Protein kinase C beta II specifically binds to and is activated by F-actin.

PubWeight™: 1.05‹?› | Rank: Top 15%

🔗 View Article (PMID 8663149)

Published in J Biol Chem on June 28, 1996

Authors

G C Blobe1, D S Stribling, D Fabbro, S Stabel, Y A Hannun

Author Affiliations

1: Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.

Articles citing this

The extended protein kinase C superfamily. Biochem J (1998) 5.84

Structural basis of protein kinase C isoform function. Physiol Rev (2008) 4.00

Protein kinase Cbeta is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice. J Pharmacol Exp Ther (2008) 1.31

Fungal metabolite gliotoxin inhibits assembly of the human respiratory burst NADPH oxidase. Infect Immun (2004) 1.27

Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCbetaII messenger ribonucleic acid. Endocrinology (2008) 1.24

Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function. Pharmacol Res (2007) 1.10

Protein kinase C and cancer: what we know and what we do not. Oncogene (2013) 1.09

Protein kinase Cepsilon actin-binding site is important for neurite outgrowth during neuronal differentiation. Mol Biol Cell (2002) 1.02

Changes in gene expression and cellular architecture in an ovarian cancer progression model. PLoS One (2011) 1.01

Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk. Proc Natl Acad Sci U S A (2000) 1.00

Protein kinase Cβ is a modulator of the dopamine D2 autoreceptor-activated trafficking of the dopamine transporter. J Neurochem (2013) 0.91

Activation of protein kinase C beta II by the stereo-specific phosphatidylserine receptor is required for phagocytosis of apoptotic thymocytes by resident murine tissue macrophages. J Biol Chem (2002) 0.90

A single point mutation in the V3 region affects protein kinase Calpha targeting and accumulation at cell-cell contacts. Mol Cell Biol (2001) 0.88

Diabetes-induced increased oxidative stress in cardiomyocytes is sustained by a positive feedback loop involving Rho kinase and PKCβ2. Am J Physiol Heart Circ Physiol (2012) 0.85

Distribution of protein kinase C isoforms after infection of macrophages with Leishmania major. Infect Immun (1998) 0.84

Functional involvement of protein kinase C-betaII and its substrate, myristoylated alanine-rich C-kinase substrate (MARCKS), in insulin-stimulated glucose transport in L6 rat skeletal muscle cells. Diabetologia (2009) 0.82

Protein kinase C regulation of K+ currents in rat ventricular myocytes and its modification by hormonal status. J Physiol (1999) 0.80

Regulation of GLUT1-mediated glucose uptake by PKClambda-PKCbeta(II) interactions in 3T3-L1 adipocytes. Biochem J (2004) 0.78

Articles by these authors

Programmed cell death induced by ceramide. Science (1993) 5.43

The complete primary structure of protein kinase C--the major phorbol ester receptor. Science (1986) 4.02

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J Biol Chem (1986) 3.05

Immunodeficiency in protein kinase cbeta-deficient mice. Science (1996) 2.79

Ceramide activates heterotrimeric protein phosphatase 2A. J Biol Chem (1993) 2.77

Role of phospholipase in generating lipid second messengers in signal transduction. FASEB J (1991) 2.56

The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol (2013) 2.48

Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase. Nat Med (1996) 2.39

The release of growth arrest by microinjection of adenovirus E1A DNA. EMBO J (1985) 2.32

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation. J Biol Chem (1989) 2.32

A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy. Cancer Res (2000) 2.32

Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses. Science (1987) 2.29

Pleiotropic control of glucose and hormone responses by PRL1, a nuclear WD protein, in Arabidopsis. Genes Dev (1998) 2.23

Ceramide and apoptosis. Trends Biochem Sci (1999) 2.19

Down-regulation of protein kinase C is due to an increased rate of degradation. Biochem J (1987) 2.14

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid. EMBO J (1995) 2.14

Interaction of protein kinase C zeta with ZIP, a novel protein kinase C-binding protein. Proc Natl Acad Sci U S A (1997) 2.11

Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine. J Biol Chem (1985) 2.11

Activation of the c-Raf protein kinase by protein kinase C phosphorylation. Oncogene (1992) 2.04

Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J Biol Chem (1990) 1.99

Purification to homogeneity of protein kinase C from bovine brain--identity with the phorbol ester receptor. EMBO J (1984) 1.97

Retracted A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity. Int J Cancer (1989) 1.93

Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. J Biol Chem (1997) 1.88

Role for ceramide in cell cycle arrest. J Biol Chem (1995) 1.83

Protein kinase C--a family affair. Mol Cell Endocrinol (1989) 1.81

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells. Curr Biol (1994) 1.80

Integration sites of adenovirus type 12 DNA in transformed hamster cells and hamster tumor cells. J Virol (1980) 1.79

Induction of apoptosis in small-cell lung cancer cells by an antisense oligodeoxynucleotide targeting the Bcl-2 coding sequence. J Natl Cancer Inst (1997) 1.78

Molecular cloning and characterization of a human mitochondrial ceramidase. J Biol Chem (2000) 1.76

Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J Biol Chem (2000) 1.73

Ceramide stimulates a cytosolic protein phosphatase. J Biol Chem (1992) 1.72

Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans. Genes Dev (2001) 1.72

Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science (1994) 1.71

Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. Cancer Res (2001) 1.71

Tissue and cellular distribution of the extended family of protein kinase C isoenzymes. J Cell Biol (1992) 1.69

