Published in Nature on December 17, 1998
Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J (1999) 6.25
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein. Proc Natl Acad Sci U S A (2007) 6.04
Human receptors for sweet and umami taste. Proc Natl Acad Sci U S A (2002) 5.91
G-protein-coupled receptor heterodimerization modulates receptor function. Nature (1999) 4.73
Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET). Proc Natl Acad Sci U S A (2000) 4.46
Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation. Nat Chem Biol (2009) 2.98
Synaptic control of motoneuronal excitability. Physiol Rev (2000) 2.93
Anatomical profiling of G protein-coupled receptor expression. Cell (2008) 2.88
Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron (2006) 2.53
Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function. EMBO J (2001) 2.28
The G protein-coupled receptor rhodopsin in the native membrane. FEBS Lett (2004) 2.19
Single- and multilocus allelic variants within the GABA(B) receptor subunit 2 (GABAB2) gene are significantly associated with nicotine dependence. Am J Hum Genet (2005) 2.18
Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors. Biochem J (2001) 2.17
GPCR monomers and oligomers: it takes all kinds. Trends Neurosci (2008) 1.97
Chemokine receptor homo- or heterodimerization activates distinct signaling pathways. EMBO J (2001) 1.94
Full characterization of GPCR monomer-dimer dynamic equilibrium by single molecule imaging. J Cell Biol (2011) 1.91
Allostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapes. Pharmacol Rev (2010) 1.89
Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits. Nature (2010) 1.86
Selective gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb receptor. Neuron (2009) 1.85
Oligomerization of opioid receptors with beta 2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation. Proc Natl Acad Sci U S A (2001) 1.82
Asymmetric conformational changes in a GPCR dimer controlled by G-proteins. EMBO J (2006) 1.66
Peripheral mechanisms of pain and analgesia. Brain Res Rev (2008) 1.55
Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes. Proc Natl Acad Sci U S A (2000) 1.53
Rescue of defective G protein-coupled receptor function in vivo by intermolecular cooperation. Proc Natl Acad Sci U S A (2010) 1.50
A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor. J Biol Chem (2001) 1.49
Dual agonist occupancy of AT1-R-α2C-AR heterodimers results in atypical Gs-PKA signaling. Nat Chem Biol (2015) 1.49
GABAB receptors modulate NMDA receptor calcium signals in dendritic spines. Neuron (2010) 1.49
The Venus flytrap of periplasmic binding proteins: an ancient protein module present in multiple drug receptors. AAPS PharmSci (1999) 1.47
The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor. J Biol Chem (2004) 1.45
Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. J Physiol (2006) 1.45
Improved methodical approach for quantitative BRET analysis of G Protein Coupled Receptor dimerization. PLoS One (2014) 1.44
Regulation of neuronal GABA(B) receptor functions by subunit composition. Nat Rev Neurosci (2012) 1.36
The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx. Proc Natl Acad Sci U S A (2000) 1.36
Function of GB1 and GB2 subunits in G protein coupling of GABA(B) receptors. Proc Natl Acad Sci U S A (2001) 1.36
Inhibitory circuits and the nature of their interactions in the human motor cortex a pharmacological TMS study. J Physiol (2007) 1.34
Mutant G protein alpha subunit activated by Gbeta gamma: a model for receptor activation? Proc Natl Acad Sci U S A (2001) 1.32
Do orphan G-protein-coupled receptors have ligand-independent functions? New insights from receptor heterodimers. EMBO Rep (2006) 1.31
Mechanisms of cross-talk between G-protein-coupled receptors resulting in enhanced release of intracellular Ca2+. Biochem J (2003) 1.30
GABAB receptor modulation of synaptic function. Curr Opin Neurobiol (2011) 1.28
Glutamate, GABA and acetylcholine signaling components in the lamina of the Drosophila visual system. PLoS One (2008) 1.27
Modulation of pain transmission by G-protein-coupled receptors. Pharmacol Ther (2007) 1.26
Molecular basis for amino acid sensing by family C G-protein-coupled receptors. Br J Pharmacol (2009) 1.25
Monitoring the formation of dynamic G-protein-coupled receptor-protein complexes in living cells. Biochem J (2005) 1.24
Closure of the Venus flytrap module of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists. Proc Natl Acad Sci U S A (2002) 1.21
Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism. J Neurochem (2010) 1.17
Ligand-induced signal transduction within heterodimeric GABA(B) receptor. Proc Natl Acad Sci U S A (2001) 1.15
Allosteric modulators of g protein-coupled receptors: future therapeutics for complex physiological disorders. J Pharmacol Exp Ther (2009) 1.15
Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning. EMBO J (2008) 1.14
G-protein-coupled receptor oligomers: two or more for what? Lessons from mGlu and GABAB receptors. J Physiol (2009) 1.14
Vertebrate membrane proteins: structure, function, and insights from biophysical approaches. Pharmacol Rev (2008) 1.14
Prolonged activation of NMDA receptors promotes dephosphorylation and alters postendocytic sorting of GABAB receptors. Proc Natl Acad Sci U S A (2010) 1.14
GABA in the endocrine pancreas: its putative role as an islet cell paracrine-signalling molecule. J Gen Physiol (2004) 1.11
Dimeric arrangement of the parathyroid hormone receptor and a structural mechanism for ligand-induced dissociation. J Biol Chem (2010) 1.10
Heterodimerization and surface localization of G protein coupled receptors. Biochem Pharmacol (2006) 1.09
Asymmetry of the rhodopsin dimer in complex with transducin. FASEB J (2013) 1.08
Intermolecular interactions between dimeric calcium-sensing receptor monomers are important for its normal function. Proc Natl Acad Sci U S A (1999) 1.07
Ca2+ activity at GABAB receptors constitutively promotes metabotropic glutamate signaling in the absence of GABA. Proc Natl Acad Sci U S A (2004) 1.07
NMDA receptor-dependent GABAB receptor internalization via CaMKII phosphorylation of serine 867 in GABAB1. Proc Natl Acad Sci U S A (2010) 1.06
The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel. Proc Natl Acad Sci U S A (2000) 1.06
Gamma-aminobutyric acid B receptor mediated inhibition of gonadotropin-releasing hormone neurons is suppressed by kisspeptin-G protein-coupled receptor 54 signaling. Endocrinology (2009) 1.05
The oligomeric state sets GABA(B) receptor signalling efficacy. EMBO J (2011) 1.05
Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor. Mol Pharmacol (2011) 1.05
Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. BMC Bioinformatics (2007) 1.04
Endothelin-1 binding to endothelin receptors in the rat anterior pituitary gland: possible formation of an ETA-ETB receptor heterodimer. Cell Mol Neurobiol (2002) 1.01
Spinal nerve ligation does not alter the expression or function of GABA(B) receptors in spinal cord and dorsal root ganglia of the rat. Neuroscience (2006) 1.01
G-protein-coupled receptors for neurotransmitter amino acids: C-terminal tails, crowded signalosomes. Biochem J (2002) 1.00
The apelin receptor inhibits the angiotensin II type 1 receptor via allosteric trans-inhibition. Br J Pharmacol (2013) 0.98
Postsynaptic GABAB receptor signalling enhances LTD in mouse cerebellar Purkinje cells. J Physiol (2007) 0.98
Allosteric modulators of GABA(B) receptors: mechanism of action and therapeutic perspective. Curr Neuropharmacol (2007) 0.98
Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors. Chem Rev (2016) 0.97
Insulin signaling, lifespan and stress resistance are modulated by metabotropic GABA receptors on insulin producing cells in the brain of Drosophila. PLoS One (2010) 0.97
Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling. J Biol Chem (2012) 0.97
Heteromeric dopamine receptor signaling complexes: emerging neurobiology and disease relevance. Neuropsychopharmacology (2013) 0.96
Dimerization between vasopressin V1b and corticotropin releasing hormone type 1 receptors. Cell Mol Neurobiol (2007) 0.96
Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors. Br J Pharmacol (2008) 0.95
ABCA1 dimer-monomer interconversion during HDL generation revealed by single-molecule imaging. Proc Natl Acad Sci U S A (2013) 0.95
Roles of GABAB receptor subtypes in presynaptic auto- and heteroreceptor function regulating GABA and glutamate release. J Neural Transm (Vienna) (2008) 0.93
Drosophila pacemaker neurons require g protein signaling and GABAergic inputs to generate twenty-four hour behavioral rhythms. Neuron (2010) 0.93
GABA transporter 1 tunes GABAergic synaptic transmission at output neurons of the mouse neostriatum. J Physiol (2008) 0.93
Blockade of ethanol-induced potentiation of glycine receptors by a peptide that interferes with Gbetagamma binding. J Pharmacol Exp Ther (2009) 0.93
Development of GABAB subunits and functional GABAB receptors in rat cultured hippocampal neurons. Neuropharmacology (2004) 0.92
A novel synthetic bivalent ligand to probe chemokine receptor CXCR4 dimerization and inhibit HIV-1 entry. Biochemistry (2012) 0.92
Prefrontal cortical GABAergic dysfunction contributes to age-related working memory impairment. J Neurosci (2014) 0.92
BRET and Time-resolved FRET strategy to study GPCR oligomerization: from cell lines toward native tissues. Front Endocrinol (Lausanne) (2012) 0.92
Dendritic assembly of heteromeric gamma-aminobutyric acid type B receptor subunits in hippocampal neurons. J Biol Chem (2009) 0.92
Pharmacological chaperones for misfolded gonadotropin-releasing hormone receptors. Adv Pharmacol (2011) 0.91
