Human pancreatic beta-cell deoxyribonucleic acid-synthesis in islet grafts decreases with increasing organ donor age but increases in response to glucose stimulation in vitro.

PubWeight™: 1.16‹?› | Rank: Top 10%

🔗 View Article (PMID 8940401)

Published in Endocrinology on December 01, 1996

Authors

B Tyrberg1, D L Eizirik, C Hellerström, D G Pipeleers, A Andersson

Author Affiliations

1: Department of Medical Cell Biology, Uppsala University, Sweden. bjorn.tyrberg@medcellbiol.uu.se

Articles citing this

Adaptive beta-cell proliferation is severely restricted with advanced age. Diabetes (2009) 3.45

Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD-severe combined immunodeficiency (SCID) mice. Diabetologia (2010) 2.26

Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6. Diabetes (2010) 2.12

Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo. Diabetes (2009) 1.70

Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function. Cell Metab (2015) 1.21

Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication. Proc Natl Acad Sci U S A (2012) 1.21

Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2rγnull Ins2Akita mice. Pancreas (2011) 0.93

Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes. BMC Endocr Disord (2002) 0.92

Impact of obesity severity and duration on pancreatic β- and α-cell dynamics in normoglycemic non-human primates. Int J Obes (Lond) (2012) 0.91

Early and Late G1/S Cyclins and Cdks Act Complementarily to Enhance Authentic Human β-Cell Proliferation and Expansion. Diabetes (2015) 0.79

Adult tissue sources for new β cells. Transl Res (2013) 0.76

Imatinib prevents beta cell death in vitro but does not improve islet transplantation outcome. Ups J Med Sci (2016) 0.75

Genetic Disruption of Adenosine Kinase in Mouse Pancreatic β-Cells Protects Against High Fat Diet-Induced Glucose Intolerance. Diabetes (2017) 0.75

Articles by these authors

Rate of chain breakage at apurinic sites in double-stranded deoxyribonucleic acid. Biochemistry (1972) 5.49

Lack of effect of acid suppression therapy on gastric atrophy. Nordic Gerd Study Group. Gastroenterology (1999) 4.41

RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages. Scand J Immunol (2005) 2.96

A transcriptional roadmap to wood formation. Proc Natl Acad Sci U S A (2001) 2.85

Transplantation of porcine fetal pancreas to diabetic patients. Lancet (1994) 2.52

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients. Diabetologia (2007) 2.48

Experimental studies on cholera immunization. II. Evidence for protective antitoxic immunity mediated by serum antibodies as well as local antibodies. Infect Immun (1972) 2.37

A new in vitro model for the study of pancreatic A and B cells. Endocrinology (1985) 2.29

Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation. Diabetes (2001) 2.20

Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells. Proc Natl Acad Sci U S A (1988) 2.11

Primary carcinoma of the duodenum. Ann Surg (1980) 2.04

High frequency of persisting or increasing islet-specific autoantibody levels after diagnosis of type 1 diabetes presenting before 40 years of age. The Belgian Diabetes Registry. Diabetes Care (2000) 2.04

Total homocysteine in plasma or serum: methods and clinical applications. Clin Chem (1993) 2.01

Wild-type Escherichia coli cells regulate the membrane lipid composition in a "window" between gel and non-lamellar structures. J Biol Chem (1996) 1.98

Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function. J Clin Invest (1992) 1.95

Use of genetically marked minicells as a probe in measurement of predation on bacteria in aquatic environments. Appl Environ Microbiol (1986) 1.87

Conditional and specific NF-kappaB blockade protects pancreatic beta cells from diabetogenic agents. Proc Natl Acad Sci U S A (2006) 1.85

Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutase. Circulation (2001) 1.79

Plasma homocysteine in the acute and convalescent phases after stroke. Stroke (1995) 1.78

Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury. Proc Natl Acad Sci U S A (1994) 1.76

Markedly decreased oxygen tension in transplanted rat pancreatic islets irrespective of the implantation site. Diabetes (2001) 1.71

Isolated mouse pancreatic islets in culture: effects of serum and different culture media on the insulin production of the islets. Diabetologia (1978) 1.67

Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis. Diabetes (2001) 1.66

Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus. Diabetes (2001) 1.66

Effects of carbohydrates on the oxygen consumption of isolated pancreatic islets of mice. Endocrinology (1967) 1.64

Desaturation and elongation of Fatty acids and insulin action. Ann N Y Acad Sci (2002) 1.64

Pancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids. J Clin Invest (1997) 1.63

A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells. J Biol Chem (2001) 1.60

Activation of old carbon by erosion of coastal and subsea permafrost in Arctic Siberia. Nature (2012) 1.55

A method for the purification of single A, B and D cells and for the isolation of coupled cells from isolated rat islets. Diabetologia (1981) 1.54

Extra-insular beta cells associated with ductules are frequent in adult human pancreas. Diabetologia (1998) 1.54

A genomic-based approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)gammaa as a pancreatic beta cell-specific biomarker. Diabetologia (2010) 1.53

Interleukin-1 beta-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase. Endocrinology (1991) 1.52

Cytokines suppress human islet function irrespective of their effects on nitric oxide generation. J Clin Invest (1994) 1.48

Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes. Diabetologia (2010) 1.48

Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis. Cell Death Differ (2009) 1.47

Inhibitory effects of interleukin 1 on insulin secretion, insulin biosynthesis, and oxidative metabolism of isolated rat pancreatic islets. Endocrinology (1987) 1.45

