Published in Cell on April 01, 1977
Fluorescent labeling of nascent RNA reveals transcription by RNA polymerase II in domains scattered throughout the nucleus. J Cell Biol (1993) 4.84
In vivo transcriptional pausing and cap formation on three Drosophila heat shock genes. Proc Natl Acad Sci U S A (1993) 4.82
Transcriptional activation and subsequent control of the human heat shock gene during adenovirus infection. Mol Cell Biol (1983) 4.15
Postinitiation transcriptional control in Drosophila melanogaster. Mol Cell Biol (1990) 3.83
A discrete element 3' of human immunodeficiency virus 1 (HIV-1) and HIV-2 mRNA initiation sites mediates transcriptional activation by an HIV trans activator. Mol Cell Biol (1988) 3.74
Intragenic pausing and anti-sense transcription within the murine c-myc locus. EMBO J (1986) 3.69
Effect of adenovirus on metabolism of specific host mRNAs: transport control and specific translational discrimination. Mol Cell Biol (1983) 3.25
Alpha-thalassaemia caused by a poly(A) site mutation reveals that transcriptional termination is linked to 3' end processing in the human alpha 2 globin gene. EMBO J (1986) 3.25
Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport. Mol Cell Biol (1985) 3.04
Cell cycle regulation of mouse H3 histone mRNA metabolism. Mol Cell Biol (1984) 2.97
Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3. EMBO J (1990) 2.75
Loop structures in hybrids of early RNA and the separated strands of adenovirus DNA. Proc Natl Acad Sci U S A (1977) 2.60
Discontinuous synthesis of mRNA in trypanosomes. EMBO J (1984) 2.57
Molecular cloning and complete primary sequence of human erythrocyte porphobilinogen deaminase. Nucleic Acids Res (1986) 2.56
Post-transcriptional regulation contributes to Drosophila clock gene mRNA cycling. EMBO J (1997) 2.38
A pause site for RNA polymerase II is associated with termination of transcription. EMBO J (1991) 2.23
The chicken lysozyme 5' matrix attachment region increases transcription from a heterologous promoter in heterologous cells and dampens position effects on the expression of transfected genes. Mol Cell Biol (1990) 1.98
Multiple discrete sites for premature RNA chain termination late in adenovirus-2 infection: enhancement by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole. Proc Natl Acad Sci U S A (1979) 1.92
One hundred years of pleiotropy: a retrospective. Genetics (2010) 1.91
Transcriptional termination between the closely linked human complement genes C2 and factor B: common termination factor for C2 and c-myc? EMBO J (1991) 1.88
Transcriptional regulation of the mu-delta heavy chain locus in normal murine B lymphocytes. J Exp Med (1984) 1.88
Cellular promoters incorporated into the adenovirus genome: cell specificity of albumin and immunoglobulin expression. Mol Cell Biol (1986) 1.73
Early termination of heterogeneous nuclear RNA transcripts in mammalian cells: accentuation by 5,6-dichloro 1-beta-D-ribofuranosylbenzimidazole. Proc Natl Acad Sci U S A (1979) 1.66
Immunoglobulin light chain mRNA is processed from large nuclear RNA. Proc Natl Acad Sci U S A (1978) 1.63
The association of transcribed genes with the nuclear matrix of Drosophila cells during heat shock. Nucleic Acids Res (1985) 1.57
Encapsidation of viral DNA requires the adenovirus L1 52/55-kilodalton protein. J Virol (1998) 1.54
New chimeric splice junction in adenovirus type 2-simian virus 40 hybrid viral mRNA. J Virol (1980) 1.53
Retracted A precise termination site in the mouse beta major-globin transcription unit. Proc Natl Acad Sci U S A (1983) 1.51
Cycloheximide stimulates early adenovirus transcription if early gene expression is allowed before treatment. J Virol (1983) 1.43
A human IFN-beta 1 gene deleted of promoter sequences upstream from the TATA box is controlled post-transcriptionally by dsRNA. Nucleic Acids Res (1984) 1.43
Adenovirus type 2 late mRNA's: structural evidence for 3'-coterminal species. J Virol (1978) 1.37
Rapid enhancement of beta 2-interferon/B-cell differentiation factor BSF-2 gene expression in human fibroblasts by diacylglycerols and the calcium ionophore A23187. Proc Natl Acad Sci U S A (1987) 1.36
Transcription boundaries of U1 small nuclear RNA. Mol Cell Biol (1985) 1.36
Transcription of the human U2 snRNA genes continues beyond the 3' box in vivo. EMBO J (1999) 1.32
Transcription of adenovirus RNA in permissive and nonpermissive infections. J Virol (1978) 1.26
Evidence from UV transcription mapping in HeLa cells that heterogeneous nuclear RNA is the messenger RNA precursor. Proc Natl Acad Sci U S A (1977) 1.24
