Published in Cell on July 01, 1984
Global analysis of patterns of gene expression during Drosophila embryogenesis. Genome Biol (2007) 6.27
The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity. Nature (1986) 3.61
Characterization and localization of the even-skipped protein of Drosophila. EMBO J (1987) 3.29
The tramtrack gene encodes a Drosophila finger protein that interacts with the ftz transcriptional regulatory region and shows a novel embryonic expression pattern. EMBO J (1990) 3.13
Organization of the cytoskeleton in early Drosophila embryos. J Cell Biol (1986) 3.06
The distribution of Ultrabithorax transcripts in Drosophila embryos. EMBO J (1985) 2.71
Development of embryonic pattern in D. melanogaster as revealed by accumulation of the nuclear engrailed protein. Cell (1985) 2.70
Molecular cloning of engrailed: a gene involved in the development of pattern in Drosophila melanogaster. Cell (1985) 2.26
Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis. Nature (1988) 2.08
Isolation of caudal, a Drosophila homeo box-containing gene with maternal expression, whose transcripts form a concentration gradient at the pre-blastoderm stage. EMBO J (1985) 2.06
Decapentaplegic transcripts are localized along the dorsal-ventral axis of the Drosophila embryo. EMBO J (1987) 2.00
On biological functions mapping to the heterochromatin of Drosophila melanogaster. Genetics (1985) 1.91
Molecular structure and spatial expression of a homeobox gene from the labial region of the Antennapedia-complex. EMBO J (1988) 1.72
Alternatively spliced transcripts of the Drosophila tramtrack gene encode zinc finger proteins with distinct DNA binding specificities. EMBO J (1992) 1.70
Molecular analysis of odd-skipped, a zinc finger encoding segmentation gene with a novel pair-rule expression pattern. EMBO J (1990) 1.48
Correlative changes in homoeotic and segmentation gene expression in Krüppel mutant embryos of Drosophila. EMBO J (1986) 1.46
Isolation of a mouse cDNA coding for a developmentally regulated, testis-specific transcript containing homeo box homology. EMBO J (1986) 1.45
Repression of the Drosophila fushi tarazu (ftz) segmentation gene. EMBO J (1991) 1.43
The 95F unconventional myosin is required for proper organization of the Drosophila syncytial blastoderm. J Cell Biol (1995) 1.39
The Abdominal-B gene of Drosophila melanogaster: overlapping transcripts exhibit two different spatial distributions. EMBO J (1988) 1.33
The gooseberry-zipper region of Drosophila: five genes encode different spatially restricted transcripts in the embryo. EMBO J (1987) 1.31
Sharp anterior boundary of homeotic gene expression conferred by the fushi tarazu protein. EMBO J (1992) 1.26
Temporal and spatial distribution of transcripts from the Deformed gene of Drosophila. EMBO J (1987) 1.21
Functional specificity of the homeodomain protein fushi tarazu: the role of DNA-binding specificity in vivo. Proc Natl Acad Sci U S A (1993) 1.20
Chromatin remodeling mediated by Drosophila GAGA factor and ISWI activates fushi tarazu gene transcription in vitro. Mol Cell Biol (1998) 1.18
Regulation of the segmentation gene fushi tarazu has been functionally conserved in Drosophila. EMBO J (1990) 1.13
Identification of the binding sites for potential regulatory proteins in the upstream enhancer element of the Drosophila fushi tarazu gene. Nucleic Acids Res (1988) 1.10
In situ hybridization at the electron microscope level: localization of transcripts on ultrathin sections of Lowicryl K4M-embedded tissue using biotinylated probes and protein A-gold complexes. J Cell Biol (1986) 1.04
Electron microscopic heteroduplex mapping identifies regions of the engrailed locus that are conserved between Drosophila melanogaster and Drosophila virilis. Mol Cell Biol (1985) 1.02
The Drosophila nuclear receptors FTZ-F1 alpha and FTZ-F1 beta compete as monomers for binding to a site in the fushi tarazu gene. Mol Cell Biol (1994) 1.01
Multiple proteins interact with the fushi tarazu proximal enhancer. Mol Cell Biol (1993) 0.99
