Published in Mol Cell Biol on December 01, 1997
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev (2000) 8.35
Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis. J Cell Biol (1999) 6.58
p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc Natl Acad Sci U S A (2001) 3.11
Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. Protein Sci (2000) 3.00
BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia. Blood (2007) 2.12
Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation. Proc Natl Acad Sci U S A (1998) 2.06
WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. Genes Dev (2002) 1.80
Bnip3 mediates mitochondrial dysfunction and cell death through Bax and Bak. Biochem J (2007) 1.76
Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells. Proc Natl Acad Sci U S A (2004) 1.72
Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway. EMBO J (2003) 1.60
Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry. EMBO J (2003) 1.59
Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus. Proc Natl Acad Sci U S A (2002) 1.52
Multiple functions of BCL-2 family proteins. Cold Spring Harb Perspect Biol (2013) 1.51
Bad can act as a key regulator of T cell apoptosis and T cell development. J Exp Med (1999) 1.46
Antiapoptotic herpesvirus Bcl-2 homologs escape caspase-mediated conversion to proapoptotic proteins. J Virol (2000) 1.43
A yeast BH3-only protein mediates the mitochondrial pathway of apoptosis. EMBO J (2011) 1.42
p53 initiates apoptosis by transcriptionally targeting the antiapoptotic protein ARC. Mol Cell Biol (2007) 1.37
The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf. Mol Cell Biol (2000) 1.31
Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis. Am J Pathol (2008) 1.26
Apoptotic effects of chrysin in human cancer cell lines. Int J Mol Sci (2010) 1.25
Caspase cleavage enhances the apoptosis-inducing effects of BAD. Mol Cell Biol (2001) 1.21
Protein phosphatase 1alpha is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosis. EMBO J (2000) 1.20
Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant. J Exp Med (1998) 1.13
Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor. Genes Dev (2010) 1.11
In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injury. J Cereb Blood Flow Metab (2011) 1.11
Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2. Protein Sci (2007) 1.11
Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage. Support Care Cancer (2006) 1.10
Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation. Cell (2013) 1.06
Transforming growth factor beta 1 induces apoptosis through cleavage of BAD in a Smad3-dependent mechanism in FaO hepatoma cells. Mol Cell Biol (2002) 1.04
Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells. J Biomed Sci (2012) 1.04
Insulin signaling regulates mitochondrial function in pancreatic beta-cells. PLoS One (2009) 1.03
Thermodynamics-based drug design: strategies for inhibiting protein-protein interactions. Future Med Chem (2011) 0.96
RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis. Sci Signal (2014) 0.96
Role of the mitochondrial signaling pathway in murine coronavirus-induced oligodendrocyte apoptosis. J Virol (2006) 0.93
Optimization of CD4/gp120 inhibitors by thermodynamic-guided alanine-scanning mutagenesis. Chem Biol Drug Des (2013) 0.92
Effector mechanism of magnolol-induced apoptosis in human lung squamous carcinoma CH27 cells. Br J Pharmacol (2003) 0.91
Phosphorylation of murine caspase-9 by the protein kinase casein kinase 2 regulates its cleavage by caspase-8. J Biol Chem (2008) 0.90
Cytokine-induced tumor suppressors: a GRIM story. Cytokine (2010) 0.88
Ligand binding and membrane insertion compete with oligomerization of the BclXL apoptotic repressor. J Mol Biol (2011) 0.88
The BH3 domain of Bcl-x(S) is required for inhibition of the antiapoptotic function of Bcl-x(L). Mol Cell Biol (1999) 0.86
Preclinical studies of apogossypolone, a novel pan inhibitor of bcl-2 and mcl-1, synergistically potentiates cytotoxic effect of gemcitabine in pancreatic cancer cells. Pancreas (2010) 0.86
Regulating apoptosis in mammalian cell cultures. Cytotechnology (2006) 0.85
Virtual screening targeting the urokinase receptor, biochemical and cell-based studies, synthesis, pharmacokinetic characterization, and effect on breast tumor metastasis. J Med Chem (2011) 0.85
L-Arginine enhances cell proliferation and reduces apoptosis in human endometrial RL95-2 cells. Reprod Biol Endocrinol (2013) 0.83
Activation of GluR6-containing kainate receptors induces ubiquitin-dependent Bcl-2 degradation via denitrosylation in the rat hippocampus after kainate treatment. J Biol Chem (2010) 0.81
Killing of sarcoma cells by proapoptotic Bcl-X(S): role of the BH3 domain and regulation by Bcl-X(L). Neoplasia (2001) 0.80
Promising personalized therapeutic options for diffuse large B-cell Lymphoma Subtypes with oncogene addictions. Clin Cancer Res (2012) 0.79
Inhibition of Bim enhances replication of varicella-zoster virus and delays plaque formation in virus-infected cells. J Virol (2013) 0.79
NMR determination that an extended BH3 motif of pro-apoptotic BID is specifically bound to BCL-XL. Magn Reson Chem (2006) 0.78
Dynamical systems analysis of mitochondrial BAK activation kinetics predicts resistance to BH3 domains. PLoS One (2008) 0.78
Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades. J Biol Chem (2015) 0.77
Tolerogenic effect of fiber tract injury: reduced EAE severity following entorhinal cortex lesion. Exp Brain Res (2006) 0.75
