Published in Structure on January 15, 1996
The neck region of the myosin motor domain acts as a lever arm to generate movement. Proc Natl Acad Sci U S A (1996) 3.61
Three conformational states of scallop myosin S1. Proc Natl Acad Sci U S A (2000) 3.06
Three-dimensional image reconstruction of dephosphorylated smooth muscle heavy meromyosin reveals asymmetry in the interaction between myosin heads and placement of subfragment 2. Proc Natl Acad Sci U S A (2001) 2.93
The prepower stroke conformation of myosin V. J Cell Biol (2002) 2.12
Calmodulin mediates Ca2+-dependent modulation of M-type K+ channels. J Gen Physiol (2003) 1.95
Sfi1p has conserved centrin-binding sites and an essential function in budding yeast spindle pole body duplication. J Cell Biol (2003) 1.88
Mlc1p is a light chain for the unconventional myosin Myo2p in Saccharomyces cerevisiae. J Cell Biol (1998) 1.70
Crystal structure of apo-calmodulin bound to the first two IQ motifs of myosin V reveals essential recognition features. Proc Natl Acad Sci U S A (2006) 1.63
The structural basis of muscle contraction. Philos Trans R Soc Lond B Biol Sci (2000) 1.59
Structural role of Sfi1p-centrin filaments in budding yeast spindle pole body duplication. J Cell Biol (2006) 1.51
Myosin motors with artificial lever arms. EMBO J (1996) 1.41
Two distinct myosin light chain structures are induced by specific variations within the bound IQ motifs-functional implications. EMBO J (2003) 1.40
Structure of the light chain-binding domain of myosin V. Proc Natl Acad Sci U S A (2005) 1.33
The stretch-activation response may be critical to the proper functioning of the mammalian heart. Proc Natl Acad Sci U S A (1999) 1.31
Regulation of bestrophin Cl channels by calcium: role of the C terminus. J Gen Physiol (2008) 1.29
Conservation of the regulated structure of folded myosin 2 in species separated by at least 600 million years of independent evolution. Proc Natl Acad Sci U S A (2008) 1.28
Mutation of the myosin converter domain alters cross-bridge elasticity. Proc Natl Acad Sci U S A (2002) 1.24
Molecular dynamics simulation of site-directed spin labeling: experimental validation in muscle fibers. Biophys J (2002) 1.23
Site-directed spin labeling reveals a conformational switch in the phosphorylation domain of smooth muscle myosin. Proc Natl Acad Sci U S A (2005) 1.20
Structural basis for the negative allostery between Ca(2+)- and Mg(2+)-binding in the intracellular Ca(2+)-receptor calbindin D9k. Protein Sci (1997) 1.19
The closed MTIP-myosin A-tail complex from the malaria parasite invasion machinery. J Mol Biol (2007) 1.15
GFP-tagged regulatory light chain monitors single myosin lever-arm orientation in a muscle fiber. Biophys J (2007) 1.13
Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor. Proc Natl Acad Sci U S A (2006) 1.09
Common structural motifs for the regulation of divergent class II myosins. J Biol Chem (2010) 1.08
Solution structure of the NaV1.2 C-terminal EF-hand domain. J Biol Chem (2009) 1.08
The role of the N-terminus of the myosin essential light chain in cardiac muscle contraction. J Mol Biol (2009) 1.07
Insights into modulation of calcium signaling by magnesium in calmodulin, troponin C and related EF-hand proteins. Biochim Biophys Acta (2011) 1.06
Altered kinetics of contraction in skeletal muscle fibers containing a mutant myosin regulatory light chain with reduced divalent cation binding. Biophys J (1996) 1.06
Force generation by kinesin and myosin cytoskeletal motor proteins. J Cell Sci (2013) 1.05
Invertebrate muscles: thin and thick filament structure; molecular basis of contraction and its regulation, catch and asynchronous muscle. Prog Neurobiol (2008) 1.03
The on-off switch in regulated myosins: different triggers but related mechanisms. J Mol Biol (2009) 1.03
Molecular mechanisms of calcium and magnesium binding to parvalbumin. Biophys J (2002) 0.96
Visualizing key hinges and a potential major source of compliance in the lever arm of myosin. Proc Natl Acad Sci U S A (2010) 0.96
