Published in Cell on December 13, 1996
IFN-gamma potentiates atherosclerosis in ApoE knock-out mice. J Clin Invest (1997) 4.18
Role of smooth muscle cells in the initiation and early progression of atherosclerosis. Arterioscler Thromb Vasc Biol (2008) 3.79
Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol (1998) 3.61
Control of cyclin D1, p27(Kip1), and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension. Mol Biol Cell (1998) 2.93
Integrins, oncogenes, and anchorage independence. J Cell Biol (1997) 2.86
Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesions. Mol Biol Cell (2002) 2.62
Cell-cycle control by physiological matrix elasticity and in vivo tissue stiffening. Curr Biol (2009) 2.37
Extracellular matrix and integrin signalling: the shape of things to come. Biochem J (1999) 2.28
Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alpha v beta 3 integrin to promote epidermal growth factor receptor phosphorylation and growth. J Cell Biol (1997) 2.16
Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix. J Cell Biol (2000) 2.09
Discoidin domain receptor 1 tyrosine kinase has an essential role in mammary gland development. Mol Cell Biol (2001) 2.01
Mechanotransduction and extracellular matrix homeostasis. Nat Rev Mol Cell Biol (2014) 1.94
Growth control by intracellular tension and extracellular stiffness. Trends Cell Biol (2008) 1.93
Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis. J Exp Med (2008) 1.93
Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling. J Cell Sci (2011) 1.90
Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival. Circ Res (2006) 1.86
Complex regulation and function of the inflammatory smooth muscle cell phenotype in atherosclerosis. J Vasc Res (2009) 1.78
Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor. J Clin Invest (1998) 1.70
The extracellular matrix can regulate vascular cell migration, proliferation, and survival: relationships to vascular disease. Int J Exp Pathol (2000) 1.70
Degraded collagen fragments promote rapid disassembly of smooth muscle focal adhesions that correlates with cleavage of pp125(FAK), paxillin, and talin. J Cell Biol (1999) 1.70
Progesterone inhibits estrogen-induced cyclin D1 and cdk4 nuclear translocation, cyclin E- and cyclin A-cdk2 kinase activation, and cell proliferation in uterine epithelial cells in mice. Mol Cell Biol (1999) 1.69
Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression. J Cell Biol (2001) 1.69
Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta. Mol Cell Biol (2002) 1.67
Integrin alpha1beta1 mediates a unique collagen-dependent proliferation pathway in vivo. J Cell Biol (1998) 1.54
Downregulation of cyclin-dependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery. J Clin Invest (1997) 1.47
The extracellular matrix: an active or passive player in fibrosis? Am J Physiol Gastrointest Liver Physiol (2011) 1.46
Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires endogenous p21, an inhibitor of cyclin-dependent kinases. J Clin Invest (1997) 1.44
Cell contact-dependent activation of alpha3beta1 integrin modulates endothelial cell responses to thrombospondin-1. Mol Biol Cell (2000) 1.41
Differential regulation of p27(Kip1) expression by mitogenic and hypertrophic factors: Involvement of transcriptional and posttranscriptional mechanisms. J Cell Biol (2000) 1.40
Fibronectin is an important regulator of flow-induced vascular remodeling. Arterioscler Thromb Vasc Biol (2009) 1.40
Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis. Am J Pathol (2004) 1.39
Apoptosis in the vasculature: mechanisms and functional importance. Br J Pharmacol (2000) 1.38
Contact with fibrillar collagen inhibits melanoma cell proliferation by up-regulating p27KIP1. Proc Natl Acad Sci U S A (2000) 1.37
Pathologic caveolin-1 regulation of PTEN in idiopathic pulmonary fibrosis. Am J Pathol (2010) 1.35
The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair. J Clin Invest (2001) 1.25
Cell spreading controls endoplasmic and nuclear calcium: a physical gene regulation pathway from the cell surface to the nucleus. Proc Natl Acad Sci U S A (2003) 1.22
p27(kip1) acts as a downstream effector of and is coexpressed with the beta1C integrin in prostatic adenocarcinoma. J Clin Invest (1999) 1.19
The stiffness of collagen fibrils influences vascular smooth muscle cell phenotype. Biophys J (2006) 1.18
Vascular Smooth Muscle Cells in Atherosclerosis. Circ Res (2016) 1.18
Vascular smooth muscle cells ablation with endovascular nonthermal irreversible electroporation. J Vasc Interv Radiol (2010) 1.17
Molecular mechanisms of collagen isotype-specific modulation of smooth muscle cell phenotype. Arterioscler Thromb Vasc Biol (2008) 1.15
KLF6 Gene and early melanoma development in a collagen I-rich extracellular environment. J Natl Cancer Inst (2010) 1.14
The thrombospondin receptor CD47 (IAP) modulates and associates with alpha2 beta1 integrin in vascular smooth muscle cells. Mol Biol Cell (1998) 1.14
