Published in Protein Sci on December 01, 2000
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell (2006) 10.19
Structural insights into the degradation of Mcl-1 induced by BH3 domains. Proc Natl Acad Sci U S A (2007) 3.41
Intrinsic disorder in transcription factors. Biochemistry (2006) 3.06
The autophagy effector Beclin 1: a novel BH3-only protein. Oncogene (2008) 2.94
Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions. J Proteome Res (2007) 2.61
Bcl-XL inhibits membrane permeabilization by competing with Bax. PLoS Biol (2008) 2.36
BH3-only proteins in apoptosis and beyond: an overview. Oncogene (2008) 2.13
Structural and biochemical bases for the inhibition of autophagy and apoptosis by viral BCL-2 of murine gamma-herpesvirus 68. PLoS Pathog (2008) 2.09
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation. J Cell Biol (2008) 2.04
A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax. Genes Dev (2007) 1.97
Molecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11. Autophagy (2008) 1.86
Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers. EMBO J (2004) 1.77
Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein. J Gen Virol (2007) 1.73
Structure-guided design of a selective BCL-X(L) inhibitor. Nat Chem Biol (2013) 1.68
Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2. J Biol Chem (2006) 1.65
Many players in BCL-2 family affairs. Trends Biochem Sci (2014) 1.64
Modeling backbone flexibility to achieve sequence diversity: the design of novel alpha-helical ligands for Bcl-xL. J Mol Biol (2007) 1.62
Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity. J Cell Biol (2003) 1.60
Enhanced metabolic stability and protein-binding properties of artificial alpha helices derived from a hydrogen-bond surrogate: application to Bcl-xL. Angew Chem Int Ed Engl (2005) 1.59
The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity. EMBO J (2003) 1.59
Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis. Cell Death Differ (2013) 1.54
Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus. Proc Natl Acad Sci U S A (2002) 1.52
Multiple functions of BCL-2 family proteins. Cold Spring Harb Perspect Biol (2013) 1.51
Evaluation of diverse α/β-backbone patterns for functional α-helix mimicry: analogues of the Bim BH3 domain. J Am Chem Soc (2011) 1.49
Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX. Cell Res (2010) 1.48
Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS. Proc Natl Acad Sci U S A (2007) 1.45
Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL. J Mol Biol (2014) 1.42
Determinants of BH3 binding specificity for Mcl-1 versus Bcl-xL. J Mol Biol (2010) 1.37
Membrane promotes tBID interaction with BCL(XL). Nat Struct Mol Biol (2009) 1.36
Decoding and unlocking the BCL-2 dependency of cancer cells. Nat Rev Cancer (2013) 1.36
BH3 mimetics to improve cancer therapy; mechanisms and examples. Drug Resist Updat (2007) 1.33
BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins. J Cell Biol (2007) 1.33
A surface groove essential for viral Bcl-2 function during chronic infection in vivo. PLoS Pathog (2005) 1.30
PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat Chem Biol (2013) 1.28
Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci (2010) 1.24
Bcl-2 homodimerization involves two distinct binding surfaces, a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax. J Biol Chem (2004) 1.20
Pharmacological manipulation of Bcl-2 family members to control cell death. J Clin Invest (2005) 1.19
tBid elicits a conformational alteration in membrane-bound Bcl-2 such that it inhibits Bax pore formation. J Biol Chem (2006) 1.15
BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain. J Biol Chem (2009) 1.12
Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2. Protein Sci (2007) 1.11
Bcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motif. J Biol Chem (2010) 1.10
Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands. J Biol Chem (2009) 1.09
Predictive Bcl-2 family binding models rooted in experiment or structure. J Mol Biol (2012) 1.09
From mitochondrial biology to magic bullet: navitoclax disarms BCL-2 in chronic lymphocytic leukemia. J Clin Oncol (2011) 1.08
Hydrophile scanning as a complement to alanine scanning for exploring and manipulating protein-protein recognition: application to the Bim BH3 domain. Protein Sci (2008) 1.08
Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins. J Med Chem (2007) 1.04
Inhibitors of the anti-apoptotic Bcl-2 proteins: a patent review. Expert Opin Ther Pat (2011) 1.04
Structural basis of Bcl-xL recognition by a BH3-mimetic α/β-peptide generated by sequence-based design. Chembiochem (2011) 1.04
Where killers meet--permeabilization of the outer mitochondrial membrane during apoptosis. Cold Spring Harb Perspect Biol (2013) 1.03
Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins. J Biol Chem (2009) 1.03
Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis. J Biol Chem (2011) 1.02
Molecular recognition of protein surfaces: high affinity ligands for the CBP KIX domain. J Am Chem Soc (2003) 1.01
Death upon a kiss: mitochondrial outer membrane composition and organelle communication govern sensitivity to BAK/BAX-dependent apoptosis. Chem Biol (2013) 1.00