Regulatory implications of a novel mode of interaction of calmodulin with a double IQ-motif target sequence from murine dilute myosin V. Protein Sci (2002) 0.95
N-methyl-D-aspartate receptor subunits are non-myosin targets of myosin regulatory light chain. J Biol Chem (2008) 0.93
Modulation of CaV1.2 channels by Mg2+ acting at an EF-hand motif in the COOH-terminal domain. J Gen Physiol (2005) 0.91
Response of rigor cross-bridges to stretch detected by fluorescence lifetime imaging microscopy of myosin essential light chain in skeletal muscle fibers. J Biol Chem (2010) 0.91
EF-hand protein dynamics and evolution of calcium signal transduction: an NMR view. J Biol Inorg Chem (2006) 0.90
Phosphorylated smooth muscle heavy meromyosin shows an open conformation linked to activation. J Mol Biol (2011) 0.89
Characterizations of myosin essential light chain's N-terminal truncation mutant Δ43 in transgenic mouse papillary muscles by using tension transients in response to sinusoidal length alterations. J Muscle Res Cell Motil (2013) 0.89
Cryo-atomic force microscopy of smooth muscle myosin. Biophys J (1997) 0.89
Orientation of the essential light chain region of myosin in relaxed, active, and rigor muscle. Biophys J (2008) 0.88
Structural coupling of the EF hand and C-terminal GTPase domains in the mitochondrial protein Miro. EMBO Rep (2013) 0.88
Role of the essential light chain in the activation of smooth muscle myosin by regulatory light chain phosphorylation. J Struct Biol (2013) 0.87
In vitro rescue study of a malignant familial hypertrophic cardiomyopathy phenotype by pseudo-phosphorylation of myosin regulatory light chain. Arch Biochem Biophys (2013) 0.86
Modification of interface between regulatory and essential light chains hampers phosphorylation-dependent activation of smooth muscle myosin. J Biol Chem (2012) 0.85
Myosin regulatory domain orientation in skeletal muscle fibers: application of novel electron paramagnetic resonance spectral decomposition and molecular modeling methods. Biophys J (2004) 0.85
The myosin C-loop is an allosteric actin contact sensor in actomyosin. Biochemistry (2009) 0.85
A novel Myosin essential light chain mutation causes hypertrophic cardiomyopathy with late onset and low expressivity. Biochem Res Int (2012) 0.83
Various Themes of Myosin Regulation. J Mol Biol (2016) 0.83
Mouse myosin-19 is a plus-end-directed, high-duty ratio molecular motor. J Biol Chem (2014) 0.82
Solution structure of the Apo C-terminal domain of the Lethocerus F1 troponin C isoform. Biochemistry (2010) 0.81
Structural characterization of the interactions between palladin and α-actinin. J Mol Biol (2011) 0.81
The Dictyostelium class I myosin, MyoD, contains a novel light chain that lacks high-affinity calcium-binding sites. Biochem J (2003) 0.81
Solution structure and dynamics of human S100A14. J Biol Inorg Chem (2012) 0.80
Kinetic equilibrium of forces and molecular events in muscle contraction. Proc Natl Acad Sci U S A (2000) 0.80
Orientation of the N-terminal lobe of the myosin regulatory light chain in skeletal muscle fibers. Biophys J (2012) 0.79
Allosteric communication in Dictyostelium myosin II. J Muscle Res Cell Motil (2012) 0.79
Time-resolved fluorescence anisotropy studies show domain-specific interactions of calmodulin with IQ target sequences of myosin V. Eur Biophys J (2003) 0.79
Modeling smooth muscle myosin's two heads: long-lived enzymatic roles and phosphorylation-dependent equilibria. Biophys J (2010) 0.79
An unstable head-rod junction may promote folding into the compact off-state conformation of regulated myosins. J Mol Biol (2007) 0.78
Crystal structure of a phosphorylated light chain domain of scallop smooth-muscle myosin. Biophys J (2011) 0.78
Evaluation of the symmetric model for myosin-linked regulation: effect of site-directed mutations in the regulatory light chain on scallop myosin. Biochem J (2003) 0.77
Essential "ankle" in the myosin lever arm. Proc Natl Acad Sci U S A (2010) 0.77
