Receptor stimulation causes slow inhibition of IRK1 inwardly rectifying K+ channels by direct protein kinase A-mediated phosphorylation.

PubWeight™: 1.06‹?› | Rank: Top 15%

🔗 View Article (PMC 39145)

Published in Proc Natl Acad Sci U S A on June 11, 1996

Authors

E Wischmeyer1, A Karschin

Author Affiliations

1: Molecular Neurobiology of Signal Transduction, Max Planck Institut für Biophysical Chemistry, Göttingen, Germany.

Articles citing this

Cholesterol sensitivity and lipid raft targeting of Kir2.1 channels. Biophys J (2004) 1.56

Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior. Proc Natl Acad Sci U S A (2012) 1.48

Shear stress regulates the endothelial Kir2.1 ion channel. Proc Natl Acad Sci U S A (2002) 1.12

Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels. Proc Natl Acad Sci U S A (1998) 1.10

Modulation of inwardly rectifying potassium channels in cultured bovine pulmonary artery endothelial cells. J Physiol (1997) 0.96

Protein kinase A-dependent biophysical phenotype for V227F-KCNJ2 mutation in catecholaminergic polymorphic ventricular tachycardia. Circ Arrhythm Electrophysiol (2009) 0.94

Protein kinase C dependent inhibition of the heteromeric Kir4.1-Kir5.1 channel. Biochim Biophys Acta (2007) 0.87

Candidate genes for antidepressant response to selective serotonin reuptake inhibitors. Neuropsychiatr Dis Treat (2005) 0.86

PI3K/Akt signalling-mediated protein surface expression sensed by 14-3-3 interacting motif. FEBS J (2009) 0.85

Growth hormone-releasing peptide-2 reduces inward rectifying K+ currents via a PKA-cAMP-mediated signalling pathway in ovine somatotropes. J Physiol (2002) 0.81

Regulation of a family of inwardly rectifying potassium channels (Kir2) by the m1 muscarinic receptor and the small GTPase Rho. Pflugers Arch (2005) 0.81

KCNJ2 mutation causes an adrenergic-dependent rectification abnormality with calcium sensitivity and ventricular arrhythmia. Heart Rhythm (2014) 0.81

Beta-adrenergic stimulation reverses the I Kr-I Ks dominant pattern during cardiac action potential. Pflugers Arch (2014) 0.80

Putative ClC-2 chloride channel mediates inward rectification in Drosophila retinal photoreceptors. J Membr Biol (2005) 0.79

Acute Ca(2+)-dependent desensitization of 5-HT(1A) receptors is mediated by activation of protein kinase A (PKA) in rat serotonergic neurons. Neuroscience (2010) 0.79

Potassium currents in the heart: Functional roles in repolarization, arrhythmia and therapeutics. J Physiol (2016) 0.79

Mass spectrometric analysis reveals a functionally important PKA phosphorylation site in a Kir3 channel subunit. Pflugers Arch (2009) 0.78

Cdo Regulates Surface Expression of Kir2.1 K+ Channel in Myoblast Differentiation. PLoS One (2016) 0.77

A novel slow hyperpolarization-activated potassium current (IK(SHA)) from a mouse hippocampal cell line. J Physiol (1997) 0.76

Fluid flow facilitates inward rectifier K(+) current by convectively restoring [K(+)] at the cell membrane surface. Sci Rep (2016) 0.75

Boosting the signal: Endothelial inward rectifier K(+) channels. Microcirculation (2016) 0.75

Articles cited by this

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch (1981) 134.60

Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science (1990) 15.75

Inactivation of the sodium channel. II. Gating current experiments. J Gen Physiol (1977) 14.17

Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature (1993) 8.20

The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins. Nature (1995) 4.96

Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel. Nature (1994) 3.54

An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. Nature (1987) 3.33

The inward rectifier potassium channel family. Curr Opin Neurobiol (1995) 3.23

Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits. Nature (1994) 3.21

Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits. Nature (1992) 2.62

Phosphorylation of the nicotinic acetylcholine receptor regulates its rate of desensitization. Nature (1986) 2.35

Functional modulation of brain sodium channels by protein kinase C phosphorylation. Science (1991) 2.11

Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain. FEBS Lett (1994) 2.10

Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimers. Proc Natl Acad Sci U S A (1995) 2.09

Voltage-dependent potentiation of L-type Ca2+ channels due to phosphorylation by cAMP-dependent protein kinase. Nature (1993) 2.06

Twelfth Gaddum memorial lecture. Drug receptors and the inhibition of nerve cells. Br J Pharmacol (1989) 2.01

G protein-coupled mechanisms and nervous signaling. Neuron (1992) 1.95

Distribution and cellular localization of mRNA coding for 5-HT1A receptor in the rat brain: correlation with receptor binding. J Neurosci (1992) 1.76

Phosphorylation and modulation of recombinant GluR6 glutamate receptors by cAMP-dependent protein kinase. Nature (1993) 1.65

Heterologous multimeric assembly is essential for K+ channel activity of neuronal and cardiac G-protein-activated inward rectifiers. Biochem Biophys Res Commun (1995) 1.65

Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptamine1A receptor gene. J Biol Chem (1990) 1.63

Kir2.1 inward rectifier K+ channels are regulated independently by protein kinases and ATP hydrolysis. Neuron (1994) 1.61

Phosphorylation and modulation of a kainate receptor (GluR6) by cAMP-dependent protein kinase. Science (1993) 1.55

Identification of domains conferring G protein regulation on inward rectifier potassium channels. Cell (1995) 1.51

Dual modulation of renal ATP-sensitive K+ channel by protein kinases A and C. Proc Natl Acad Sci U S A (1991) 1.47

Regulation of ROMK1 K+ channel activity involves phosphorylation processes. Proc Natl Acad Sci U S A (1994) 1.46

Effect of forskolin on voltage-gated K+ channels is independent of adenylate cyclase activation. Science (1988) 1.43

Potassium channel stimulation by natriuretic peptides through cGMP-dependent dephosphorylation. Nature (1993) 1.31

Functional modulation of GABAA receptors by cAMP-dependent protein phosphorylation. Science (1992) 1.29

Direct G protein activation of ion channels? Annu Rev Neurosci (1994) 1.19

Receptors that couple to 2 classes of G proteins increase cAMP and activate CFTR expressed in Xenopus oocytes. Receptors Channels (1993) 1.15

G beta gamma directly binds to the carboxyl terminus of the G protein-gated muscarinic K+ channel, GIRK1. Biochem Biophys Res Commun (1995) 1.12

Heterologously expressed serotonin 1A receptors couple to muscarinic K+ channels in heart. Proc Natl Acad Sci U S A (1991) 1.10

Protein kinase C-mediated inhibition of an inward rectifier potassium channel by substance P in nucleus basalis neurons. Neuron (1995) 1.10

G protein control of potassium channel activity in a mast cell line. J Gen Physiol (1990) 1.10

Physiological and molecular characterization of an IRK-type inward rectifier K+ channel in a tumour mast cell line. Pflugers Arch (1995) 1.08

A G-protein-activated inwardly rectifying K+ channel (GIRK4) from human hippocampus associates with other GIRK channels. J Neurosci (1996) 1.03

Cell-specific physical and functional coupling of human 5-HT1A receptors to inhibitory G protein alpha-subunits and lack of coupling to Gs alpha. Biochemistry (1993) 1.02

A region of the muscarinic-gated atrial K+ channel critical for activation by G protein beta gamma subunits. Neuron (1994) 1.02

Contributions of the C-terminal domain to gating properties of inward rectifier potassium channels. Neuron (1995) 1.00

Molecular cloning, functional expression and localization of an inward rectifier potassium channel in the mouse brain. FEBS Lett (1993) 0.99

Protein kinase C mediates neurotensin inhibition of inwardly rectifying potassium currents in rat substantia nigra dopaminergic neurons. Neurosci Lett (1995) 0.90

Regulation of an inwardly rectifying K channel in the T84 epithelial cell line by calcium, nucleotides and kinases. J Membr Biol (1994) 0.87

Phosphatase is responsible for run down, and probably G protein-mediated inhibition of inwardly rectifying K+ currents in guinea pig chromaffin cells. J Gen Physiol (1995) 0.86

Molecular mechanisms of pain: serotonin1A receptor agonists trigger transactivation by c-fos of the prodynorphin gene in spinal cord neurons. Neuron (1993) 0.86

Enhancement of beta-adrenergic responses by Gi-linked receptors in rat hippocampus. Neuron (1993) 0.85

Articles by these authors

GABA(B)-receptor subtypes assemble into functional heteromeric complexes. Nature (1998) 4.33

IRK(1-3) and GIRK(1-4) inwardly rectifying K+ channel mRNAs are differentially expressed in the adult rat brain. J Neurosci (1996) 2.45

TASK-3, a novel tandem pore domain acid-sensitive K+ channel. An extracellular histiding as pH sensor. J Biol Chem (2000) 1.94

Overlapping distribution of K(ATP) channel-forming Kir6.2 subunit and the sulfonylurea receptor SUR1 in rodent brain. FEBS Lett (1997) 1.63

The epithelial inward rectifier channel Kir7.1 displays unusual K+ permeation properties. J Neurosci (1998) 1.47

Expression pattern in brain of TASK-1, TASK-3, and a tandem pore domain K(+) channel subunit, TASK-5, associated with the central auditory nervous system. Mol Cell Neurosci (2001) 1.37

Calmodulin dependence of presynaptic metabotropic glutamate receptor signaling. Science (1999) 1.32

Neuronal inwardly rectifying K(+) channels differentially couple to PDZ proteins of the PSD-95/SAP90 family. J Neurosci (2000) 1.28

Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei. J Neurosci (1998) 1.24

THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. J Biol Chem (2000) 1.20

The metabotropic GABAB receptor directly interacts with the activating transcription factor 4. J Biol Chem (2000) 1.19

Acute suppression of inwardly rectifying Kir2.1 channels by direct tyrosine kinase phosphorylation. J Biol Chem (1998) 1.16

