PubRank

D M Klinman

Author PubWeight™ 110.73‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 1995 12.24
2 DNA vaccines: immunology, application, and optimization*. Annu Rev Immunol 2000 4.51
3 Varicella vaccination: evidence for frequent reactivation of the vaccine strain in healthy children. Nat Med 2000 3.07
4 Systemic autoimmune disease arises from polyclonal B cell activation. J Exp Med 1987 2.71
5 Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs. J Immunol 2001 2.61
6 Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells. J Immunol 2001 2.49
7 Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria. J Immunol 1999 2.23
8 Genomic DNA released by dying cells induces the maturation of APCs. J Immunol 2001 2.03
9 Human immunodeficiency virus infection induces both polyclonal and virus-specific B cell activation. J Clin Invest 1992 1.84
10 Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expression. J Exp Med 1997 1.73
11 Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides. J Immunol 1999 1.58
12 Distinct patterns of cytokine secretion characterize new onset synovitis versus chronic rheumatoid arthritis. J Rheumatol 1998 1.55
13 A plasmid encoding murine granulocyte-macrophage colony-stimulating factor increases protection conferred by a malaria DNA vaccine. J Immunol 1998 1.54
14 Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides. Proc Natl Acad Sci U S A 1999 1.48
15 Rapid immune activation by CpG motifs in bacterial DNA. Systemic induction of IL-6 transcription through an antioxidant-sensitive pathway. J Immunol 1996 1.46
16 Studies of consomic mice bearing the Y chromosome of the BXSB mouse. J Immunol 1985 1.44
17 Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides. J Immunol 2001 1.33
18 Autoimmunity and increased c-myb transcription. Science 1984 1.27
19 Complexity of the cytokine and antibody response elicited by immunizing mice with Plasmodium yoelii circumsporozoite protein plasmid DNA. J Immunol 1995 1.24
20 Microbial products induce autoimmune disease by an IL-12-dependent pathway. J Immunol 1997 1.21
21 Protection against anthrax toxin by vaccination with a DNA plasmid encoding anthrax protective antigen. Vaccine 1999 1.20
22 CpG oligodeoxynucleotides and interleukin-12 improve the efficacy of Mycobacterium bovis BCG vaccination in mice challenged with M. tuberculosis. Infect Immun 2000 1.19
23 Proliferation of anti-DNA-producing NZB B cells in a non-autoimmune environment. J Immunol 1986 1.17
24 Oncogene expression in autoimmune and normal peripheral blood mononuclear cells. J Exp Med 1986 1.15
25 Simultaneous induction of multiple antigen-specific cytotoxic T lymphocytes in nonhuman primates by immunization with a mixture of four Plasmodium falciparum DNA plasmids. Infect Immun 1998 1.09
26 Induction of neonatal tolerance by plasmid DNA vaccination of mice. J Clin Invest 1996 1.08
27 Efficacy, immunogenicity, safety, and use of live attenuated chickenpox vaccine. J Pediatr 1995 1.08
28 Sequence analysis and expression of an X-linked, lymphocyte-regulated gene family (XLR). J Exp Med 1987 1.07
29 Sex hormone levels correlate with the activity of cytokine-secreting cells in vivo. Immunology 2000 1.06
30 NIH conference. Systemic lupus erythematosus. Ann Intern Med 1991 1.06
31 Theoretical and experimental approaches to generalized autoimmunity. Immunol Rev 1990 1.03
32 Plasmid DNA encoding transforming growth factor-beta1 suppresses chronic disease in a streptococcal cell wall-induced arthritis model. J Clin Invest 1998 1.03
33 Heterogeneous expression and coordinate regulation of endogenous retroviral sequences in human peripheral blood mononuclear cells. AIDS Res Hum Retroviruses 1992 1.02
34 Pathogenesis of systemic lupus erythematosus. Rheum Dis Clin North Am 1988 1.02
35 CpG motifs of DNA vaccines induce the expression of chemokines and MHC class II molecules on myocytes. Eur J Immunol 2001 1.01
