Published in Cell on May 01, 1982
Replacement and amplification of bacterial genes with sequences altered in vitro. Proc Natl Acad Sci U S A (1983) 6.24
Adaptive mutation: the uses of adversity. Annu Rev Microbiol (1993) 3.17
A small region of the mouse mammary tumor virus long terminal repeat confers glucocorticoid hormone regulation on a linked heterologous gene. Proc Natl Acad Sci U S A (1983) 2.79
gamma 2-Thymidine kinase chimeras are identically transcribed but regulated a gamma 2 genes in herpes simplex virus genomes and as beta genes in cell genomes. Mol Cell Biol (1985) 2.44
Cells that constitutively express the herpes simplex virus immediate-early protein ICP4 allow efficient activation of viral delayed-early genes in trans. J Virol (1985) 2.40
Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells. Proc Natl Acad Sci U S A (1986) 2.19
Expression of herpes simplex virus beta and gamma genes integrated in mammalian cells and their induction by an alpha gene product. Mol Cell Biol (1983) 2.15
Gene conversion plays the major role in controlling the stability of large tandem repeats in yeast. EMBO J (1996) 2.14
Glucocorticoid regulation of mouse mammary tumor virus: identification of a short essential DNA region. EMBO J (1983) 2.12
Deletion and amplification of the HGPRT locus in Chinese hamster cells. Mol Cell Biol (1983) 2.10
Recombination events after transient infection and stable integration of DNA into mouse cells. Mol Cell Biol (1985) 1.99
Stable transformation of mouse L cells for human membrane T-cell differentiation antigens, HLA and beta 2-microglobulin: selection by fluorescence-activated cell sorting. Proc Natl Acad Sci U S A (1983) 1.80
Processing of herpes simplex virus proteins and evidence that translation of thymidine kinase mRNA is initiated at three separate AUG codons. J Virol (1983) 1.62
Transactivation of a late herpes simplex virus promoter. Mol Cell Biol (1984) 1.53
Positive control of the herpes simplex virus thymidine kinase gene requires upstream DNA sequences. J Virol (1983) 1.50
Host-specificities of papillomavirus, Moloney murine sarcoma virus and simian virus 40 enhancer sequences. EMBO J (1983) 1.38
A conserved nucleotide sequence, coding for a segment of the C-propeptide, is found at the same location in different collagen genes. Nucleic Acids Res (1983) 1.37
Cloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutant. Proc Natl Acad Sci U S A (1998) 1.30
Rapid spontaneous dihydrofolate reductase gene amplification shown by fluorescence-activated cell sorting. Proc Natl Acad Sci U S A (1983) 1.30
Unequal homologous recombination between tandemly arranged sequences stably incorporated into cultured rat cells. Mol Cell Biol (1985) 1.28
Human U1 small nuclear RNA genes: extensive conservation of flanking sequences suggests cycles of gene amplification and transposition. Mol Cell Biol (1985) 1.27
Inducible gene expression by DNA rearrangements in human cells. Mol Cell Biol (1986) 1.19
A Mup promoter-thymidine kinase reporter gene shows relaxed tissue-specific expression and confers male sterility upon transgenic mice. Mol Cell Biol (1988) 1.18
Transcription from the polyoma late promoter in cells stably transformed by chimeric plasmids. Mol Cell Biol (1985) 1.16
Antifreeze protein genes are tandemly linked and clustered in the genome of the winter flounder. Proc Natl Acad Sci U S A (1985) 1.09
The 5'-flanking sequence of human interferon-beta 1 gene is responsible for viral induction of transcription. Nucleic Acids Res (1983) 1.08
Inactivation of a transfected gene in human fibroblasts can occur by deletion, amplification, phenotypic switching, or methylation. Mol Cell Biol (1987) 1.04
Stable transformation of mouse teratocarcinoma stem cells with the dominant selective marker Eco.gpt and retention of their developmental potentialities. EMBO J (1983) 1.04
A new moderately repetitive DNA sequence family of novel organization. Nucleic Acids Res (1987) 1.02
Segregation and rearrangement of coamplified genes in different lineages of mutant cells that overproduce adenylate deaminase. Mol Cell Biol (1986) 1.01
Oncogene amplification during tumorigenesis of established rat fibroblasts reversibly transformed by activated human ras oncogenes. Mol Cell Biol (1986) 1.01
Moderate-level gene amplification in methotrexate-resistant Chinese hamster ovary cells is accompanied by chromosomal translocations at or near the site of the amplified DHFR gene. Mol Cell Biol (1984) 0.97
The chromosomal location of mouse interferon alpha genes. EMBO J (1984) 0.93
Preferential amplification of rearranged sequences near amplified adenylate deaminase genes. Mol Cell Biol (1988) 0.92
The herpes simplex virus type 1 thymidine kinase is expressed in the testes of transgenic mice under the control of a cryptic promoter. Mol Cell Biol (1991) 0.91
A truncated herpes simplex virus thymidine kinase phosphorylates thymidine and nucleoside analogs and does not cause sterility in transgenic mice. Mol Cell Biol (1995) 0.91
Insertional activation of a promoterless thymidine kinase gene. Mol Cell Biol (1988) 0.88
Unstable transformation of mouse 3T3 cells by transfection with DNA from normal human lymphocytes. EMBO J (1984) 0.86