Interaction of the C-terminal tail region of the metabotropic glutamate receptor 7 with the protein kinase C substrate PICK1. Eur J Neurosci (2000) 1.15

Tyrosine decaging leads to substantial membrane trafficking during modulation of an inward rectifier potassium channel. J Gen Physiol (2001) 1.13

Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels. Proc Natl Acad Sci U S A (1998) 1.10

Physiological and molecular characterization of an IRK-type inward rectifier K+ channel in a tumour mast cell line. Pflugers Arch (1995) 1.08

Dynamic activation of K(ATP) channels in rhythmically active neurons. J Physiol (2001) 1.08

Slow and incomplete inactivations of voltage-gated channels dominate encoding in synthetic neurons. Biophys J (1993) 1.08

Mutations in the ROMK gene in antenatal Bartter syndrome are associated with impaired K+ channel function. Biochem Biophys Res Commun (1997) 1.07

Brain localization and behavioral impact of the G-protein-gated K+ channel subunit GIRK4. J Neurosci (2000) 1.06

Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits. FEBS Lett (2001) 1.04

A G-protein-activated inwardly rectifying K+ channel (GIRK4) from human hippocampus associates with other GIRK channels. J Neurosci (1996) 1.03

Kir6.1 is the principal pore-forming subunit of astrocyte but not neuronal plasma membrane K-ATP channels. Mol Cell Neurosci (2001) 1.01

Subunit interactions in the assembly of neuronal Kir3.0 inwardly rectifying K+ channels. Mol Cell Neurosci (1997) 0.99

The role of conserved aspartate and serine residues in ligand binding and in function of the 5-HT1A receptor: a site-directed mutation study. FEBS Lett (1992) 0.99

Ontogeny of gene expression of Kir channel subunits in the rat. Mol Cell Neurosci (1997) 0.96

Gain of function mutants: ion channels and G protein-coupled receptors. Annu Rev Neurosci (2000) 0.91

Stable cation coordination at a single outer pore residue defines permeation properties in Kir channels. FEBS Lett (2000) 0.91

Immunocytochemical studies on astroglia of the cat retina under normal and pathological conditions. J Comp Neurol (1986) 0.89

Cellular localization of the potassium channel Kir7.1 in guinea pig and human kidney. Kidney Int (2001) 0.89

Functional characterization of two 5-HT3 receptor splice variants isolated from a mouse hippocampal cell line. Pflugers Arch (1996) 0.87

A hyperprostaglandin E syndrome mutation in Kir1.1 (renal outer medullary potassium) channels reveals a crucial residue for channel function in Kir1.3 channels. J Biol Chem (1998) 0.87

Vaccinia virus as vector to express ion channel genes. Methods Enzymol (1992) 0.85

The shape and distribution of astrocytes in the retina of the adult rabbit. Cell Tissue Res (1986) 0.84

Cloning, structure and assignment to chromosome 19q13 of the human Kir2.4 inwardly rectifying potassium channel gene (KCNJ14). Mamm Genome (2000) 0.83

Alternative splicing generates a novel isoform of the rat metabotropic GABA(B)R1 receptor. Eur J Neurosci (1999) 0.83

Expression of ion channels and receptors in Xenopus oocytes using vaccinia virus. FASEB J (1991) 0.83

Distribution and localization of a G protein-coupled inwardly rectifying K+ channel in the rat. FEBS Lett (1994) 0.82

Partial gene structure and assignment to chromosome 2q37 of the human inwardly rectifying K+ channel (Kir7.1) gene (KCNJ13). Genomics (1998) 0.81

Expression of Drosophila Shaker potassium channels in mammalian cells infected with recombinant vaccinia virus. Proc Natl Acad Sci U S A (1989) 0.78

Two pharmacological classes of quisqualate-induced electrical responses in rat retinal ganglion cells in vitro. Eur J Pharmacol (1989) 0.78

Expression cloning of rat cerebellar adenosine A1 receptor by coupling to Kir channels. Neuroreport (1997) 0.77

Expression in animal cells of the 5-HT1A receptor by a vaccinia virus vector system. FEBS Lett (1992) 0.76

A novel slow hyperpolarization-activated potassium current (IK(SHA)) from a mouse hippocampal cell line. J Physiol (1997) 0.76

Shape and distribution of astrocytes in the cat retina. Invest Ophthalmol Vis Sci (1986) 0.76

Functional heterogeneity of ROMK mutations linked to hyperprostaglandin E syndrome. Kidney Int (2001) 0.75

Functional expression and cellular mRNA localization of a G protein-activated K+ inward rectifier isolated from rat brain. Biochem Biophys Res Commun (1996) 0.75

Evolutionary link between prokaryotic and eukaryotic K+ channels. J Exp Biol (1998) 0.75

Genomic structure and promoter analysis of the rat kir7.1 potassium channel gene (Kcnj13). FEBS Lett (2000) 0.75

Processing of GABABR1 in heterologous expression systems. Ann N Y Acad Sci (1999) 0.75