Published in Circulation on July 01, 1996
Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial. J Natl Cancer Inst (2008) 2.07
Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia. J Clin Invest (2000) 1.94
Vitamin C blocks inflammatory platelet-activating factor mimetics created by cigarette smoking. J Clin Invest (1997) 1.87
Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation. J Clin Invest (2000) 1.78
Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention. Chem Res Toxicol (2010) 1.58
Alcohol-induced generation of lipid peroxidation products in humans. J Clin Invest (1999) 1.55
Quantitative high performance liquid chromatography/tandem mass spectrometric analysis of the four classes of F(2)-isoprostanes in human urine. Proc Natl Acad Sci U S A (1999) 1.45
IPF2alpha-I: an index of lipid peroxidation in humans. Proc Natl Acad Sci U S A (1998) 1.43
Localization of distinct F2-isoprostanes in human atherosclerotic lesions. J Clin Invest (1997) 1.38
Markers of oxidant stress that are clinically relevant in aging and age-related disease. Mech Ageing Dev (2013) 1.24
Oxidative stress biomarkers and lifestyles in Japanese healthy people. J Clin Biochem Nutr (2009) 1.18
Smoking and increased Alzheimer's disease risk: a review of potential mechanisms. Alzheimers Dement (2014) 1.15
F2-isoprostanes as an indicator and risk factor for coronary heart disease. Free Radic Biol Med (2010) 1.04
Fibrinogen beta-chain tyrosine nitration is a prothrombotic risk factor. J Biol Chem (2008) 1.04
Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity. Biochemistry (2006) 1.02
Women and smokers have elevated urinary F(2)-isoprostane metabolites: a novel extraction and LC-MS methodology. Lipids (2008) 1.00
The role of tobacco smoke induced mitochondrial damage in vascular dysfunction and atherosclerosis. Mutat Res (2007) 1.00
Socioeconomic status, antioxidant micronutrients, and correlates of oxidative damage: the Coronary Artery Risk Development in Young Adults (CARDIA) study. Psychosom Med (2009) 0.99
Oestrogen metabolites in relation to isoprostanes as a measure of oxidative stress. Clin Endocrinol (Oxf) (2007) 0.99
Pleiotropic benefit of monomeric and oligomeric flavanols on vascular health--a randomized controlled clinical pilot study. PLoS One (2011) 0.97
Cystic fibrosis-related diabetes: from CFTR dysfunction to oxidative stress. Clin Biochem Rev (2009) 0.96
Raised levels of F(2)-isoprostanes and prostaglandin F(2alpha) in different rheumatic diseases. Ann Rheum Dis (2001) 0.95
Clinical importance of aspirin and clopidogrel resistance. World J Cardiol (2010) 0.95
Plasma carbonyls do not correlate with lung function or computed tomography measures of lung density in older smokers. Biomarkers (2008) 0.95
Demographic and lifestyle factors and selenium levels in men and women in the U.S. Nutr Res Pract (2011) 0.90
Dietary fat subgroups, zinc, and vegetable components are related to urine F2a-isoprostane concentration, a measure of oxidative stress, in midlife women. J Nutr (2007) 0.88
Vasoconstrictor actions of isoprostanes via tyrosine kinase and Rho kinase in human and canine pulmonary vascular smooth muscles. Br J Pharmacol (2001) 0.86
No effect of cigarette smoking dose on oxidized plasma proteins. Environ Res (2007) 0.86
Study of cardiovascular disease biomarkers among tobacco consumers, part 2: biomarkers of biological effect. Inhal Toxicol (2015) 0.86
Supplement use and mortality: the SENECA study. Eur J Nutr (2008) 0.86
Synthesis of 8-epi-prostaglandin F2alpha by human endothelial cells: role of prostaglandin H2 synthase. Biochem J (1999) 0.85
Serum uric Acid in smokers. Oman Med J (2008) 0.84
An eicosanoid-centric view of atherothrombotic risk factors. Cell Mol Life Sci (2012) 0.84
Vascular endothelial dysfunction and pharmacological treatment. World J Cardiol (2015) 0.83
Compartmental analysis of plasma and liver n-3 essential fatty acids in alcohol-dependent men during withdrawal. J Lipid Res (2008) 0.83
