Published in J Exp Med on September 01, 1995
The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis. Immunity (2007) 4.74
Type I interferons keep activated T cells alive. J Exp Med (1999) 3.98
Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane. J Cell Biol (2003) 3.01
Correlating notch signaling with thymocyte maturation. Immunity (1998) 2.82
Cytokine-induced survival of activated T cells in vitro and in vivo. Proc Natl Acad Sci U S A (1998) 2.71
Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc Natl Acad Sci U S A (1996) 2.65
Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo. J Exp Med (2000) 2.51
Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils. J Exp Med (1996) 2.39
IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. Blood (2007) 2.24
Antigen-mediated T cell expansion regulated by parallel pathways of death. Proc Natl Acad Sci U S A (2008) 2.20
Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis. Proc Natl Acad Sci U S A (2004) 2.18
Interleukin 4 (IL-4) or IL-7 prevents the death of resting T cells: stat6 is probably not required for the effect of IL-4. J Exp Med (1997) 2.15
Combined deficiency of p50 and cRel in CD4+ T cells reveals an essential requirement for nuclear factor kappaB in regulating mature T cell survival and in vivo function. J Exp Med (2003) 1.93
Identification of a novel regulatory domain in Bcl-X(L) and Bcl-2. EMBO J (1997) 1.83
Transgenic expression of the coxsackie/adenovirus receptor enables adenoviral-mediated gene delivery in naive T cells. Proc Natl Acad Sci U S A (2000) 1.68
Differential requirement of PKC-theta in the development and function of natural regulatory T cells. Mol Immunol (2008) 1.63
BCL11B is required for positive selection and survival of double-positive thymocytes. J Exp Med (2007) 1.59
Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation. Genes Dev (2010) 1.50
Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis. J Biol Chem (2012) 1.49
Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol Cell Biol (2004) 1.48
Antiinflammatory effects of CD95 ligand (FasL)-induced apoptosis. J Exp Med (1998) 1.48
An essential role for nuclear factor kappaB in promoting double positive thymocyte apoptosis. J Exp Med (1999) 1.44
Effects of mycobacteria on regulation of apoptosis in mononuclear phagocytes. Infect Immun (1997) 1.44
Bax alpha perturbs T cell development and affects cell cycle entry of T cells. EMBO J (1996) 1.43
Bcl-XL is qualitatively different from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line. BMC Cancer (2006) 1.33
Emerging Bcl-2 inhibitors for the treatment of cancer. Expert Opin Emerg Drugs (2010) 1.32
A surface groove essential for viral Bcl-2 function during chronic infection in vivo. PLoS Pathog (2005) 1.30
IL-15 regulates homeostasis and terminal maturation of NKT cells. J Immunol (2011) 1.29
Differential expression of BCL-2 family proteins in ALK-positive and ALK-negative anaplastic large cell lymphoma of T/null-cell lineage. Am J Pathol (2001) 1.21
Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system. Proc Natl Acad Sci U S A (2013) 1.21
Elevated T cell receptor signaling identifies a thymic precursor to the TCRαβ(+)CD4(-)CD8β(-) intraepithelial lymphocyte lineage. Immunity (2014) 1.19
A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells. Immunity (1997) 1.19
Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage-induced apoptosis. J Clin Invest (1999) 1.19
Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistance. Free Radic Biol Med (2012) 1.17
SCG10 is a JNK target in the axonal degeneration pathway. Proc Natl Acad Sci U S A (2012) 1.16
Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199. Cancer Discov (2014) 1.14
Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion. PLoS Biol (2007) 1.13
BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway. Proc Natl Acad Sci U S A (1996) 1.13
Why target PIM1 for cancer diagnosis and treatment? Future Oncol (2010) 1.12
TNFα cooperates with IFN-γ to repress Bcl-xL expression to sensitize metastatic colon carcinoma cells to TRAIL-mediated apoptosis. PLoS One (2011) 1.08
Retracted Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis. J Biol Chem (2011) 1.07
Two mature products of MIR-491 coordinate to suppress key cancer hallmarks in glioblastoma. Oncogene (2014) 1.05
CD40 ligation reverses T cell tolerance in acute myeloid leukemia. J Clin Invest (2013) 1.04
Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene. Am J Pathol (1997) 1.03
β-Catenin induces T-cell transformation by promoting genomic instability. Proc Natl Acad Sci U S A (2013) 1.03
Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: role in Ca(2+) signaling and disease. Cell Calcium (2011) 1.01