Coupled folding and binding of the disordered protein PUMA does not require particular residual structure. J Am Chem Soc (2014) 1.00
A novel Bcl-2-like inhibitor of apoptosis is encoded by the parapoxvirus ORF virus. J Virol (2007) 0.97
Ligand-independent antiapoptotic function of estrogen receptor-beta in lung cancer cells. Mol Endocrinol (2010) 0.97
Structure-guided rational design of α/β-peptide foldamers with high affinity for BCL-2 family prosurvival proteins. Chembiochem (2013) 0.96
In silico and in vitro elucidation of BH3 binding specificity toward Bcl-2. Biochemistry (2012) 0.96
Mapping the interaction of pro-apoptotic tBID with pro-survival BCL-XL. Biochemistry (2009) 0.94
Small molecules, big targets: drug discovery faces the protein-protein interaction challenge. Nat Rev Drug Discov (2016) 0.93
Development of small-molecule PUMA inhibitors for mitigating radiation-induced cell death. Curr Top Med Chem (2011) 0.93
Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins. J Med Chem (2007) 0.93
Getting away with murder: how does the BCL-2 family of proteins kill with immunity? Ann N Y Acad Sci (2013) 0.91
Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2. Proc Natl Acad Sci U S A (2008) 0.90
The DNA-binding domain mediates both nuclear and cytosolic functions of p53. Nat Struct Mol Biol (2014) 0.90
Analysis of Flexibility and Hotspots in Bcl-xL and Mcl-1 Proteins for the Design of Selective Small-Molecule Inhibitors. ACS Med Chem Lett (2012) 0.89
Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression. J Med Chem (2012) 0.89
Ligand binding and membrane insertion compete with oligomerization of the BclXL apoptotic repressor. J Mol Biol (2011) 0.88
Characterization of a novel interaction between Bcl-2 members Diva and Harakiri. PLoS One (2010) 0.86
A multimeric model for murine anti-apoptotic protein Bcl-2 and structural insights for its regulation by post-translational modification. J Mol Model (2003) 0.86
Targeting γ-herpesvirus 68 Bcl-2-mediated down-regulation of autophagy. J Biol Chem (2014) 0.86
From laptop to benchtop to bedside: structure-based drug design on protein targets. Curr Pharm Des (2012) 0.85
Mitochondrial regulation of cell survival and death during low-oxygen conditions. Antioxid Redox Signal (2009) 0.85
Targeting the apoptosis pathway in hematologic malignancies. Leuk Lymphoma (2014) 0.85
Bcl-xl does not have to bind Bax to protect T cells from death. J Exp Med (2006) 0.85
Molecular basis of Bcl-X(L)-p53 interaction: insights from molecular dynamics simulations. PLoS One (2011) 0.84
Design and synthesis of type-III mimetics of omega-conotoxin GVIA. J Comput Aided Mol Des (2001) 0.84
Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL. Biochem J (2011) 0.84
The functional differences between pro-survival and pro-apoptotic B cell lymphoma 2 (Bcl-2) proteins depend on structural differences in their Bcl-2 homology 3 (BH3) domains. J Biol Chem (2014) 0.84
BH3-only proteins and their effects on cancer. Adv Exp Med Biol (2010) 0.83
Locating Herpesvirus Bcl-2 Homologs in the Specificity Landscape of Anti-Apoptotic Bcl-2 Proteins. J Mol Biol (2015) 0.82
Identification of ligand-target pairs from combined libraries of small molecules and unpurified protein targets in cell lysates. J Am Chem Soc (2014) 0.82
Molecular basis for Bcl-2 homology 3 domain recognition in the Bcl-2 protein family: identification of conserved hot spot interactions. J Biol Chem (2009) 0.82
The N-terminus and alpha-5, alpha-6 helices of the pro-apoptotic protein Bax, modulate functional interactions with the anti-apoptotic protein Bcl-xL. BMC Cell Biol (2007) 0.82
Interdependence of Bad and Puma during ionizing-radiation-induced apoptosis. PLoS One (2014) 0.81
Intrinsic order and disorder in the bcl-2 member harakiri: insights into its proapoptotic activity. PLoS One (2011) 0.80
Dynamics of Bcl-xL in water and membrane: molecular simulations. PLoS One (2013) 0.80
Role of protein flexibility in the design of Bcl-X(L) targeting agents: insight from molecular dynamics. J Comput Aided Mol Des (2008) 0.80
An Integrated Bioinformatics and Computational Biology Approach Identifies New BH3-Only Protein Candidates. Open Biol J (2012) 0.79
Reconstitution and engineering of apoptotic protein interactions on the bacterial cell surface. J Mol Biol (2009) 0.79
BcL-xL conformational changes upon fragment binding revealed by NMR. PLoS One (2013) 0.78
The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane. FEBS J (2016) 0.78
Molecular dynamics simulations of pro-apoptotic BH3 peptide helices in aqueous medium: relationship between helix stability and their binding affinities to the anti-apoptotic protein Bcl-X(L). J Comput Aided Mol Des (2011) 0.78
Genetic visualization of protein interactions harnessing liquid phase transitions. Sci Rep (2017) 0.78
Biophysical basis of the promiscuous binding of B-cell lymphoma protein 2 apoptotic repressor to BH3 ligands. J Mol Recognit (2013) 0.77
Behavior of solvent-exposed hydrophobic groove in the anti-apoptotic Bcl-XL protein: clues for its ability to bind diverse BH3 ligands from MD simulations. PLoS One (2013) 0.77
Redefining the BH3 Death Domain as a 'Short Linear Motif'. Trends Biochem Sci (2015) 0.77
