Published in Mol Med on January 01, 1996
Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J Exp Med (1997) 5.53
Ethanol-induced apoptosis in mouse liver: Fas- and cytochrome c-mediated caspase-3 activation pathway. Am J Pathol (2001) 1.20
Metabolic depletion of ATP by fructose inversely controls CD95- and tumor necrosis factor receptor 1-mediated hepatic apoptosis. J Exp Med (2000) 1.11
Animal models of acute hepatic failure. Int J Exp Pathol (2000) 1.10
Liver failure following partial hepatectomy. HPB (Oxford) (2006) 1.03
Ron receptor regulates Kupffer cell-dependent cytokine production and hepatocyte survival following endotoxin exposure in mice. Hepatology (2011) 1.02
Involvement of TNF in limiting liver pathology and promoting parasite survival during schistosome infection. Int J Parasitol (2004) 0.98
Regulating TRAIL receptor-induced cell death at the membrane : a deadly discussion. Recent Pat Anticancer Drug Discov (2011) 0.97
Tumor necrosis factor receptor p55 is essential for intrahepatic granuloma formation and hepatocellular apoptosis in a murine model of bacterium-induced fulminant hepatitis. Infect Immun (1997) 0.94
Signals and cells involved in regulating liver regeneration. Cells (2012) 0.94
Lysosomes and Fas-mediated liver cell death. Biochem J (2007) 0.81
Depletion of hepatic glutathione prevents death receptor-dependent apoptotic and necrotic liver injury in mice. Am J Pathol (2000) 0.81
2,3,7,8-TCDD enhances the sensitivity of mice to concanavalin A immune-mediated liver injury. Toxicol Appl Pharmacol (2012) 0.78
D-Galactosamine Intoxication in Experimental Animals: Is it Only an Experimental Model of Acute Liver Failure? Med Sci Monit (2015) 0.77
Lead increases lipopolysaccharide-induced liver-injury through tumor necrosis factor-alpha overexpression by monocytes/macrophages: role of protein kinase C and P42/44 mitogen-activated protein kinase. Environ Health Perspect (2006) 0.77
Hepatoprotective effect of nitric oxide in experimental model of acute hepatic failure. World J Gastroenterol (2014) 0.75
Looking beneath the surface: the cell death pathway of Fas/APO-1 (CD95). Mol Med (1996) 0.75
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods (1983) 114.35
Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature (1980) 17.69
The Fas death factor. Science (1995) 13.81
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell (1991) 10.96
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell (1993) 9.84
Lethal effect of the anti-Fas antibody in mice. Nature (1993) 9.20
Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell (1993) 9.06
A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes. J Immunol Methods (1986) 8.88
Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes. Nature (1993) 7.10
A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor. J Exp Med (1989) 7.07
A novel domain within the 55 kd TNF receptor signals cell death. Cell (1993) 5.59
A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF. Cell (1988) 5.42
Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature (1995) 4.95
Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice. J Exp Med (1987) 4.63
Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity. J Exp Med (1993) 4.53
Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. Exp Cell Res (1973) 4.32
T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor. J Exp Med (1992) 4.31
Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J Biol Chem (1995) 3.83
A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. J Biol Chem (1993) 3.81
The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. J Immunol (1992) 3.66
Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen. J Biol Chem (1992) 3.48
Purification and characterization of the Fas-ligand that induces apoptosis. J Exp Med (1994) 3.11
Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-alpha requires transcriptional arrest. J Immunol (1994) 2.87
Expression of the functional soluble form of human fas ligand in activated lymphocytes. EMBO J (1995) 2.87
Self-association of the "death domains" of the p55 tumor necrosis factor (TNF) receptor and Fas/APO1 prompts signaling for TNF and Fas/APO1 effects. J Biol Chem (1995) 2.78
Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am J Pathol (1995) 2.55
Effect of bcl-2 on Fas antigen-mediated cell death. J Immunol (1993) 2.50
