Published in Infect Immun on March 01, 1996
Life below the gum line: pathogenic mechanisms of Porphyromonas gingivalis. Microbiol Mol Biol Rev (1998) 6.28
Complete genome sequence of the oral pathogenic Bacterium porphyromonas gingivalis strain W83. J Bacteriol (2003) 4.41
Functional differences among FimA variants of Porphyromonas gingivalis and their effects on adhesion to and invasion of human epithelial cells. Infect Immun (2002) 1.39
Porphyromonas gingivalis gingipains and adhesion to epithelial cells. Infect Immun (2001) 1.38
Glyceraldehyde-3-phosphate dehydrogenase of Streptococcus oralis functions as a coadhesin for Porphyromonas gingivalis major fimbriae. Infect Immun (2004) 1.35
Bacterial invasion of epithelial cells and spreading in periodontal tissue. Periodontol 2000 (2010) 1.15
A peptide domain on gingipain R which confers immunity against Porphyromonas gingivalis infection in mice. Infect Immun (1998) 1.14
Surface structure, hydrophobicity, phagocytosis, and adherence to matrix proteins of Bacillus cereus cells with and without the crystalline surface protein layer. Infect Immun (1998) 1.12
Targeted disruption of fibronectin-integrin interactions in human gingival fibroblasts by the RI protease of Porphyromonas gingivalis W50. Infect Immun (1999) 1.10
Binding of Porphyromonas gingivalis fimbriae to proline-rich glycoproteins in parotid saliva via a domain shared by major salivary components. Infect Immun (1998) 1.08
Porphyromonas gingivalis fimbriae use beta2 integrin (CD11/CD18) on mouse peritoneal macrophages as a cellular receptor, and the CD18 beta chain plays a functional role in fimbrial signaling. Infect Immun (1998) 1.05
Contact-dependent protein secretion in Porphyromonas gingivalis. Infect Immun (1998) 1.05
Flow cytometric analysis of adherence of Porphyromonas gingivalis to oral epithelial cells. Infect Immun (2007) 0.94
Adsorption of components of the plasma kinin-forming system on the surface of Porphyromonas gingivalis involves gingipains as the major docking platforms. Infect Immun (2010) 0.90
Porphyromonas gingivalis gingipain-R enhances interleukin-8 but decreases gamma interferon-inducible protein 10 production by human gingival fibroblasts in response to T-cell contact. Infect Immun (2001) 0.87
Fimbriae and the hemagglutinating adhesin HA-Ag2 mediate adhesion of Porphyromonas gingivalis to epithelial cells. Infect Immun (1997) 0.85
Localization of HArep-containing genes on the chromosome of Porphyromonas gingivalis W83. Infect Immun (1999) 0.79
Characterization of the relA gene of Porphyromonas gingivalis. J Bacteriol (2000) 0.78
Inhibitory effects of protamines on proteolytic and adhesive activities of Porphyromonas gingivalis. Infect Immun (1999) 0.76
Epithelial cell surface sites involved in the polyvalent adherence of Porphyromonas gingivalis: a convincing role for neuraminic acid and glucuronic acid. Infect Immun (2003) 0.76
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Biology of asaccharolytic black-pigmented Bacteroides species. Microbiol Rev (1988) 4.17
Purification and characterization of a novel type of fimbriae from the oral anaerobe Bacteroides gingivalis. J Bacteriol (1984) 3.27
Lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins. J Biol Chem (1994) 2.90
Bacterial adhesion to oral tissues: a model for infectious diseases. J Dent Res (1989) 2.87
Purification and characterization of a 50-kDa cysteine proteinase (gingipain) from Porphyromonas gingivalis. J Biol Chem (1992) 1.99
Molecular cloning and structural characterization of the Arg-gingipain proteinase of Porphyromonas gingivalis. Biosynthesis as a proteinase-adhesin polyprotein. J Biol Chem (1995) 1.98
Activation of complement components C3 and C5 by a cysteine proteinase (gingipain-1) from Porphyromonas (Bacteroides) gingivalis. J Biol Chem (1992) 1.96
Interaction of Treponema denticola TD-4, GM-1, and MS25 with human gingival fibroblasts. Infect Immun (1990) 1.78
Collagenolytic activity associated with Bacteroides species and Actinobacillus actinomycetemcomitans. J Periodontal Res (1982) 1.69
Bacteroides gingivalis fimbriae stimulate production of thymocyte-activating factor by human gingival fibroblasts. Infect Immun (1988) 1.69
Characterization of collagenolytic activity from strains of Bacteroides gingivalis. J Periodontal Res (1988) 1.56
Purification and characterization of a novel arginine-specific cysteine proteinase (argingipain) involved in the pathogenesis of periodontal disease from the culture supernatant of Porphyromonas gingivalis. J Biol Chem (1994) 1.56
