Published in Cell on June 14, 1996
The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth. EMBO J (1996) 3.78
Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. EMBO J (1997) 3.27
A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling. Mol Cell Biol (2000) 3.04
Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast. EMBO J (1998) 2.75
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses. J Cell Biol (2000) 2.48
Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation. Mol Cell Biol (1998) 2.35
P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: correlation of physical and cytogenetic maps in chromosomal region 86E-87F. Genetics (1997) 2.14
The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase. Mol Cell Biol (2000) 2.07
Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2. Mol Cell Biol (2002) 2.03
Essential role of Gab1 for signaling by the c-Met receptor in vivo. J Cell Biol (2000) 1.97
Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity. Mol Cell Biol (2000) 1.94
Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway. Mol Cell Biol (1999) 1.93
Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation. Mol Cell Biol (2000) 1.92
Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2. Mol Cell Biol (1999) 1.79
A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development. Mol Cell Biol (1997) 1.77
The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase. Mol Cell Biol (1999) 1.67
Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase. Mol Cell Biol (1998) 1.66
The heat shock protein 83 (Hsp83) is required for Raf-mediated signalling in Drosophila. EMBO J (1997) 1.66
Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages. Mol Cell Biol (1998) 1.61
Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. J Cell Biol (2001) 1.52
Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps. Mol Cell Biol (2000) 1.38
The cyclin-dependent kinase inhibitor Dacapo promotes replication licensing during Drosophila endocycles. EMBO J (2007) 1.30
Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals. Proc Natl Acad Sci U S A (1999) 1.29
Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development. Dev Dyn (2005) 1.21
Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells. Mol Cell Biol (2004) 1.15
PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2. EMBO J (2002) 1.14
An F1 genetic screen for maternal-effect mutations affecting embryonic pattern formation in Drosophila melanogaster. Genetics (2004) 1.09
Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinase. Mol Cell Biol (2001) 1.07
A transgenic Drosophila model demonstrates that the Helicobacter pylori CagA protein functions as a eukaryotic Gab adaptor. PLoS Pathog (2008) 1.07
Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo. Proc Natl Acad Sci U S A (2007) 1.06
Gab3, a new DOS/Gab family member, facilitates macrophage differentiation. Mol Cell Biol (2002) 1.06
Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis. Mol Biol Cell (2002) 1.04
The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction. Mol Cell Biol (2001) 1.01
Tyrosine phosphorylation of p62dok by p210bcr-abl inhibits RasGAP activity. Proc Natl Acad Sci U S A (2000) 1.00
Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals. EMBO J (2000) 1.00
A role for the SHP-2 tyrosine phosphatase in nerve growth-induced PC12 cell differentiation. Mol Biol Cell (1997) 0.96
A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila. PLoS Biol (2014) 0.95
Activation of the Drosophila C3G leads to cell fate changes and overproliferation during development, mediated by the RAS-MAPK pathway and RAP1. EMBO J (1999) 0.95
Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent. Mol Cell Biol (2003) 0.94
Analysis of corkscrew signaling in the Drosophila epidermal growth factor receptor pathway during myogenesis. Genetics (2001) 0.93
A dual role for the adaptor protein DRK in Drosophila olfactory learning and memory. J Neurosci (2009) 0.91
Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation. Mol Cell Biol (2002) 0.89
Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: identification, molecular cloning and effects on cell migration. Biochem J (2003) 0.87
Disabled is a putative adaptor protein that functions during signaling by the sevenless receptor tyrosine kinase. Mol Cell Biol (1998) 0.87
Identification of genomic regions that interact with a viable allele of the Drosophila protein tyrosine phosphatase corkscrew. Genetics (2000) 0.87
Identification of autosomal regions involved in Drosophila Raf function. Genetics (2000) 0.87
Gab docking proteins in cardiovascular disease, cancer, and inflammation. Int J Inflam (2013) 0.85
Deconstructing host-pathogen interactions in Drosophila. Dis Model Mech (2011) 0.84
The adaptor protein soc-1/Gab1 modifies growth factor receptor output in Caenorhabditis elegans. Genetics (2006) 0.83
Receptor tyrosine kinases in Drosophila development. Cold Spring Harb Perspect Biol (2013) 0.83
Expression of Gab1 lacking the pleckstrin homology domain is associated with neoplastic progression. Mol Cell Biol (2001) 0.80
DRK/DOS/SOS converge with Crk/Mbc/dCed-12 to activate Rac1 during glial engulfment of axonal debris. Proc Natl Acad Sci U S A (2014) 0.79
Insulin receptor-mediated signaling via phospholipase C-γ regulates growth and differentiation in Drosophila. PLoS One (2011) 0.78