Inactivation of Kupffer cells prevents early alcohol-induced liver injury. Hepatology (1994) 2.37
T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6. J Exp Med (1994) 2.31
Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor. Hepatology (1995) 2.21
Contenders in FasL/TNF death signaling. Cell (1995) 2.21
Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor. Cell (1993) 2.17
Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways. J Immunol (1994) 2.06
Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death. EMBO J (1994) 2.05
Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice. Biochem Pharmacol (1989) 1.87
The active form of tumor necrosis factor is a trimer. J Biol Chem (1987) 1.86
Immunohistochemical detection of Fas antigen in liver tissue of patients with chronic hepatitis C. Hepatology (1994) 1.80
Anti-Fas monoclonal antibody is cytocidal to human immunodeficiency virus-infected cells without augmenting viral replication. Proc Natl Acad Sci U S A (1990) 1.68
HBsAg retention sensitizes the hepatocyte to injury by physiological concentrations of interferon-gamma. Hepatology (1992) 1.68
Pathogenesis of the toxic shock syndrome: T cell mediated lethal shock caused by the superantigen TSST-1. Eur J Immunol (1993) 1.54
Nonparenchymal cells and hepatotoxicity. Semin Liver Dis (1990) 1.50
The E1b oncogene of adenovirus confers cellular resistance to cytotoxicity of tumor necrosis factor and monoclonal anti-Fas antibody. Int Immunol (1991) 1.45
Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release. J Immunol (1995) 1.45
Effect of agents which modify reticuloendothelial system function on acute phalloidin-induced lethality and hepatotoxicity in mice. Toxicol Appl Pharmacol (1995) 1.43
Fas-mediated apoptosis in primary cultured mouse hepatocytes. Exp Cell Res (1994) 1.41
Cytoplasmic truncation of the p55 tumour necrosis factor (TNF) receptor abolishes signalling, but not induced shedding of the receptor. EMBO J (1992) 1.39
The involvement of Kupffer cells in carbon tetrachloride toxicity. Toxicol Appl Pharmacol (1993) 1.38
Modulation of macrophage functioning abrogates the acute hepatotoxicity of acetaminophen. Hepatology (1995) 1.36
Tumor necrosis factor in the pathogenesis of infectious diseases. Crit Care Med (1993) 1.29
Activin induces cell death in hepatocytes in vivo and in vitro. Hepatology (1993) 1.25
Fas and tumor necrosis factor receptor-mediated cell death: similarities and distinctions. J Exp Med (1994) 1.23
Effect of transforming growth factor beta on cell death of cultured rat hepatocytes. Cancer Res (1991) 1.20
Aggregation of the intracellular domain of the type 1 tumor necrosis factor receptor defined by the two-hybrid system. J Biol Chem (1994) 1.19
Hepatic injury and lethal shock in galactosamine-sensitized mice induced by the superantigen staphylococcal enterotoxin B. Gastroenterology (1994) 1.18
Intestinal endotoxins as mediators of hepatic injury--an idea whose time has come again. Hepatology (1989) 1.15
The APO-1/Fas (CD95) receptor is expressed in homozygous MRL/lpr mice. Eur J Immunol (1994) 1.12
Transhepatic metabolism of TNF-alpha, IL-6, and endotoxin in the early hepatic reperfusion period after human liver transplantation. Transplantation (1994) 1.07
Tumor necrosis factor-induced hepatic DNA fragmentation as an early marker of T cell-dependent liver injury in mice. Gastroenterology (1995) 1.04
Overcoming tumor necrosis factor and drug resistance of human tumor cell lines by combination treatment with anti-Fas antibody and drugs or toxins. Cancer Res (1993) 0.95
The anti-CD3-induced syndrome: a consequence of massive in vivo cell activation. Curr Top Microbiol Immunol (1991) 0.92
Segregation of APO-1/Fas antigen- and tumor necrosis factor receptor-mediated apoptosis. Eur J Immunol (1994) 0.91
Lipopolysaccharide-neutralizing antibody reduces hepatocyte injury from acute hepatotoxin administration. Hepatology (1994) 0.82
Role of Kupffer cells in rat liver injury induced by diethyldithiocarbamate. Eur J Pharmacol (1995) 0.79
Immune response in mice that lack the interferon-gamma receptor. Science (1993) 12.15
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature (1992) 9.01
Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature (1994) 8.85
Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes. Nature (1993) 7.10
Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature (1993) 6.54