Association of proteases of Porphyromonas (Bacteroides) gingivalis with its adhesion to Actinomyces viscosus. J Dent Res (1991) 1.52
Isolation of a membrane-associated Bacteroides gingivalis glycylprolyl protease. Infect Immun (1987) 1.50
Attachment of Bacteroides gingivalis to collagenous substrata. J Dent Res (1988) 1.49
Identification of proteases from periodontopathogenic bacteria as activators of latent human neutrophil and fibroblast-type interstitial collagenases. Infect Immun (1992) 1.45
Identification of Porphyromonas gingivalis components that mediate its interactions with fibronectin. J Bacteriol (1991) 1.39
Purification and characterization of a collagen-degrading protease from Porphyromonas gingivalis. J Biol Chem (1994) 1.37
Degradation of the human proteinase inhibitors alpha-1-antitrypsin and alpha-2-macroglobulin by Bacteroides gingivalis. Infect Immun (1984) 1.37
A protease of Bacteroides gingivalis degrades cell surface and matrix glycoproteins of cultured gingival fibroblasts and induces secretion of collagenase and plasminogen activator. Infect Immun (1989) 1.35
Molecular cloning and sequencing of the fimbrilin gene of Porphyromonas gingivalis strains and characterization of recombinant proteins. Biochem Biophys Res Commun (1993) 1.34
Purification and characterization of an immunoglobulin A1 protease from Bacteroides melaninogenicus. Infect Immun (1984) 1.33
Inactivation of key factors of the plasma proteinase cascade systems by Bacteroides gingivalis. Infect Immun (1985) 1.32
Selective modulation of bacterial attachment to oral epithelial cells by enzyme activities associated with poor oral hygiene. J Periodontal Res (1990) 1.27
The degradation of type I collagen and human plasma fibronectin by the trypsin-like enzyme and extracellular membrane vesicles of Bacteroides gingivalis W50. Arch Oral Biol (1988) 1.25
Degradation of basement membrane collagen by proteases from some anaerobic oral micro-organisms. Oral Microbiol Immunol (1988) 1.18
Further studies on the degradation of immunoglobulins by black-pigmented Bacteroides. Oral Microbiol Immunol (1989) 1.15
Adherence and hydrophobicity of invasive and noninvasive strains of Porphyromonas gingivalis. Oral Microbiol Immunol (1993) 1.15
Inactivation of human serum bactericidal activity by a trypsinlike protease isolated from Porphyromonas gingivalis. Infect Immun (1992) 1.08
Biochemical characterization of Porphyromonas (Bacteroides) gingivalis collagenase. Infect Immun (1992) 1.06
Purification and characterization of a protease from Porphyromonas gingivalis capable of degrading salt-solubilized collagen. Infect Immun (1993) 1.03
Degradation of human secretory immunoglobulin A by protease isolated from the anaerobic periodontopathogenic bacterium, Bacteroides gingivalis. Arch Oral Biol (1987) 0.98
Characterization of N-CBz-glycyl-glycyl-arginyl peptidase and glycyl-prolyl peptidase of Bacteroides gingivalis. J Periodontal Res (1987) 0.94
Correlation of haemagglutination activity with trypsin-like protease activity of Porphyromonas gingivalis. Arch Oral Biol (1992) 0.94
Molecular and immunological characterization of the fimbriae of Porphyromonas gingivalis. Microbiol Immunol (1994) 0.93
Suppression of bactericidal activity of human polymorphonuclear leukocytes by Bacteroides gingivalis. Infect Immun (1990) 0.92
Further evidence for a possible role of trypsin-like activity in the adherence of Porphyromonas gingivalis. Can J Microbiol (1992) 0.91
Induction of mucosal and serum immune responses to a specific antigen of periodontal bacteria. Adv Exp Med Biol (1992) 0.87
Purification of an 80,000-Mr glycylprolyl peptidase from Bacteroides gingivalis. Infect Immun (1989) 0.87
The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature (1997) 33.47
A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature (1988) 27.60
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med (2001) 16.51
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med (2002) 14.15
Essential Bacillus subtilis genes. Proc Natl Acad Sci U S A (2003) 14.01
Construction of a colicin E1-R factor composite plasmid in vitro: means for amplification of deoxyribonucleic acid. J Bacteriol (1975) 13.95
Biology, immunology, and cariogenicity of Streptococcus mutans. Microbiol Rev (1980) 13.40
The IN protein of Moloney murine leukemia virus processes the viral DNA ends and accomplishes their integration in vitro. Cell (1990) 7.99
The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc Natl Acad Sci U S A (1989) 7.41
Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1. DNA Res (1999) 7.39
Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor. Nature (1991) 7.11
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci U S A (1997) 7.08
The nucleotide sequence of pUB110: some salient features in relation to replication and its regulation. Plasmid (1986) 7.07
Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter. Cell (1999) 6.83
Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3. DNA Res (1998) 6.79
Essential role of Stat6 in IL-4 signalling. Nature (1996) 6.56
The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity (1994) 6.18
Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science (1995) 6.03
Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. Hepatoma Prevention Study Group. N Engl J Med (1996) 6.01
Typing hepatitis C virus by polymerase chain reaction with type-specific primers: application to clinical surveys and tracing infectious sources. J Gen Virol (1992) 5.93
Retroviral DNA integration directed by HIV integration protein in vitro. Science (1990) 5.87
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell (2000) 5.64
Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins. Mol Cell (2000) 5.49
The 5'-terminal sequence of the hepatitis C virus genome. Jpn J Exp Med (1990) 5.46
Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus. J Virol (1993) 5.41
Full-length sequence of a hepatitis C virus genome having poor homology to reported isolates: comparative study of four distinct genotypes. Virology (1992) 5.16
Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med (1993) 4.91
Syringe method for stepwise chemical synthesis of oligonucleotides. Nucleic Acids Res (1982) 4.70
TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J (2000) 4.55
Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res (1995) 4.52
The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat Med (1998) 4.48
Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor. Life Sci (1992) 4.39
Norwalk virus infection of volunteers: new insights based on improved assays. J Infect Dis (1994) 4.37
Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum. Development (1999) 4.26
SCE-963, a new broad-spectrum cephalosporin: in vitro and in vivo antibacterial activities. Antimicrob Agents Chemother (1978) 4.06
Identification and characterization of the potential promoter regions of 1031 kinds of human genes. Genome Res (2001) 4.03
Evaluation of acridinium-ester-labeled DNA probes for identification of Mycobacterium tuberculosis and Mycobacterium avium-Mycobacterium intracellulare complex in culture. J Clin Microbiol (1991) 3.88
A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J (1994) 3.88
A neomycin resistance gene cassette selectable in a single copy state in the Bacillus subtilis chromosome. Nucleic Acids Res (1989) 3.87
Real-time detection system for quantification of hepatitis C virus genome. Gastroenterology (1999) 3.83
Transcriptional sequencing: A method for DNA sequencing using RNA polymerase. Proc Natl Acad Sci U S A (1998) 3.78
High guanine plus cytosine content in the third letter of codons of an extreme thermophile. DNA sequence of the isopropylmalate dehydrogenase of Thermus thermophilus. J Biol Chem (1984) 3.76
An endothelial receptor for oxidized low-density lipoprotein. Nature (1997) 3.76
Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J Clin Invest (1998) 3.76
Calcium-induced conformational transition revealed by the solution structure of apo calmodulin. Nat Struct Biol (1995) 3.75
Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature (1988) 3.69
The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing. J Biol Chem (1986) 3.64
IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production. J Immunol (1998) 3.56
A new endoscopic mucosal resection procedure using an insulation-tipped electrosurgical knife for rectal flat lesions: report of two cases. Gastrointest Endosc (1999) 3.55
Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites. EMBO Rep (2001) 3.47
Molecular mechanics of calcium-myristoyl switches. Nature (1997) 3.36
Sequence analysis of hepatitis C virus isolated from a fulminant hepatitis patient. J Med Virol (2001) 3.29
Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: variability and stability. Virology (1992) 3.22
Risk factors for lymph node metastasis from intramucosal gastric carcinoma. Cancer (1996) 3.21
Artificial surfactant therapy in hyaline-membrane disease. Lancet (1980) 3.21
A high-throughput SNP typing system for genome-wide association studies. J Hum Genet (2001) 3.18