An Evaluation of the Clinical Evidence on the Role of Inflammation and Oxidative Stress in Smoking-Mediated Cardiovascular Disease. Biomark Insights (2008) 0.83
Plasma Carotenoids and Biomarkers of Oxidative Stress in Patients with prior Head and Neck Cancer. Biomark Insights (2009) 0.82
Lung cancer biomarkers for the assessment of modified risk tobacco products: an oxidative stress perspective. Biomarkers (2013) 0.81
Markers of oxidative stress and systemic vasoconstriction in pregnant women drinking > or =48 g of alcohol per day. Alcohol Clin Exp Res (2008) 0.81
Association of oxidative stress, iron, and centralized fat mass in healthy postmenopausal women. J Womens Health (Larchmt) (2009) 0.81
Long-term vitamin E supplementation fails to reduce lipid peroxidation in people at cardiovascular risk: analysis of underlying factors. Curr Control Trials Cardiovasc Med (2002) 0.80
No effect of 14 day consumption of whole grain diet compared to refined grain diet on antioxidant measures in healthy, young subjects: a pilot study. Nutr J (2010) 0.80
Classifying oxidative stress by F2-isoprostane levels across human diseases: A meta-analysis. Redox Biol (2017) 0.79
Improved method of plasma 8-Isoprostane measurement and association analyses with habitual drinking and smoking. World J Gastroenterol (2006) 0.77
Associations between functional polymorphisms in antioxidant defense genes and urinary oxidative stress biomarkers in healthy, premenopausal women. Genes Nutr (2011) 0.77
Effect of long-term vitamin E and selenium supplementation on urine F2-isoprostanes, a biomarker of oxidative stress. Free Radic Biol Med (2016) 0.76
Vitamins e and C alleviate the germ cell loss and oxidative stress in cryptorchidism when administered separately but not when combined in rats. ISRN Pharmacol (2012) 0.75
Longitudinal Impact of Smoking and Smoking Cessation on Inflammatory Markers of Cardiovascular Disease Risk. Arterioscler Thromb Vasc Biol (2016) 0.75
Evaluation of Plasma Isoprostane in Patients with Oral Lichen Planus. J Dent (Shiraz) (2016) 0.75
Aspirin treatment failure: is this a real phenomenon? A review of the aetiology and how to treat it. JRSM Short Rep (2013) 0.75
A Japanese cross-sectional multicentre study of biomarkers associated with cardiovascular disease in smokers and non-smokers. Biomarkers (2015) 0.75
High 15-F2t-Isoprostane Levels in Patients with a Previous History of Nonmelanoma Skin Cancer: The Effects of Supplementary Antioxidant Therapy. Biomed Res Int (2015) 0.75
The relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation is modified by donor smoking and reperfusion hyperoxia. J Heart Lung Transplant (2016) 0.75
Effect of common single nucleotide polymorphisms in COX-1 gene on related metabolic activity in diabetic patients treated with acetylsalicylic acid. Arch Med Sci (2013) 0.75
Unhealthy smokers: scopes for prophylactic intervention and clinical treatment. BMC Neurosci (2017) 0.75
Effects of preoperative aspirin on perioperative platelet activation and dysfunction in patients undergoing off-pump coronary artery bypass graft surgery: A prospective randomized study. PLoS One (2017) 0.75
1-Hydroxypyrene and oxidative stress marker levels among painting workers and office workers at shipyard. Int Arch Occup Environ Health (2014) 0.75
The effects of septoplasty surgery on serum oxidative stress levels. Eur Arch Otorhinolaryngol (2017) 0.75
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet (2013) 8.16
Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med (2001) 5.96
Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. Proc Natl Acad Sci U S A (1999) 4.16
Hypertensive emergencies. Lancet (2000) 3.96
Acute admissions to medical beds. J R Coll Gen Pract (1972) 3.80
Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free Radic Biol Med (2005) 3.13
Platelet activation in unstable coronary disease. N Engl J Med (1986) 2.60
Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock. Cell (2001) 2.59
Effects of vitamin E on lipid peroxidation in healthy persons. JAMA (2001) 2.58
