Published in Biophys J on December 01, 1996
Amphetamine induces dopamine efflux through a dopamine transporter channel. Proc Natl Acad Sci U S A (2005) 1.98
Dopamine transporters depolarize neurons by a channel mechanism. Proc Natl Acad Sci U S A (2004) 1.46
Serotonin transporters--structure and function. J Membr Biol (2007) 1.40
Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter. J Biol Chem (2009) 1.33
Enhancement of Na(+) uptake currents, time-dependent inward-rectifying K(+) channel currents, and K(+) channel transcripts by K(+) starvation in wheat root cells. Plant Physiol (2000) 1.32
Patch-clamp and amperometric recordings from norepinephrine transporters: channel activity and voltage-dependent uptake. Proc Natl Acad Sci U S A (1998) 1.26
Unifying concept of serotonin transporter-associated currents. J Biol Chem (2011) 1.24
Dopamine transporter/syntaxin 1A interactions regulate transporter channel activity and dopaminergic synaptic transmission. Proc Natl Acad Sci U S A (2008) 1.21
The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters. J Biol Chem (2012) 1.19
A quantitative model of amphetamine action on the 5-HT transporter. Br J Pharmacol (2014) 1.11
Ionic currents in the human serotonin transporter reveal inconsistencies in the alternating access hypothesis. Biophys J (2003) 1.10
A nodule-specific dicarboxylate transporter from alder is a member of the peptide transporter family. Plant Physiol (2004) 1.04
Bioenergetics of neurotransmitter transport. J Bioenerg Biomembr (1998) 0.99
A conserved asparagine residue in transmembrane segment 1 (TM1) of serotonin transporter dictates chloride-coupled neurotransmitter transport. J Biol Chem (2011) 0.96
Flux coupling in the human serotonin transporter. Biophys J (2002) 0.95
Conformational basis for the Li(+)-induced leak current in the rat gamma-aminobutyric acid (GABA) transporter-1. J Physiol (2002) 0.94
Early fluorescence signals detect transitions at mammalian serotonin transporters. Biophys J (2002) 0.93
Novel properties of a mouse gamma-aminobutyric acid transporter (GAT4). J Membr Biol (2005) 0.88
Chloride channel function in the yeast TRK-potassium transporters. J Membr Biol (2004) 0.86
Electrical coupling between the human serotonin transporter and voltage-gated Ca(2+) channels. Cell Calcium (2014) 0.85
The second sodium site in the dopamine transporter controls cation permeation and is regulated by chloride. J Biol Chem (2014) 0.84
Neurotransmitter transport: models in flux. Proc Natl Acad Sci U S A (1998) 0.83
Conserved glutamate residues Glu-343 and Glu-519 provide mechanistic insights into cation/nucleoside cotransport by human concentrative nucleoside transporter hCNT3. J Biol Chem (2009) 0.82
Elucidating conformational changes in the gamma-aminobutyric acid transporter-1. J Biol Chem (2009) 0.82
New views of multi-ion channels. J Gen Physiol (1998) 0.81
Anion currents in yeast K+ transporters (TRK) characterize a structural homologue of ligand-gated ion channels. Pflugers Arch (2011) 0.79
Electrogenic Binding of Intracellular Cations Defines a Kinetic Decision Point in the Transport Cycle of the Human Serotonin Transporter. J Biol Chem (2016) 0.79
1-Methylpyridinium-4-(4-phenylmethanethiosulfonate) iodide, MTS-MPP+, a novel scanning cysteine accessibility method (SCAM) reagent for monoamine transporter studies. Bioorg Med Chem (2006) 0.77
Inhibitors of the gamma-aminobutyric acid transporter 1 (GAT1) do not reveal a channel mode of conduction. Neurochem Int (2009) 0.77
Amphetamine activates calcium channels through dopamine transporter-mediated depolarization. Cell Calcium (2015) 0.76
A current view of serotonin transporters. F1000Res (2016) 0.75