Improving the therapeutic potential of endostatin by fusing it with the BAX BH3 death domain. Cell Death Dis (2014) 0.77
1H, 13C and 15N resonance assignments of a Bcl-xL/Bad peptide complex. J Biomol NMR (2005) 0.77
Molecular dynamics study of peptide segments of the BH3 domain of the proapoptotic proteins Bak, Bax, Bid and Hrk bound to the Bcl-xL and Bcl-2 proteins. J Comput Aided Mol Des (2004) 0.76
AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR. J Biomol NMR (1996) 29.55
Protein backbone angle restraints from searching a database for chemical shift and sequence homology. J Biomol NMR (1999) 26.99
The Bcl-2 protein family: arbiters of cell survival. Science (1998) 16.08
Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. Science (1997) 9.73
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell (1995) 8.75
X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature (1996) 8.37
Stereospecific nuclear magnetic resonance assignments of the methyl groups of valine and leucine in the DNA-binding domain of the 434 repressor by biosynthetically directed fractional 13C labeling. Biochemistry (1989) 5.61
Helix propagation and N-cap propensities of the amino acids measured in alanine-based peptides in 40 volume percent trifluoroethanol. Protein Sci (1996) 2.93
Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes. Proc Natl Acad Sci U S A (1999) 2.44
Elucidating the folding problem of helical peptides using empirical parameters. II. Helix macrodipole effects and rational modification of the helical content of natural peptides. J Mol Biol (1995) 2.43
Torsion-angle molecular dynamics as a new efficient tool for NMR structure calculation. J Magn Reson (1997) 2.31
Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL. Mol Cell Biol (1997) 2.15
Helix propensities are identical in proteins and peptides. Biochemistry (1997) 1.71
Elucidating the folding problem of helical peptides using empirical parameters. III. Temperature and pH dependence. J Mol Biol (1995) 1.62
Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins. J Biol Chem (1997) 1.58
Side chain and backbone assignments in isotopically labeled proteins from two heteronuclear triple resonance experiments. FEBS Lett (1992) 1.56
Cleavage at cysteine after cyanylation. Methods Enzymol (1977) 1.52
Equilibrium and kinetic inhibition assays based upon fluorescence polarization. Methods Enzymol (1981) 1.36
Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity. Proc Natl Acad Sci U S A (2000) 1.22
Recent progress on the regulation of apoptosis by Bcl-2 family members. Adv Immunol (1998) 0.99
Structure-based design, synthesis, and X-ray crystallography of a high-affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic. J Med Chem (1999) 0.92
The sequence of the human genome. Science (2001) 101.55
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79
Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet (2005) 24.57
Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care (1997) 23.95
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science (2001) 23.42
Gene transfer into mouse lyoma cells by electroporation in high electric fields. EMBO J (1982) 17.98
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science (1995) 16.19
p21 is a universal inhibitor of cyclin kinases. Nature (1993) 15.55
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell (1993) 14.39
Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics. J Bacteriol (1997) 12.21
p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell (1998) 11.54
CTLA-4 can function as a negative regulator of T cell activation. Immunity (1994) 9.80
Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. Science (1997) 9.73
The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. Diabetes Care (1999) 9.16
WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res (1994) 9.00
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell (2000) 8.95
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell (1995) 8.75
Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell (1997) 8.61
Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med (2000) 8.47
X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature (1996) 8.37
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev (2000) 8.35
Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science (1997) 7.95
The frequency of chimeric molecules as a consequence of PCR co-amplification of 16S rRNA genes from different bacterial species. Microbiology (1996) 7.78
Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science (1989) 7.78
Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron (1996) 7.20
Discovering high-affinity ligands for proteins: SAR by NMR. Science (1996) 7.10
Frequency of formation of chimeric molecules as a consequence of PCR coamplification of 16S rRNA genes from mixed bacterial genomes. Appl Environ Microbiol (1997) 7.09
A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature (1996) 7.04
Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science (1995) 7.00
Differential T cell costimulatory requirements in CD28-deficient mice. Science (1993) 6.93
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science (1999) 6.93
Ecological degradation in protected areas: the case of Wolong Nature Reserve for giant pandas. Science (2001) 6.52