The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension. N Engl J Med (1989) 2.36
No evidence for lipid peroxidation in severe preeclampsia. Am J Obstet Gynecol (2001) 2.28
Platelet-active drugs : the relationships among dose, effectiveness, and side effects. Chest (2001) 2.25
Genetic and pharmacological analysis of prostanoid receptor function. J Clin Invest (2001) 2.19
Estimated rate of prostacyclin secretion into the circulation of normal man. J Clin Invest (1981) 2.18
Insights into antibody-associated encephalitis--Bickerstaff's 1950's papers revisited. J Neurol Sci (2013) 2.13
Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man. J Clin Invest (1983) 2.13
Neuroprotective properties of statins in cerebral ischemia and stroke. Stroke (1999) 2.12
Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids. J Pharmacol Exp Ther (1999) 2.10
Dose-related kinetics of aspirin. Presystemic acetylation of platelet cyclooxygenase. N Engl J Med (1984) 2.00
Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice. Nat Med (1998) 1.98
Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs. Blood (1987) 1.96
Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles. J Clin Invest (1997) 1.90
Activation of caspase 3 (CPP32)-like proteases is essential for TNF-alpha-induced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxin shock model. J Immunol (1998) 1.82
Increased formation of distinct F2 isoprostanes in hypercholesterolemia. Circulation (1999) 1.79
Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity. Ann Neurol (2000) 1.79
Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation. J Clin Invest (2000) 1.78
Combined administration of aspirin and a specific thrombin inhibitor in man. Circulation (1991) 1.74
Analysis of prostacyclin and thromboxane biosynthesis in cardiovascular disease. Circulation (1983) 1.73
Increased prostacyclin biosynthesis in patients with severe atherosclerosis and platelet activation. N Engl J Med (1984) 1.73
Modulation of monocyte-endothelial cell interactions by platelet microparticles. J Clin Invest (1998) 1.73
Angioplasty increases coronary sinus F2-isoprostane formation: evidence for in vivo oxidative stress during PTCA. J Am Coll Cardiol (2001) 1.71
A double blind placebo controlled crossover study of prostacyclin in man. Life Sci (1979) 1.67
Occupational asthma in newly employed workers in intensive swine confinement facilities. Eur Respir J (2004) 1.63
Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. J Biol Chem (1993) 1.59
Suppression of thromboxane A2 but not of systemic prostacyclin by controlled-release aspirin. N Engl J Med (1991) 1.58
Thromboxane A2 synthesis in pregnancy-induced hypertension. Lancet (1990) 1.56
Alcohol-induced generation of lipid peroxidation products in humans. J Clin Invest (1999) 1.55
Platelet activation by superoxide anion and hydroxyl radicals intrinsically generated by platelets that had undergone anoxia and then reoxygenated. Circulation (1997) 1.54
Isoprostanes: potential markers of oxidant stress in atherothrombotic disease. Arterioscler Thromb Vasc Biol (1997) 1.53
Isoprostanes: formation, analysis and use as indices of lipid peroxidation in vivo. J Biol Chem (1999) 1.53
Two polymorphisms in the human lipoprotein lipase (LPL) gene. Nucleic Acids Res (1987) 1.51
Marked platelet activation in vivo after intravenous streptokinase in patients with acute myocardial infarction. Circulation (1988) 1.49
Quality of life after infrainguinal bypass grafting surgery. Dutch Bypass Oral Anticoagulants or Aspirin (BOA) Study Group. J Vasc Surg (1999) 1.49
Indices of lipid peroxidation in vivo: strengths and limitations. Free Radic Biol Med (2000) 1.48
Dipyridamole. N Engl J Med (1987) 1.48
Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice. Circulation (2001) 1.46
Quantitative high performance liquid chromatography/tandem mass spectrometric analysis of the four classes of F(2)-isoprostanes in human urine. Proc Natl Acad Sci U S A (1999) 1.45
