) 12.92

pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res (1990) 12.75

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell (1991) 10.96

Lethal effect of the anti-Fas antibody in mice. Nature (1993) 9.20

Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell (1993) 9.06

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature (1998) 8.93

Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor. Nature (1986) 7.73

Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science (1994) 7.34

Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell (1994) 7.23

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature (1998) 6.47

Isolation and characterization of the human chromosomal gene for polypeptide chain elongation factor-1 alpha. J Biol Chem (1989) 5.09

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature (1996) 4.92

The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha. Nature (1980) 4.82

Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature (1995) 4.20

Downregulation of Fas ligand by shedding. Nat Med (1998) 3.83

A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. J Biol Chem (1993) 3.81

Synthesis in E. coli of a polypeptide with human leukocyte interferon activity. Nature (1980) 3.78

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. J Immunol (1992) 3.66

Chromospheric alfvenic waves strong enough to power the solar wind. Science (2007) 3.58

Human leukocyte and fibroblast interferons are structurally related. Nature (1980) 3.57

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44

Essential roles of the Fas ligand in the development of hepatitis. Nat Med (1997) 3.05

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death. Cell Death Differ (2005) 2.91

Expression of the functional soluble form of human fas ligand in activated lymphocytes. EMBO J (1995) 2.87

Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain. Proc Natl Acad Sci U S A (1986) 2.83

Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice. Proc Natl Acad Sci U S A (1993) 2.81

Polypeptide chain elongation factor 1 alpha (EF-1 alpha) from yeast: nucleotide sequence of one of the two genes for EF-1 alpha from Saccharomyces cerevisiae. EMBO J (1984) 2.77

Expression cloning of a receptor for murine granulocyte colony-stimulating factor. Cell (1990) 2.74

Human Fas ligand: gene structure, chromosomal location and species specificity. Int Immunol (1994) 2.74

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver. Nat Genet (1995) 2.65

Expression of the Fas ligand in cells of T cell lineage. J Immunol (1995) 2.54

Fas ligand in human serum. Nat Med (1996) 2.53

Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis. Science (1997) 2.52

The nucleotide sequence of a cloned human leukocyte interferon cDNA. Gene (1980) 2.51

Effect of bcl-2 on Fas antigen-mediated cell death. J Immunol (1993) 2.50

Caspase 1-independent IL-1beta release and inflammation induced by the apoptosis inducer Fas ligand. Nat Med (1998) 2.47

Rational design of potent antagonists to the human growth hormone receptor. Science (1992) 2.45

Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis. J Clin Invest (1999) 2.43

At least three human type alpha interferons: structure of alpha 2. Science (1980) 2.38

Chromosomal gene structure of human myeloperoxidase and regulation of its expression by granulocyte colony-stimulating factor. J Biol Chem (1987) 2.36

Molecular cloning and sequence determination of the nuclear gene coding for mitochondrial elongation factor Tu of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1983) 2.33

Two species of human CRK cDNA encode proteins with distinct biological activities. Mol Cell Biol (1992) 2.30

LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response. J Immunol (2000) 2.27

Total en bloc spondylectomy for solitary spinal metastases. Int Orthop (1994) 2.22

Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nat Med (2000) 2.18

Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver. Science (2001) 2.17

mRNA capping enzyme. Isolation and characterization of the gene encoding mRNA guanylytransferase subunit from Saccharomyces cerevisiae. J Biol Chem (1992) 2.12

The chromosomal gene structure and two mRNAs for human granulocyte colony-stimulating factor. EMBO J (1986) 1.98

Three different mRNAs encoding human granulocyte colony-stimulating factor receptor. Proc Natl Acad Sci U S A (1990) 1.97

Isolation and characterization of the cDNA for murine granulocyte colony-stimulating factor. Proc Natl Acad Sci U S A (1986) 1.94

Molecular characterization of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1alpha,25-dihydroxyvitamin D(3). J Biol Chem (1999) 1.93

Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide. Neuron (1992) 1.90

Target cell specificity of two species of human interferon-alpha produced in Escherichia coli and of hybrid molecules derived from them. Proc Natl Acad Sci U S A (1981) 1.89

High Fas ligand expression on lymphocytes in lesions of ulcerative colitis. Gut (1998) 1.88

Caspase-independent cell killing by Fas-associated protein with death domain. J Cell Biol (1998) 1.87

Functional domains of the granulocyte colony-stimulating factor receptor. EMBO J (1991) 1.82

Localization of Evi-2 to chromosome 11: linkage to other proto-oncogene and growth factor loci using interspecific backcross mice. Oncogene Res (1988) 1.82

Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing. J Exp Med (1997) 1.80

Necrotic death pathway in Fas receptor signaling. J Cell Biol (2000) 1.68

Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay. Carcinogenesis (1996) 1.65

Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts. Proc Natl Acad Sci U S A (2000) 1.65

A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human. Genetics (1989) 1.65

TCR/CD3 coupling to Fas-based cytotoxicity. J Exp Med (1995) 1.64

Purification and characterization of the receptor for murine granulocyte colony-stimulating factor. J Biol Chem (1990) 1.60

Molecular cloning and expression of a cDNA encoding the secretin receptor. EMBO J (1991) 1.60

The estimated incidence of cystic fibrosis in Japan. J Pediatr Gastroenterol Nutr (1997) 1.58

Smoke-like echo in the left atrial cavity in mitral valve disease: its features and significance. J Am Coll Cardiol (1985) 1.58

Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody. J Exp Med (1995) 1.57

Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death. J Exp Med (1996) 1.56

The chromosomal gene structure for murine granulocyte colony-stimulating factor. Eur J Biochem (1987) 1.55

Evasion of cytotoxic T lymphocyte (CTL) responses by nef-dependent induction of Fas ligand (CD95L) expression on simian immunodeficiency virus-infected cells. J Exp Med (1997) 1.52

Relationships between perceived workload, stress and oxidative DNA damage. Int Arch Occup Environ Health (2001) 1.51

Growth and differentiation signals mediated by different regions in the cytoplasmic domain of granulocyte colony-stimulating factor receptor. Cell (1993) 1.51

Dialysis patients' preferences regarding cardiopulmonary resuscitation and withdrawal of dialysis in Japan. Am J Kidney Dis (2001) 1.51

Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice. J Exp Med (1997) 1.51

Improvement in pulmonary function in mitral stenosis after percutaneous transvenous mitral commissurotomy. Chest (1990) 1.48

Application of Doppler color flow imaging to determine valve area in mitral stenosis. J Am Coll Cardiol (1991) 1.47

Growth of Japanese breastfed infants compared to national references and World Health Organization growth standards. Acta Paediatr (2013) 1.47

A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection. J Exp Med (1996) 1.46

Molecular analysis of the human interferon-alpha gene family. Gene (1981) 1.44

Fas-mediated apoptosis in primary cultured mouse hepatocytes. Exp Cell Res (1994) 1.41

Enhanced and accelerated lymphoproliferation in Fas-null mice. Proc Natl Acad Sci U S A (1996) 1.40

Involvement of Fas ligand and Fas-mediated pathway in the cytotoxicity of human natural killer cells. J Immunol (1996) 1.39

Reoperation for moyamoya disease refractory to encephalo-duro-arterio-synangiosis. Acta Neurochir (Wien) (1990) 1.39

Lack of chronic immune activation in HIV-infected chimpanzees correlates with the resistance of T cells to Fas/Apo-1 (CD95)-induced apoptosis and preservation of a T helper 1 phenotype. J Immunol (1997) 1.38

Abrogation of Fas-induced fulminant hepatic failure in mice by hepatocyte growth factor. Biochem Biophys Res Commun (1998) 1.37

An auxiliary mode of apoptotic DNA fragmentation provided by phagocytes. Genes Dev (2000) 1.36

Fas-mediated apoptosis of CD4+ and CD8+ T cells from human immunodeficiency virus-infected persons: differential in vitro preventive effect of cytokines and protease antagonists. Blood (1996) 1.35

ERM (ezrin/radixin/moesin)-based molecular mechanism of microvillar breakdown at an early stage of apoptosis. J Cell Biol (1997) 1.35

Intracardiac flow pattern in mitral regurgitation studied with combined use of the ultrasonic pulsed doppler technique and cross-sectional echocardiography. Am J Cardiol (1980) 1.33

Molecular cloning and characterization of cDNA for human myeloperoxidase. J Biol Chem (1987) 1.33

Structure and expression of human IFN-alpha genes. Philos Trans R Soc Lond B Biol Sci (1982) 1.33

Constitutive activation of the Fas ligand gene in mouse lymphoproliferative disorders. EMBO J (1995) 1.33

Apoptosis: cell death defined by caspase activation. Cell Death Differ (1999) 1.32

Localisation and direction of mitral regurgitant flow in mitral orifice studied with combined use of ultrasonic pulsed Doppler technique and two dimensional echocardiography. Br Heart J (1982) 1.31

Regulatory elements responsible for inducible expression of the granulocyte colony-stimulating factor gene in macrophages. Mol Cell Biol (1990) 1.29

Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6. EMBO J (1997) 1.29

A new bioassay for human granulocyte colony-stimulating factor (hG-CSF) using murine myeloblastic NFS-60 cells as targets and estimation of its levels in sera from normal healthy persons and patients with infectious and hematological disorders. Exp Hematol (1989) 1.29

Overexpression of Fas antigen on T cells in advanced HIV-1 infection: differential ligation constantly induces apoptosis. AIDS (1996) 1.28