Synergistic activities of multiple phosphotyrosine residues mediate full signaling from the Drosophila Torso receptor tyrosine kinase. Proc Natl Acad Sci U S A (1999) 0.78
Gab adapter proteins as therapeutic targets for hematologic disease. Adv Hematol (2011) 0.78
Phosphatidylinositol 3'-kinase associates with an insulin receptor substrate-1 serine kinase distinct from its intrinsic serine kinase. Biochem J (1998) 0.76
Apical accumulation of the Sevenless receptor tyrosine kinase during Drosophila eye development is promoted by the small GTPase Rap1. Genetics (2014) 0.75
Protein tyrosine phosphatase-1B regulates the tyrosine phosphorylation of the adapter Grb2-associated binder 1 (Gab1) in the retina. Cell Commun Signal (2013) 0.75
The sequence of the human genome. Science (2001) 101.55
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science (1997) 16.09
Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association. Nat Genet (2001) 13.05
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell (1997) 12.83
Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science (2001) 7.85
An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem (1999) 6.88
Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science (2001) 6.84
Drosophila S6 kinase: a regulator of cell size. Science (1999) 6.76
A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes. Nature (1984) 6.62
An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr Biol (2001) 6.15
Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4. Cell (1999) 5.38
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A (1999) 4.90
Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell (1995) 4.73
Adenovirus E1A activation domain binds the basic repeat in the TATA box transcription factor. Cell (1991) 4.66
Genetic evidence for selective transport of opsin and arrestin by kinesin-II in mammalian photoreceptors. Cell (2000) 4.51
Activation of memory circuits during cue-elicited cocaine craving. Proc Natl Acad Sci U S A (1996) 4.31
SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol Cell Biol (2000) 4.30
Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev (2000) 4.05
Raf functions downstream of Ras1 in the Sevenless signal transduction pathway. Nature (1992) 4.03
Hippocampal and entorhinal atrophy in mild cognitive impairment: prediction of Alzheimer disease. Neurology (2007) 3.97
A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. Cell (1993) 3.94
The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth. EMBO J (1996) 3.78
A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat Genet (2000) 3.63
Statistical power and optimal design for multisite randomized trials. Psychol Methods (2000) 3.58
Olfactory deficits in patients with mild cognitive impairment predict Alzheimer's disease at follow-up. Am J Psychiatry (2000) 3.54
Disrupted circadian rhythms in VIP- and PHI-deficient mice. Am J Physiol Regul Integr Comp Physiol (2003) 3.37
Size and shape effects in the biodistribution of intravascularly injected particles. J Control Release (2009) 3.08
CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFβ signaling. Oncogene (2011) 3.08
Sevenless, a cell-specific homeotic gene of Drosophila, encodes a putative transmembrane receptor with a tyrosine kinase domain. Science (1987) 3.06
A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways. Cell (1994) 3.04
Relapse to cocaine-seeking after hippocampal theta burst stimulation. Science (2001) 2.97
Clinical and molecular cytogenetic characterisation of a newly recognised microdeletion syndrome involving 2p15-16.1. J Med Genet (2006) 2.97
Lead exposure and intelligence in 7-year-old children: the Yugoslavia Prospective Study. Environ Health Perspect (1997) 2.88
Functional deficits in patients with mild cognitive impairment: prediction of AD. Neurology (2002) 2.79
The biological lifetime of nitric oxide: implications for the perivascular dynamics of NO and O2. Proc Natl Acad Sci U S A (2001) 2.75
Highly purified recombinant adeno-associated virus vectors are biologically active and free of detectable helper and wild-type viruses. Hum Gene Ther (1999) 2.73
Spatial distribution of transcripts from the segmentation gene fushi tarazu during Drosophila embryonic development. Cell (1984) 2.72
The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye. Genes Dev (1996) 2.71
A transmission/disequilibrium test that allows for genotyping errors in the analysis of single-nucleotide polymorphism data. Am J Hum Genet (2001) 2.68
Study of 962 patients indicates progressive muscular atrophy is a form of ALS. Neurology (2009) 2.60
PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development. Development (1999) 2.56
Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53. Genes Dev (1994) 2.54
Spatial distribution of Antennapedia transcripts during Drosophila development. EMBO J (1983) 2.50
The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway. Nature (1994) 2.44
Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains. J Biol Chem (2000) 2.43
Estrogen-related receptor alpha 1 functionally binds as a monomer to extended half-site sequences including ones contained within estrogen-response elements. Mol Endocrinol (1997) 2.34
Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Cell (1999) 2.33
Synergistic cooperation of TFE3 and smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 gene. Genes Dev (1998) 2.29
Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3'-kinase SH2 domains: a model for SH2-mediated receptor-target interactions. EMBO J (1992) 2.29
Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus. Science (1996) 2.28
An international two-stage genome-wide search for schizophrenia susceptibility genes. Nat Genet (1995) 2.26
The Yugoslavia Prospective Lead Study: contributions of prenatal and postnatal lead exposure to early intelligence. Neurotoxicol Teratol (2001) 2.25
NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation. Oncogene (2011) 2.22
Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye. Cell (1991) 2.20
Ginsenoside-Rd improves outcome of acute ischaemic stroke - a randomized, double-blind, placebo-controlled, multicenter trial. Eur J Neurol (2012) 2.18
Regulation of Antennapedia transcript distribution by the bithorax complex in Drosophila. Nature (1984) 2.16
An epidemiological study of insomnia among the Japanese general population. Sleep (2000) 2.09
Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors. Ann N Y Acad Sci (2001) 2.09
Genetic control of cell size. Curr Opin Genet Dev (2000) 2.08
Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway. Oncogene (2007) 2.07
SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling. Proc Natl Acad Sci U S A (1999) 2.06
Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrite reduction. Evaluation of its role in nitric oxide generation in anoxic tissues. J Biol Chem (2001) 2.06
The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway. EMBO J (1994) 2.06
Delayed dark-adaptation and lipofuscin accumulation in abcr+/- mice: implications for involvement of ABCR in age-related macular degeneration. Invest Ophthalmol Vis Sci (2001) 2.05
Reelin gene alleles and susceptibility to autism spectrum disorders. Mol Psychiatry (2002) 2.05
Social networks, social support, and mortality among older people in Japan. J Gerontol (1994) 2.01
Predicting global atmospheric ice nuclei distributions and their impacts on climate. Proc Natl Acad Sci U S A (2010) 2.00
Inactivation of erythropoietin leads to defects in cardiac morphogenesis. Development (1999) 2.00
Serum leptin level is a regulator of bone mass. Proc Natl Acad Sci U S A (2004) 1.99
The regulation of glucose-excited neurons in the hypothalamic arcuate nucleus by glucose and feeding-relevant peptides. Diabetes (2004) 1.96
Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling. Mol Cell (1999) 1.91
G protein signaling from activated rat frizzled-1 to the beta-catenin-Lef-Tcf pathway. Science (2001) 1.90
Molecular interactions between Vestigial and Scalloped promote wing formation in Drosophila. Genes Dev (1998) 1.89
Reduced neurogenesis after neonatal seizures. J Neurosci (2001) 1.89
Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells. Proc Natl Acad Sci U S A (1994) 1.88
Adenovirus-mediated heme oxygenase-1 gene delivery inhibits injury-induced vascular neointima formation. Circulation (2001) 1.88
Nanolitre liquid patterning in aqueous environments for spatially defined reagent delivery to mammalian cells. Nat Mater (2009) 1.87
Rescue of the Drosophila phototransduction mutation trp by germline transformation. Science (1985) 1.85
Efficient asymmetric synthesis of biologically important tryptophan analogues via a palladium-mediated heteroannulation reaction. J Org Chem (2001) 1.85
Improved dual-energy material discrimination for dual-source CT by means of additional spectral filtration. Med Phys (2009) 1.85
PDK1 regulates growth through Akt and S6K in Drosophila. Proc Natl Acad Sci U S A (2001) 1.85
Deficiency in fatty acid synthase leads to premature cell death and dramatic alterations in plant morphology. Plant Cell (2000) 1.84
Targeted mutation in the col5a2 gene reveals a regulatory role for type V collagen during matrix assembly. Nat Genet (1995) 1.83
Protective CD4+ and CD8+ T cells against influenza virus induced by vaccination with nucleoprotein DNA. J Virol (1998) 1.82
miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells. Cell Death Differ (2009) 1.82
Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo. Circulation (1999) 1.82
Family-based linkage disequilibrium mapping using SNP marker haplotypes: application to a potential locus for schizophrenia at chromosome 22q11. Mol Psychiatry (2000) 1.81
Priming of cytotoxic T lymphocytes by DNA vaccines: requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes. Mol Med (1997) 1.81
Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution. Proc Natl Acad Sci U S A (1997) 1.80
Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain. Cell (1988) 1.80
A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC. J Biol Chem (2001) 1.77
The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction. Mol Cell (2001) 1.76
Synaptotagmin VII as a plasma membrane Ca(2+) sensor in exocytosis. Neuron (2001) 1.76
Development and validation of a gamma interferon ELISPOT assay for quantitation of cellular immune responses to varicella-zoster virus. Clin Diagn Lab Immunol (2001) 1.75
The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins. J Cell Biol (2001) 1.75
Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila. Cell (1987) 1.75
Detection of mammary tumor virus env gene-like sequences in human breast cancer. Cancer Res (1995) 1.75
Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure. Genes Dev (1997) 1.74