A new family of tandem repetitive early histone genes in the sea urchin Lytechinus pictus: evidence for concerted evolution within tandem arrays. Nucleic Acids Res (1984) 0.86
Mutation at autosomal loci of Chinese hamster ovary cells: involvement of a high-frequency event silencing two linked alleles. Mol Cell Biol (1983) 0.85
Distinct mouse DNA sequences enable establishment and persistence of plasmid DNA polymers in mouse cells. Nucleic Acids Res (1989) 0.84
Transfection of mouse fibroblast cells with a promoterless herpes simplex virus thymidine kinase gene: number of integrated gene copies and structure of single and amplified gene sequences. Mol Cell Biol (1985) 0.83
A novel, plasmid-based system for studying gene rearrangements in mammalian cells. Mol Cell Biol (1991) 0.78
Amplification and expression of heterologous ornithine decarboxylase in Chinese hamster cells. Mol Cell Biol (1988) 0.77
Deletion of stably integrated DNA is suppressed by cadmium and zinc. Proc Natl Acad Sci U S A (1989) 0.75
CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev (1999) 24.83
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell (1986) 22.26
DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells. Proc Natl Acad Sci U S A (1979) 21.22
Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell (1979) 21.15
Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor. Cell (1978) 19.44
Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell (1977) 18.95
A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell (1991) 18.19
Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev (1995) 13.66
Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: identification of an upstream control region. Cell (1981) 12.73
Intragenic DNA spacers interrupt the ovalbumin gene. Proc Natl Acad Sci U S A (1978) 11.03
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell (1994) 9.48
Visualizing an olfactory sensory map. Cell (1996) 8.79
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev (1994) 8.52
A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell (1996) 8.41
The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family. Cell (1985) 7.16
A spatial map of olfactory receptor expression in the Drosophila antenna. Cell (1999) 6.42
Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol Cell Biol (1995) 6.41
Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science (1992) 6.40
A soluble form of CD4 (T4) protein inhibits AIDS virus infection. Nature (1988) 6.39
The transfer and stable integration of the HSV thymidine kinase gene into mouse cells. Cell (1978) 6.38
Allelic inactivation regulates olfactory receptor gene expression. Cell (1994) 5.93
A novel ras-related gene family. Cell (1985) 5.81
The length of the cervix and the risk of spontaneous premature delivery. National Institute of Child Health and Human Development Maternal Fetal Medicine Unit Network. N Engl J Med (1996) 5.52
Cyclin E-CDK2 is a regulator of p27Kip1. Genes Dev (1997) 5.49
The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J (1999) 5.44
The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature (1998) 5.40
An olfactory sensory map in the fly brain. Cell (2000) 5.29
Selective digestion of transcriptionally active ovalbumin genes from oviduct nuclei. Proc Natl Acad Sci U S A (1976) 5.27
Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature (1994) 5.12
Differences in human alpha- and beta-globin gene expression in mouse erythroleukemia cells: the role of intragenic sequences. Cell (1984) 5.12
A novel family of genes encoding putative pheromone receptors in mammals. Cell (1995) 4.88
Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. Cell (1991) 4.88
Crystal structure of an HIV-binding recombinant fragment of human CD4. Nature (1990) 4.81
Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science (1993) 4.81
Topographic organization of sensory projections to the olfactory bulb. Cell (1994) 4.74
A chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila. Cell (2001) 4.64
A map of cytoplasmic RNA transcripts from lytic adenovirus type 2, determined by electron microscopy of RNA:DNA hybrids. Cell (1977) 4.26
Longitudinal cohort study of the epidemiology of malaria infections in an area of intense malaria transmission II. Descriptive epidemiology of malaria infection and disease among children. Am J Trop Med Hyg (1999) 4.24
Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. Nat Med (1997) 4.21
Transforming DNA integrates into the host chromosome. Cell (1981) 3.98
Synthesis of globin ribonucleic acid from duck-reticulocyte chromatin in vitro. Proc Natl Acad Sci U S A (1973) 3.93
The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes. Cell (1985) 3.91
Altering genotype and phenotype by DNA-mediated gene transfer. Science (1980) 3.82
Efficacy of sulfadoxine-pyrimethamine for prevention of placental malaria in an area of Kenya with a high prevalence of malaria and human immunodeficiency virus infection. Am J Trop Med Hyg (1998) 3.74
Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle. Science (1996) 3.74
Integration, transcription, and control of a Drosophila heat shock gene in mouse cells. Proc Natl Acad Sci U S A (1981) 3.70
Introduction and expression of a rabbit beta-globin gene in mouse fibroblasts. Proc Natl Acad Sci U S A (1979) 3.53
Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium. Cell (1993) 3.53
Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1987) 3.50
Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination. Mol Cell (2000) 3.42
Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation. Genes Dev (1996) 3.40
Transformation of mammalian cells with an amplifiable dominant-acting gene. Proc Natl Acad Sci U S A (1980) 3.39
Heterogeneous causes constituting the single syndrome of preeclampsia: a hypothesis and its implications. Am J Obstet Gynecol (1996) 3.34
Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta. Science (1993) 3.28
Specific sites of interaction between histones and DNA in chromatin. Proc Natl Acad Sci U S A (1974) 3.25
Cleavage of DNA in nuclei and chromatin with staphylococcal nuclease. Biochemistry (1975) 3.20
Cell cycle control of DNA replication by a homologue from human cells of the p34cdc2 protein kinase. Science (1990) 3.19
Analysis of DNA of isolated chromatin subunits. Proc Natl Acad Sci U S A (1975) 3.17
Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. Genes Dev (1999) 3.11
Molecular characterization of a functional cDNA encoding the serotonin 1c receptor. Science (1988) 3.02
Mice deficient in G(olf) are anosmic. Neuron (1998) 3.00
A link between cyclin A expression and adhesion-dependent cell cycle progression. Science (1993) 2.96
Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. Oncogene (1996) 2.96
Reduced susceptibility of Anopheles gambiae to permethrin associated with the use of permethrin-impregnated bednets and curtains in Kenya. Med Vet Entomol (1994) 2.95
Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen. Nature (1987) 2.89
HIV infection does not require endocytosis of its receptor, CD4. Cell (1988) 2.88
The regulated expression of beta-globin genes introduced into mouse erythroleukemia cells. Cell (1983) 2.75
Isolation of transforming DNA: cloning the hamster aprt gene. Cell (1980) 2.73
Odorant receptors govern the formation of a precise topographic map. Cell (1998) 2.60
Regulated expression of human growth hormone genes in mouse cells. Cell (1982) 2.58
Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein. J Cell Biol (1996) 2.56
Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitors. Cell (1996) 2.55
Elevated oxidase and esterase levels associated with permethrin tolerance in Anopheles gambiae from Kenyan villages using permethrin-impregnated nets. Med Vet Entomol (1999) 2.50
Rules to replicate by. Cell (1994) 2.48
A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase. Nature (2001) 2.48
An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells. Development (1994) 2.46
Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. Proc Natl Acad Sci U S A (1999) 2.39
Negative control of DNA replication in composite SV40-bovine papilloma virus plasmids. Cell (1986) 2.35
Genes expressed in neurons of adult male Drosophila. Cell (1997) 2.31
Malaria control in Bungoma District, Kenya: a survey of home treatment of children with fever, bednet use and attendance at antenatal clinics. Bull World Health Organ (2001) 2.31
Presence in human breast cancer of RNA homologous to mouse mammary tumour virus RNA. Nature (1972) 2.31
Molecular cloning and nucleotide sequence of the streptavidin gene. Nucleic Acids Res (1986) 2.30
Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade. Mol Cell (1998) 2.29
Failure of metronidazole to prevent preterm delivery among pregnant women with asymptomatic Trichomonas vaginalis infection. N Engl J Med (2001) 2.23
Elevated levels of S-nitrosoalbumin in preeclampsia plasma. Circ Res (2001) 2.21
Genes transcribed at diverse rates have a similar conformation in chromatin. Proc Natl Acad Sci U S A (1977) 2.17
Epidemiology of giardiasis in Wisconsin: increasing incidence of reported cases and unexplained seasonal trends. Am J Trop Med Hyg (1992) 2.13
Cell cycle regulated phosphorylation of RPA-32 occurs within the replication initiation complex. EMBO J (1992) 2.13
Dexamethasone for the treatment of depression: a randomized, placebo-controlled, double-blind trial. Am J Psychiatry (1995) 2.13
Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti. Proc Natl Acad Sci U S A (1999) 2.12
A family of glutamate receptor genes: evidence for the formation of heteromultimeric receptors with distinct channel properties. Neuron (1990) 2.10
The gene encoding the T-cell surface protein T4 is located on human chromosome 12. Proc Natl Acad Sci U S A (1986) 2.08
Genetic variation in Pneumocystis carinii isolates from different geographic regions: implications for transmission. Emerg Infect Dis (2000) 2.08
Preeclampsia is associated with abnormal expression of adhesion molecules by invasive cytotrophoblasts. J Clin Invest (1993) 2.07
Molecular cloning and single-channel properties of the cyclic nucleotide-gated channel from catfish olfactory neurons. Neuron (1992) 2.04
The structure of the globin genes in chromatin. Biochemistry (1975) 2.02
Particles containing RNA-instructed DNA polymerase and virus-related RNA in human breast cancers. Proc Natl Acad Sci U S A (1972) 2.02
The family of genes encoding odorant receptors in the channel catfish. Cell (1993) 2.02