Published in Cell on November 01, 1996
Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation. EMBO J (1999) 3.95
Hematopoietic stem cell fate is established by the Notch-Runx pathway. Genes Dev (2005) 3.27
Correlating notch signaling with thymocyte maturation. Immunity (1998) 2.82
Mammalian glycosylation in immunity. Nat Rev Immunol (2008) 2.74
Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Genes Dev (1998) 2.70
Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes. Immunity (2000) 2.58
Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions. J Exp Med (2004) 2.58
Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice. EMBO J (2000) 2.41
Targeting the Notch1 and mTOR pathways in a mouse T-ALL model. Blood (2009) 2.29
Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol Cell Biol (1997) 2.12
Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol Cell Biol (1998) 1.99
NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa. Mol Cell Biol (1998) 1.96
The bHLH gene Hes1 is essential for expansion of early T cell precursors. Genes Dev (1999) 1.95
Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation. J Exp Med (2001) 1.94
NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL. Blood (2008) 1.84
Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors. Am J Pathol (2006) 1.80
Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C. Mol Cell Biol (1999) 1.61
Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors. EMBO J (1999) 1.61
Spectrum and frequency of jagged1 (JAG1) mutations in Alagille syndrome patients and their families. Am J Hum Genet (1998) 1.57
Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2. Mol Cell Biol (2000) 1.54
Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines. Mol Cell Biol (1998) 1.48
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Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals. Proc Natl Acad Sci U S A (2004) 1.42
Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice. Mol Cell Biol (1999) 1.38
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Notch signalling via RBP-J promotes myeloid differentiation. EMBO J (2000) 1.28
Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells. J Exp Med (2000) 1.26
The N- and C-terminal regions of RBP-J interact with the ankyrin repeats of Notch1 RAMIC to activate transcription. Nucleic Acids Res (2001) 1.24
Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nat Immunol (2008) 1.23
Is there a role for Notch signalling in human breast cancer? Breast Cancer Res (2003) 1.21
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Activated Notch1 modulates gene expression in B cells similarly to Epstein-Barr viral nuclear antigen 2. J Virol (2000) 1.16
HD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cells. Proc Natl Acad Sci U S A (1998) 1.16
p107 regulates neural precursor cells in the mammalian brain. J Cell Biol (2004) 1.15
Propensity of adult lymphoid progenitors to progress to DN2/3 stage thymocytes with Notch receptor ligation. J Immunol (2005) 1.15
Identification of Notch1 as a frequent target for provirus insertional mutagenesis in T-cell lymphomas induced by leukemogenic mutants of mouse mammary tumor virus. J Virol (2000) 1.15
Gamma -secretase inhibitors repress thymocyte development. Proc Natl Acad Sci U S A (2001) 1.15
The notch pathway intermediate HES-1 silences CD4 gene expression. Mol Cell Biol (1998) 1.14
Presenilin-dependent gamma-secretase activity modulates thymocyte development. Proc Natl Acad Sci U S A (2001) 1.13
Activated mouse Notch1 transactivates Epstein-Barr virus nuclear antigen 2-regulated viral promoters. J Virol (1999) 1.08
Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer. Cancer Res (2008) 1.07
Notch signaling in CD4 and CD8 T cell development. Curr Opin Immunol (2008) 1.06
Essential role of Notch signaling in effector memory CD8+ T cell-mediated airway hyperresponsiveness and inflammation. J Exp Med (2008) 1.05
Presenilins regulate alphabeta T cell development by modulating TCR signaling. J Exp Med (2007) 1.02
Modulated expression of the epidermal growth factor-like homeotic protein dlk influences stromal-cell-pre-B-cell interactions, stromal cell adipogenesis, and pre-B-cell interleukin-7 requirements. Mol Cell Biol (1998) 1.01
Notch inhibitors as a new tool in the war on cancer: a pathway to watch. Curr Pharm Biotechnol (2009) 1.00
An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway. J Neurosci (2013) 1.00
Notch signaling during vascular development. Proc Natl Acad Sci U S A (2001) 0.99
Notch activation as a driver of osteogenic sarcoma. Cancer Cell (2014) 0.99
Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism. J Clin Invest (2003) 0.99
WASp verprolin homology, cofilin homology, and acidic region domain-mediated actin polymerization is required for T cell development. Proc Natl Acad Sci U S A (2002) 0.99
Notch1 confers a resistance to glucocorticoid-induced apoptosis on developing thymocytes by down-regulating SRG3 expression. Proc Natl Acad Sci U S A (2001) 0.98
Activated Notch2 potentiates CD8 lineage maturation and promotes the selective development of B1 B cells. Mol Cell Biol (2003) 0.97
Two distinct pathways of positive selection for thymocytes. Proc Natl Acad Sci U S A (1998) 0.96
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A cellular automata-based mathematical model for thymocyte development. PLoS One (2009) 0.89
Visualization of CD4/CD8 T cell commitment. J Exp Med (1998) 0.87
Reversal of the CD4(+)/CD8(+) T-cell ratio in lymph node cells upon in vitro mitogenic stimulation by highly purified, water-soluble S3-S4 dimer of pertussis toxin. Infect Immun (2001) 0.86
Ubiquitinations in the notch signaling pathway. Int J Mol Sci (2013) 0.86
Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cells. Blood (2007) 0.84
Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch. J Immunol (2013) 0.84
T-cell regulation of peripheral tolerance and immunity: the potential role for Notch signalling. Immunology (2000) 0.84
Growth factor independent-1 maintains Notch1-dependent transcriptional programming of lymphoid precursors. PLoS Genet (2013) 0.83
Normal immune system development in mice lacking the Deltex-1 RING finger domain. Mol Cell Biol (2005) 0.83
A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL). Dis Model Mech (2013) 0.82
Thymocyte apoptosis. J Clin Immunol (1999) 0.81
Commitment of immature CD4+8+ thymocytes to the CD4 lineage requires CD3 signaling but does not require expression of clonotypic T cell receptor (TCR) chains. J Exp Med (1997) 0.81
Nonoverlapping functions for Notch1 and Notch3 during murine steady-state thymic lymphopoiesis. Blood (2011) 0.81
Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence. Nat Commun (2016) 0.80
Notch ligand delta-like 4-pretreated dendritic cells alleviate allergic airway responses by enhancing IL-10 production. PLoS One (2013) 0.79
Developmental exposure to 2,3,7,8 tetrachlorodibenzo-p-dioxin attenuates later-life Notch1-mediated T cell development and leukemogenesis. Toxicol Appl Pharmacol (2015) 0.78
Connecting the dots: artificial antigen presenting cell-mediated modulation of natural killer T cells. J Interferon Cytokine Res (2012) 0.78
Lck domains differentially contribute to pre-T cell receptor (TCR)- and TCR-alpha/beta-regulated developmental transitions. J Exp Med (2000) 0.77
PKCθ links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton. Elife (2017) 0.75
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Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains. Sci Adv (2017) 0.75
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