Implantation of standardized beta-cell grafts in a liver segment of IDDM patients: graft and recipients characteristics in two cases of insulin-independence under maintenance immunosuppression for prior kidney graft. Diabetologia (1998) 1.44

Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays. Diabetes (2001) 1.43

Interplay of nutrients and hormones in the regulation of insulin release. Endocrinology (1985) 1.41

IL-1beta and IFN-gamma induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice. Diabetologia (2003) 1.41

Primary carcinoma of the appendix. Ann Surg (1976) 1.41

Seasonality in clinical onset of type 1 diabetes in belgian patients above the age of 10 is restricted to HLA-DQ2/DQ8-negative males, which explains the male to female excess in incidence. Diabetologia (2004) 1.40

Cellular localization of somatostatin in endocrine-like cells and neurons of the rat with special references to the A1-cells of the pancreatic islets and to the hypothalamus. Acta Endocrinol Suppl (Copenh) (1975) 1.34

Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells. Diabetologia (2008) 1.34

Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes. Diabetes (1999) 1.34

The stimulus-secretion coupling of glucose-induced insulin release. XIV. Glucose regulation of insular biosynthetic activity. Endocrinology (1973) 1.33

Determinants of the selective toxicity of alloxan to the pancreatic B cell. Proc Natl Acad Sci U S A (1982) 1.32

Hard metal lung disease: importance of cobalt in coolants. Thorax (1980) 1.32

Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis. Cell Death Differ (2010) 1.30

A sensitive method for measuring polymerized and depolymerized forms of tubulin in tissues. J Cell Biol (1977) 1.30

Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells. Endocrinology (1997) 1.30

Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs. Diabetologia (2007) 1.29

Microtubule assembly and the intracellular transport of secretory granules in pancreatic islets. Science (1976) 1.28

Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells. Diabetologia (2001) 1.28

Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes. Diabetologia (2012) 1.27

Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-). Diabetes (2000) 1.27

Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation. J Clin Invest (1996) 1.25

Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells. Diabetologia (1998) 1.25

Rapid deposition of amyloid in human islets transplanted into nude mice. Diabetologia (1995) 1.23

Long-term effects of glucose on insulin release and glucose oxidation by mouse pancreatic islets maintained in tissue culture. Biochem J (1974) 1.23

Glucose stimulation of insulin secretion from the isolated pancreas of foetal and newborn rats. Diabetologia (1969) 1.22

Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: implications for the pathogenesis of insulin-dependent diabetes mellitus. Mol Med (1995) 1.22

Candidate genes for type 1 diabetes modulate pancreatic islet inflammation and β-cell apoptosis. Diabetes Obes Metab (2013) 1.21

Evidence for the presence of type I insulin-like growth factor receptors on rat pancreatic A and B cells. Endocrinology (1987) 1.20

Failure of glucose to elicit a normal secretory response in fetal pancreatic beta cells results from glucose insensitivity of the ATP-regulated K+ channels. Proc Natl Acad Sci U S A (1989) 1.19

Volvulus of the cecum. Ann Surg (1975) 1.19

Measurements of oxygen tension in native and transplanted rat pancreatic islets. Diabetes (1998) 1.19

Impacts of elevated terrestrial nutrient loads and temperature on pelagic food-web efficiency and fish production. Glob Chang Biol (2013) 1.19

Pancreatic beta cell heterogeneity in glucose-induced insulin secretion. J Biol Chem (1992) 1.19

Stimulated endocrine cell proliferation and differentiation in transplanted human pancreatic islets: effects of the ob gene and compensatory growth of the implantation organ. Diabetes (2001) 1.18

Effects of glucose on the ultrastructure and insulin biosynthesis of isolated mouse pancreatic islets maintained in tissue culture. Diabetologia (1974) 1.16

Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis. Diabetologia (2010) 1.16

Molecular characterization of early-stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q. Oncogene (2006) 1.15

Cytokeratins as markers of ductal cell differentiation and islet neogenesis in the neonatal rat pancreas. Diabetes (1994) 1.15

Diabetes in pregnancy: effects on the foetal and newborn rat with particular regard to body weight, serum insulin concentration and pancreatic contents of insulin, glucagon and somatostatin. Acta Endocrinol (Copenh) (1980) 1.15

Prospects for predicting and stopping the development of type 1 of diabetes. Best Pract Res Clin Endocrinol Metab (2001) 1.15

Differences in adrenergic recognition by pancreatic A and B cells. Science (1986) 1.14

An investigation of glucagon biosynthesis in isolated pancreatic islets of guinea pigs. FEBS Lett (1972) 1.13

Epidemiology of HIV in Estonia. AIDS Res Hum Retroviruses (2001) 1.13

Global profiling of coxsackievirus- and cytokine-induced gene expression in human pancreatic islets. Diabetologia (2005) 1.13

Differences in glucose handling by pancreatic A- and B-cells. J Biol Chem (1984) 1.13

Regulation of adenosine 3',5'-monophosphate levels in the pancreatic B cell. Endocrinology (1985) 1.12

A mammalian endonuclease specific for apurinic sites in double-stranded deoxyribonucleic acid. II. Further studies on the substrate specificity. J Biol Chem (1974) 1.12

Oxis (formoterol given by Turbuhaler) showed as rapid an onset of action as salbutamol given by a pMDI. Respir Med (2000) 1.12

Increased incidence of congenital malformations in the offspring of diabetic rats and their prevention by maternal insulin therapy. Diabetes (1982) 1.12