Published in Annu Rev Med on January 01, 1997
Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins. Proc Natl Acad Sci U S A (1999) 2.41
Control of apoptosis during angiogenesis by survivin expression in endothelial cells. Am J Pathol (2000) 2.10
Inhibition of melanoma tumor growth in vivo by survivin targeting. Proc Natl Acad Sci U S A (2001) 1.89
Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes Dev (2003) 1.76
Main roads to melanoma. J Transl Med (2009) 1.67
Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Proc Natl Acad Sci U S A (2001) 1.62
Altered cytochrome c display precedes apoptotic cell death in Drosophila. J Cell Biol (1999) 1.49
Expression of different survivin variants in gastric carcinomas: first clues to a role of survivin-2B in tumour progression. Br J Cancer (2002) 1.45
Caspase activation and specific cleavage of substrates after coxsackievirus B3-induced cytopathic effect in HeLa cells. J Virol (1998) 1.41
Ectopic expression of hepatitis C virus core protein differentially regulates nuclear transcription factors. J Virol (1998) 1.29
Poliovirus induces apoptosis in the mouse central nervous system. J Virol (1999) 1.27
Apoptosis plays an important role in experimental rabies virus infection. J Virol (1997) 1.21
Gastroprotective Activity of Polygonum chinense Aqueous Leaf Extract on Ethanol-Induced Hemorrhagic Mucosal Lesions in Rats. Evid Based Complement Alternat Med (2012) 1.09
Inflammasome activation in obesity-related inflammatory diseases and autoimmunity. Discov Med (2011) 1.08
Vaccinia virus F1L protein is a tail-anchored protein that functions at the mitochondria to inhibit apoptosis. J Virol (2005) 1.08
FAS-antisense 1 lncRNA and production of soluble versus membrane Fas in B-cell lymphoma. Leukemia (2014) 1.05
Calcium signaling and cytotoxicity. Environ Health Perspect (1999) 1.04
Apoptosis in the osteonecrosis of the femoral head. Clin Orthop Surg (2010) 1.04
CaMKII in cerebral ischemia. Acta Pharmacol Sin (2011) 1.04
Acute toxicity and gastroprotective role of M. pruriens in ethanol-induced gastric mucosal injuries in rats. Biomed Res Int (2013) 1.01
Modulation of apoptosis by human papillomavirus (HPV) oncoproteins. Arch Virol (2006) 1.00
Targeted disruption of Bcl-xL in mouse keratinocytes inhibits both UVB- and chemically induced skin carcinogenesis. Mol Carcinog (2009) 0.97
Expression level of wild-type survivin in gastric cancer is an independent predictor of survival. World J Gastroenterol (2004) 0.94
Role of Nr13 in regulation of programmed cell death in the bursa of Fabricius. Genes Dev (1999) 0.91
Hormonal regulation of physiological cell turnover and apoptosis. Cell Tissue Res (2000) 0.89
Involvement of Cox-2 in the metastatic potential of chemotherapy-resistant breast cancer cells. BMC Cancer (2011) 0.88
Gastroprotective effects of Corchorus olitorius leaf extract against ethanol-induced gastric mucosal hemorrhagic lesions in rats. J Gastroenterol Hepatol (2013) 0.88
Modulation of apoptotic pathways by human papillomaviruses (HPV): mechanisms and implications for therapy. Viruses (2012) 0.87
Modulation of human neutrophil functions in vitro by Treponema denticola major outer sheath protein. Infect Immun (2006) 0.86
BH3 Profiling Reveals Selectivity by Herpesviruses for Specific Bcl-2 Proteins To Mediate Survival of Latently Infected Cells. J Virol (2015) 0.84
Bcl-x(L) expression in vivo in rheumatoid synovium. Clin Rheumatol (2006) 0.83
The apoptotic machinery as a biological complex system: analysis of its omics and evolution, identification of candidate genes for fourteen major types of cancer, and experimental validation in CML and neuroblastoma. BMC Med Genomics (2009) 0.82
Ribozyme inhibition of the protein kinase C alpha triggers apoptosis in glioma cells. Br J Cancer (1999) 0.82
Necrotic Effect versus Apoptotic Nature of Camptothecin in Human Cervical Cancer Cells. Iran J Cancer Prev (2012) 0.82
Diagnosis of cell death by means of infrared spectroscopy. Biophys J (2009) 0.82
Survivin expression in colorectal carcinomas: correlations with clinicopathological parameters and survival. Dig Dis Sci (2009) 0.82
Regulation of cell death by transfer RNA. Antioxid Redox Signal (2013) 0.80
Expression of the survivin-2B splice variant related to the progression of colorectal carcinoma. J Korean Surg Soc (2011) 0.79
Mitochondrial DNA mutations in differentiated thyroid cancer with respect to the age factor. World J Surg (2007) 0.78
Norcantharidin induces melanoma cell apoptosis through activation of TR3 dependent pathway. Cancer Biol Ther (2011) 0.78
Recent advances: paediatric surgery. BMJ (1999) 0.78
Combinational effects of hexane insoluble fraction of Ficus septica Burm. F. and doxorubicin chemotherapy on T47D breast cancer cells. Asian Pac J Trop Biomed (2013) 0.78
The therapeutic potential of adenosine triphosphate as an immune modulator in the treatment of HIV/AIDS: a combination approach with HAART. Curr HIV Res (2011) 0.77
Apoptosis-related gene expression in glioblastoma (LN-18) and medulloblastoma (Daoy) cell lines. Hum Cell (2013) 0.77
Shorter exposures to harder X-rays trigger early apoptotic events in Xenopus laevis embryos. PLoS One (2010) 0.77