MicroRNA-214 protects against hypoxia/reoxygenation induced cell damage and myocardial ischemia/reperfusion injury via suppression of PTEN and Bim1 expression. Oncotarget (2016) 0.75
Biochemical and biophysical investigations of the interaction between human glucokinase and pro-apoptotic BAD. PLoS One (2017) 0.75
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell (1993) 20.72
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature (1988) 14.66
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell (1993) 14.39
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L) Cell (1996) 10.83
Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. Science (1997) 9.73
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell (1995) 8.75
X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature (1996) 8.37
BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature (1994) 6.69
BID: a novel BH3 domain-only death agonist. Genes Dev (1996) 5.90
The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins. Proc Natl Acad Sci U S A (1992) 5.43
MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc Natl Acad Sci U S A (1993) 5.13
Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med (1995) 4.88
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell (1994) 4.66
Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc Natl Acad Sci U S A (1995) 4.22
The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor alpha. Mol Cell Biol (1992) 4.17
Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell (1996) 4.04
Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature (1992) 3.96
Bax-independent inhibition of apoptosis by Bcl-XL. Nature (1996) 3.82
A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. EMBO J (1995) 3.70
Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death. Proc Natl Acad Sci U S A (1993) 3.66
Induction of apoptosis by the Bcl-2 homologue Bak. Nature (1995) 3.56
Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc Natl Acad Sci U S A (1994) 3.26
Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. Oncogene (1995) 2.89
Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2. J Biol Chem (1996) 2.79
Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Nature (1995) 2.48
Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage. Genes Dev (1996) 2.30
The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein. Genes Dev (1996) 2.23
Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2. Nature (1997) 2.09
bcl-w, a novel member of the bcl-2 family, promotes cell survival. Oncogene (1996) 1.87
Identification of a novel regulatory domain in Bcl-X(L) and Bcl-2. EMBO J (1997) 1.83
Bcl-x(L) can inhibit apoptosis in cells that have undergone Fas-induced protease activation. Proc Natl Acad Sci U S A (1997) 1.78
Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K. Mol Cell Biol (1996) 1.77
New members of the Bcl-2 family and their protein partners. Curr Opin Genet Dev (1996) 1.52
An alternatively spliced C. elegans ced-4 RNA encodes a novel cell death inhibitor. Cell (1996) 1.42
Bcl-x(S) anatagonizes the protective effects of Bcl-x(L). J Biol Chem (1996) 1.35
A peptide sequence from Bax that converts Bcl-2 into an activator of apoptosis. J Biol Chem (1996) 1.24
Adenovirus E1B 19-kDa death suppressor protein interacts with Bax but not with Bad. J Biol Chem (1996) 1.11
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science (2001) 23.42
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science (1995) 16.19
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell (1993) 14.39
CTLA-4 can function as a negative regulator of T cell activation. Immunity (1994) 9.80
Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. Science (1997) 9.73
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell (2000) 8.95
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell (1995) 8.75
Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell (1997) 8.61
X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature (1996) 8.37
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev (2000) 8.35
Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science (1989) 7.78
Discovering high-affinity ligands for proteins: SAR by NMR. Science (1996) 7.10
Differential T cell costimulatory requirements in CD28-deficient mice. Science (1993) 6.93
The B7 and CD28 receptor families. Immunol Today (1994) 6.38
CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL. Immunity (1995) 5.77
BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev (2001) 5.66
Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol Cell Biol (2001) 5.10
Role of the CD28 receptor in T-cell activation. Immunol Today (1990) 4.89
T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression. Mol Cell Biol (1987) 4.76
Bcl-x(L) forms an ion channel in synthetic lipid membranes. Nature (1997) 4.55
Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange. Mol Cell (1999) 4.55
Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate. Nature (1994) 4.49
Levels of c-myc oncogene mRNA are invariant throughout the cell cycle. Nature (1985) 4.35
Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc Natl Acad Sci U S A (1995) 4.22
In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol Cell (2000) 4.10
14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol Cell (2000) 4.05
Structural basis for the inhibition of caspase-3 by XIAP. Cell (2001) 3.91
Bax-independent inhibition of apoptosis by Bcl-XL. Nature (1996) 3.82
c-myc oncogene protein synthesis is independent of the cell cycle in human and avian cells. Nature (1985) 3.72
T-cell regulation by CD28 and CTLA-4. Nat Rev Immunol (2001) 3.59