GABA(B) and group I metabotropic glutamate receptors in the striatopallidal complex in primates. J Anat (2000) 0.91
Endogenous RGS proteins enhance acute desensitization of GABA(B) receptor-activated GIRK currents in HEK-293T cells. Pflugers Arch (2004) 0.91
Coordinated action of NSF and PKC regulates GABAB receptor signaling efficacy. EMBO J (2006) 0.91
Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice. Neuropharmacology (2013) 0.91
Antidepressant-like activity of CGP 36742 and CGP 51176, selective GABAB receptor antagonists, in rodents. Br J Pharmacol (2006) 0.90
Direct interaction of GABAB receptors with M2 muscarinic receptors enhances muscarinic signaling. J Neurosci (2009) 0.90
Oligomerization of G-protein-coupled receptors: lessons from the yeast Saccharomyces cerevisiae. Eukaryot Cell (2005) 0.90
GABA(A) receptors in normal development and seizures: friends or foes? Curr Neuropharmacol (2008) 0.90
Structural mechanism of ligand activation in human GABA(B) receptor. Nature (2013) 0.89
Baclofen inhibits guinea pig magnocellular neurones via activation of an inwardly rectifying K+ conductance. J Physiol (2003) 0.89
The external globus pallidus: progress and perspectives. Eur J Neurosci (2016) 0.89
GABAergic activation of an inwardly rectifying K+ current in mouse cerebellar Purkinje cells. J Physiol (2005) 0.89
Past, present and future therapeutics for cerebellar ataxias. Curr Neuropharmacol (2010) 0.88
Control of kinetic properties of AMPA receptor channels by nuclear RNA editing. Science (1994) 5.21
Molecular cloning and characterization of the rat NMDA receptor. Nature (1991) 4.45
Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophy. Nat Med (2000) 4.09
Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes Dev (1992) 3.85
Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature (1997) 3.22
Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus. Eur J Neurosci (1996) 3.22
Sequence and expression of a metabotropic glutamate receptor. Nature (1991) 2.97
Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene. Cell (1995) 2.81
Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate. J Biol Chem (1993) 2.80
Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice. Nature (1998) 2.72
Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)). Neuron (2001) 2.51
IRK(1-3) and GIRK(1-4) inwardly rectifying K+ channel mRNAs are differentially expressed in the adult rat brain. J Neurosci (1996) 2.45
Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus. Nature (1989) 2.44
A family of metabotropic glutamate receptors. Neuron (1992) 2.38
Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501. Mol Pharmacol (2001) 2.32
Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J Biol Chem (1993) 2.30
Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function. EMBO J (2001) 2.28
Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA. Nature (1991) 2.25
Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction. J Biol Chem (1992) 2.21
Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells. Cell (1994) 2.20
International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function. Pharmacol Rev (2002) 2.15
Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins. Neuron (1994) 2.15
Changing patterns of self-poisoning in a UK health district. QJM (1996) 2.13
mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science (2000) 2.09
GABAB receptors - the first 7TM heterodimers. Trends Pharmacol Sci (1999) 1.94
TASK-3, a novel tandem pore domain acid-sensitive K+ channel. An extracellular histiding as pH sensor. J Biol Chem (2000) 1.94
Molecular characterization of a functional cDNA for rat substance P receptor. J Biol Chem (1989) 1.91
C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABA(b) receptors. J Neurosci (2001) 1.90
Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide. Neuron (1992) 1.90
Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2. Science (1996) 1.81
Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats. J Comp Neurol (1994) 1.80
Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites. Neuroscience (2001) 1.80
Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor. N Engl J Med (2000) 1.76
Control of electrical activity in central neurons by modulating the gating of small conductance Ca2+-activated K+ channels. J Biol Chem (2000) 1.76
Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sites. J Chem Neuroanat (1997) 1.76
Activation of natural killer T cells by alpha-galactosylceramide in the presence of CD1d provides protection against colitis in mice. Gastroenterology (2000) 1.75
Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: an in situ hybridization study. J Comp Neurol (1993) 1.74
Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat. Neuroscience (1993) 1.69
Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone. Nature (1996) 1.69
Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination. Cell (1998) 1.69