One-step derivation of mesenchymal stem cell (MSC)-like cells from human pluripotent stem cells on a fibrillar collagen coating. PLoS One (2012) 1.12
Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells. Proc Natl Acad Sci U S A (2006) 1.11
A three-dimensional collagen lattice activates NF-kappaB in human fibroblasts: role in integrin alpha2 gene expression and tissue remodeling. J Cell Biol (1998) 1.09
Type I collagen structure regulates cell morphology and EGF signaling in primary rat hepatocytes through cAMP-dependent protein kinase A. Mol Biol Cell (2005) 1.06
Diminished callus size and cartilage synthesis in alpha 1 beta 1 integrin-deficient mice during bone fracture healing. Am J Pathol (2002) 1.05
Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen. J Biol Chem (2005) 1.04
Injectable skeletal muscle matrix hydrogel promotes neovascularization and muscle cell infiltration in a hindlimb ischemia model. Eur Cell Mater (2012) 1.03
Increased C-telopeptide cross-linking of tendon type I collagen in fibromodulin-deficient mice. J Biol Chem (2014) 0.96
Role of c-fos and E2F in the induction of cyclin A transcription and vascular smooth muscle cell proliferation. J Clin Invest (1998) 0.93
Extracellular matrix fibronectin stimulates the self-assembly of microtissues on native collagen gels. Tissue Eng Part A (2010) 0.93
Low α(2)β(1) integrin function enhances the proliferation of fibroblasts from patients with idiopathic pulmonary fibrosis by activation of the β-catenin pathway. Am J Pathol (2012) 0.92
p27 expression in inflammatory bowel disease-associated neoplasia. Further evidence of a unique molecular pathogenesis. Am J Pathol (1999) 0.92
Regulation of smooth muscle cell migration and integrin expression by the Gax transcription factor. J Clin Invest (1999) 0.92
Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring. Adv Wound Care (New Rochelle) (2015) 0.91
Mammary epithelial cell-cycle progression via the alpha(2)beta(1) integrin: unique and synergistic roles of the alpha(2) cytoplasmic domain. Am J Pathol (2001) 0.91
The antifibrotic drug halofuginone inhibits proliferation and collagen production by human leiomyoma and myometrial smooth muscle cells. Fertil Steril (2009) 0.90
Discoidin domain receptor-1 deficiency attenuates atherosclerotic calcification and smooth muscle cell-mediated mineralization. Am J Pathol (2009) 0.89
Three-dimensional collagen represses cyclin E1 via β1 integrin in invasive breast cancer cells. Breast Cancer Res Treat (2010) 0.87
Extracellular matrix collagen alters cell proliferation and cell cycle progression of human uterine leiomyoma smooth muscle cells. PLoS One (2013) 0.85
Entrapped collagen type 1 promotes differentiation of embryonic pancreatic precursor cells into glucose-responsive beta-cells when cultured in three-dimensional PEG hydrogels. Tissue Eng Part A (2009) 0.85
Extracellular matrix as a driver for lung regeneration. Ann Biomed Eng (2014) 0.83
New insights into the kinetic resistance to anticancer agents. Cytotechnology (1998) 0.82
Aortic carboxypeptidase-like protein is expressed in fibrotic human lung and its absence protects against bleomycin-induced lung fibrosis. Am J Pathol (2009) 0.81
Collagen inhibitory peptide R1R2 mediates vascular remodeling by decreasing inflammation and smooth muscle cell activation. PLoS One (2015) 0.81
Blockade of TGF-β by catheter-based local intravascular gene delivery does not alter the in-stent neointimal response, but enhances inflammation in pig coronary arteries. Int J Cardiol (2010) 0.80
Glycoprotein VI/Fc receptor gamma chain-independent tyrosine phosphorylation and activation of murine platelets by collagen. Biochem J (2004) 0.80
Microenvironmental control of the breast cancer cell cycle. Anat Rec (Hoboken) (2012) 0.80
Regulation and Relevance of Myofibroblast Responses in Idiopathic Pulmonary Fibrosis. Curr Pathobiol Rep (2013) 0.77
The arterial microenvironment: the where and why of atherosclerosis. Biochem J (2016) 0.77
An overview of potential molecular mechanisms involved in VSMC phenotypic modulation. Histochem Cell Biol (2015) 0.76
Fibrillar Type I Collagen Enhances the Differentiation and Proliferation of Myofibroblasts by Lowering α2β1 Integrin Expression in Cardiac Fibrosis. Biomed Res Int (2017) 0.75
Organotypic Cultures of Intervertebral Disc Cells: Responses to Growth Factors and Signaling Pathways Involved. Biomed Res Int (2015) 0.75
Tissue-engineered endometrial model for the study of cell-cell interactions. Reprod Sci (2014) 0.75
Olfactory Receptors Modulate Physiological Processes in Human Airway Smooth Muscle Cells. Front Physiol (2016) 0.75
Integrin alpha(7)beta(1) COMPels smooth muscle cells to maintain their quiescence. Circ Res (2010) 0.75
Translational control of the fibroblast-extracellular matrix association: An application to pulmonary fibrosis. Translation (Austin) (2013) 0.75