The B7 and CD28 receptor families. Immunol Today (1994) 6.38
TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal. Biochem Biophys Res Commun (1999) 6.33
Readmission after hospitalization for congestive heart failure among Medicare beneficiaries. Arch Intern Med (1997) 5.93
The cost effectiveness of combination antiretroviral therapy for HIV disease. N Engl J Med (2001) 5.89
CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL. Immunity (1995) 5.77
BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev (2001) 5.66
A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation. Proc Natl Acad Sci U S A (1992) 5.60
D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell (1992) 5.51
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem Biol (1997) 5.49
Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice. Science (1992) 5.46
Blood transfusion in elderly patients with acute myocardial infarction. N Engl J Med (2001) 5.43
IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res (1998) 5.41
p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27. Curr Biol (1999) 5.40
Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br J Cancer (2001) 5.36
Genetic diversity and disease control in rice. Nature (2000) 5.34
A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function. Nat Cell Biol (2000) 5.29
Racial differences in the use of cardiac catheterization after acute myocardial infarction. N Engl J Med (2001) 5.29
Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex. Science (2000) 5.27
Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol Cell Biol (2001) 5.10
Residual HIV-1 RNA in blood plasma of patients taking suppressive highly active antiretroviral therapy. JAMA (1999) 4.98
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A (1999) 4.90
Role of the CD28 receptor in T-cell activation. Immunol Today (1990) 4.89
Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines. Proc Natl Acad Sci U S A (2001) 4.79
T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression. Mol Cell Biol (1987) 4.76
Structure of the gene V protein of bacteriophage f1 determined by multiwavelength x-ray diffraction on the selenomethionyl protein. Proc Natl Acad Sci U S A (1994) 4.67
DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell (1995) 4.64
Differential signaling via the same axon of neocortical pyramidal neurons. Proc Natl Acad Sci U S A (1998) 4.59
Secondary structure of the 5' nontranslated regions of hepatitis C virus and pestivirus genomic RNAs. Nucleic Acids Res (1992) 4.58
Familial transmission of substance use disorders. Arch Gen Psychiatry (1998) 4.57
POWER_SAGE: comparing statistical tests for SAGE experiments. Bioinformatics (2000) 4.56
Bcl-x(L) forms an ion channel in synthetic lipid membranes. Nature (1997) 4.55
Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange. Mol Cell (1999) 4.55
BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci (2001) 4.54
Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate. Nature (1994) 4.49
Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci U S A (1996) 4.45
Levels of c-myc oncogene mRNA are invariant throughout the cell cycle. Nature (1985) 4.35
Do "America's Best Hospitals" perform better for acute myocardial infarction? N Engl J Med (1999) 4.30
Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc Natl Acad Sci U S A (1995) 4.22
Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc Natl Acad Sci U S A (1996) 4.20
In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol Cell (2000) 4.10
Fringe is a glycosyltransferase that modifies Notch. Nature (2000) 4.09
Broadly protective vaccine for Staphylococcus aureus based on an in vivo-expressed antigen. Science (1999) 4.08
14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol Cell (2000) 4.05
Aggregation-based crystal growth and microstructure development in natural iron oxyhydroxide biomineralization products. Science (2000) 4.03
Structural basis for the inhibition of caspase-3 by XIAP. Cell (2001) 3.91
Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing. Proc Natl Acad Sci U S A (1994) 3.85
Bax-independent inhibition of apoptosis by Bcl-XL. Nature (1996) 3.82
Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc Natl Acad Sci U S A (1996) 3.78
c-myc oncogene protein synthesis is independent of the cell cycle in human and avian cells. Nature (1985) 3.72
Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes Dev (1993) 3.70
Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility. Nat Genet (1997) 3.69
The presynaptic particle web: ultrastructure, composition, dissolution, and reconstitution. Neuron (2001) 3.68
XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair. Cell (2001) 3.66
Signal timing across the macaque visual system. J Neurophysiol (1998) 3.66
Role of miR-143 targeting KRAS in colorectal tumorigenesis. Oncogene (2009) 3.64
T-cell regulation by CD28 and CTLA-4. Nat Rev Immunol (2001) 3.59
A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. EMBO J (1996) 3.57
The alternative oxidase lowers mitochondrial reactive oxygen production in plant cells. Proc Natl Acad Sci U S A (1999) 3.53
The DISC Predictive Scales (DPS): efficiently screening for diagnoses. J Am Acad Child Adolesc Psychiatry (2001) 3.52