Myosin light chains: Teaching old dogs new tricks. Bioarchitecture (2014) 0.77
MDR1 function is sensitive to the phosphorylation state of myosin regulatory light chain. Biochem Biophys Res Commun (2010) 0.76
Cardiac myosin-binding protein C: A protein once at loose ends finds its regulatory groove. Proc Natl Acad Sci U S A (2016) 0.76
The mitochondrial Ras-related GTPase Miro: views from inside and outside the metazoan kingdom. Front Plant Sci (2014) 0.76
Does Interaction between the Motor and Regulatory Domains of the Myosin Head Occur during ATPase Cycle? Evidence from Thermal Unfolding Studies on Myosin Subfragment 1. PLoS One (2015) 0.75
Regulation of Polycystin-1 Function by Calmodulin Binding. PLoS One (2016) 0.75
Myosin individualized: single nucleotide polymorphisms in energy transduction. BMC Genomics (2010) 0.75
Genome-Wide Identification and Analyses of Calmodulins and Calmodulin-like Proteins in Lotus japonicas. Front Plant Sci (2017) 0.75
Structural and functional diversity of EF-hand proteins: Evolutionary perspectives. Protein Sci (2017) 0.75
Streptococcal M protein: alpha-helical coiled-coil structure and arrangement on the cell surface. Proc Natl Acad Sci U S A (1981) 5.56
Use of hospital services by homeless families in an inner London health district. BMJ (1989) 4.71
Randomised placebo-controlled trial of ritonavir in advanced HIV-1 disease. The Advanced HIV Disease Ritonavir Study Group. Lancet (1998) 4.54
American Cancer Society guidelines for the early detection of cancer: update of early detection guidelines for prostate, colorectal, and endometrial cancers. Also: update 2001--testing for early lung cancer detection. CA Cancer J Clin (2001) 4.41
Three conformational states of scallop myosin S1. Proc Natl Acad Sci U S A (2000) 3.06
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head. Cell (1999) 2.99
Structure of the regulatory domain of scallop myosin at 2.8 A resolution. Nature (1994) 2.78
A tropomyosin-like protein from human platelets. J Mol Biol (1972) 2.65
Tropomyosin crystal structure and muscle regulation. J Mol Biol (1986) 2.65
Interim report on pandemic H1N1 influenza virus infections in South Africa, April to October 2009: epidemiology and factors associated with fatal cases. Euro Surveill (2009) 2.47
Cooperative effects of INK4a and ras in melanoma susceptibility in vivo. Genes Dev (1997) 2.47
Paramyosin and the filaments of molluscan "catch" muscles. II. Native filaments: isolation and characterization. J Mol Biol (1971) 2.42
Heptad breaks in alpha-helical coiled coils: stutters and stammers. Proteins (1996) 2.30
Crystal structure and molecular interactions of tropomyosin. Nature (1979) 2.16
Deciphering the design of the tropomyosin molecule. Proc Natl Acad Sci U S A (2001) 2.14
Laparoscopic live donor nephrectomy: the recipient. Transplantation (2000) 2.11
Leishmaniasis acquired in Belgium. Lancet (1991) 1.93
Expression profiling of renal epithelial neoplasms: a method for tumor classification and discovery of diagnostic molecular markers. Am J Pathol (2001) 1.89
X-ray diffraction from microtubules. J Mol Biol (1971) 1.84
Crystallographic findings on the internally uncoupled and near-rigor states of myosin: further insights into the mechanics of the motor. Proc Natl Acad Sci U S A (2002) 1.81
Tumor progression in four mammary epithelial cell lines derived from the same patient. Cancer Res (1990) 1.80
Tropomyosin: crystal structure, polymorphism and molecular interactions. J Mol Biol (1969) 1.79
A general method for the introduction of enzymes, by means of immunoglobulin-coated liposomes, into lysosomes of deficient cells. Proc Natl Acad Sci U S A (1975) 1.76
Tropomyosin paracrystals formed by divalent cations. Science (1966) 1.73
The Test for Severe Impairment: an instrument for the assessment of patients with severe cognitive dysfunction. J Am Geriatr Soc (1992) 1.72
Incidence and natural history of phrenic neuropathy occurring during open heart surgery. Chest (1993) 1.68