Molecular and neuronal substrate for the selective attenuation of anxiety. Science (2000) 5.07
A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest (1992) 4.39
Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes. Nature (1999) 4.36
Targeted disruption of the MHC class II Aa gene in C57BL/6 mice. Int Immunol (1993) 3.73
MHC class II molecules are not required for survival of newly generated CD4+ T cells, but affect their long-term life span. Immunity (1996) 3.20
A crucial role for B cells in neuroinvasive scrapie. Nature (1998) 3.19
Attenuation of allergic airway inflammation in IL-4 deficient mice. Clin Exp Allergy (1994) 3.04
Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-alpha requires transcriptional arrest. J Immunol (1994) 2.87
Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. J Immunol (1995) 2.87
Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha. J Exp Med (1995) 2.80
Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am J Pathol (1995) 2.55
Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice. Am J Respir Cell Mol Biol (1995) 2.41
Effect of filgrastim treatment on inflammatory cytokines and lymphocyte functions. Clin Pharmacol Ther (1999) 2.33
Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A. Gastroenterology (1996) 2.27
Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor. Hepatology (1995) 2.21
Thymus medulla consisting of epithelial islets each derived from a single progenitor. Nature (2001) 2.18
Glutathione peroxidase. Methods Enzymol (1981) 2.07
The refined structure of the selenoenzyme glutathione peroxidase at 0.2-nm resolution. Eur J Biochem (1983) 2.05
The protooncogene TCL1 is an Akt kinase coactivator. Mol Cell (2000) 1.96
Differentiation of follicular dendritic cells and full antibody responses require tumor necrosis factor receptor-1 signaling. J Exp Med (1996) 1.93
Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice. Biochem Pharmacol (1989) 1.87
Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-alpha double-deficient mice. Int Immunol (1996) 1.83
Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor. Proc Natl Acad Sci U S A (1997) 1.66
CD40 ligand has potent antiviral activity. Nat Med (1995) 1.64
Mutations affecting either generation or survival of cells influence the pool size of mature B cells. Immunity (1999) 1.61
Granulocyte colony-stimulating factor treatment protects rodents against lipopolysaccharide-induced toxicity via suppression of systemic tumor necrosis factor-alpha. J Immunol (1992) 1.60
A schizophrenia-related sensorimotor deficit links alpha 3-containing GABAA receptors to a dopamine hyperfunction. Proc Natl Acad Sci U S A (2005) 1.60
Prolonged contraction-relaxation cycle of fast-twitch muscles in parvalbumin knockout mice. Am J Physiol (1999) 1.60
In interleukin-4-deficient mice, alum not only generates T helper 1 responses equivalent to freund's complete adjuvant, but continues to induce T helper 2 cytokine production. Eur J Immunol (1996) 1.59
Antiviral activity of tumor necrosis factor (TNF) is mediated via p55 and p75 TNF receptors. J Exp Med (1997) 1.59
Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane-bound TNF in experimental cerebral malaria. Eur J Immunol (1997) 1.56
In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis. Eur J Immunol (1997) 1.53
Effect of granulocyte colony-stimulating factor treatment on ex vivo blood cytokine response in human volunteers. Blood (1995) 1.52
Multivalent structure of an alphabetaT cell receptor. Proc Natl Acad Sci U S A (1999) 1.52
Oral immunization of interleukin-4 (IL-4) knockout mice with a recombinant Salmonella strain or cholera toxin reveals that CD4+ Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin A responses. Infect Immun (1996) 1.50
A novel technique for selective NF-kappaB inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia-reperfusion. Gut (2009) 1.49
Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells. J Exp Med (1996) 1.49
The fate of extracellular glutathione in the rat. Biochim Biophys Acta (1978) 1.45
Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release. J Immunol (1995) 1.45
Aplastic anemia rescued by exhaustion of cytokine-secreting CD8+ T cells in persistent infection with lymphocytic choriomeningitis virus. J Exp Med (1998) 1.44
Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans. EMBO J (1993) 1.44