Maturation of polycistronic pre-mRNA in Trypanosoma brucei: analysis of trans splicing and poly(A) addition at nascent RNA transcripts from the hsp70 locus. Mol Cell Biol (1991) 1.23
Transcription unit mapping in adenovirus: regions of termination. J Virol (1986) 1.18
In vivo identification of sequence elements required for normal function of the adenovirus major late transcriptional control region. Nucleic Acids Res (1986) 1.17
Tissue-specific expression of the mouse dioxin-inducible P(1)450 and P(3)450 genes: differential transcriptional activation and mRNA stability in liver and extrahepatic tissues. Mol Cell Biol (1986) 1.17
Reflections on the history of pre-mRNA processing and highlights of current knowledge: a unified picture. RNA (2013) 1.14
The cellular transcription factor E2f requires viral E1A and E4 gene products for increased DNA-binding activity and functions to stimulate adenovirus E2A gene expression. J Virol (1989) 1.13
Transcriptional and post-transcriptional regulation of globin gene accumulation in murine erythroleukemia cells. Mol Cell Biol (1983) 1.13
Synthesis and processing of adenoviral RNA in isolated nuclei. J Virol (1979) 1.13
Regulation of phosphoenolpyruvate carboxykinase gene transcription by insulin and cAMP: reciprocal actions on initiation and elongation. Proc Natl Acad Sci U S A (1988) 1.07
Transcription and polyadenylation in a short human intergenic region. Nucleic Acids Res (1997) 1.06
Tissue-specific DNase I hypersensitive sites in a foreign globin gene in transgenic mice. Nucleic Acids Res (1986) 1.01
Mapping of RNA polymerase on mammalian genes in cells and nuclei. Mol Biol Cell (1992) 1.00
Mutations in the E1a gene of adenovirus type 5 alter the tumorigenic properties of transformed cloned rat embryo fibroblast cells. Proc Natl Acad Sci U S A (1986) 0.94
Control of globin gene transcription by erythropoietin in erythroblasts from friend virus-infected mice. Mol Cell Biol (1985) 0.94
Active beta-globin gene transcription occurs in methylated, DNase I-resistant chromatin of nonerythroid chicken cells. Mol Cell Biol (1990) 0.90
The state of cellular differentiation determines the activity of the adenovirus E1A enhancer element: evidence for negative regulation of enhancer function. J Virol (1990) 0.89
Comparison of late mRNA splicing among class B and class C adenoviruses. J Virol (1979) 0.84
m(6)A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover. Genes Dev (2017) 0.84
Multiple mRNA species for adenovirus type 2 polypeptides III and pVII. J Virol (1980) 0.82
5' Caps in hnRNA: absence of m32,2,7G and size distribution of capped molecules. Nucleic Acids Res (1977) 0.81
1,25-Dihydroxyvitamin D3 transcriptionally regulates tumour necrosis factor mRNA during HL-60 cell differentiation. Immunology (1988) 0.81
DNA sequences downstream of the adenovirus type 2 fiber polyadenylation site contain transcription termination signals. J Virol (1987) 0.81
Mapping of adenovirus late promoters with nascent mercurated RNA. Proc Natl Acad Sci U S A (1978) 0.80
Regulation of adenovirus and cellular gene expression and of cellular transformation by the E1B-encoded 175-amino-acid protein. J Virol (1988) 0.80
Depression of transcription and translation during daily torpor in the Djungarian hamster (Phodopus sungorus). J Comp Physiol B (2004) 0.79
The nucleus introduced. Cold Spring Harb Perspect Biol (2011) 0.78
Isolation of Catharanthus roseus (L.) G. Don Nuclei and Measurement of Rate of Tryptophan decarboxylase Gene Transcription Using Nuclear Run-On Transcription Assay. PLoS One (2015) 0.76
Joys and surprises of a career studying eukaryotic gene expression. J Biol Chem (2013) 0.76
Identification of the major polyadenylylated transcription products and the genes active in their synthesis in a rat insulinoma. Proc Natl Acad Sci U S A (1978) 0.75
E.B. Wilson Lecture, 1998. Eukaryotic RNAs: once more from the beginning. Mol Biol Cell (1999) 0.75
Nuclear processing of viral high-molecular-weight RNA in cells infected with herpes simplex virus type 1. J Virol (1980) 0.75
Discovery of RNA splicing and genes in pieces. Proc Natl Acad Sci U S A (2016) 0.75
Stat3 as an oncogene. Cell (1999) 17.39
Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol (2002) 15.33
POLYRIBOSOMES IN NORMAL AND POLIOVIRUS-INFECTED HELA CELLS AND THEIR RELATIONSHIP TO MESSENGER-RNA. Proc Natl Acad Sci U S A (1963) 12.17
Evidence for virus-specific noncapsid proteins in poliovirus-infected HeLa cells. Proc Natl Acad Sci U S A (1965) 11.84