The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. J Biol Chem (1997) 1.69

Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2. Eur J Biochem (1995) 1.69

Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C? J Biol Chem (1998) 1.67

Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae. J Biol Chem (2000) 1.65

Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols. Proc Natl Acad Sci U S A (1986) 1.63

Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid. J Biol Chem (1999) 1.63

Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide. J Biol Chem (1993) 1.63

FADD is required for multiple signaling events downstream of the receptor Fas. Cell Growth Differ (1999) 1.62

Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity. Proc Natl Acad Sci U S A (1995) 1.62

The role of ceramide in cell signaling. Biochim Biophys Acta (1998) 1.59

Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4. J Natl Cancer Inst (2001) 1.59

Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha. J Biol Chem (1994) 1.55

Bcl-2 interrupts the ceramide-mediated pathway of cell death. Proc Natl Acad Sci U S A (1996) 1.53

Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion. Am J Pathol (1997) 1.52

Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death. J Biol Chem (1998) 1.52

The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts. Oncogene (1993) 1.50

Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties. J Biol Chem (1996) 1.49

Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis. FASEB J (2001) 1.45

Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae. J Biol Chem (1993) 1.43

Quantitative determination of ceramide using diglyceride kinase. Methods Enzymol (2000) 1.41

Ceramide: an endogenous regulator of apoptosis and growth suppression. Immunol Today (1995) 1.40

Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. J Biol Chem (1994) 1.40

Signalling from TPA to MAP kinase requires protein kinase C, raf and MEK: reconstitution of the signalling pathway in vitro. Oncogene (1994) 1.38

Gaucher disease: genetic heterogeneity within and among the subtypes detected by immunoblotting. Am J Hum Genet (1987) 1.38

Protein kinase C and mammary cell differentiation: involvement of protein kinase C alpha in the induction of beta-casein expression. Cell Growth Differ (1994) 1.37

Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases. J Biol Chem (1986) 1.35

Selectivity in integration sites of adenoviral DNA. Cold Spring Harb Symp Quant Biol (1980) 1.35

A molecular code dictates sequence-specific DNA recognition by homeodomains. EMBO J (1996) 1.34

Site of linkage between adenovirus type 12 and cell DNAs in hamster tumour line CLAC3. Nature (1981) 1.34

Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase. Proc Natl Acad Sci U S A (1996) 1.34

Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor. Am J Pathol (1999) 1.34

Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C. Cell Signal (1995) 1.34

Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. J Biol Chem (1997) 1.33

Ceramide activates the stress-activated protein kinases. J Biol Chem (1995) 1.33

Imatinib: a selective tyrosine kinase inhibitor. Eur J Cancer (2002) 1.32

FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase 1. J Biol Chem (2001) 1.29

Expression of four protein kinase C isoforms in rat fibroblasts. Distinct subcellular distribution and regulation by calcium and phorbol esters. J Biol Chem (1992) 1.29

Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione. J Biol Chem (1997) 1.29

Immunocytochemical expression of tissue specific transcription factor-1 in lung carcinoma. J Clin Pathol (1997) 1.29

Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis. J Biol Chem (1997) 1.29

Effect of VEGF receptor inhibitor PTK787/ZK222584 [correction of ZK222548] combined with ionizing radiation on endothelial cells and tumour growth. Br J Cancer (2001) 1.28

EGF induces biphasic S6 kinase activation: late phase is protein kinase C-dependent and contributes to mitogenicity. Cell (1989) 1.28

Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B. J Biol Chem (1993) 1.27

Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. J Biol Chem (2000) 1.26

Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae. J Biol Chem (2000) 1.25

Regulation of protein kinase C and role in cancer biology. Cancer Metastasis Rev (1994) 1.25

Quantitation of protein kinase C by immunoblot--expression in different cell lines and response to phorbol esters. J Cell Physiol (1987) 1.25

Sequence-specific DNA recognition by the thyroid transcription factor-1 homeodomain. Nucleic Acids Res (1994) 1.25

Modulation of ceramide metabolism enhances viral protein apoptin's cytotoxicity in prostate cancer. Mol Ther (2006) 1.24

Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest. Proc Natl Acad Sci U S A (1995) 1.24

Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria. J Biol Chem (2001) 1.24

Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha. J Biol Chem (1993) 1.23

Protein kinase C activation in mixed micelles. Mechanistic implications of phospholipid, diacylglycerol, and calcium interdependencies. J Biol Chem (1986) 1.23

Determination of ceramides and diglycerides by the diglyceride kinase assay. Anal Biochem (2001) 1.23

(1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase. J Biol Chem (1996) 1.23

Ceramide: a stress signal and mediator of growth suppression and apoptosis. J Cell Biochem (1995) 1.23

Studies on the phosphorylation of protein kinase C-alpha. Biochem J (1992) 1.22

Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J Biol Chem (1994) 1.21

Pyrrolopyrimidine c-Src inhibitors reduce growth, adhesion, motility and invasion of prostate cancer cells in vitro. Eur J Cancer (2003) 1.20

On the mechanism of recombination between adenoviral and cellular DNAs: the structure of junction sites. Curr Top Microbiol Immunol (1984) 1.20

The use of diglyceride kinase for quantifying ceramide. Trends Biochem Sci (1999) 1.20