Greatly accelerated lymphadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor I. J Immunol (1996) 1.43
Importance of Kupffer cells for T-cell-dependent liver injury in mice. Am J Pathol (2000) 1.42
Improved innate immunity of endotoxin-tolerant mice increases resistance to Salmonella enterica serovar typhimurium infection despite attenuated cytokine response. Infect Immun (2001) 1.40
Stress-induced enhancement of skin immune function: A role for gamma interferon. Proc Natl Acad Sci U S A (2000) 1.39
Molecules and mechanisms operating in septic shock: lessons from knockout mice. Immunol Today (1997) 1.38
Hyperventilation induces release of cytokines from perfused mouse lung. Am J Respir Crit Care Med (1998) 1.36
Disruption of the murine interleukin-4 gene inhibits disease progression during Leishmania mexicana infection but does not increase control of Leishmania donovani infection. Infect Immun (1995) 1.35
A novel biologically active seleno-organic compound--II. Activity of PZ 51 in relation to glutathione peroxidase. Biochem Pharmacol (1984) 1.34
In vitro differentiation of human monocytes to macrophages: change of PDE profile and its relationship to suppression of tumour necrosis factor-alpha release by PDE inhibitors. Br J Pharmacol (1997) 1.34
Origin of CD4-CD8-B220+ T cells in MRL-lpr/lpr mice. Clues from a T cell receptor beta transgenic mouse. J Immunol (1993) 1.33
Efficient control of gene expression by single step integration of the tetracycline system in transgenic mice. Nat Biotechnol (1996) 1.32
Alternate mucosal immune system: organized Peyer's patches are not required for IgA responses in the gastrointestinal tract. J Immunol (2000) 1.32
Abnormal thymocyte development and production of autoreactive T cells in T cell receptor transgenic autoimmune mice. J Immunol (1991) 1.32
The amino-acid sequence of bovine glutathione peroxidase. Hoppe Seylers Z Physiol Chem (1984) 1.31
Severity of symptoms and demyelination in MOG-induced EAE depends on TNFR1. Eur J Immunol (1999) 1.29
Different roles for interleukin-4 during the course of Toxoplasma gondii infection. Infect Immun (1996) 1.29
The shape of cell death. Biochem Biophys Res Commun (1997) 1.28
Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. Gastroenterology (1998) 1.28
The role of Th1 and Th2 cells for mucosal IgA responses. Ann N Y Acad Sci (1996) 1.26
Granulocyte-macrophage colony-stimulating factor and IFN-gamma restore the systemic TNF-alpha response to endotoxin in lipopolysaccharide-desensitized mice. J Immunol (1997) 1.26
Apoptosis in the absence of poly-(ADP-ribose) polymerase. Biochem Biophys Res Commun (1997) 1.25
T-independent activation of B cells by vesicular stomatitis virus: no evidence for the need of a second signal. Cell Immunol (1996) 1.23
Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75), in murine toxoplasmosis. J Immunol (1998) 1.22
The level and half-life of glutathione in human plasma. FEBS Lett (1980) 1.21
Impaired neuroglial activation in interleukin-6 deficient mice. Glia (1997) 1.21
Acute paracetamol intoxication of starved mice leads to lipid peroxidation in vivo. Biochem Pharmacol (1979) 1.20
Strongly compromised inflammatory response to brain injury in interleukin-6-deficient mice. Glia (1999) 1.18
Selenium and drug metabolism--I. Multiple modulations of mouse liver enzymes. Biochem Pharmacol (1983) 1.18
Mice deficient for tenascin-R display alterations of the extracellular matrix and decreased axonal conduction velocities in the CNS. J Neurosci (1999) 1.18
Drug-induced lipid peroxidation in mice--I. Modulation by monooxygenase activity, glutathione and selenium status. Biochem Pharmacol (1981) 1.15
T helper 2 cells are subject to high dose oral tolerance and are not essential for its induction. J Immunol (1995) 1.14
Apoptosis, excitotoxicity, and neuropathology. Exp Cell Res (1998) 1.14
Acute hepatotoxicity of Pseudomonas aeruginosa exotoxin A in mice depends on T cells and TNF. J Immunol (1998) 1.13
TNF-alpha-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis. J Immunol (2001) 1.13
Human monocytes express functional receptors for granulocyte colony-stimulating factor that mediate suppression of monokines and interferon-gamma. Blood (2000) 1.13
Lipopolysaccharide-induced interleukin-10 in mice: role of endogenous tumor necrosis factor-alpha. Eur J Immunol (1995) 1.13