Subunit composition of kainate receptors in hippocampal interneurons. Neuron (2000) 1.66
Increasing rate of deliberate self poisoning. BMJ (1994) 1.65
Overlapping distribution of K(ATP) channel-forming Kir6.2 subunit and the sulfonylurea receptor SUR1 in rodent brain. FEBS Lett (1997) 1.63
Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4. J Neurosci (1993) 1.63
Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat. J Comp Neurol (1994) 1.59
Secondary prevention following myocardial infarction: evidence from an audit in South Wales that the National Service Framework for coronary heart disease does not address all the issues. Qual Saf Health Care (2002) 1.57
Controlled trial of azathioprine in Crohn's disease. Lancet (1971) 1.56
Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. J Biol Chem (1994) 1.54
Kainate receptor-mediated responses in the CA1 field of wild-type and GluR6-deficient mice. J Neurosci (1999) 1.52
Nanoindentation discriminates the elastic properties of individual human bone lamellae under dry and physiological conditions. Bone (2002) 1.50
Glutamate and GABA receptor signalling in the developing brain. Neuroscience (2005) 1.48
The epithelial inward rectifier channel Kir7.1 displays unusual K+ permeation properties. J Neurosci (1998) 1.47
Expression, structure, and function of the CD23 antigen. Adv Immunol (1991) 1.46
Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb. Nature (1993) 1.46
A prospective study of amylase-rich pleural effusions with special reference to amylase isoenzyme analysis. Chest (1992) 1.42
Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex. Neuron (1994) 1.42
CGP 35348: a centrally active blocker of GABAB receptors. Eur J Pharmacol (1990) 1.40
[Palliative care. Various concepts revisited]. Rev Med Suisse Romande (1995) 1.39
[Obesity surgery: the refusal rate of health care cost reimbursement despite expert opinion]. Dtsch Med Wochenschr (2006) 1.39
Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site. Neuron (2000) 1.39
Expression pattern in brain of TASK-1, TASK-3, and a tandem pore domain K(+) channel subunit, TASK-5, associated with the central auditory nervous system. Mol Cell Neurosci (2001) 1.37
ESPEN Guidelines on Enteral Nutrition: Gastroenterology. Clin Nutr (2006) 1.36
Intracellular retention of recombinant GABAB receptors. J Biol Chem (1998) 1.33
Calmodulin dependence of presynaptic metabotropic glutamate receptor signaling. Science (1999) 1.32
Recruitment and retention program for minority and disadvantaged students. J Med Educ (1978) 1.28
Pharmacologic rescue of lethal seizures in mice deficient in succinate semialdehyde dehydrogenase. Nat Genet (2001) 1.28
Neuronal inwardly rectifying K(+) channels differentially couple to PDZ proteins of the PSD-95/SAP90 family. J Neurosci (2000) 1.28
Sleep related human growth hormone (GH) release: a test of physiologic growth hormone secretion in children. J Clin Endocrinol Metab (1972) 1.27
GABAB receptor protein and mRNA distribution in rat spinal cord and dorsal root ganglia. Eur J Neurosci (2000) 1.27
Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion. J Neurosci (1999) 1.26
Immunohistochemical study of a rat membrane protein which induces a selective potassium permeation: its localization in the apical membrane portion of epithelial cells. J Membr Biol (1990) 1.25
The N-terminal domain of gamma-aminobutyric Acid(B) receptors is sufficient to specify agonist and antagonist binding. Mol Pharmacol (1999) 1.24
Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei. J Neurosci (1998) 1.24
Pre- and postsynaptic localization of a metabotropic glutamate receptor, mGluR2, in the rat brain: an immunohistochemical study with a monoclonal antibody. Neurosci Lett (1996) 1.24
Immunohistochemical localization of metabotropic glutamate receptors, mGluR7a and mGluR7b, in the central nervous system of the adult rat and mouse: a light and electron microscopic study. J Comp Neurol (1998) 1.23
Localization of metabotropic GABA receptor subunits GABAB1 and GABAB2 relative to synaptic sites in the rat developing cerebellum. Eur J Neurosci (2006) 1.23
The effects of GABA(B) agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat. Pain (2001) 1.22
THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. J Biol Chem (2000) 1.20
The metabotropic GABAB receptor directly interacts with the activating transcription factor 4. J Biol Chem (2000) 1.19
Distribution of the messenger RNA for the prostaglandin E receptor subtype EP3 in the mouse nervous system. Neuroscience (1994) 1.19
Immunological and functional characteristics of peripheral blood and synovial fluid lymphocytes from patients with rheumatoid arthritis. Scand J Immunol (1978) 1.19
Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: involvement of serine 269 of the GABA(B)R1 subunit. Mol Pharmacol (2000) 1.19