Regulation of the phosphate regulon of Escherichia coli. Activation of pstS transcription by PhoB protein in vitro. J Mol Biol (1988) 3.14
Structure and antigenicity of the major specific glycolipid antigen of Mycobacterium leprae. J Biol Chem (1982) 3.11
Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene. J Biol Chem (2000) 3.11
Size and shape effects in the biodistribution of intravascularly injected particles. J Control Release (2009) 3.08
Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT. Nat Genet (1996) 3.07
Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature (1997) 3.07
Genetic instability occurs in the majority of young patients with colorectal cancer. Nat Med (1995) 3.07
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc Natl Acad Sci U S A (1981) 3.04
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes (2000) 3.01
Human thyroid peroxidase: complete cDNA and protein sequence, chromosome mapping, and identification of two alternately spliced mRNAs. Proc Natl Acad Sci U S A (1987) 3.00
Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide. Proc Natl Acad Sci U S A (1988) 2.99
Complete genome sequence of an aerobic thermoacidophilic crenarchaeon, Sulfolobus tokodaii strain7. DNA Res (2001) 2.99
Cloning of the genes for penicillinase, penP and penI, of Bacillus licheniformis in some vector plasmids and their expression in Escherichia coli, Bacillus subtilis, and Bacillus licheniformis. J Bacteriol (1981) 2.93
Single-molecule analysis of chemotactic signaling in Dictyostelium cells. Science (2001) 2.89
Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature (1998) 2.88
Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiae. EMBO J (1996) 2.87
The 2.8 A structure of hydroxylamine oxidoreductase from a nitrifying chemoautotrophic bacterium, Nitrosomonas europaea. Nat Struct Biol (1997) 2.81
Significance of myocytes with positive DNA in situ nick end-labeling (TUNEL) in hearts with dilated cardiomyopathy: not apoptosis but DNA repair. Circulation (1999) 2.80
Familial gastrointestinal stromal tumours with germline mutation of the KIT gene. Nat Genet (1998) 2.80
Nature of phosphorus limitation in the ultraoligotrophic eastern Mediterranean. Science (2005) 2.79
Clonal isolation of muscle-derived cells capable of enhancing muscle regeneration and bone healing. J Cell Biol (2000) 2.75
Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex. Neuron (1998) 2.73
Finer features for functional microdevices. Nature (2001) 2.73
Solution structure of the homodimeric core domain of Escherichia coli histidine kinase EnvZ. Nat Struct Biol (1999) 2.72
Detection of hepatitis C virus RNA by a two-stage polymerase chain reaction with two pairs of primers deduced from the 5'-noncoding region. Jpn J Exp Med (1990) 2.72
The arcB gene of Escherichia coli encodes a sensor-regulator protein for anaerobic repression of the arc modulon. Mol Microbiol (1990) 2.71
Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc Natl Acad Sci U S A (1996) 2.70
Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design. Proc Natl Acad Sci U S A (1999) 2.69
The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. J Biol Chem (2001) 2.69
Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos. Dev Biol (1999) 2.69
Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter. Mol Cell Biol (2001) 2.68
Nucleotide sequence of the hag gene encoding flagellin of Escherichia coli. J Bacteriol (1986) 2.68
Plasmid specifying total degradation of 3-chlorobenzoate by a modified ortho pathway. J Bacteriol (1981) 2.66
Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver. Nat Genet (1995) 2.65
Solid phase synthesis of oligoribonucleotides using o-nitrobenzyl protection of 2'-hydroxyl via a phosphite triester approach. Nucleic Acids Res (1986) 2.64
Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells. Cancer Res (1998) 2.63
Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression. Mol Cell Biol (1995) 2.62
Six Arabidopsis thaliana homologues of the human respiratory burst oxidase (gp91phox). Plant J (1998) 2.59
Isolation and characterization of four plasmids from Bacillus subtilis. J Bacteriol (1977) 2.59
Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. Nature (1996) 2.57
Comparative study on the antibacterial activity of phytochemical flavanones against methicillin-resistant Staphylococcus aureus. J Ethnopharmacol (1996) 2.57
De novo mutations of voltage-gated sodium channel alphaII gene SCN2A in intractable epilepsies. Neurology (2009) 2.53