Expression of bcl-X(L) restores cell survival, but not proliferation off effector differentiation, in CD28-deficient T lymphocytes. J Exp Med (2000) 1.01
The transcriptional repressor NKAP is required for the development of iNKT cells. Nat Commun (2013) 0.99
Higher expression of Bax in regulatory T cells increases vascular inflammation. Front Biosci (2008) 0.98
Enzymatically active single chain caspase-8 maintains T-cell survival during clonal expansion. Cell Death Differ (2010) 0.98
A critical role for protein kinase C-theta-mediated T cell survival in cardiac allograft rejection. J Immunol (2008) 0.97
Targeted disruption of Bcl-xL in mouse keratinocytes inhibits both UVB- and chemically induced skin carcinogenesis. Mol Carcinog (2009) 0.97
Differences in Bcl-2 expression by T-cell subsets alter their balance after in vivo irradiation to favor CD4+Bcl-2hi NKT cells. Eur J Immunol (2009) 0.96
Fibroblasts prevent apoptosis of IL-2-deprived T cells without inducing proliferation: a selective effect on Bcl-XL expression. Immunology (1996) 0.96
Regulatory T cells require TCR signaling for their suppressive function. J Immunol (2015) 0.95
Bcl-xL overexpression attenuates glutathione depletion in FL5.12 cells following interleukin-3 withdrawal. Biochem J (1997) 0.94
Regulation of Bcl-xL expression in human keratinocytes by cell-substratum adhesion and the epidermal growth factor receptor. Proc Natl Acad Sci U S A (1997) 0.93
Deficiency of the Bax gene attenuates denervation-induced apoptosis. Apoptosis (2006) 0.93
Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy. FEBS J (2015) 0.90
A portrait of the Bcl-2 protein family: life, death, and the whole picture. J Clin Immunol (1999) 0.90
Distinct sites of action of Bcl-2 and Bcl-xL in the ceramide pathway of apoptosis. Biochem J (1998) 0.90
Molecular and genetic prognostic factors of prostate cancer. World J Urol (2003) 0.89
T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice. J Exp Med (2002) 0.88
Enhanced T cell apoptosis within Drak2-deficient mice promotes resistance to autoimmunity. J Immunol (2008) 0.86
A facile method to establish human induced pluripotent stem cells from adult blood cells under feeder-free and xeno-free culture conditions: a clinically compliant approach. Stem Cells Transl Med (2015) 0.84
Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cells. Blood (2007) 0.84
Anti-oxidant treatment enhances anti-tumor cytotoxicity of (-)-gossypol. Cancer Biol Ther (2008) 0.84
Syk interacts with and phosphorylates nucleolin to stabilize Bcl-x(L) mRNA and promote cell survival. Mol Cell Biol (2014) 0.84
Progressive apoptosis resistance prior to senescence and control by the anti-apoptotic protein BCL-xL. Mech Ageing Dev (2008) 0.83
Diacylglycerol kinase alpha activity promotes survival of CD4+ 8+ double positive cells during thymocyte development. Immunology (2002) 0.81
Computational modeling of signaling pathways mediating cell cycle checkpoint control and apoptotic responses to ionizing radiation-induced DNA damage. Dose Response (2011) 0.81
Regulation of tumor necrosis factor-α-induced microvascular endothelial cell hyperpermeability by recombinant B-cell lymphoma-extra large. J Surg Res (2013) 0.81
Loss of DRAK2 signaling enhances allogeneic transplant survival by limiting effector and memory T cell responses. Am J Transplant (2012) 0.80
Role of T-cell-specific nuclear factor κB in islet allograft rejection. Transplantation (2012) 0.79
Expression of c-Jun and Bcl-2 family proteins in apoptotic photoreceptors of RCS rats. Jpn J Ophthalmol (2006) 0.78
Differential Gene Expression Patterns in Chicken Cardiomyocytes during Hydrogen Peroxide-Induced Apoptosis. PLoS One (2016) 0.78
A role for DRAK2 in the germinal center reaction and the antibody response. Autoimmunity (2008) 0.78
Peripheral T-cell tolerance in hosts with acute myeloid leukemia. Oncoimmunology (2013) 0.78
The role of apoptosis in immune hyporesponsiveness following AAV8 liver gene transfer. Mol Ther (2013) 0.78
GM-CSF protects rat photoreceptors from death by activating the SRC-dependent signalling and elevating anti-apoptotic factors and neurotrophins. Graefes Arch Clin Exp Ophthalmol (2012) 0.78
Developing and activated T cell survival depends on differential signaling pathways to regulate anti-apoptotic Bcl-x(L). Clin Dev Immunol (2011) 0.78
Time course changes of anti- and pro-apoptotic proteins in apigenin-induced genotoxicity. Chin Med (2013) 0.77
PLZF Controls the Development of Fetal-Derived IL-17+Vγ6+ γδ T Cells. J Immunol (2015) 0.77
Histone Deacetylase 3 Is Required for Efficient T Cell Development. Mol Cell Biol (2015) 0.77
HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia. Leukemia (2015) 0.76