An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature (1995) 4.14
Neurotransmitter transporters: recent progress. Annu Rev Neurosci (1993) 3.80
Ion fluxes associated with excitatory amino acid transport. Neuron (1995) 3.76
Cloning and expression of a rat brain GABA transporter. Science (1990) 3.08
Cloning and expression of a functional serotonin transporter from rat brain. Nature (1991) 2.86
Extracellular access to the Na,K pump: pathway similar to ion channel. Science (1993) 2.28
Channel-like function of the Na,K pump probed at microsecond resolution in giant membrane patches. Science (1994) 2.14
Cloning of a serotonin transporter affected by antidepressants. Science (1991) 2.12
Mechanism of transport and storage of neurotransmitters. CRC Crit Rev Biochem (1987) 1.99
Conducting states of a mammalian serotonin transporter. Neuron (1994) 1.96
From synapse to vesicle: the reuptake and storage of biogenic amine neurotransmitters. Biochim Biophys Acta (1993) 1.89
Active transport of 5-hydroxytryptamine by plasma membrane vesicles isolated from human blood platelets. J Biol Chem (1977) 1.57
Sodium-dependent norepinephrine-induced currents in norepinephrine-transporter-transfected HEK-293 cells blocked by cocaine and antidepressants. J Exp Biol (1995) 1.41
Glutamate-gated chloride channel with glutamate-transporter-like properties in cone photoreceptors of the tiger salamander. J Neurophysiol (1995) 1.40
Channel behavior in a gamma-aminobutyrate transporter. Proc Natl Acad Sci U S A (1996) 1.37
Mechanism of imipramine inhibition of platelet 5-hydroxytryptamine transport. J Biol Chem (1979) 1.32
Noise analysis of the glutamate-activated current in photoreceptors. Biophys J (1996) 1.32
Permeation properties of neurotransmitter transporters. Annu Rev Pharmacol Toxicol (1994) 1.32
The serotonin transporter-imipramine "receptor". J Biol Chem (1983) 1.19
Pore models for transporters? Biophys J (1996) 1.06
Examination of the relationship between the uptake site for 5-hydroxytryptamine and the high affinity binding site for [3H]imipramine. II. The role of sodium ions. Neuropharmacology (1987) 1.01
Serotonin uptake and serotonin uptake inhibition. Ann N Y Acad Sci (1990) 0.99
The role of chloride ion in platelet serotonin transport. J Biol Chem (1982) 0.94
Uptake of [3H]serotonin into plasma membrane vesicles from mouse cerebral cortex. J Biol Chem (1988) 0.91
From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor. Proc Natl Acad Sci U S A (1998) 3.99
A rat brain Na+ channel alpha subunit with novel gating properties. Neuron (1988) 3.48
The inward rectifier potassium channel family. Curr Opin Neurobiol (1995) 3.23
Steady states, charge movements, and rates for a cloned GABA transporter expressed in Xenopus oocytes. Neuron (1993) 3.10
Cloning and expression of a rat brain GABA transporter. Science (1990) 3.08
Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors. Nature (1995) 3.06
Rates and equilibria at the acetylcholine receptor of Electrophorus electroplaques: a study of neurally evoked postsynaptic currents and of voltage-jump relaxations. J Gen Physiol (1977) 2.86
Genetic inactivation of an inwardly rectifying potassium channel (Kir4.1 subunit) in mice: phenotypic impact in retina. J Neurosci (2000) 2.72
Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds. Nat Neurosci (1999) 2.63
RGS proteins reconstitute the rapid gating kinetics of gbetagamma-activated inwardly rectifying K+ channels. Proc Natl Acad Sci U S A (1997) 2.43
Voltage clamping of Xenopus laevis oocytes utilizing agarose-cushion electrodes. Pflugers Arch (1994) 2.40
A neutral amino acid change in segment IIS4 dramatically alters the gating properties of the voltage-dependent sodium channel. Proc Natl Acad Sci U S A (1990) 2.35