Nitinol-Based Nanotubular Arrays with Controlled Diameters Upregulate Human Vascular Cell ECM Production. ACS Biomater Sci Eng (2016) 0.75
Differentiation of Murine Bone Marrow-Derived Smooth Muscle Progenitor Cells Is Regulated by PDGF-BB and Collagen. PLoS One (2016) 0.75
Overexpression of Prolyl-4-Hydroxylase-α1 Stabilizes but Increases Shear Stress-Induced Atherosclerotic Plaque in Apolipoprotein E-Deficient Mice. Dis Markers (2016) 0.75
Expression of the cyclin-dependent kinase inhibitor, p21Waf-1/Cip-1/Sdi-1, in human vascular smooth muscle cells in the proliferating state. Heart Vessels (1998) 0.75
CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev (1999) 24.83
The pathogenesis of atherosclerosis--an update. N Engl J Med (1986) 14.59
Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev (1995) 13.66
The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. J Cell Biol (1971) 10.72
A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc Natl Acad Sci U S A (1974) 9.94
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell (1994) 9.48
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb (1994) 8.54
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev (1994) 8.52
A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell (1996) 8.41
The biology of platelet-derived growth factor. Cell (1986) 7.17
Expression and secretion of type beta transforming growth factor by activated human macrophages. Proc Natl Acad Sci U S A (1987) 6.76
The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum. Am J Pathol (1975) 6.42
Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol Cell Biol (1995) 6.41
Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science (1992) 6.40
Atherosclerosis and the arterial smooth muscle cell: Proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis. Science (1973) 6.38
The length of the cervix and the risk of spontaneous premature delivery. National Institute of Child Health and Human Development Maternal Fetal Medicine Unit Network. N Engl J Med (1996) 5.52
Cyclin E-CDK2 is a regulator of p27Kip1. Genes Dev (1997) 5.49
The pathogenesis of atherosclerosis (second of two parts). N Engl J Med (1976) 5.48
The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J (1999) 5.44
The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature (1998) 5.40
Skeletal muscle mass and distribution in 468 men and women aged 18-88 yr. J Appl Physiol (1985) (2000) 5.24
The pathogenesis of atherosclerosis (first of two parts). N Engl J Med (1976) 5.22
Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature (1994) 5.12
The smooth muscle cell in culture. Physiol Rev (1979) 5.03
Cadaver validation of skeletal muscle measurement by magnetic resonance imaging and computerized tomography. J Appl Physiol (1985) (1998) 5.01
Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. Cell (1991) 4.88
A significant part of macrophage-derived growth factor consists of at least two forms of PDGF. Cell (1985) 4.81
Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science (1993) 4.81
The platelet-derived growth factor. Cell (1978) 4.77
The elastic fiber. I. The separation and partial characterization of its macromolecular components. J Cell Biol (1969) 4.51
Human atherosclerosis. II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions. Am J Pathol (1986) 4.51
Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation. Arteriosclerosis (1984) 4.40
Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF. Science (1991) 4.27
A map of cytoplasmic RNA transcripts from lytic adenovirus type 2, determined by electron microscopy of RNA:DNA hybrids. Cell (1977) 4.26
Longitudinal cohort study of the epidemiology of malaria infections in an area of intense malaria transmission II. Descriptive epidemiology of malaria infection and disease among children. Am J Trop Med Hyg (1999) 4.24
Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. Nat Med (1997) 4.21
A macrophage-dependent factor that stimulates the proliferation of fibroblasts in vitro. Am J Pathol (1976) 3.86
Altering genotype and phenotype by DNA-mediated gene transfer. Science (1980) 3.82
The fibroblast and wound repair. Biol Rev Camb Philos Soc (1968) 3.78
Efficacy of sulfadoxine-pyrimethamine for prevention of placental malaria in an area of Kenya with a high prevalence of malaria and human immunodeficiency virus infection. Am J Trop Med Hyg (1998) 3.74
Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle. Science (1996) 3.74
The fine structure of elastic fibers. J Cell Biol (1966) 3.68
Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the ApoE-deficient mouse. Arterioscler Thromb Vasc Biol (1998) 3.66
Endothelial cells of hematopoietic origin make a significant contribution to adult blood vessel formation. Circ Res (2000) 3.64
Two classes of PDGF receptor recognize different isoforms of PDGF. Science (1988) 3.59
Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content. J Appl Physiol (1985) (2000) 3.54