A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. EMBO J (1996) 3.57
Differential expression of c-myb mRNA in murine B lymphomas by a block to transcription elongation. Science (1987) 3.49
An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3' untranslated region of lymphokine mRNA. Mol Cell Biol (1991) 3.48
Expression of the c-myb proto-oncogene during cellular proliferation. Nature (1986) 3.45
IL-7 enhances the survival and maintains the size of naive T cells. J Immunol (2001) 3.39
bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria. Development (1994) 3.34
Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death. Genes Dev (1998) 3.33
Characterization of XIAP-deficient mice. Mol Cell Biol (2001) 3.32
Use of single voided urine samples to estimate quantitative proteinuria. N Engl J Med (1983) 3.32
Bcl-2-family proteins: the role of the BH3 domain in apoptosis. Trends Cell Biol (1998) 3.32
Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc Natl Acad Sci U S A (1994) 3.26
Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain. Nature (2001) 3.22
Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. J Biol Chem (2001) 3.22
Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis? Nat Cell Biol (1999) 3.17
'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737. Oncogene (2006) 3.10
NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain. Nature (1997) 3.04
Molecular basis of T cell inactivation by CTLA-4. Science (1998) 3.00
Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. Protein Sci (2000) 3.00
Effects of CD28 costimulation on long-term proliferation of CD4+ T cells in the absence of exogenous feeder cells. J Immunol (1997) 2.98
Bcl-XL and Bcl-2 repress a common pathway of cell death. J Exp Med (1995) 2.94
CD28 is an inducible T cell surface antigen that transduces a proliferative signal in CD3+ mature thymocytes. J Immunol (1990) 2.84
Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membrane. J Biol Chem (2001) 2.76
Sequence-specific binding of human Ets-1 to the T cell receptor alpha gene enhancer. Science (1990) 2.76
Regulation of surface and intracellular expression of CTLA4 on mouse T cells. J Immunol (1996) 2.69
Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking. Science (1991) 2.65
Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion. J Exp Med (1993) 2.62
Solution structure of the antiapoptotic protein bcl-2. Proc Natl Acad Sci U S A (2001) 2.60
Structure and ligand recognition of the phosphotyrosine binding domain of Shc. Nature (1995) 2.59
Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets. J Immunol (1993) 2.55
Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival. Proc Natl Acad Sci U S A (2000) 2.46
A general method for assigning NMR spectra of denatured proteins using 3D HC(CO)NH-TOCSY triple resonance experiments. J Biomol NMR (1993) 2.35
Absence of B7-dependent responses in CD28-deficient mice. Immunity (1994) 2.32
Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage. Genes Dev (1996) 2.30
The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability. Cell Death Differ (2000) 2.29
AU RNA-binding factors differ in their binding specificities and affinities. J Biol Chem (1992) 2.25
Bcl-x(L) prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol (2000) 2.24
CD28 ligation in T-cell activation: evidence for two signal transduction pathways. Blood (1990) 2.21
NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP. Nature (1999) 2.18
Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment. Cell (1987) 2.15
A computer-based protocol for semiautomated assignments and 3D structure determination of proteins. J Biomol NMR (1994) 2.14
Rational design of stable lyophilized protein formulations: some practical advice. Pharm Res (1997) 2.13
Expression of bcl-xL can confer a multidrug resistance phenotype. Blood (1995) 2.11
CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity (1996) 2.09
Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins. Mol Cell Biol (1995) 2.07
Evolutionarily conserved Ets family members display distinct DNA binding specificities. J Exp Med (1992) 2.04
Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis. Cell Death Differ (2003) 2.01
Bclx regulates the survival of double-positive thymocytes. Proc Natl Acad Sci U S A (1995) 2.00
Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: regulatory role for the protooncogene ETS1. Proc Natl Acad Sci U S A (1990) 1.96
Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function. Br J Haematol (1982) 1.96
The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB. Mol Cell Biol (1993) 1.94
Leakage of cement in percutaneous transpedicular vertebroplasty for painful osteoporotic compression fractures. J Bone Joint Surg Br (2003) 1.91
Apoptosis and disease: regulation and clinical relevance of programmed cell death. Annu Rev Med (1997) 1.91
Model for mammalian metallothionein structure. Proc Natl Acad Sci U S A (1983) 1.91
NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP. J Biol Chem (2000) 1.88
Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production. Oncogene (2011) 1.87
The central effectors of cell death in the immune system. Annu Rev Immunol (1999) 1.87
Identification of a novel regulatory domain in Bcl-X(L) and Bcl-2. EMBO J (1997) 1.83
CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival. Genes Dev (1997) 1.83
Solution structure of an rRNA methyltransferase (ErmAM) that confers macrolide-lincosamide-streptogramin antibiotic resistance. Nat Struct Biol (1997) 1.82
Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases. Cancer J Sci Am (1997) 1.80