Published in Development on December 01, 1999
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A (2001) 6.99
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev (2001) 6.15
TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes Dev (2001) 4.68
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice. Proc Natl Acad Sci U S A (2001) 4.62
Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev (2000) 4.05
The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. Genes Dev (2004) 3.59
Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model. Proc Natl Acad Sci U S A (2003) 3.34
Nutrition-responsive glia control exit of neural stem cells from quiescence. Cell (2010) 3.19
Essential role of PDK1 in regulating cell size and development in mice. EMBO J (2002) 2.93
Akt1 governs breast cancer progression in vivo. Proc Natl Acad Sci U S A (2007) 2.67
Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila. Nature (2011) 2.65
Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Proc Natl Acad Sci U S A (2005) 2.58
Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell (2012) 2.39
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest (2006) 2.38
Expression of Drosophila FOXO regulates growth and can phenocopy starvation. BMC Dev Biol (2003) 1.92
PDK1 regulates growth through Akt and S6K in Drosophila. Proc Natl Acad Sci U S A (2001) 1.85
Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing. Genes Dev (2002) 1.69
Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance. J Biol (2008) 1.65
Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression. EMBO J (2000) 1.63
Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis. Mol Cell Biol (2002) 1.57
Genetic control of size in Drosophila. Philos Trans R Soc Lond B Biol Sci (2000) 1.55
A dp53-dependent mechanism involved in coordinating tissue growth in Drosophila. PLoS Biol (2010) 1.53
A tumor suppressor homolog, AtPTEN1, is essential for pollen development in Arabidopsis. Plant Cell (2002) 1.47
The developmental control of size in insects. Wiley Interdiscip Rev Dev Biol (2013) 1.32
Mechanisms of TSC-mediated control of synapse assembly and axon guidance. PLoS One (2007) 1.23
Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways. Mol Cell Biol (2004) 1.18
Genomic sequence of a 320-kb segment of the Z chromosome of Bombyx mori containing a kettin ortholog. Mol Genet Genomics (2003) 1.15
High-throughput sequencing to reveal genes involved in reproduction and development in Bactrocera dorsalis (Diptera: Tephritidae). PLoS One (2012) 1.11
Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cells. Mol Cell Biol (2011) 1.11
Ptena and ptenb genes play distinct roles in zebrafish embryogenesis. Dev Dyn (2005) 1.00
LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap. Oncogene (2012) 1.00
PTEN expression causes feedback upregulation of insulin receptor substrate 2. Mol Cell Biol (2001) 0.97
PI3 kinase signaling is involved in Abeta-induced memory loss in Drosophila. Proc Natl Acad Sci U S A (2010) 0.96
A genetic screen for modifiers of Drosophila caspase Dcp-1 reveals caspase involvement in autophagy and novel caspase-related genes. BMC Cell Biol (2010) 0.95
Phosphoinositide 3-kinase signaling in retinal rod photoreceptors. Invest Ophthalmol Vis Sci (2011) 0.95
Insulin delays the progression of Drosophila cells through G2/M by activating the dTOR/dRaptor complex. EMBO J (2006) 0.93
Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling. Dis Model Mech (2008) 0.93
TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation. Proc Natl Acad Sci U S A (2000) 0.91
Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo. BMC Biol (2011) 0.89
High glucose upregulation of early-onset Parkinson's disease protein DJ-1 integrates the PRAS40/TORC1 axis to mesangial cell hypertrophy. Cell Signal (2011) 0.89
Molecular mechanism of size control in development and human diseases. Cell Res (2011) 0.88
The effort to make mosaic analysis a household tool. Development (2012) 0.87
A Cullin1-based SCF E3 ubiquitin ligase targets the InR/PI3K/TOR pathway to regulate neuronal pruning. PLoS Biol (2013) 0.86
Regulation of the activity of the tumor suppressor PTEN by thioredoxin in Drosophila melanogaster. Exp Cell Res (2007) 0.86