Transcription analysis of the porcine alveolar macrophage response to Mycoplasma hyopneumoniae. PLoS One (2014) 0.76
Toxic effects of xylazine on endothelial cells in combination with cocaine and 6-monoacetylmorphine. Toxicol In Vitro (2014) 0.76
Nuclear receptor subfamily 4, group A, member 1 inhibits extrinsic apoptosis and reduces caspase-8 activity in H2O2-induced human HUC-F2 fibroblasts. Redox Rep (2014) 0.76
Canine distemper virus induces apoptosis in cervical tumor derived cell lines. Virol J (2011) 0.75
Prophylactic effects of Clausena excavata Burum. f. leaf extract in ethanol-induced gastric ulcers. Drug Des Devel Ther (2016) 0.75
CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma. BMC Cancer (2015) 0.75
Effects of Helicobacter pylori infection on gastric epithelial cell kinetics in patients with chronic renal failure. World J Gastroenterol (2005) 0.75
Fourier transform infrared microspectroscopy monitoring of 5-fluorouracil-induced apoptosis in SW620 colon cancer cells. Mol Med Rep (2014) 0.75
Stilbene 5c, a microtubule poison with vascular disrupting properties that induces multiple modes of growth arrest and cell death. Biochem Pharmacol (2013) 0.75
Co-expression of ING4 and P53 enhances hypopharyngeal cancer chemosensitivity to cisplatin in vivo. Mol Med Rep (2016) 0.75
TMBIM-mediated Ca(2+) homeostasis and cell death. Biochim Biophys Acta (2017) 0.75
Targeting the apoptotic Mcl-1-PUMA interface with a dual-acting compound. Oncotarget (2017) 0.75
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science (2001) 23.42
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science (1995) 16.19
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell (1993) 14.39
CTLA-4 can function as a negative regulator of T cell activation. Immunity (1994) 9.80
Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. Science (1997) 9.73
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell (2000) 8.95
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell (1995) 8.75
Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell (1997) 8.61
X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature (1996) 8.37
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev (2000) 8.35
Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science (1989) 7.78
Differential T cell costimulatory requirements in CD28-deficient mice. Science (1993) 6.93
The B7 and CD28 receptor families. Immunol Today (1994) 6.38
CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL. Immunity (1995) 5.77
BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev (2001) 5.66
Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol Cell Biol (2001) 5.10
Role of the CD28 receptor in T-cell activation. Immunol Today (1990) 4.89
T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression. Mol Cell Biol (1987) 4.76
Bcl-x(L) forms an ion channel in synthetic lipid membranes. Nature (1997) 4.55
Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange. Mol Cell (1999) 4.55
Levels of c-myc oncogene mRNA are invariant throughout the cell cycle. Nature (1985) 4.35
Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc Natl Acad Sci U S A (1995) 4.22
In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol Cell (2000) 4.10
Bax-independent inhibition of apoptosis by Bcl-XL. Nature (1996) 3.82
c-myc oncogene protein synthesis is independent of the cell cycle in human and avian cells. Nature (1985) 3.72
T-cell regulation by CD28 and CTLA-4. Nat Rev Immunol (2001) 3.59
A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. EMBO J (1996) 3.57
Differential expression of c-myb mRNA in murine B lymphomas by a block to transcription elongation. Science (1987) 3.49
An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3' untranslated region of lymphokine mRNA. Mol Cell Biol (1991) 3.48
Expression of the c-myb proto-oncogene during cellular proliferation. Nature (1986) 3.45
IL-7 enhances the survival and maintains the size of naive T cells. J Immunol (2001) 3.39
bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria. Development (1994) 3.34
Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death. Genes Dev (1998) 3.33
Characterization of XIAP-deficient mice. Mol Cell Biol (2001) 3.32
Bcl-2-family proteins: the role of the BH3 domain in apoptosis. Trends Cell Biol (1998) 3.32
Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc Natl Acad Sci U S A (1994) 3.26
Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. J Biol Chem (2001) 3.22
Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis? Nat Cell Biol (1999) 3.17
Molecular basis of T cell inactivation by CTLA-4. Science (1998) 3.00
Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. Protein Sci (2000) 3.00
Effects of CD28 costimulation on long-term proliferation of CD4+ T cells in the absence of exogenous feeder cells. J Immunol (1997) 2.98
Bcl-XL and Bcl-2 repress a common pathway of cell death. J Exp Med (1995) 2.94
CD28 is an inducible T cell surface antigen that transduces a proliferative signal in CD3+ mature thymocytes. J Immunol (1990) 2.84
Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membrane. J Biol Chem (2001) 2.76
Sequence-specific binding of human Ets-1 to the T cell receptor alpha gene enhancer. Science (1990) 2.76