Molecular cloning of fused, a gene required for normal segmentation in the Drosophila melanogaster embryo. Mol Cell Biol (1987) 0.99
FTZ-Factor1 and Fushi tarazu interact via conserved nuclear receptor and coactivator motifs. EMBO J (2001) 0.98
Genetic analysis of two female-sterile loci affecting eggshell integrity and embryonic pattern formation in Drosophila melanogaster. Genetics (1990) 0.95
Determinants of Drosophila fushi tarazu mRNA instability. Mol Cell Biol (1996) 0.91
The nuclear receptor E75A has a novel pair-rule-like function in patterning the milkweed bug, Oncopeltus fasciatus. Dev Biol (2009) 0.90
Activation of a late H2B histone gene in blastula-stage sea urchin embryos by an unusual enhancer element located 3' of the gene. Mol Cell Biol (1990) 0.89
Stage-specific phosphorylation of the fushi tarazu protein during Drosophila development. EMBO J (1989) 0.87
Drosophila homolog of the mammalian jun oncogene is expressed during embryonic development and activates transcription in mammalian cells. Proc Natl Acad Sci U S A (1990) 0.86
Surprising flexibility in a conserved Hox transcription factor over 550 million years of evolution. Proc Natl Acad Sci U S A (2010) 0.85
A binding site for multiple transcriptional activators in the fushi tarazu proximal enhancer is essential for gene expression in vivo. Mol Cell Biol (1998) 0.85
Genetic characterization of the homeodomain-independent activity of the Drosophila fushi tarazu gene product. Genetics (1996) 0.84
An essential role of even-skipped for homeotic gene expression in the Drosophila visceral mesoderm. EMBO J (1989) 0.83
Stripy Ftz target genes are coordinately regulated by Ftz-F1. Dev Biol (2009) 0.83
A phosphorylation site in the ftz homeodomain is required for activity. EMBO J (1998) 0.82
Time space translation: a hox mechanism for vertebrate a-p patterning. Curr Genomics (2012) 0.81
Hox genes, evo-devo, and the case of the ftz gene. Chromosoma (2015) 0.81
Variation and constraint in Hox gene evolution. Proc Natl Acad Sci U S A (2013) 0.79
Asymmetric localization of Drosophila pair-rule transcripts from displaced nuclei: evidence for directional nuclear export. EMBO J (1996) 0.77
Multi-target Chromogenic Whole-mount In Situ Hybridization for Comparing Gene Expression Domains in Drosophila Embryos. J Vis Exp (2016) 0.75
Cell Sorting and Noise-Induced Cell Plasticity Coordinate to Sharpen Boundaries between Gene Expression Domains. PLoS Comput Biol (2017) 0.75
Odd-paired controls frequency doubling in Drosophila segmentation by altering the pair-rule gene regulatory network. Elife (2016) 0.75
Genesis of a spatial pattern in the cellular slime mold Polysphondylium pallidum. Proc Natl Acad Sci U S A (1987) 0.75
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C-terminal residues specific to Vasa among DEAD-box helicases are required for its functions in piRNA biogenesis and embryonic patterning. Dev Genes Evol (2016) 0.75
Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science (2001) 7.85
Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science (1995) 7.35
Detection in situ of genomic regulatory elements in Drosophila. Proc Natl Acad Sci U S A (1987) 7.02
Drosophila S6 kinase: a regulator of cell size. Science (1999) 6.76
A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes. Nature (1984) 6.62
Homeo boxes in the study of development. Science (1987) 6.21
An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr Biol (2001) 6.15
P-element-mediated enhancer detection: a versatile method to study development in Drosophila. Genes Dev (1989) 5.76
Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans. Science (1994) 5.75
Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4. Cell (1999) 5.38
Translational and transcriptional control elements in the untranslated leader of the heat-shock gene hsp22. Cell (1986) 5.00
A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans. Cell (1984) 4.95
The white gene as a marker in a new P-element vector for gene transfer in Drosophila. Nucleic Acids Res (1987) 4.92