Honey bee PTEN--description, developmental knockdown, and tissue-specific expression of splice-variants correlated with alternative social phenotypes. PLoS One (2011) 0.85
Receptor tyrosine kinases in Drosophila development. Cold Spring Harb Perspect Biol (2013) 0.83
Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas. Mol Cancer (2015) 0.82
Ptenb mediates gastrulation cell movements via Cdc42/AKT1 in zebrafish. PLoS One (2011) 0.82
Cyclin-dependent kinase regulatory subunit 1 promotes cell proliferation by insulin regulation. Cell Cycle (2015) 0.81
The nuclear receptor DHR3 modulates dS6 kinase-dependent growth in Drosophila. PLoS Genet (2010) 0.81
Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues. Elife (2013) 0.81
The nucleus- and endoplasmic reticulum-targeted forms of protein tyrosine phosphatase 61F regulate Drosophila growth, life span, and fecundity. Mol Cell Biol (2013) 0.80
Light-regulated translocation of signaling proteins in Drosophila photoreceptors. J Physiol Paris (2006) 0.79
Phosphatase and tensin homologue deleted on chromosome 10. Niger Med J (2013) 0.78
Insulin signaling misregulation underlies circadian and cognitive deficits in a Drosophila fragile X model. Mol Psychiatry (2016) 0.78
Loss of the tumor suppressor Pten promotes proliferation of Drosophila melanogaster cells in vitro and gives rise to continuous cell lines. PLoS One (2012) 0.78
The Drosophila insulin-degrading enzyme restricts growth by modulating the PI3K pathway in a cell-autonomous manner. Mol Biol Cell (2014) 0.77
Somatic insulin signaling regulates a germline starvation response in Drosophila egg chambers. Dev Biol (2014) 0.77
The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster. BMB Rep (2016) 0.77
Drosophila as a Potential Model for Ocular Tumors. Ocul Oncol Pathol (2015) 0.77
Neurofibromatosis-like phenotype in Drosophila caused by lack of glucosylceramide extension. Proc Natl Acad Sci U S A (2012) 0.77
Ecological Trade-offs between Migration and Reproduction Are Mediated by the Nutrition-Sensitive Insulin-Signaling Pathway. Int J Biol Sci (2016) 0.77
Polarized deposition of basement membrane proteins depends on Phosphatidylinositol synthase and the levels of Phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A (2014) 0.77
Dally Proteoglycan Mediates the Autonomous and Nonautonomous Effects on Tissue Growth Caused by Activation of the PI3K and TOR Pathways. PLoS Biol (2015) 0.76
The Rho Guanine Nucleotide Exchange Factor DRhoGEF2 Is a Genetic Modifier of the PI3K Pathway in Drosophila. PLoS One (2016) 0.75
Genetic Screen in Drosophila Larvae Links ird1 Function to Toll Signaling in the Fat Body and Hemocyte Motility. PLoS One (2016) 0.75
Cross talk between miR-214 and PTEN attenuates glomerular hypertrophy under diabetic conditions. Sci Rep (2016) 0.75
Phosphatase and Tensin Homolog Is a Growth Repressor of Both Rhizoid and Gametophore Development in the Moss Physcomitrella patens. Plant Physiol (2015) 0.75
The insulin receptor is required for the development of the Drosophila peripheral nervous system. PLoS One (2013) 0.75
A genetically encoded biosensor for visualizing hypoxia responses in vivo. Biol Open (2016) 0.75
Parvin overexpression uncovers tissue-specific genetic pathways and disrupts F-actin to induce apoptosis in the developing epithelia in Drosophila. PLoS One (2012) 0.75
Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature (2001) 16.89
A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet (1997) 10.93
Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science (2001) 7.85
Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell (1985) 6.93
Drosophila S6 kinase: a regulator of cell size. Science (1999) 6.76
A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes. Nature (1984) 6.62
An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr Biol (2001) 6.15
TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res (1997) 5.92
Reducing frailty and falls in older persons: an investigation of Tai Chi and computerized balance training. Atlanta FICSIT Group. Frailty and Injuries: Cooperative Studies of Intervention Techniques. J Am Geriatr Soc (1996) 5.54
p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27. Curr Biol (1999) 5.40
Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4. Cell (1999) 5.38
Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Nature (1999) 5.03
Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell (2001) 4.98
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A (1999) 4.90
Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. Neuron (1997) 4.33
Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. Nat Genet (1999) 4.23
Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell (1990) 4.07
A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts. Cell (1994) 4.05
Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev (2000) 4.05
Raf functions downstream of Ras1 in the Sevenless signal transduction pathway. Nature (1992) 4.03
A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. Cell (1993) 3.94
Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing. Nature (1996) 3.81
The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth. EMBO J (1996) 3.78
A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. Nat Genet (1998) 3.41
Sevenless, a cell-specific homeotic gene of Drosophila, encodes a putative transmembrane receptor with a tyrosine kinase domain. Science (1987) 3.06
PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells. Proc Natl Acad Sci U S A (1998) 3.05
A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways. Cell (1994) 3.04
The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338. Nature (1998) 2.93
Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres. Neuron (1995) 2.83
Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans. J Biol Chem (1988) 2.79
MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia. Oncogene (2007) 2.79
Global gene expression profiles of Bacillus subtilis grown under anaerobic conditions. J Bacteriol (2000) 2.77
KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis. Science (1996) 2.77
Spatial distribution of transcripts from the segmentation gene fushi tarazu during Drosophila embryonic development. Cell (1984) 2.72
The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye. Genes Dev (1996) 2.71
Processing of the notch ligand delta by the metalloprotease Kuzbanian. Science (1999) 2.71
Exploring the basis for Tai Chi Chuan as a therapeutic exercise approach. Arch Phys Med Rehabil (1997) 2.70
Simplification of antibiotic dose adjustments in renal insufficiency: the DREM system. Lancet (1992) 2.69
Introduction of fast MR imaging in the assessment of hepatic steatosis. Magn Reson Imaging (1997) 2.69
Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases. Curr Biol (2000) 2.67
Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nat Genet (1999) 2.60
Antitermination by bacteriophage lambda Q protein. Cold Spring Harb Symp Quant Biol (1998) 2.57
Spatial distribution of Antennapedia transcripts during Drosophila development. EMBO J (1983) 2.50
The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway. Nature (1994) 2.44
Draft guidance for industry extended-release solid oral dosage forms. Development, evaluation and application of in vitro-in vivo correlations. Adv Exp Med Biol (1997) 2.35
Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Cell (1999) 2.33
Altered integrin expression and the malignant phenotype: the contribution of multiple integrated integrin receptors. J Mammary Gland Biol Neoplasia (1998) 2.30
Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus. Science (1996) 2.28
Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Proc Natl Acad Sci U S A (1993) 2.27
Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway. Genes Dev (1997) 2.26
Tropical origins for recent North Atlantic climate change. Science (2001) 2.25
Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye. Cell (1991) 2.20
Regulation of Antennapedia transcript distribution by the bithorax complex in Drosophila. Nature (1984) 2.16
Molecular cloning and structural analysis of murine thymidine kinase genomic and cDNA sequences. Mol Cell Biol (1985) 2.13
Comparison of the Agilent, ROMA/NimbleGen and Illumina platforms for classification of copy number alterations in human breast tumors. BMC Genomics (2008) 2.11
Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers-Danlos-like changes in bone and other connective tissues. J Bone Miner Res (2002) 2.08
Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency. Blood (2000) 2.08
Genetic control of cell size. Curr Opin Genet Dev (2000) 2.08
Inkjet printing for high-throughput cell patterning. Biomaterials (2004) 2.06