The crystal structure of modified bovine fibrinogen. Proc Natl Acad Sci U S A (2000) 1.67
Electron microscopy of thin filaments decorated with a Ca2+-regulated myosin. J Mol Biol (1980) 1.64
Underestimation of chronic hepatitis B virus infection in the United States of America. J Viral Hepat (2008) 1.58
Ritonavir and saquinavir combination therapy for the treatment of HIV infection. AIDS (1999) 1.58
Association of an HLA-DQ allele with clinical tuberculosis. JAMA (1998) 1.58
Microtubule structure at 18 A resolution. J Mol Biol (1987) 1.56
Social and community resources and long-term recovery from treated and untreated alcoholism. J Stud Alcohol (1997) 1.55
A model for fibrinogen: domains and sequence. Science (1985) 1.53
A 29 residue region of the sarcomeric myosin rod is necessary for filament formation. J Mol Biol (1997) 1.52
Troponin and its interactions with tropomyosin. An electron microscope study. J Mol Biol (1982) 1.48
Cross-bridge arrangements in Limulus muscle. J Mol Biol (1974) 1.48
A model of Ca(2+)-free calmodulin binding to unconventional myosins reveals how calmodulin acts as a regulatory switch. Structure (1996) 1.48
Paramyosin and the filaments of molluscan "catch" muscles. I. Paramyosin: structure and assembly. J Mol Biol (1971) 1.47
Structure of co-crystals of tropomyosin and troponin. Nature (1987) 1.47
Disabled-2 inactivation is an early step in ovarian tumorigenicity. Oncogene (1999) 1.46
Pitch diversity in alpha-helical coiled coils. Proteins (1993) 1.44
Sexual and physical abuse histories and psychiatric symptoms among male psychiatric outpatients. Am J Psychiatry (1990) 1.43
What transplantation can teach us about health care reform. The Ethics and Social Impact Committee. N Engl J Med (1994) 1.40
DNA ploidy of ameloblastoma and ameloblastic carcinoma of the jaws. Analysis by image and flow cytometry. Arch Pathol Lab Med (1993) 1.39
Determinants of prolonged length of hospital stay after coronary bypass surgery. Circulation (1989) 1.39
Factors associated with long-term institutionalization of older people with dementia: data from the Canadian Study of Health and Aging. J Gerontol A Biol Sci Med Sci (2001) 1.35
Motions of tropomyosin. Crystal as metaphor. Biophys J (1980) 1.35
Isolation of mouse stromal cells associated with a human tumor using differential diphtheria toxin sensitivity. Am J Pathol (1999) 1.33
Structure and modulation of neural cell adhesion molecules in early and late embryogenesis. Cold Spring Harb Symp Quant Biol (1983) 1.32
Domains, motions and regulation in the myosin head. J Muscle Res Cell Motil (1988) 1.31
Granulomatous mastitis. A review of 5 cases. S Afr Med J (1977) 1.29
A model from electron microscopy for the molecular structure of fibrinogen and fibrin. Nature (1981) 1.29
The recognition, assessment and management of dementing disorders: conclusions from the Canadian Consensus Conference on Dementia. Can J Neurol Sci (2001) 1.27
Differential expression of active mitogen-activated protein kinase in cutaneous endothelial neoplasms: implications for biologic behavior and response to therapy. J Am Acad Dermatol (2001) 1.25
Tumor angiogenesis as a prognostic factor in oral cavity tumors. Am J Surg (1994) 1.24
Structures of four Ca2+-bound troponin C at 2.0 A resolution: further insights into the Ca2+-switch in the calmodulin superfamily. Structure (1997) 1.23
Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis. Carcinogenesis (2001) 1.23
Diversity of cross-bridge configurations in invertebrate muscles. Nature (1975) 1.23
Immunohistochemical localization of rat angiotensin II AT1 receptor. Am J Physiol (1993) 1.23
Actin filaments in muscle: pattern of myosin and tropomyosin/troponin attachments. J Mol Biol (1978) 1.20
Discriminatory immunohistochemical staining of urothelial carcinoma in situ and non-neoplastic urothelium: an analysis of cytokeratin 20, p53, and CD44 antigens. Am J Surg Pathol (2001) 1.20
Inhibition of degranulation and interleukin-6 production in mast cells derived from mice deficient in protein kinase Cbeta. Blood (2000) 1.19