Control elements of the Drosophila segmentation gene fushi tarazu. Cell (1985) 4.83
Fly and frog homoeo domains show homologies with yeast mating type regulatory proteins. Nature (1984) 4.33
The structure of the Antennapedia homeodomain determined by NMR spectroscopy in solution: comparison with prokaryotic repressors. Cell (1989) 4.13
Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev (2000) 4.05
Raf functions downstream of Ras1 in the Sevenless signal transduction pathway. Nature (1992) 4.03
A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. Cell (1993) 3.94
Regulation and function of the Drosophila segmentation gene fushi tarazu. Cell (1987) 3.91
The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth. EMBO J (1996) 3.78
Homeotic genes and the homeobox. Annu Rev Genet (1986) 3.60
Protein--DNA contacts in the structure of a homeodomain--DNA complex determined by nuclear magnetic resonance spectroscopy in solution. EMBO J (1990) 3.50
Structural organization and sequence of the homeotic gene Antennapedia of Drosophila melanogaster. EMBO J (1986) 3.49
Genomic and cDNA clones of the homeotic locus Antennapedia in Drosophila. EMBO J (1983) 3.47
P-element-mediated enhancer detection: an efficient method for isolating and characterizing developmentally regulated genes in Drosophila. Genes Dev (1989) 3.45
Sevenless, a cell-specific homeotic gene of Drosophila, encodes a putative transmembrane receptor with a tyrosine kinase domain. Science (1987) 3.06
A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways. Cell (1994) 3.04
The interaction with DNA of wild-type and mutant fushi tarazu homeodomains. EMBO J (1990) 2.97
Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila. Cell (1984) 2.89
Position effects on eukaryotic gene expression. Annu Rev Cell Biol (1990) 2.82
Redesigning the body plan of Drosophila by ectopic expression of the homoeotic gene Antennapedia. Nature (1987) 2.81
A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1. Nature (1994) 2.76
The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye. Genes Dev (1996) 2.71
PAX-6 in development and evolution. Annu Rev Neurosci (1997) 2.68
Isolation of a homoeo box-containing gene from the engrailed region of Drosophila and the spatial distribution of its transcripts. Nature (1990) 2.67
DNA binding properties of the purified Antennapedia homeodomain. Proc Natl Acad Sci U S A (1990) 2.60
Isolation and sequence-specific DNA binding of the Antennapedia homeodomain. EMBO J (1988) 2.57
Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development. Development (1998) 2.56
PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development. Development (1999) 2.56
Unequal crossing-over associated with asymmetrical synapsis between nomadic elements in the Drosophila melanogaster genome. Proc Natl Acad Sci U S A (1983) 2.52
Efficient chromosomal transposition of a Tc1/mariner- like transposon Sleeping Beauty in mice. Proc Natl Acad Sci U S A (2001) 2.51
Expression of the caudal gene in the germ line of Drosophila: formation of an RNA and protein gradient during early embryogenesis. Cell (1987) 2.50
Spatial distribution of Antennapedia transcripts during Drosophila development. EMBO J (1983) 2.50
The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway. Nature (1994) 2.44
Nuclear magnetic resonance solution structure of the fushi tarazu homeodomain from Drosophila and comparison with the Antennapedia homeodomain. J Mol Biol (1994) 2.43
Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Cell (1999) 2.33
Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51. Biochem Biophys Res Commun (1998) 2.31
Selective translation of heat shock mRNA in Drosophila melanogaster depends on sequence information in the leader. EMBO J (1985) 2.30
Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus. Science (1996) 2.28
The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factors. Genes Dev (1992) 2.24
Expression and function of the segmentation gene fushi tarazu during Drosophila neurogenesis. Science (1988) 2.23
