Published in Am J Pathol on October 01, 1996
Modulation of release of proinflammatory bacterial compounds by antibacterials: potential impact on course of inflammation and outcome in sepsis and meningitis. Clin Microbiol Rev (2002) 1.61
Infection of neonatal mice with sindbis virus results in a systemic inflammatory response syndrome. J Virol (1999) 1.56
In vivo expression of interleukin-37 reduces local and systemic inflammation in concanavalin A-induced hepatitis. ScientificWorldJournal (2011) 1.27
Transgenic expression of cyclooxygenase-2 in hepatocytes accelerates endotoxin-induced acute liver failure. J Immunol (2008) 1.04
Ron receptor regulates Kupffer cell-dependent cytokine production and hepatocyte survival following endotoxin exposure in mice. Hepatology (2011) 1.02
Peptidomimetic fluoromethylketone rescues mice from lethal endotoxic shock. Mol Med (1999) 1.00
Gelam honey has a protective effect against lipopolysaccharide (LPS)-induced organ failure. Int J Mol Sci (2012) 0.93
Heat shock protein 72 enhances autophagy as a protective mechanism in lipopolysaccharide-induced peritonitis in rats. Am J Pathol (2011) 0.92
Effects of S-allyl cysteine on lung and liver tissue in a rat model of lipopolysaccharide-induced sepsis. Naunyn Schmiedebergs Arch Pharmacol (2014) 0.86
Antileukoproteinase protects against hepatic inflammation, but not apoptosis in the response of D-galactosamine-sensitized mice to lipopolysaccharide. Br J Pharmacol (2007) 0.82
Depletion of hepatic glutathione prevents death receptor-dependent apoptotic and necrotic liver injury in mice. Am J Pathol (2000) 0.81
Protective effect of phosphatidylcholine on lipopolysaccharide-induced acute inflammation in multiple organ injury. Korean J Physiol Pharmacol (2013) 0.81
Apoptosis in the chorion laeve of term patients with histologic chorioamnionitis. Infect Dis Obstet Gynecol (2002) 0.79
LPS pretreatment ameliorates D-galactosamine/lipopolysaccharide-induced acute liver failure in rat. Int J Clin Exp Pathol (2014) 0.77
Sepsis: prognostic role of apoptosis regulators in gastrointestinal cells. World J Surg (2007) 0.76
Splenic CD11c(low)CD45RB(high) dendritic cells derived from endotoxin-tolerant mice attenuate experimental acute liver failure. Sci Rep (2016) 0.75
Assessment of Free Radical Scavenging Activity of Dimethylglycine Sodium Salt and Its Role in Providing Protection against Lipopolysaccharide-Induced Oxidative Stress in Mice. PLoS One (2016) 0.75
Edaravone protects endotoxin-induced liver injury by inhibiting apoptosis and reducing proinflammatory cytokines. Braz J Med Biol Res (2014) 0.75
Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science (1985) 19.41
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature (1988) 13.42
Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell (1995) 7.13
Altered immune responses in mice lacking inducible nitric oxide synthase. Nature (1995) 6.20
Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci U S A (1995) 4.84
Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits. J Clin Invest (1988) 4.76
Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet (1992) 4.64
The pathogenesis of sepsis. Ann Intern Med (1991) 4.34
Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron (1995) 4.07
An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci U S A (1990) 3.98
A fluorometric assay for the measurement of nitrite in biological samples. Anal Biochem (1993) 3.92
In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note. Hepatology (1995) 3.67
Sepsis syndrome: a valid clinical entity. Methylprednisolone Severe Sepsis Study Group. Crit Care Med (1989) 3.41
Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat. J Clin Invest (1990) 3.39
NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide. Proc Natl Acad Sci U S A (1990) 3.28
Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-alpha requires transcriptional arrest. J Immunol (1994) 2.87
Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock. J Exp Med (1989) 2.69
Neutrophils and the adult respiratory distress syndrome. Am Rev Respir Dis (1983) 2.63
Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am J Pathol (1995) 2.55
Inhibition of nitric oxide synthesis in septic shock: how much is beneficial? Lancet (1992) 2.44
Prevention by granulocyte depletion of increased vascular permeability of sheep lung following endotoxemia. J Clin Invest (1981) 2.28
Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase. J Clin Invest (1992) 2.14
Modulation of nitrogen oxide synthesis in vivo: NG-monomethyl-L-arginine inhibits endotoxin-induced nitrate/nitrate biosynthesis while promoting hepatic damage. J Leukoc Biol (1990) 2.11
Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines. J Biol Chem (1994) 2.04
Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis. Ann Intern Med (1994) 2.00
Internucleosomal DNA cleavage should not be the sole criterion for identifying apoptosis. Int J Radiat Biol (1992) 1.98
Tumor necrosis factor induces apoptosis (programmed cell death) in normal endothelial cells in vitro. Am J Pathol (1991) 1.88
Pathogenesis of disseminated intravascular coagulation in sepsis. JAMA (1993) 1.88
Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice. Biochem Pharmacol (1989) 1.87
Apoptosis in leukocytes. J Leukoc Biol (1995) 1.58
Platelet-activating factor: an endogenous mediator for bowel necrosis in endotoxemia. FASEB J (1987) 1.52
Is platelet activating factor (PAF) a mediator of endotoxin shock? Eur J Pharmacol (1985) 1.50
Activation-induced apoptosis in human macrophages: developmental regulation of a novel cell death pathway by macrophage colony-stimulating factor and interferon gamma. J Exp Med (1995) 1.42
Clinical detection of LPS and animal models of endotoxemia. Immunobiology (1993) 1.34
Inhibition of nitric oxide synthesis during endotoxemia promotes intrahepatic thrombosis and an oxygen radical-mediated hepatic injury. J Leukoc Biol (1992) 1.25
Apoptosis is induced by transforming growth factor-beta 1 within 5 hours in regressing liver without significant fragmentation of the DNA. Hepatology (1993) 1.13
The cell in shock: the origin of multiple organ failure. Resuscitation (1991) 1.08
Relationship between tumor necrosis factor-alpha and neutrophils in endotoxin-induced liver injury. Am J Physiol (1993) 1.05
Leukotriene-mediated liver injury. Biochem Pharmacol (1988) 1.03
Demonstration of extensive chromatin cleavage in transplanted Morris hepatoma 7777 tissue: apoptosis or necrosis? Am J Pathol (1993) 0.99
Antioxidants modulate induction of programmed endothelial cell death (apoptosis) by endotoxin. Arch Surg (1994) 0.99
Ca2+ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen. FASEB J (1993) 0.99
Nitric oxide synthesis serves to reduce hepatic damage during acute murine endotoxemia. Crit Care Med (1992) 0.92
Regulation of hepatic protein synthesis in chronic inflammation and sepsis. Am J Physiol (1992) 0.92
Interleukin-1 and nitric oxide protect against tumor necrosis factor alpha-induced liver injury through distinct pathways. Hepatology (1995) 0.89
Induction of heat shock response leads to apoptosis in endothelial cells previously exposed to endotoxin. Am J Physiol (1993) 0.89
The induction of lipid peroxidation by E. coli lipopolysaccharide on rat hepatocytes as an important factor in the etiology of endotoxic liver damage. Biochim Biophys Acta (1993) 0.89
Differential hemodynamic effects of L-NMMA in endotoxemic and normal dogs. Am J Physiol (1995) 0.84
The systemic inflammatory response syndrome (SIRS): immunology and potential immunotherapy. Infection (1994) 0.84
Protection against rat endotoxic shock by p55 tumor necrosis factor (TNF) receptor immunoadhesin: comparison with anti-TNF monoclonal antibody. J Infect Dis (1994) 0.82
Biochemical pharmacology of inflammatory liver injury in mice. Methods Enzymol (1990) 0.81
Endotoxin induces organ-specific endothelial cell injury. Shock (1995) 0.79
Alteration of xanthine oxidase activity in sinusoidal endothelial cells and morphological changes of Kupffer cells in hypoxic and reoxygenated rat liver. Hepatology (1995) 0.78
An electron microscopic study of the liver of endotoxin-shocked dogs treated with a combination of propiomazine and levarterenol. Lab Invest (1969) 0.77
Effects of a platelet-activating factor antagonist, CV-3988, on different shock models in the rat. Circ Shock (1986) 0.77
Selective segmental hepatic necrosis produced by the Shwartzman mechanism in rabbits. Virchows Arch A Pathol Anat Histopathol (1989) 0.77
A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest (1992) 4.39
Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-alpha requires transcriptional arrest. J Immunol (1994) 2.87
Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor. J Cell Biol (2001) 2.68
Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am J Pathol (1995) 2.55
Effect of filgrastim treatment on inflammatory cytokines and lymphocyte functions. Clin Pharmacol Ther (1999) 2.33
Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A. Gastroenterology (1996) 2.27
Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor. Hepatology (1995) 2.21
Glutathione peroxidase. Methods Enzymol (1981) 2.07
The refined structure of the selenoenzyme glutathione peroxidase at 0.2-nm resolution. Eur J Biochem (1983) 2.05
Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice. Biochem Pharmacol (1989) 1.87
Age-related macular degeneration. The lipofusion component N-retinyl-N-retinylidene ethanolamine detaches proapoptotic proteins from mitochondria and induces apoptosis in mammalian retinal pigment epithelial cells. J Biol Chem (2000) 1.84
Granulocyte colony-stimulating factor treatment protects rodents against lipopolysaccharide-induced toxicity via suppression of systemic tumor necrosis factor-alpha. J Immunol (1992) 1.60
In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis. Eur J Immunol (1997) 1.53
Effect of granulocyte colony-stimulating factor treatment on ex vivo blood cytokine response in human volunteers. Blood (1995) 1.52
Intracellular ATP, a switch in the decision between apoptosis and necrosis. Toxicol Lett (1998) 1.50
A novel technique for selective NF-kappaB inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia-reperfusion. Gut (2009) 1.49
Imidazole-buffered osmium tetroxide: an excellent stain for visualization of lipids in transmission electron microscopy. Histochem J (1982) 1.47
The fate of extracellular glutathione in the rat. Biochim Biophys Acta (1978) 1.45
Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release. J Immunol (1995) 1.45
Rapid, noninflammatory and PS-dependent phagocytic clearance of necrotic cells. Cell Death Differ (2003) 1.44
Importance of Kupffer cells for T-cell-dependent liver injury in mice. Am J Pathol (2000) 1.42
Improved innate immunity of endotoxin-tolerant mice increases resistance to Salmonella enterica serovar typhimurium infection despite attenuated cytokine response. Infect Immun (2001) 1.40
A DNA damage repair mechanism is involved in the origin of chromosomal translocations t(4;11) in primary leukemic cells. Oncogene (1999) 1.39
Triggering of apoptosis by cathepsins. Cell Death Differ (2001) 1.39
The novel SAR-binding domain of scaffold attachment factor A (SAF-A) is a target in apoptotic nuclear breakdown. EMBO J (1997) 1.37
Hyperventilation induces release of cytokines from perfused mouse lung. Am J Respir Crit Care Med (1998) 1.36
CXCR4 and CD4 mediate a rapid CD95-independent cell death in CD4(+) T cells. Proc Natl Acad Sci U S A (1998) 1.35
A novel biologically active seleno-organic compound--II. Activity of PZ 51 in relation to glutathione peroxidase. Biochem Pharmacol (1984) 1.34
In vitro differentiation of human monocytes to macrophages: change of PDE profile and its relationship to suppression of tumour necrosis factor-alpha release by PDE inhibitors. Br J Pharmacol (1997) 1.34
The amino-acid sequence of bovine glutathione peroxidase. Hoppe Seylers Z Physiol Chem (1984) 1.31
Selective nitration of prostacyclin synthase and defective vasorelaxation in atherosclerotic bovine coronary arteries. Am J Pathol (1999) 1.31
Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity. Proc Natl Acad Sci U S A (1999) 1.30
Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. Gastroenterology (1998) 1.28
Neuronal cell death: a demise with different shapes. Trends Pharmacol Sci (1999) 1.28
Energy supply and the shape of death in neurons and lymphoid cells. Cell Death Differ (1997) 1.27
Granulocyte-macrophage colony-stimulating factor and IFN-gamma restore the systemic TNF-alpha response to endotoxin in lipopolysaccharide-desensitized mice. J Immunol (1997) 1.26
Characterization of Rhodobacter capsulatus genes encoding a molybdenum transport system and putative molybdenum-pterin-binding proteins. J Bacteriol (1993) 1.22
The level and half-life of glutathione in human plasma. FEBS Lett (1980) 1.21
Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation. Br J Pharmacol (2007) 1.21
Acute paracetamol intoxication of starved mice leads to lipid peroxidation in vivo. Biochem Pharmacol (1979) 1.20
Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice. Cell Death Differ (1998) 1.19
Selenium and drug metabolism--I. Multiple modulations of mouse liver enzymes. Biochem Pharmacol (1983) 1.18
Irradiation-induced progenitor cell death in the developing brain is resistant to erythropoietin treatment and caspase inhibition. Cell Death Differ (2004) 1.18
The 55-kD tumor necrosis factor receptor and CD95 independently signal murine hepatocyte apoptosis and subsequent liver failure. Mol Med (1996) 1.16
Promoters controlling expression of the alternative nitrogenase and the molybdenum uptake system in Rhodobacter capsulatus are activated by NtrC, independent of sigma54, and repressed by molybdenum. J Bacteriol (1996) 1.15
Drug-induced lipid peroxidation in mice--I. Modulation by monooxygenase activity, glutathione and selenium status. Biochem Pharmacol (1981) 1.15
Acute hepatotoxicity of Pseudomonas aeruginosa exotoxin A in mice depends on T cells and TNF. J Immunol (1998) 1.13
TNF-alpha-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis. J Immunol (2001) 1.13
Human monocytes express functional receptors for granulocyte colony-stimulating factor that mediate suppression of monokines and interferon-gamma. Blood (2000) 1.13
Lipopolysaccharide-induced interleukin-10 in mice: role of endogenous tumor necrosis factor-alpha. Eur J Immunol (1995) 1.13
Cytoskeletal breakdown and apoptosis elicited by NO donors in cerebellar granule cells require NMDA receptor activation. J Neurochem (1996) 1.13
Inducible nitric oxide synthase is critical for immune-mediated liver injury in mice. J Clin Invest (2001) 1.12
Role of sinusoidal endothelial cells of the liver in concanavalin A-induced hepatic injury in mice. Hepatology (1996) 1.12
[Glutathion peroxidase. I. Isolation and determinations of molecular weight]. Hoppe Seylers Z Physiol Chem (1971) 1.11
Metabolic depletion of ATP by fructose inversely controls CD95- and tumor necrosis factor receptor 1-mediated hepatic apoptosis. J Exp Med (2000) 1.11
Novel urinary metabolite of alpha-tocopherol, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin E supply? Am J Clin Nutr (1995) 1.10
Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing. Cell Death Differ (2010) 1.09
Selective cytochemical localization of peroxidase, cytochrome oxidase and catalase in rat liver with 3,3'-diaminobenzidine. Histochemistry (1981) 1.08
Apoptosis and necrosis: different execution of the same death. Biochem Soc Symp (1999) 1.07
Phagocytosis of nonapoptotic cells dying by caspase-independent mechanisms. J Immunol (2000) 1.06
Caspase inhibition reduces apoptosis and increases survival of nigral transplants. Nat Med (1999) 1.06
Simultaneous release of adenylate kinase and cytochrome c in cell death. Cell Death Differ (1998) 1.06
The multiple functions of heme oxygenase-1 in the liver. Z Gastroenterol (2012) 1.06
Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins. Gastroenterology (1997) 1.05
Concanavalin A hepatotoxicity in mice: tumor necrosis factor-mediated organ failure independent of caspase-3-like protease activation. Hepatology (1999) 1.05
Effect of tauroursodeoxycholic acid on bile-acid-induced apoptosis and cytolysis in rat hepatocytes. J Hepatol (1998) 1.04
Structure analysis and molecular model of the selenoenzyme glutathione peroxidase at 2.8 A resolution. J Mol Biol (1979) 1.04
Tumor necrosis factor-induced hepatic DNA fragmentation as an early marker of T cell-dependent liver injury in mice. Gastroenterology (1995) 1.04
Biased distribution of chromosomal breakpoints involving the MLL gene in infants versus children and adults with t(4;11) ALL. Oncogene (2001) 1.04
Leukotriene-mediated liver injury. Biochem Pharmacol (1988) 1.03
Selenoenzymes regulate the activity of leukocyte 5-lipoxygenase via the peroxide tone. J Biol Chem (1993) 1.03
The function of plant heat shock promoter elements in the regulated expression of chimaeric genes in transgenic tobacco. Mol Gen Genet (1989) 1.02
Leukocyte alterations do not account for hepatitis induced by endotoxin or TNF alpha in galactosamine-sensitized mice. Biochem Pharmacol (1990) 1.02
Synthesis of ganglioside GD3 and its comparison with bovine GD3 with regard to oligodendrocyte apoptosis mitochondrial damage. Chemistry (2001) 1.01
ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-alpha. Immunol Lett (1997) 1.01