36 Bone marrow and thymus expression of interferon-gamma results in severe B-cell lineage reduction, T-cell lineage alterations, and hematopoietic progenitor deficiencies. Blood 1997 1.00
37 CpG oligodeoxynucleotides induce murine macrophages to up-regulate chemokine mRNA expression. Cell Immunol 2000 0.99
38 A suppressive oligodeoxynucleotide inhibits ocular inflammation. Clin Exp Immunol 2009 0.98
39 IgE receptor-positive non-B/non-T cells dominate the production of interleukin 4 and interleukin 6 in immunized mice. Proc Natl Acad Sci U S A 1995 0.98
40 Individual cells simultaneously produce both IL-4 and IL-6 in vivo. Cytokine 1994 0.98
41 Disassociation of sex hormone levels and cytokine production in SLE patients. Lupus 2001 0.96
42 Multivalent cross-linking of membrane Ig sensitizes murine B cells to a broader spectrum of CpG-containing oligodeoxynucleotide motifs, including their methylated counterparts, for stimulation of proliferation and Ig secretion. Int Immunol 1999 0.96
43 Toward clinical trials of DNA vaccines against malaria. Immunol Cell Biol 1997 0.95
44 The interaction of the xid and me genes. J Immunol 1987 0.95
45 Do DNA vaccines induce autoimmune disease? Hum Gene Ther 1997 0.95
46 Response of peripheral blood mononuclear cells from lupus patients to stimulation by CpG oligodeoxynucleotides. Rheumatology (Oxford) 2003 0.95
47 Autoantibody production is associated with polyclonal B cell activation in autoimmune mice which express the lpr or gld genes. Eur J Immunol 1988 0.95
48 Activation of microglia and astrocytes by CpG oligodeoxynucleotides. Neuroreport 2001 0.95
49 NIH conference. Angioimmunoblastic lymphadenopathy with dysproteinemia. Ann Intern Med 1988 0.93
50 Phenotype and frequency of cells secreting IL-2, IL-4, IL-6, IL-10, IFN and TNF-alpha in human peripheral blood. Cytokine 1995 0.93
51 Prime-boost vaccination with plasmid DNA and a chimeric adenovirus type 5 vector with type 35 fiber induces protective immunity against HIV. Gene Ther 2005 0.92
52 Murine cytomegalovirus infection-induced polyclonal B cell activation is independent of CD4+ T cells and CD40. Virology 1998 0.92
53 Immune responses in asymptomatic HIV-1-infected patients after HIV-DNA immunization followed by highly active antiretroviral treatment. J Immunol 1999 0.90
54 Altered frequency of type 1 cytokine secreting cells in the peripheral blood of patients with primary Sjögren's syndrome. J Rheumatol 1998 0.90
55 Increased activation and altered ratio of interferon-gamma: interleukin-4 secreting cells in MRL-lpr/lpr mice. Autoimmunity 1995 0.90
56 DNAse treatment does not improve the survival of lupus prone (NZB x NZW)F1 mice. Lupus 1998 0.90
57 Effect of HIV infection on the frequency of cytokine-secreting cells in human peripheral blood. AIDS Res Hum Retroviruses 1996 0.90
58 IFN-gamma is a potent inducer of Ig secretion by sort-purified murine B cells activated through the mIg, but not the CD40, signaling pathway. Int Immunol 1996 0.89
59 The natural history of disease expression in CD4 and CD8 gene-deleted New Zealand black (NZB) mice. J Immunol 1996 0.89
60 Factors associated with the development of neonatal tolerance after the administration of a plasmid DNA vaccine. J Immunol 1999 0.88
61 Effects of bacterial DNA on cytokine production by (NZB/NZW)F1 mice. J Immunol 1998 0.87
62 Idiotypy and autoimmunity. Arthritis Rheum 1986 0.85
63 Response of porcine peripheral blood mononuclear cells to CpG-containing oligodeoxynucleotides. Vet Microbiol 2001 0.84
64 Genetic studies in NZB mice. VI. Association of autoimmune traits in recombinant inbred lines. J Immunol 1984 0.84
65 Contribution of interleukin-3 to antigen-induced Th2 cytokine production. Eur J Immunol 1996 0.84
66 Activity and safety of DNA plasmids encoding IL-4 and IFN gamma. Gene Ther 1999 0.83
67 Positive and negative regulatory elements contribute to CpG oligonucleotide-mediated regulation of human IL-6 gene expression. Eur J Immunol 2000 0.83