Isolation of a hybrid plasmid with homologous sequences to a transposing element of Drosophila melanogaster. Cell (1980) 2.23
Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye. Cell (1991) 2.20
Regulation of Antennapedia transcript distribution by the bithorax complex in Drosophila. Nature (1984) 2.16
Two hybrid plasmids with D. melanogaster DNA sequences complementary to mRNA coding for the major heat shock protein. Cell (1978) 2.10
Genetic control of cell size. Curr Opin Genet Dev (2000) 2.08
Cloning of an X. laevis gene expressed during early embryogenesis coding for a peptide region homologous to Drosophila homeotic genes. Cell (1984) 2.08
RNA binding and translational suppression by bicoid. Nature (1996) 2.08
Molecular cloning of lethal(2)giant larvae, a recessive oncogene of Drosophila melanogaster. EMBO J (1985) 2.07
Isolation of caudal, a Drosophila homeo box-containing gene with maternal expression, whose transcripts form a concentration gradient at the pre-blastoderm stage. EMBO J (1985) 2.06
The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway. EMBO J (1994) 2.06
twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development. Mol Cell (1999) 2.06
Two mouse piwi-related genes: miwi and mili. Mech Dev (2001) 2.05
Molecular cloning of the white locus region of Drosophila melanogaster using a large transposable element. EMBO J (1982) 2.04
The specificities of Sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain. Cell (1990) 1.99
DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila. Cell (1996) 1.94
The 5S genes of Drosophila melanogaster. Cell (1977) 1.94
Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1. Science (1994) 1.91
Rescue of the Drosophila phototransduction mutation trp by germline transformation. Science (1985) 1.85
PDK1 regulates growth through Akt and S6K in Drosophila. Proc Natl Acad Sci U S A (2001) 1.85
Direct homeodomain-DNA interaction in the autoregulation of the fushi tarazu gene. Nature (1992) 1.84
Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain. Cell (1988) 1.80
Physical map of two D. melanogaster DNA segments containing sequences coding for the 70,000 dalton heat shock protein. Cell (1979) 1.80
Cloning of the homeotic Sex combs reduced gene in Drosophila and in situ localization of its transcripts. EMBO J (1985) 1.77
Analysis of the ftz upstream element: germ layer-specific enhancers are independently autoregulated. Genes Dev (1990) 1.75
Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila. Cell (1987) 1.75
Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure. Genes Dev (1997) 1.74
Molecular structure and spatial expression of a homeobox gene from the labial region of the Antennapedia-complex. EMBO J (1988) 1.72
Direct interaction of the Polycomb protein with Antennapedia regulatory sequences in polytene chromosomes of Drosophila melanogaster. EMBO J (1991) 1.72
Germ line dependence of the deep orange maternal effect in Drosophila. Dev Biol (1977) 1.69
The pruned gene encodes the Drosophila serum response factor and regulates cytoplasmic outgrowth during terminal branching of the tracheal system. Development (1996) 1.67
The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development. Development (1994) 1.66
The heat shock protein 83 (Hsp83) is required for Raf-mediated signalling in Drosophila. EMBO J (1997) 1.66
Homeodomain proteins and the regulation of gene expression. Curr Opin Cell Biol (1990) 1.65
Control of Drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the Raf kinase. Cell (1995) 1.64
Spatial and temporal targeting of gene expression in Drosophila by means of a tetracycline-dependent transactivator system. Development (1998) 1.62
Elucidation of the role of breathless, a Drosophila FGF receptor homolog, in tracheal cell migration. Genes Dev (1994) 1.61
Zebrafish Mesp family genes, mesp-a and mesp-b are segmentally expressed in the presomitic mesoderm, and Mesp-b confers the anterior identity to the developing somites. Development (2000) 1.59
Mutations Modulating Raf signaling in Drosophila eye development. Genetics (1996) 1.58