Published in Nature on August 09, 1979
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A photoisomerizable muscarinic antagonist. Studies of binding and of conductance relaxations in frog heart. J Gen Physiol (1982) 1.17
Functional stoichiometry at the nicotinic receptor. The photon cross section for phase 1 corresponds to two bis-Q molecules per channel. J Gen Physiol (1982) 0.94
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An attempt to distinguish between the actions of neuromuscular blocking drugs on the acetylcholine receptor and on its associated ionic channel. Proc Natl Acad Sci U S A (1980) 0.85
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Steady states, charge movements, and rates for a cloned GABA transporter expressed in Xenopus oocytes. Neuron (1993) 3.10
Cloning and expression of a rat brain GABA transporter. Science (1990) 3.08
Glycerol reverses the misfolding phenotype of the most common cystic fibrosis mutation. J Biol Chem (1996) 3.07
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Rates and equilibria at the acetylcholine receptor of Electrophorus electroplaques: a study of neurally evoked postsynaptic currents and of voltage-jump relaxations. J Gen Physiol (1977) 2.86
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Voltage clamping of Xenopus laevis oocytes utilizing agarose-cushion electrodes. Pflugers Arch (1994) 2.40
A neutral amino acid change in segment IIS4 dramatically alters the gating properties of the voltage-dependent sodium channel. Proc Natl Acad Sci U S A (1990) 2.35
Evidence that the M2 membrane-spanning region lines the ion channel pore of the nicotinic receptor. Science (1988) 2.31
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Kir4.1 potassium channel subunit is crucial for oligodendrocyte development and in vivo myelination. J Neurosci (2001) 2.23
Conductance increases produced by bath application of cholinergic agonists to Electrophorus electroplaques. J Gen Physiol (1975) 2.19
Numerical reconstruction of the quantal event at nicotinic synapses. Biophys J (1979) 2.17
In vivo incorporation of unnatural amino acids into ion channels in Xenopus oocyte expression system. Methods Enzymol (1998) 2.15
Allosteric control of gating and kinetics at P2X(4) receptor channels. J Neurosci (1999) 2.10
Heteromeric olfactory cyclic nucleotide-gated channels: a subunit that confers increased sensitivity to cAMP. Proc Natl Acad Sci U S A (1994) 2.10
Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimers. Proc Natl Acad Sci U S A (1995) 2.09
An open-channel blocker interacts with adjacent turns of alpha-helices in the nicotinic acetylcholine receptor. Neuron (1990) 2.06
Conducting states of a mammalian serotonin transporter. Neuron (1994) 1.96
Novel pore-lining residues in CFTR that govern permeation and open-channel block. Neuron (1994) 1.96
Enhancement of neurotransmitter release induced by brain-derived neurotrophic factor in cultured hippocampal neurons. J Neurosci (1998) 1.91
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Mitochondrial DNA. I. Intramitochondrial distribution and structural relations of single- and double-length circular DNA. J Mol Biol (1969) 1.83
Ion binding and permeation at the GABA transporter GAT1. J Neurosci (1996) 1.82
Messenger RNA coding for only the alpha subunit of the rat brain Na channel is sufficient for expression of functional channels in Xenopus oocytes. Proc Natl Acad Sci U S A (1986) 1.79
Voltage-dependent block of the cystic fibrosis transmembrane conductance regulator Cl- channel by two closely related arylaminobenzoates. J Gen Physiol (1993) 1.74
Rat brain expresses a heterogeneous family of calcium channels. Proc Natl Acad Sci U S A (1990) 1.73
A large anion-selective channel has seven conductance levels. Nature (1986) 1.63
A covalently bound photoisomerizable agonist: comparison with reversibly bound agonists at Electrophorus electroplaques. J Gen Physiol (1980) 1.59
Postsynaptic action of cobra toxin at the myoneural junction. Nature (1970) 1.59
Intervening sequences in human fetal globin genes adopt left-handed Z helices. J Biol Chem (1984) 1.58
Activation of a potassium current by rapid photochemically generated step increases of intracellular calcium in rat sympathetic neurons. Proc Natl Acad Sci U S A (1987) 1.58
Photoregulation of an enzymic process by means of a light-sensitive ligand. Science (1968) 1.58
A multi-substrate single-file model for ion-coupled transporters. Biophys J (1996) 1.57
Functional analysis of the weaver mutant GIRK2 K+ channel and rescue of weaver granule cells. Neuron (1996) 1.56
Dose-response relations for unnatural amino acids at the agonist binding site of the nicotinic acetylcholine receptor: tests with novel side chains and with several agonists. Mol Pharmacol (1996) 1.50
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Optical method for quantifying rates of mucus secretion from single submucosal glands. Am J Physiol Lung Cell Mol Physiol (2001) 1.47
Expression and modulation of voltage-gated calcium channels after RNA injection in Xenopus oocytes. Science (1986) 1.46
Mouse-Torpedo hybrid acetylcholine receptors: functional homology does not equal sequence homology. Proc Natl Acad Sci U S A (1985) 1.46
Delta F508-CFTR channels: kinetics, activation by forskolin, and potentiation by xanthines. Am J Physiol (1996) 1.46
Preferential derivation of abnormal human G-group-like chromosomes from chromosome 15. Hum Genet (1977) 1.46