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science (1994) 11.33
An adenylic acid-rich sequence in messenger RNA of HeLa cells and its possible relationship to reiterated sites in DNA. Proc Natl Acad Sci U S A (1971) 11.01
Polyadenylic acid sequences: role in conversion of nuclear RNA into messenger RNA. Science (1971) 10.54
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell (1995) 10.16
Variety in the level of gene control in eukaryotic cells. Nature (1982) 9.61
Transcriptional control in the production of liver-specific mRNAs. Cell (1981) 9.35
Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem (1995) 8.52
HIV-1 infection among intravenous drug users in Manhattan, New York City, from 1977 through 1987. JAMA (1989) 6.68
A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Science (1993) 6.44
The role of STATs in transcriptional control and their impact on cellular function. Oncogene (2000) 6.42
Steps in the processing of Ad2 mRNA: poly(A)+ nuclear sequences are conserved and poly(A) addition precedes splicing. Cell (1978) 6.36
Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev (1990) 6.33
Ribonucleic acids from animal cells. Bacteriol Rev (1968) 6.13
Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science (1992) 6.09
Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control. Genes Dev (1988) 6.08
Aspects of the synthesis of poliovirus RNA and the formation of virus particles. Virology (1966) 5.85
Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell (1994) 5.79
The primary transcription unit of the mouse beta-major globin gene. Cell (1981) 5.75
Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein. Science (1992) 5.71
Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha. Proc Natl Acad Sci U S A (1992) 5.50
Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro. Genes Dev (1989) 5.09
Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science (1995) 4.90
Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat Genet (1996) 4.84
Transcriptional induction of two genes in human cells by beta interferon. Proc Natl Acad Sci U S A (1984) 4.84
Rapidly labeled HeLa cell nuclear RNA. I. Identification by zone sedimentation of a heterogeneous fraction separate from ribosomal precursor RNA. J Mol Biol (1966) 4.83
Compilation of tRNA sequences and sequences of tRNA genes. Nucleic Acids Res (1989) 4.79
The initiation sites for RNA transcription in Ad2 DNA. Cell (1977) 4.76
A common nuclear signal transduction pathway activated by growth factor and cytokine receptors. Science (1993) 4.65
Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element. Proc Natl Acad Sci U S A (1987) 4.61
Identification of the membrane protein and "core" protein of Sindbis virus. Proc Natl Acad Sci U S A (1968) 4.52
Addition of polyadenylate sequences to virus-specific RNA during adenovirus replication. Proc Natl Acad Sci U S A (1971) 4.48
Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes. Mol Cell Biol (1989) 4.47
Characterization of a new low molecular weight RNA in HeLa cell ribosomes. J Mol Biol (1968) 4.44
Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry. J Virol (1996) 4.43
Sindbis virus infection of chick and hamster cells: synthesis of virus-specific proteins. Virology (1969) 4.38
Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways. EMBO J (1993) 4.35
The definition of a large viral transcription unit late in Ad2 infection of HeLa cells: mapping by effects of ultraviolet irradiation. Cell (1977) 4.13
ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains. Proc Natl Acad Sci U S A (1990) 4.11
A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev (1995) 4.11
Stat3 activation is required for cellular transformation by v-src. Mol Cell Biol (1998) 4.09
A transcriptional hierarchy involved in mammalian cell-type specification. Nature (1992) 4.08
Is clearance of HIV-1 viraemia at seroconversion mediated by neutralising antibodies? Lancet (1992) 4.05
Biogenesis of mRNA: genetic regulation in mammalian cells. Science (1973) 4.01
Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Genes Dev (1991) 4.01
Evidence that all messenger RNA molecules (except histone messenger RNA) contain Poly (A) sequences and that the Poly(A) has a nuclear function. J Mol Biol (1972) 3.93
Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins. Mol Cell Biol (1992) 3.90
Low molecular weight RNAs hydrogen-bonded to nuclear and cytoplasmic poly(A)-terminated RNA from cultured Chinese hamster ovary cells. Cell (1978) 3.82
Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell (1998) 3.79
Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev (1994) 3.76
The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. Proc Natl Acad Sci U S A (1992) 3.74
Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins. Nature (1993) 3.73
The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo. Cell (1994) 3.71
Production of mRNA in Chinese hamster cells: relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequences. Cell (1979) 3.67
Organization of intrahippocampal projections originating from CA3 pyramidal cells in the rat. J Comp Neurol (1990) 3.67
Transcriptional induction by interferon. New protein(s) determine the extent and length of the induction. J Biol Chem (1986) 3.63
Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma. Proc Natl Acad Sci U S A (1996) 3.62
HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally. Genes Dev (1990) 3.50
Structural difference between the 5' termini of viral and cellular mRNA in poliovirus-infected cells: possible basis for the inhibition of host protein synthesis. J Virol (1976) 3.46
Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc Natl Acad Sci U S A (2000) 3.44
The decrease in size and synthetic activity of poliovirus polysomes late in the infectious cycle. Virology (1967) 3.41
Competition hybridization by "pre-saturation" of HeLa cell DNA. J Mol Biol (1969) 3.40
Implications of RNA-RNA splicing in evolution of eukaryotic cells. Science (1978) 3.39
The turnover of nuclear DNA-like RNA in HeLa cells. J Cell Biol (1968) 3.39
A poly(A) addition site and a downstream termination region are required for efficient cessation of transcription by RNA polymerase II in the mouse beta maj-globin gene. Proc Natl Acad Sci U S A (1987) 3.38
Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J Exp Med (1995) 3.37
Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either. Mol Cell Biol (1990) 3.31
Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor. EMBO J (1991) 3.28
Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling. Proc Natl Acad Sci U S A (1996) 3.26
Effect of adenovirus on metabolism of specific host mRNAs: transport control and specific translational discrimination. Mol Cell Biol (1983) 3.25
Rapidly labeled HeLa cell nuclear RNA. II. Base composition and cellular localization of a heterogeneous RNA fraction. J Mol Biol (1966) 3.22
Double-stranded regions in heterogeneous nuclear RNA from Hela cells. Proc Natl Acad Sci U S A (1972) 3.21
Biogenesis and characterization of histone messenger RNA in HeLa cells. J Mol Biol (1972) 3.14
Polyadenylic acid segment in mRNA becomes shorter with age. Nat New Biol (1973) 3.09
Early Ad-2 transcription units: only promoter-proximal RNA continues to be made in the presence of DRB. Virology (1979) 3.06
SV40-specific RNA in the nucleus and polyribosomes of transformed cells. Proc Natl Acad Sci U S A (1970) 3.05
Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport. Mol Cell Biol (1985) 3.04
Methylated, blocked 5 termini in HeLa cell mRNA. Proc Natl Acad Sci U S A (1975) 3.02
Changes in liver-specific compared to common gene transcription during primary culture of mouse hepatocytes. Mol Cell Biol (1983) 3.01
Regulation of the primary expression of the early adenovirus transcription units. J Virol (1979) 2.92
Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region. Proc Natl Acad Sci U S A (1986) 2.92
Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity. Proc Natl Acad Sci U S A (1995) 2.92
Identification of a Stat gene that functions in Drosophila development. Cell (1996) 2.90
Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1. Proc Natl Acad Sci U S A (1998) 2.88
Genetic analysis of adenovirus type 2 III. Temperature sensitivity of processing viral proteins. J Virol (1976) 2.88
Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst. Proc Natl Acad Sci U S A (1994) 2.85
Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci U S A (1994) 2.81
HTLV-III/LAV viral antigens in lymph nodes of homosexual men with persistent generalized lymphadenopathy and AIDS. Am J Pathol (1986) 2.77
Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3. EMBO J (1990) 2.75
Globin RNA transcription: a possible termination site and demonstration of transcriptional control correlated with altered chromatin structure. Cell (1982) 2.72
Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells. Mol Cell Biol (1992) 2.72
Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons. Mol Cell Biol (1991) 2.71