Evidence that the M2 membrane-spanning region lines the ion channel pore of the nicotinic receptor. Science (1988) 2.31
A-type potassium channels expressed from Shaker locus cDNA. Proc Natl Acad Sci U S A (1988) 2.26
Kir4.1 potassium channel subunit is crucial for oligodendrocyte development and in vivo myelination. J Neurosci (2001) 2.23
Conductance increases produced by bath application of cholinergic agonists to Electrophorus electroplaques. J Gen Physiol (1975) 2.19
Numerical reconstruction of the quantal event at nicotinic synapses. Biophys J (1979) 2.17
In vivo incorporation of unnatural amino acids into ion channels in Xenopus oocyte expression system. Methods Enzymol (1998) 2.15
Allosteric control of gating and kinetics at P2X(4) receptor channels. J Neurosci (1999) 2.10
Heteromeric olfactory cyclic nucleotide-gated channels: a subunit that confers increased sensitivity to cAMP. Proc Natl Acad Sci U S A (1994) 2.10
Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimers. Proc Natl Acad Sci U S A (1995) 2.09
An open-channel blocker interacts with adjacent turns of alpha-helices in the nicotinic acetylcholine receptor. Neuron (1990) 2.06
Conducting states of a mammalian serotonin transporter. Neuron (1994) 1.96
Novel pore-lining residues in CFTR that govern permeation and open-channel block. Neuron (1994) 1.96
Enhancement of neurotransmitter release induced by brain-derived neurotrophic factor in cultured hippocampal neurons. J Neurosci (1998) 1.91
Relaxation measurements on the acetylcholine receptor. Proc Natl Acad Sci U S A (1975) 1.86
Ion binding and permeation at the GABA transporter GAT1. J Neurosci (1996) 1.82
Messenger RNA coding for only the alpha subunit of the rat brain Na channel is sufficient for expression of functional channels in Xenopus oocytes. Proc Natl Acad Sci U S A (1986) 1.79
Voltage-dependent block of the cystic fibrosis transmembrane conductance regulator Cl- channel by two closely related arylaminobenzoates. J Gen Physiol (1993) 1.74
Rat brain expresses a heterogeneous family of calcium channels. Proc Natl Acad Sci U S A (1990) 1.73
A covalently bound photoisomerizable agonist: comparison with reversibly bound agonists at Electrophorus electroplaques. J Gen Physiol (1980) 1.59
Postsynaptic action of cobra toxin at the myoneural junction. Nature (1970) 1.59
Activation of a potassium current by rapid photochemically generated step increases of intracellular calcium in rat sympathetic neurons. Proc Natl Acad Sci U S A (1987) 1.58
Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+). J Biol Chem (1999) 1.58
A multi-substrate single-file model for ion-coupled transporters. Biophys J (1996) 1.57
Functional analysis of the weaver mutant GIRK2 K+ channel and rescue of weaver granule cells. Neuron (1996) 1.56
Dose-response relations for unnatural amino acids at the agonist binding site of the nicotinic acetylcholine receptor: tests with novel side chains and with several agonists. Mol Pharmacol (1996) 1.50
Expression and modulation of voltage-gated calcium channels after RNA injection in Xenopus oocytes. Science (1986) 1.46
Mouse-Torpedo hybrid acetylcholine receptors: functional homology does not equal sequence homology. Proc Natl Acad Sci U S A (1985) 1.46
Time course of the increase in the myocardial slow inward current after a photochemically generated concentration jump of intracellular cAMP. Proc Natl Acad Sci U S A (1983) 1.41
Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety. Proc Natl Acad Sci U S A (2001) 1.39
Physiological and pharmacological manipulations with light flashes. Annu Rev Biophys Bioeng (1982) 1.39
Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations. J Gen Physiol (1992) 1.39
cDNA cloning of a serotonin 5-HT1C receptor by electrophysiological assays of mRNA-injected Xenopus oocytes. Proc Natl Acad Sci U S A (1987) 1.39
Backbone mutations in transmembrane domains of a ligand-gated ion channel: implications for the mechanism of gating. Cell (1999) 1.37
State-dependent cross-inhibition between transmitter-gated cation channels. Nature (2000) 1.37
Dynamic selectivity filters in ion channels. Neuron (1999) 1.36
Comparing and contrasting Escherichia coli and Mycobacterium tuberculosis mechanosensitive channels (MscL). New gain of function mutations in the loop region. J Biol Chem (2000) 1.35
Inhibition of an inwardly rectifying K+ channel by G-protein alpha-subunits. Nature (1996) 1.34
Ca channels induced in Xenopus oocytes by rat brain mRNA. J Neurosci (1987) 1.34
An engineered Tetrahymena tRNAGln for in vivo incorporation of unnatural amino acids into proteins by nonsense suppression. J Biol Chem (1996) 1.33
A G protein-gated K channel is activated via beta 2-adrenergic receptors and G beta gamma subunits in Xenopus oocytes. J Gen Physiol (1995) 1.33
Transmitter release by presynaptic impulses in the squid stellate ganglion. Nature (1970) 1.32
Permeation properties of neurotransmitter transporters. Annu Rev Pharmacol Toxicol (1994) 1.32
Involvement of a GTP-binding protein in mediation of serotonin and acetylcholine responses in Xenopus oocytes injected with rat brain messenger RNA. Brain Res (1986) 1.30
Evidence for the involvement of more than one mRNA species in controlling the inactivation process of rat and rabbit brain Na channels expressed in Xenopus oocytes. J Neurosci (1988) 1.29
Expression of a dominant negative TrkB receptor, T1, reveals a requirement for presynaptic signaling in BDNF-induced synaptic potentiation in cultured hippocampal neurons. Proc Natl Acad Sci U S A (1998) 1.29
Listening to neurotransmitter transporters. Neuron (1996) 1.28
Membrane transport mechanisms probed by capacitance measurements with megahertz voltage clamp. Proc Natl Acad Sci U S A (1995) 1.28
New photoactivatable cyclic nucleotides produce intracellular jumps in cyclic AMP and cyclic GMP concentrations. Nature (1984) 1.28
Cyclic nucleotide-gated channels: structural basis of ligand efficacy and allosteric modulation. Q Rev Biophys (1997) 1.27
Light-flash physiology with synthetic photosensitive compounds. Physiol Rev (1987) 1.26
An intermediate state of the gamma-aminobutyric acid transporter GAT1 revealed by simultaneous voltage clamp and fluorescence. J Gen Physiol (2000) 1.25
Activation of heteromeric G protein-gated inward rectifier K+ channels overexpressed by adenovirus gene transfer inhibits the excitability of hippocampal neurons. Proc Natl Acad Sci U S A (1997) 1.24
Photoinduced removal of nifedipine reveals mechanisms of calcium antagonist action on single heart cells. J Gen Physiol (1985) 1.24
Functional expression of the heteromeric "olfactory" cyclic nucleotide-gated channel in the hippocampus: a potential effector of synaptic plasticity in brain neurons. J Neurosci (1997) 1.23
Light-activated drug confirms a mechanism of ion channel blockade. Nature (1979) 1.22
At least two mRNA species contribute to the properties of rat brain A-type potassium channels expressed in Xenopus oocytes. Neuron (1988) 1.21
Inactivation of cloned Na channels expressed in Xenopus oocytes. J Gen Physiol (1990) 1.21
Role of voltage-sensitive receptors in nicotinic transmission. Biophys J (1978) 1.20
Response of acetylcholine receptors to rapid photochemically produced increases in agonist concentration. Nature (1977) 1.20