Effects of celecoxib on major prostaglandins in asthma. Clin Exp Allergy (2010) 1.45
Clinical implications of prostaglandin and thromboxane A2 formation (1). N Engl J Med (1988) 1.45
IPF2alpha-I: an index of lipid peroxidation in humans. Proc Natl Acad Sci U S A (1998) 1.43
Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning. Free Radic Biol Med (2005) 1.42
8-epi PGF2 alpha generation during coronary reperfusion. A potential quantitative marker of oxidant stress in vivo. Circulation (1997) 1.41
Paracetamol poisoning: the action line and the timing of acetylcysteine therapy. Ir Med J (1996) 1.40
Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice. Proc Natl Acad Sci U S A (2001) 1.38
Inhibition of eicosanoid biosynthesis by glucocorticoids in humans. Proc Natl Acad Sci U S A (1990) 1.38
Confusion in reperfusion. Problems in the clinical development of antithrombotic drugs. Circulation (1997) 1.38
Localization of distinct F2-isoprostanes in human atherosclerotic lesions. J Clin Invest (1997) 1.38
Ablation of cyclooxygenase-2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus. J Neurosci (2011) 1.37
In vivo indexes of platelet and vascular function during fish-oil administration in patients with atherosclerosis. N Engl J Med (1986) 1.36
11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation. Proc Natl Acad Sci U S A (1986) 1.35
Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease. Am J Med (2000) 1.34
Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a postmitochondrial processing of caspase-8. Toxicol Sci (2000) 1.30
Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation. J Clin Invest (2001) 1.29
The response to thromboxane A2 analogues in human platelets. Discrimination of two binding sites linked to distinct effector systems. J Biol Chem (1990) 1.29
The isoprostanes in biology and medicine. Trends Endocrinol Metab (2001) 1.29
Cyclooxygenase-dependent formation of the isoprostane, 8-epi prostaglandin F2 alpha. J Biol Chem (1995) 1.28
Biochemical evidence of a chronic abnormality in platelet and vascular function in healthy individuals who smoke cigarettes. Circulation (1987) 1.27
Patients' aims for epilepsy surgery: desires beyond seizure freedom. Epilepsia (2001) 1.25
Validation of a new quality of life measure for children with epilepsy. Epilepsia (2000) 1.25
Distinct roles of prostaglandin H synthases 1 and 2 in T-cell development. J Clin Invest (1999) 1.25
Increased formation of the isoprostanes IPF2alpha-I and 8-epi-prostaglandin F2alpha in acute coronary angioplasty: evidence for oxidant stress during coronary reperfusion in humans. Circulation (1997) 1.23
Reduction of isoprostanes and regression of advanced atherosclerosis by apolipoprotein E. J Biol Chem (2001) 1.23
Glutathione peroxidase-deficient mice are more susceptible to neutrophil-mediated hepatic parenchymal cell injury during endotoxemia: importance of an intracellular oxidant stress. Hepatology (1999) 1.23
Eicosanoid forming enzyme mRNA in human tissues. Analysis by quantitative polymerase chain reaction. J Biol Chem (1991) 1.22
Endogenous prostacyclin biosynthesis and platelet function during selective inhibition of thromboxane synthase in man. J Clin Invest (1983) 1.21
Arachidonic acid in platelet microparticles up-regulates cyclooxygenase-2-dependent prostaglandin formation via a protein kinase C/mitogen-activated protein kinase-dependent pathway. J Biol Chem (1999) 1.21
Cardiovascular responses to the isoprostanes iPF(2alpha)-III and iPE(2)-III are mediated via the thromboxane A(2) receptor in vivo. Circulation (2000) 1.21
Clinical implications of prostaglandin and thromboxane A2 formation (2). N Engl J Med (1988) 1.19
Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase. Proc Natl Acad Sci U S A (1990) 1.19
Endogenous biosynthesis of arachidonic acid epoxides in humans: increased formation in pregnancy-induced hypertension. Proc Natl Acad Sci U S A (1990) 1.17
Nomenclature of isoprostanes: a proposal. Prostaglandins (1997) 1.17