Why cyclosporin is an effective drug. Immunol Today (1993) 1.45
Amplified ribosomal RNA genes in a rat hepatoma cell line are enriched in 5-methylcytosine. Proc Natl Acad Sci U S A (1981) 1.44
Differential methylation of mitochondrial and nuclear DNA in cultured mouse, hamster and virus-transformed hamster cells. In vivo and in vitro methylation. J Mol Biol (1973) 1.41
Time course of the increase in the myocardial slow inward current after a photochemically generated concentration jump of intracellular cAMP. Proc Natl Acad Sci U S A (1983) 1.41
Photoregulation of biological activity by photocromic reagents. II. Inhibitors of acetylcholinesterase. Proc Natl Acad Sci U S A (1969) 1.40
Mitochondrial DNA. II. Structure and physicochemical properties of isolated DNA. J Mol Biol (1969) 1.40
Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety. Proc Natl Acad Sci U S A (2001) 1.39
Physiological and pharmacological manipulations with light flashes. Annu Rev Biophys Bioeng (1982) 1.39
Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations. J Gen Physiol (1992) 1.39
cDNA cloning of a serotonin 5-HT1C receptor by electrophysiological assays of mRNA-injected Xenopus oocytes. Proc Natl Acad Sci U S A (1987) 1.39
Backbone mutations in transmembrane domains of a ligand-gated ion channel: implications for the mechanism of gating. Cell (1999) 1.37
State-dependent cross-inhibition between transmitter-gated cation channels. Nature (2000) 1.37
Monoclonal antibodies to the acetylcholine receptor by a normally functioning auto-anti-idiotypic mechanism. Nature (1983) 1.37
Single-channel currents produced by the serotonin transporter and analysis of a mutation affecting ion permeation. Biophys J (1996) 1.37
The inactivation of chymotrypsin by diphenylcarbamyl chloride and its reactivation by nucleophilic agents. Biochemistry (1966) 1.36
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Comparing and contrasting Escherichia coli and Mycobacterium tuberculosis mechanosensitive channels (MscL). New gain of function mutations in the loop region. J Biol Chem (2000) 1.35
Anti-idiotypic route to anti-acetylcholine receptor antibodies and experimental myasthenia gravis. Proc Natl Acad Sci U S A (1982) 1.35
Inhibition of an inwardly rectifying K+ channel by G-protein alpha-subunits. Nature (1996) 1.34
A restriction endonuclease cleavage map of mitochondrial DNA from transformed hamster cells. Nucleic Acids Res (1978) 1.34
Ca channels induced in Xenopus oocytes by rat brain mRNA. J Neurosci (1987) 1.34
An engineered Tetrahymena tRNAGln for in vivo incorporation of unnatural amino acids into proteins by nonsense suppression. J Biol Chem (1996) 1.33
A G protein-gated K channel is activated via beta 2-adrenergic receptors and G beta gamma subunits in Xenopus oocytes. J Gen Physiol (1995) 1.33
Transmitter release by presynaptic impulses in the squid stellate ganglion. Nature (1970) 1.32
Involvement of a GTP-binding protein in mediation of serotonin and acetylcholine responses in Xenopus oocytes injected with rat brain messenger RNA. Brain Res (1986) 1.30
Expression of a dominant negative TrkB receptor, T1, reveals a requirement for presynaptic signaling in BDNF-induced synaptic potentiation in cultured hippocampal neurons. Proc Natl Acad Sci U S A (1998) 1.29
Evidence for the involvement of more than one mRNA species in controlling the inactivation process of rat and rabbit brain Na channels expressed in Xenopus oocytes. J Neurosci (1988) 1.29
New photoactivatable cyclic nucleotides produce intracellular jumps in cyclic AMP and cyclic GMP concentrations. Nature (1984) 1.28
Cyclic nucleotide-gated channels: structural basis of ligand efficacy and allosteric modulation. Q Rev Biophys (1997) 1.27
Calcium-stimulated Cl- secretion in Calu-3 human airway cells requires CFTR. Am J Physiol (1997) 1.27
Light-flash physiology with synthetic photosensitive compounds. Physiol Rev (1987) 1.26
Abnormal DNA patterns in animal mitochondria: ethidium bromide-induced breakdown of closed circular DNA and conditions leading to oligomer accumulation. Proc Natl Acad Sci U S A (1970) 1.26
Effects of ethidium bromide on the cytochrome content and ultrastructure of L cell mitochondria. J Cell Biol (1971) 1.26
An intermediate state of the gamma-aminobutyric acid transporter GAT1 revealed by simultaneous voltage clamp and fluorescence. J Gen Physiol (2000) 1.25
Differential effects of ethidium bromide on mitochondrial and nuclear DNA synthesis in vivo in cultured mammalian cells. Exp Cell Res (1972) 1.25
Antigenicity of fullerenes: antibodies specific for fullerenes and their characteristics. Proc Natl Acad Sci U S A (1998) 1.25
Activation of heteromeric G protein-gated inward rectifier K+ channels overexpressed by adenovirus gene transfer inhibits the excitability of hippocampal neurons. Proc Natl Acad Sci U S A (1997) 1.24
Photoinduced removal of nifedipine reveals mechanisms of calcium antagonist action on single heart cells. J Gen Physiol (1985) 1.24
Functional expression of the heteromeric "olfactory" cyclic nucleotide-gated channel in the hippocampus: a potential effector of synaptic plasticity in brain neurons. J Neurosci (1997) 1.23
The preparation of antigenic hapten-carrier conjugates: a survey. Methods Enzymol (1980) 1.23
Differences between mitochondrial and cytoplasmic transfer RNA and aminoacyl transfer RNA synthetases from rat liver. Proc Natl Acad Sci U S A (1968) 1.22