Biochemical and biophysical investigations of the interaction between human glucokinase and pro-apoptotic BAD. PLoS One (2017) 0.75
CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation. Nat Commun (2016) 0.75
NKAP Regulates Invariant NKT Cell Proliferation and Differentiation into ROR-γt-Expressing NKT17 Cells. J Immunol (2016) 0.75
PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage. Cell Death Differ (2016) 0.75
HDAC3 Is Required for the Downregulation of RORγt during Thymocyte Positive Selection. J Immunol (2016) 0.75
Viral Escape Mutant Epitope Maintains TCR Affinity for Antigen yet Curtails CD8 T Cell Responses. PLoS One (2016) 0.75
Regulation of thymocyte homeostasis by Fliz1. Immunology (2002) 0.75
PIM1: a promising target in patients with triple-negative breast cancer. Med Oncol (2017) 0.75
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell (1993) 20.72
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell (1993) 14.39
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell (1995) 8.75
bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell (1991) 8.27
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell (1991) 8.13
Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell (1993) 7.25
BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature (1994) 6.69
CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL. Immunity (1995) 5.77
Apoptosis and programmed cell death in immunity. Annu Rev Immunol (1992) 4.47
Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase. EMBO J (1990) 3.62
Molecular regulation of apoptosis: genetic controls on cell death. Cell (1993) 3.57
bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria. Development (1994) 3.34
Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes. J Immunol (1993) 3.28
Immunohistochemical analysis of in vivo patterns of Bcl-X expression. Cancer Res (1994) 2.63
Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. Immunity (1994) 2.40
Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population. Mol Cell Biol (1990) 2.25
Bclx regulates the survival of double-positive thymocytes. Proc Natl Acad Sci U S A (1995) 2.00
bcl-2 proto-oncogene expression during human T cell development. Evidence for biphasic regulation. J Immunol (1993) 1.57
Cellular aspects of early T-cell development. Curr Opin Immunol (1992) 1.16
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science (2001) 23.42
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell (1993) 20.72
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science (1995) 16.19
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature (1990) 14.46
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell (1993) 14.39
BCL-2 family members and the mitochondria in apoptosis. Genes Dev (1999) 13.52
Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell (1993) 10.83
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L) Cell (1996) 10.83
CTLA-4 can function as a negative regulator of T cell activation. Immunity (1994) 9.80
Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. Science (1997) 9.73
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell (2001) 9.33
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell (2000) 8.95
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell (1995) 8.75
Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell (1997) 8.61
X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature (1996) 8.37
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev (2000) 8.35
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell (1991) 8.13
Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science (1989) 7.78
Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell (1985) 7.29
Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell (1993) 7.25
Differential T cell costimulatory requirements in CD28-deficient mice. Science (1993) 6.93
Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science (1995) 6.84
BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature (1994) 6.69
bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell (1989) 6.66
Altered Hox expression and segmental identity in Mll-mutant mice. Nature (1995) 6.60
BCL-2 family: regulators of cell death. Annu Rev Immunol (1998) 6.41
The B7 and CD28 receptor families. Immunol Today (1994) 6.38
Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature (1999) 6.37
Cell death in development. Cell (1999) 6.01
BID: a novel BH3 domain-only death agonist. Genes Dev (1996) 5.90
Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis. EMBO J (1998) 5.78
CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL. Immunity (1995) 5.77
BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev (2001) 5.66
BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci U S A (1991) 5.50