The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway. EMBO J (1994) 2.06
Hemodynamic determinants of the mitral annulus diastolic velocities by tissue Doppler. J Am Coll Cardiol (2001) 2.04
A genetic determinant of the striatal dopamine response to alcohol in men. Mol Psychiatry (2010) 2.02
DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila. Cell (1996) 1.94
Molecular genetics of human retinal disease. Annu Rev Genet (1999) 1.88
Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells. Immunity (2000) 1.87
Direct experimental evidence for the existence, structural basis and function of astral forces during anaphase B in vivo. J Cell Sci (1991) 1.87
PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2). Curr Biol (2001) 1.86
Mu opioid receptor phosphorylation, desensitization, and ligand efficacy. J Biol Chem (1997) 1.86
Rescue of the Drosophila phototransduction mutation trp by germline transformation. Science (1985) 1.85
Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Nature (2000) 1.85
PDK1 regulates growth through Akt and S6K in Drosophila. Proc Natl Acad Sci U S A (2001) 1.85
The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase. Proc Natl Acad Sci U S A (1993) 1.81
Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain. Cell (1988) 1.80
Cytosolic Ca2+ acts by two separate pathways to modulate the supply of release-competent vesicles in chromaffin cells. Neuron (1998) 1.79
Early events in liver allograft rejection. Delineation of sites of simultaneous intragraft and recipient lymphoid tissue sensitization. Am J Pathol (1991) 1.78
Stargardt's ABCR is localized to the disc membrane of retinal rod outer segments. Nat Genet (1997) 1.78
Cardiovascular and respiratory effects of cannabis in cat and rat. Br J Pharmacol (1973) 1.75
Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila. Cell (1987) 1.75
Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure. Genes Dev (1997) 1.74
High affinity interactions of nucleolin with G-G-paired rDNA. J Biol Chem (1999) 1.73
Transgenic rabbits expressing human apolipoprotein(a) develop more extensive atherosclerotic lesions in response to a cholesterol-rich diet. Arterioscler Thromb Vasc Biol (2001) 1.72
Total arteriovenous CO2 removal: simplifying extracorporeal support for respiratory failure. Ann Thorac Surg (1997) 1.71
Diffusion-weighted imaging in predicting and monitoring the response of uterine cervical cancer to combined chemoradiation. Clin Radiol (2009) 1.70
Organization and evolution of D region class I genes in the mouse major histocompatibility complex. J Exp Med (1986) 1.68
The pruned gene encodes the Drosophila serum response factor and regulates cytoplasmic outgrowth during terminal branching of the tracheal system. Development (1996) 1.67
The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development. Development (1994) 1.66
Chronic neuropathic pain is accompanied by global changes in gene expression and shares pathobiology with neurodegenerative diseases. Neuroscience (2002) 1.66
The heat shock protein 83 (Hsp83) is required for Raf-mediated signalling in Drosophila. EMBO J (1997) 1.66
Control of Drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the Raf kinase. Cell (1995) 1.64
New clinically relevant sheep model of severe respiratory failure secondary to combined smoke inhalation/cutaneous flame burn injury. Crit Care Med (2000) 1.63
Elucidation of the role of breathless, a Drosophila FGF receptor homolog, in tracheal cell migration. Genes Dev (1994) 1.61
Search for supersymmetry using final states with one lepton, jets, and missing transverse momentum with the ATLAS detector in √s=7 TeV pp collisions. Phys Rev Lett (2011) 1.60
Genetic analysis of olfactory behavior in Drosophila: a new screen yields the ota mutants. Genetics (1989) 1.59
Mutations Modulating Raf signaling in Drosophila eye development. Genetics (1996) 1.58
Molecular organization of the nodal region is not altered in spontaneously diabetic BB-Wistar rats. J Neurosci Res (2001) 1.56
Cloning and transcriptional analysis of the segmentation gene fushi tarazu of Drosophila. Cell (1984) 1.55
Reflex vascular responses to vasoactive substances. Eur J Pharmacol (1970) 1.55
Genetic control of size in Drosophila. Philos Trans R Soc Lond B Biol Sci (2000) 1.55