HSV shedding. Antiviral Res (2004) 1.18
Pediatric total parenteral nutrition. Liver histopathology. Arch Pathol Lab Med (1981) 1.18
Analysis of the three-alpha-helix motif in the spectrin superfamily of proteins. Biophys J (1992) 1.18
Restoration of positioning control following Disabled-2 expression in ovarian and breast tumor cells. Oncogene (2000) 1.18
Effects of various doses of estradiol on chlamydial genital infection in ovariectomized guinea pigs. Sex Transm Dis (1985) 1.17
Bioethicists' statement on the U.S. Supreme Court's Cruzan decision. N Engl J Med (1990) 1.15
Neuroendocrine tumors of the thymus: a clinicopathological and prognostic study. Ann Thorac Surg (2001) 1.15
Paramyosin inhibits complement C1. J Immunol (1992) 1.14
Should the indications for laparascopic live donor nephrectomy of the right kidney be the same as for the open procedure? Anomalous left renal vasculature is not a contraindiction to laparoscopic left donor nephrectomy. Transplantation (2001) 1.14
Relationship of cytokeratin 20 and CD44 protein expression with WHO/ISUP grade in pTa and pT1 papillary urothelial neoplasia. Mod Pathol (2000) 1.14
Segments from vertebrate smooth muscle myosin rods. J Mol Biol (1971) 1.13
Structure of tropomyosin at 9 angstroms resolution. J Mol Biol (1992) 1.13
Crystalline states of a modified fibrinogen. J Mol Biol (1977) 1.12
Surveillance of transmitted HIV-1 drug resistance in Gauteng and KwaZulu-Natal Provinces, South Africa, 2005-2009. Clin Infect Dis (2012) 1.11
From the National Institutes of Health. Summary of a workshop on cytomegalovirus infections during organ transplantation. J Infect Dis (1979) 1.11
A new myosin fragment: visualization of the regulatory domain. Nature (1984) 1.11
Spikes and fimbriae: alpha-helical proteins form surface projections on microorganisms. Proc Natl Acad Sci U S A (1981) 1.10
Tropomyosin crystal dynamics. Cold Spring Harb Symp Quant Biol (1972) 1.10
Proteolytic degradation of myosin and the meromyosins by a water-insoluble polyanionic derivative of trypsin: properties of a helical subunit isolated from heavy meromyosin. J Mol Biol (1967) 1.09
Immunolocalization of activated transforming growth factor beta1 in juvenile nasopharyngeal angiofibroma. Arch Otolaryngol Head Neck Surg (2000) 1.08
The generation and characterization of a cell line derived from a sporadic renal angiomyolipoma: use of telomerase to obtain stable populations of cells from benign neoplasms. Am J Pathol (2001) 1.08
Crystal structure of the central region of bovine fibrinogen (E5 fragment) at 1.4-A resolution. Proc Natl Acad Sci U S A (2001) 1.07
Concordant induction of 15-lipoxygenase-1 and mutant p53 expression in human prostate adenocarcinoma: correlation with Gleason staging. Carcinogenesis (2000) 1.07
Is nicotine more addictive than cocaine? Br J Addict (1991) 1.07
Captopril-induced skin eruptions. J Clin Pharmacol (1982) 1.07
Target sequence recognition by the calmodulin superfamily: implications from light chain binding to the regulatory domain of scallop myosin. Proc Natl Acad Sci U S A (1995) 1.07
Overestimation of infarct size by quantitative two-dimensional echocardiography: the role of tethering and of analytic procedures. Circulation (1986) 1.06
Malignant mixed tumor of the gallbladder: report of two cases and a review of the literature. Cancer (1982) 1.06
Microtubule structure at low resolution by x-ray diffraction. Proc Natl Acad Sci U S A (1977) 1.05
Bepridil opens the regulatory N-terminal lobe of cardiac troponin C. Proc Natl Acad Sci U S A (2000) 1.05
Racial differences in social support and mental health in men with HIV infection: a pilot study. AIDS Care (1991) 1.05
The independent effects of oxygen radical scavengers on canine infarct size. Reduction by superoxide dismutase but not catalase. Circ Res (1985) 1.05
Assembly of myosin. J Mol Biol (1971) 1.05
Myosin rod phosphorylation and the catch state of molluscan muscles. Science (1987) 1.05