Isolation of single-copy human genes from a library of yeast artificial chromosome clones. Science (1989) 5.29
Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J Immunol (1990) 5.26
Molecular thanatopsis: a discourse on the BCL2 family and cell death. Blood (1996) 5.13
Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol Cell Biol (2001) 5.10
Role of the CD28 receptor in T-cell activation. Immunol Today (1990) 4.89
Clustered arrangement of immunoglobulin lambda constant region genes in man. Nature (1981) 4.87
T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression. Mol Cell Biol (1987) 4.76
Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem (1999) 4.56
Bcl-x(L) forms an ion channel in synthetic lipid membranes. Nature (1997) 4.55
Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange. Mol Cell (1999) 4.55
Levels of c-myc oncogene mRNA are invariant throughout the cell cycle. Nature (1985) 4.35
Induction of anti-HIV neutralizing antibodies by synthetic peptides. EMBO J (1986) 4.32
Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc Natl Acad Sci U S A (1995) 4.22
BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases. Proc Natl Acad Sci U S A (1996) 4.20
Regulated targeting of BAX to mitochondria. J Cell Biol (1998) 4.17
In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol Cell (2000) 4.10
Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14; 18). Nature (1991) 4.06
BAX is required for neuronal death after trophic factor deprivation and during development. Neuron (1996) 4.02
BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol Cell Biol (1999) 4.00
Bax-independent inhibition of apoptosis by Bcl-XL. Nature (1996) 3.82
Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma. EMBO J (1988) 3.77
Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells. Proc Natl Acad Sci U S A (1981) 3.73
c-myc oncogene protein synthesis is independent of the cell cycle in human and avian cells. Nature (1985) 3.72
Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2. Proc Natl Acad Sci U S A (1997) 3.66
Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells. Nature (1981) 3.64
T-cell regulation by CD28 and CTLA-4. Nat Rev Immunol (2001) 3.59
A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. EMBO J (1996) 3.57
BAX-dependent transport of cytochrome c reconstituted in pure liposomes. Nat Cell Biol (2000) 3.53
Differential expression of c-myb mRNA in murine B lymphomas by a block to transcription elongation. Science (1987) 3.49
An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3' untranslated region of lymphokine mRNA. Mol Cell Biol (1991) 3.48
Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. Mol Cell (1999) 3.46
Expression of the c-myb proto-oncogene during cellular proliferation. Nature (1986) 3.45
Checkpoints of dueling dimers foil death wishes. Cell (1994) 3.45
IL-7 enhances the survival and maintains the size of naive T cells. J Immunol (2001) 3.39
Prevention of lymphocyte cell death in sepsis improves survival in mice. Proc Natl Acad Sci U S A (1999) 3.35
bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria. Development (1994) 3.34
Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death. Genes Dev (1998) 3.33
Characterization of XIAP-deficient mice. Mol Cell Biol (2001) 3.32
Bcl-2-family proteins: the role of the BH3 domain in apoptosis. Trends Cell Biol (1998) 3.32
Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes. J Immunol (1993) 3.28
Expression of interleukin 2 receptors on activated human B cells. J Exp Med (1984) 3.27
Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc Natl Acad Sci U S A (1994) 3.26
Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. J Biol Chem (2001) 3.22
Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence. J Biol Chem (1993) 3.21
Mcl-1 deficiency results in peri-implantation embryonic lethality. Genes Dev (2000) 3.21
Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners. Proc Natl Acad Sci U S A (1987) 3.18
Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis? Nat Cell Biol (1999) 3.17
p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc Natl Acad Sci U S A (2001) 3.11
Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature (1997) 3.10
Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis. Science (2000) 3.06
Molecular basis of T cell inactivation by CTLA-4. Science (1998) 3.00
Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. Protein Sci (2000) 3.00
Effects of CD28 costimulation on long-term proliferation of CD4+ T cells in the absence of exogenous feeder cells. J Immunol (1997) 2.98
Immunoglobulin-gene rearrangements as unique clonal markers in human lymphoid neoplasms. N Engl J Med (1983) 2.96
Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. J Immunol (1999) 2.92