Tris+/Na+ permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 region. J Gen Physiol (1992) 1.20
Co-expression of Gbeta5 enhances the function of two Ggamma subunit-like domain-containing regulators of G protein signaling proteins. J Biol Chem (2000) 1.19
Determinants of nicotinic receptor gating in natural and unnatural side chain structures at the M2 9' position. Neuron (1996) 1.19
A photoisomerizable muscarinic antagonist. Studies of binding and of conductance relaxations in frog heart. J Gen Physiol (1982) 1.17
Cloning, expression, and localization of a rat brain high-affinity glycine transporter. Proc Natl Acad Sci U S A (1992) 1.16
Receptors that couple to 2 classes of G proteins increase cAMP and activate CFTR expressed in Xenopus oocytes. Receptors Channels (1993) 1.15
A cocaine-sensitive Drosophila serotonin transporter: cloning, expression, and electrophysiological characterization. Proc Natl Acad Sci U S A (1994) 1.13
Amino acid residues that control pH modulation of transport-associated current in mammalian serotonin transporters. J Neurosci (1998) 1.13
The tethered agonist approach to mapping ion channel proteins--toward a structural model for the agonist binding site of the nicotinic acetylcholine receptor. Chem Biol (2001) 1.13
Single-molecule measurements calibrate green fluorescent protein surface densities on transparent beads for use with 'knock-in' animals and other expression systems. J Neurosci Methods (2001) 1.13
Tyrosine decaging leads to substantial membrane trafficking during modulation of an inward rectifier potassium channel. J Gen Physiol (2001) 1.13
Response of acetylcholine receptors to photoisomerizations of bound agonist molecules. Biophys J (1978) 1.12
Subunit stoichiometry of a heteromultimeric G protein-coupled inward-rectifier K+ channel. J Biol Chem (1996) 1.10
Varenicline is a potent agonist of the human 5-hydroxytryptamine3 receptor. J Pharmacol Exp Ther (2011) 1.10
Heterologously expressed serotonin 1A receptors couple to muscarinic K+ channels in heart. Proc Natl Acad Sci U S A (1991) 1.10
Genetic approaches identify differential roles for alpha4beta2* nicotinic receptors in acute models of antinociception in mice. J Pharmacol Exp Ther (2007) 1.10
Slow and incomplete inactivations of voltage-gated channels dominate encoding in synthetic neurons. Biophys J (1993) 1.08
Second messengers, trafficking-related proteins, and amino acid residues that contribute to the functional regulation of the rat brain GABA transporter GAT1. J Neurosci (1997) 1.07
Modulation of early growth response (EGR) transcription factor-dependent gene expression by using recombinant adenovirus. Gene (2000) 1.06
Rat brain 5-HT1C receptors are encoded by a 5-6 kbase mRNA size class and are functionally expressed in injected Xenopus oocytes. J Neurosci (1987) 1.06
Vulnerability of desensitized or curare-treated acetylcholine receptors to irreversible blockade by cobra toxin. Mol Pharmacol (1972) 1.06
Activation of acetylcholine receptor channels by covalently bound agonists in cultured rat myoballs. J Physiol (1986) 1.05
ROMK1 (Kir1.1) causes apoptosis and chronic silencing of hippocampal neurons. J Neurophysiol (2000) 1.04
Evidence for a functional interaction between integrins and G protein-activated inward rectifier K+ channels. J Biol Chem (1998) 1.04
Expression of an atrial G-protein-activated potassium channel in Xenopus oocytes. Proc Natl Acad Sci U S A (1993) 1.02
Site-specific, photochemical proteolysis applied to ion channels in vivo. Proc Natl Acad Sci U S A (1997) 1.02
A C-terminal peptide of the GIRK1 subunit directly blocks the G protein-activated K+ channel (GIRK) expressed in Xenopus oocytes. J Physiol (1997) 1.01