Platelet factors stimulate fibroblasts and smooth muscle cells quiescent in plasma serum to proliferate. J Cell Biol (1976) 3.48
Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination. Mol Cell (2000) 3.42
Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation. Genes Dev (1996) 3.40
Platelet-derived growth factor. I. High yield purification and evidence for multiple forms. J Biol Chem (1982) 3.35
Heterogeneous causes constituting the single syndrome of preeclampsia: a hypothesis and its implications. Am J Obstet Gynecol (1996) 3.34
Two different subunits associate to create isoform-specific platelet-derived growth factor receptors. J Biol Chem (1989) 3.33
Estimation of skeletal muscle mass by bioelectrical impedance analysis. J Appl Physiol (1985) (2000) 3.31
Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta. Science (1993) 3.28
Localization of PDGF-B protein in macrophages in all phases of atherogenesis. Science (1990) 3.27
Platelet-derived growth factor. II. Specific binding to cultured cells. J Biol Chem (1982) 3.20
Cell cycle control of DNA replication by a homologue from human cells of the p34cdc2 protein kinase. Science (1990) 3.19
Wound healing and collagen formation. V. Quantitative electron microscope radioautographic observations of proline-H3 utilization by fibroblasts. J Cell Biol (1965) 3.18
Experimental arteriosclerosis. I. Fibrous plaque formation in primates, an electron microscope study. J Exp Med (1972) 3.17
Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. Genes Dev (1999) 3.11
Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis. J Clin Invest (1976) 3.04
PDGF and FGF stimulate wound healing in the genetically diabetic mouse. Am J Pathol (1990) 3.04
Interleukin-1 mitogenic activity for fibroblasts and smooth muscle cells is due to PDGF-AA. Science (1989) 2.98
A link between cyclin A expression and adhesion-dependent cell cycle progression. Science (1993) 2.96
Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. Oncogene (1996) 2.96
Reduced susceptibility of Anopheles gambiae to permethrin associated with the use of permethrin-impregnated bednets and curtains in Kenya. Med Vet Entomol (1994) 2.95
Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins. Cell (1982) 2.92
HHF35, a muscle-actin-specific monoclonal antibody. I. Immunocytochemical and biochemical characterization. Am J Pathol (1987) 2.91
Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1). J Biol Chem (2001) 2.91
Estrogens as a cause of human cancer: the Richard and Hinda Rosenthal Foundation award lecture. Cancer Res (1988) 2.90
TGF-beta induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop. Cell (1990) 2.82
Coordinate control of 3T3 cell proliferation by platelet-derived growth factor and plasma components. Proc Natl Acad Sci U S A (1978) 2.80
Early changes in phosphatidylinositol and arachidonic acid metabolism in quiescent swiss 3T3 cells stimulated to divide by platelet-derived growth factor. J Biol Chem (1981) 2.77
The smooth muscle cell. I. In vivo synthesis of connective tissue proteins. J Cell Biol (1971) 2.74
Total-body skeletal muscle mass: development and cross-validation of anthropometric prediction models. Am J Clin Nutr (2000) 2.71
Thyroid dysfunction in a prospectively followed series of patients with progressive systemic sclerosis. J Endocrinol Invest (1990) 2.70
Development and testing of nursing home quality indicators. Health Care Financ Rev (1995) 2.68
The development of the rat flexor digital tendon, a fine structure study. J Ultrastruct Res (1967) 2.61
Production of platelet-derived growth factor-like molecules and reduced expression of platelet-derived growth factor receptors accompany transformation by a wide spectrum of agents. Proc Natl Acad Sci U S A (1984) 2.58
Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein. J Cell Biol (1996) 2.56
Homocystinemia. Vascular injury and arterial thrombosis. N Engl J Med (1974) 2.55
Hyperlipidemia and atherosclerosis. Science (1976) 2.55
Elevated oxidase and esterase levels associated with permethrin tolerance in Anopheles gambiae from Kenyan villages using permethrin-impregnated nets. Med Vet Entomol (1999) 2.50
Rules to replicate by. Cell (1994) 2.48
A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase. Nature (2001) 2.48
Gene amplification and gene correction in somatic cells. Cell (1982) 2.46
Human wound repair. I. Epidermal regeneration. J Cell Biol (1968) 2.39
Visualization of fibrous cap thickness and rupture in human atherosclerotic carotid plaque in vivo with high-resolution magnetic resonance imaging. Circulation (2000) 2.38
Negative control of DNA replication in composite SV40-bovine papilloma virus plasmids. Cell (1986) 2.35
Phenotype-dependent response of cultured aortic smooth muscle to serum mitogens. J Cell Biol (1981) 2.33
Malaria control in Bungoma District, Kenya: a survey of home treatment of children with fever, bednet use and attendance at antenatal clinics. Bull World Health Organ (2001) 2.31