Regulation of surface and intracellular expression of CTLA4 on mouse T cells. J Immunol (1996) 2.69
Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking. Science (1991) 2.65
Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion. J Exp Med (1993) 2.62
Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets. J Immunol (1993) 2.55
Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival. Proc Natl Acad Sci U S A (2000) 2.46
Absence of B7-dependent responses in CD28-deficient mice. Immunity (1994) 2.32
Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage. Genes Dev (1996) 2.30
The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability. Cell Death Differ (2000) 2.29
AU RNA-binding factors differ in their binding specificities and affinities. J Biol Chem (1992) 2.25
Bcl-x(L) prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol (2000) 2.24
CD28 ligation in T-cell activation: evidence for two signal transduction pathways. Blood (1990) 2.21
Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL. Mol Cell Biol (1997) 2.15
Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment. Cell (1987) 2.15
Expression of bcl-xL can confer a multidrug resistance phenotype. Blood (1995) 2.11
CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity (1996) 2.09
Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins. Mol Cell Biol (1995) 2.07
Evolutionarily conserved Ets family members display distinct DNA binding specificities. J Exp Med (1992) 2.04
Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis. Cell Death Differ (2003) 2.01
Bclx regulates the survival of double-positive thymocytes. Proc Natl Acad Sci U S A (1995) 2.00
Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: regulatory role for the protooncogene ETS1. Proc Natl Acad Sci U S A (1990) 1.96
Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function. Br J Haematol (1982) 1.96
The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB. Mol Cell Biol (1993) 1.94
Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production. Oncogene (2011) 1.87
The central effectors of cell death in the immune system. Annu Rev Immunol (1999) 1.87
Identification of a novel regulatory domain in Bcl-X(L) and Bcl-2. EMBO J (1997) 1.83
CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival. Genes Dev (1997) 1.83
Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases. Cancer J Sci Am (1997) 1.80
bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice. J Exp Med (1996) 1.79
CD28 is required for germinal center formation. J Immunol (1996) 1.78
Bcl-x(L) can inhibit apoptosis in cells that have undergone Fas-induced protease activation. Proc Natl Acad Sci U S A (1997) 1.78
Induction of nuclear factor kappaB by the CD30 receptor is mediated by TRAF1 and TRAF2. Mol Cell Biol (1997) 1.78
Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein. Science (1993) 1.77
CD28 costimulation prevents cell death during primary T cell activation. J Immunol (1996) 1.76
Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2. Proc Natl Acad Sci U S A (1994) 1.76
Evidence for the involvement of three distinct signals in the induction of IL-2 gene expression in human T lymphocytes. J Immunol (1989) 1.75
The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A. Immunity (2000) 1.74
Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules. Proc Natl Acad Sci U S A (1998) 1.71
Selective expression of RAG-2 in chicken B cells undergoing immunoglobulin gene conversion. Cell (1991) 1.68
Chicken IgL gene rearrangement involves deletion of a circular episome and addition of single nonrandom nucleotides to both coding segments. Cell (1989) 1.67
Multiple mechanisms regulate c-myc gene expression during normal T cell activation. EMBO J (1988) 1.66
Macroautophagy versus mitochondrial autophagy: a question of fate? Cell Death Differ (2005) 1.65
Growth factors can enhance lymphocyte survival without committing the cell to undergo cell division. Proc Natl Acad Sci U S A (1995) 1.65
A smoking cessation program for pregnant women: an exploratory study. Am J Public Health (1978) 1.64
Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1alpha-induced metabolic reprograming. Oncogene (2010) 1.63
Apoptosis meets signal transduction: elimination of a BAD influence. Cell (1996) 1.63
Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanisms. EMBO J (1999) 1.62
Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion. Am J Physiol Endocrinol Metab (2000) 1.62
Structural analysis of CTLA-4 function in vivo. J Immunol (2000) 1.61
Association between cyclosporin neurotoxicity and hypomagnesaemia. Lancet (1984) 1.60
Short-term K(+) deprivation provokes insulin resistance of cellular K(+) uptake revealed with the K(+) clamp. Am J Physiol Renal Physiol (2001) 1.59
Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period. Stroke (1986) 1.58
Monocyte-endothelial adhesion in chronic rheumatoid arthritis. In situ detection of selectin and integrin-dependent interactions. J Clin Invest (1993) 1.56
The FLI-1 and chimeric EWS-FLI-1 oncoproteins display similar DNA binding specificities. J Biol Chem (1994) 1.56
Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine. J Clin Invest (1991) 1.55
Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. J Immunol (1997) 1.52