68 CpG ODN-mediated regulation of IL-12 p40 transcription. Eur J Immunol 2000 0.83
69 The regulation of DNA vaccines. Curr Opin Biotechnol 2001 0.82
70 Abnormal numbers of cytokine producing cells in patients with polymyositis and dermatomyositis. Clin Exp Rheumatol 1997 0.82
71 Quantitation of autoantibody-secreting B cells in systemic lupus erythematosus. Autoimmunity 1989 0.80
72 Mouse monoclonal antibodies to human immunodeficiency virus glycoprotein 120 generated by repeated immunization with glycoprotein 120 from a single isolate, or by sequential immunization with glycoprotein 120 from three isolates. Hybridoma 1995 0.80
73 Prevention of neonatal tolerance by a plasmid encoding granulocyte-macrophage colony stimulating factor. Vaccine 1999 0.80
74 Modulation of c-myb transcription in autoimmune disease by cyclophosphamide. J Immunol 1985 0.79
75 Long-term effect of primary immunization on subsequent immune responsiveness. Cell Immunol 1997 0.79
76 Preserving primary cDNA libraries. Anal Biochem 1987 0.79
77 Analysis of B-cell subpopulations. I. Relationships among splenic xid, Ly 1+, and Lyb 5+ B cells. Cell Immunol 1985 0.78
78 Dialyzable serum components can support the growth of hybridoma cell lines in vitro. J Immunol Methods 1981 0.78
79 Immunization with recombinant gp160 prolongs the survival of HIV-1 transgenic mice. AIDS Res Hum Retroviruses 1993 0.78
80 Effect of anti-Ia treatment on the production of anti-DNA antibody by NZB mice. Eur J Immunol 1986 0.78
81 Genetic and molecular genetic studies of murine and human lupus. J Rheumatol Suppl 1987 0.77
82 Administration of a phosphorothioate oligonucleotide antisense to murine endogenous retroviral MCF env causes immune effects in vivo in a sequence-specific manner. Clin Immunol Immunopathol 1993 0.77
83 Lack of correlation between the number of circulating B cells and the concentration of serum antibodies reactive with the HIV-1 envelope glycoprotein. J Acquir Immune Defic Syndr 1994 0.77
84 Cross-reactivity of IgM- and IgG-secreting B cells in autoimmune mice. Arthritis Rheum 1993 0.76
85 The genetic basis of autoimmune disease in MRL-lpr/lpr mice. Int Rev Immunol 1994 0.76
86 Treatment with dextran-conjugated anti-IgD delays the development of autoimmunity in MRL-lpr/lpr mice. J Immunol 1994 0.76
87 Contribution of mast cells to the T helper 2 response induced by simultaneous subcutaneous and oral immunization. Immunology 1999 0.76
88 Disseminated rashes and varicella vaccine. Pediatr Infect Dis J 2001 0.75
89 Cross-reactivity of IgM- and IgG-secreting B cells in murine chronic graft-versus-host reaction. Clin Immunol Immunopathol 1994 0.75
90 Development of a diphtheria toxin mutant conjugate directed against antigen-specific B cells expressing high affinity surface Ig. J Immunol 1990 0.75
91 Transfer of anti-DNA-producing B cells from NZB to unmanipulated xid recipients: effects of age, sex, and environment. Clin Immunol Immunopathol 1987 0.75
92 Analysis of nondominant idiotypes expressed during alloimmune responses. Cell Immunol 1984 0.75
93 Studies of marrow progenitor abnormalities in lupus-prone mice. II. Further studies of NZB Thy 1(neg)Lin(neg) bone marrow cells. Clin Immunol Immunopathol 1994 0.75
94 Antibodies from patients and mice with autoimmune diseases react with recombinant hnRNP core protein A1. J Autoimmun 1988 0.75
95 Studies of the effects of Y chromosome factors on the expression of autoimmune disease. Ann N Y Acad Sci 1986 0.75
96 Class I major histocompatibility gene products of the brown Norway rat display two major antigenic regions. J Immunol 1982 0.75
97 Activation of IL-4 and IL-6 secreting cells by antigen. Cytokine 1995 0.75
98 Effect of cyclophosphamide therapy on oncogene expression in angioimmunoblastic lymphadenopathy. Lancet 1986 0.75
99 Increased utilization of polyreactive B cells during periods of generalized immune activation. Autoimmunity 1995 0.75