Positive selection of thymocytes bearing alpha beta T cell receptors.

PubWeight™: 1.20‹?› | Rank: Top 10%

🔗 View Article (PMID 9099796)

Published in Curr Opin Immunol on April 01, 1997

Authors

P Marrack1, J Kappler

Author Affiliations

1: Howard Hughes Medical Institute, Department of Medicine, National Jewish Center, Denver, CO 80206, USA. P.Marrack@ispop.njc.org

Articles citing this

Directed migration of positively selected thymocytes visualized in real time. PLoS Biol (2005) 2.46

The murine gammaherpesvirus 68 v-cyclin gene is an oncogene that promotes cell cycle progression in primary lymphocytes. J Virol (1999) 1.42

Molecular control of steady-state dendritic cell maturation and immune homeostasis. Annu Rev Immunol (2013) 1.13

Programmed cell death of dendritic cells in immune regulation. Immunol Rev (2010) 1.10

Human dendritic cell subsets for vaccination. J Clin Immunol (2005) 1.09

Essential role of Notch signaling in effector memory CD8+ T cell-mediated airway hyperresponsiveness and inflammation. J Exp Med (2008) 1.05

Crosstalk pathway for inhibition of glucocorticoid-induced apoptosis by T cell receptor signaling. Proc Natl Acad Sci U S A (2000) 1.00

Modulation of thymic selection by expression of an immediate-early gene, early growth response 1 (Egr-1). J Exp Med (1998) 0.95

Immature thymocytes undergoing receptor rearrangements are resistant to an Atm-dependent death pathway activated in mature T cells by double-stranded DNA breaks. J Exp Med (2000) 0.90

Activation of naturally occurring lung CD4(+)CD25(+) regulatory T cells requires CD8 and MHC I interaction. Proc Natl Acad Sci U S A (2007) 0.89

Thymus-specific serine protease contributes to the diversification of the functional endogenous CD4 T cell receptor repertoire. J Exp Med (2010) 0.88

Costimulatory signals are required for induction of transcription factor Nur77 during negative selection of CD4(+)CD8(+) thymocytes. Proc Natl Acad Sci U S A (1999) 0.85

A quantitative real time PCR method to analyze T cell receptor Vbeta subgroup expansion by staphylococcal superantigens. J Transl Med (2010) 0.84

Phenotypes and clinical significance of circulating CD4(+)CD25(+) regulatory T cells (Tregs) in patients with acute-on-chronic liver failure (ACLF). J Transl Med (2012) 0.83

Molecular features of the complementarity determining region 3 motif of the T cell population and subsets in the blood of patients with chronic severe hepatitis B. J Transl Med (2011) 0.82

Positive selection of self-MHC-reactive T cells by individual peptide-MHC class II complexes. Proc Natl Acad Sci U S A (2002) 0.81

Immune regulation through mitochondrion-dependent dendritic cell death induced by T regulatory cells. J Immunol (2011) 0.81

Phospholipase Cγ2 plays a role in TCR signal transduction and T cell selection. J Immunol (2012) 0.80

Phorbol esters and cAMP differentially regulate the expression of CD4 and CD8 in human thymocytes. BMC Immunol (2002) 0.78

Molecular characterization of T cell receptor beta variable in the peripheral blood T cell repertoire in subjects with active tuberculosis or latent tuberculosis infection. BMC Infect Dis (2013) 0.78

High-Throughput Analysis of the T Cell Receptor Beta Chain Repertoire in PBMCs from Chronic Hepatitis B Patients with HBeAg Seroconversion. Can J Infect Dis Med Microbiol (2016) 0.77

Induction of thymocyte positive selection does not convey immediate resistance to negative selection. Immunology (2002) 0.75

Articles by these authors

(truncated to the top 100)

The staphylococcal enterotoxins and their relatives. Science (1990) 11.99

Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5: expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity. Immunol Rev (1983) 10.81

The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody. J Exp Med (1983) 7.55

Interaction of Staphylococcus aureus toxin "superantigens" with human T cells. Proc Natl Acad Sci U S A (1989) 7.48

Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing. J Exp Med (1983) 6.97

Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science (2000) 6.22

The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype. J Exp Med (1984) 4.29

Evidence implicating L3T4 in class II MHC antigen reactivity; monoclonal antibody GK1.5 (anti-L3T4a) blocks class II MHC antigen-specific proliferation, release of lymphokines, and binding by cloned murine helper T lymphocyte lines. J Immunol (1983) 4.28

T cells compete for access to antigen-bearing antigen-presenting cells. J Exp Med (2000) 4.16

Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes. Immunity (1998) 4.15

Interleukin-induced increase in Ia expression by normal mouse B cells. J Exp Med (1984) 4.14

The T cell receptor. Science (1987) 4.00

Type I interferons keep activated T cells alive. J Exp Med (1999) 3.98

Superantigens and their potential role in human disease. Adv Immunol (1993) 3.88

The role of the T cell receptor in positive and negative selection of developing T cells. Science (1990) 3.64

The major histocompatibility complex-restricted antigen receptor on T cells. II. Role of the L3T4 product. J Exp Med (1983) 3.54

Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas. Proc Natl Acad Sci U S A (1982) 3.41

The toxicity of staphylococcal enterotoxin B in mice is mediated by T cells. J Exp Med (1990) 3.31

Superantigens interact with MHC class II molecules outside of the antigen groove. Cell (1990) 3.20

An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro. Proc Natl Acad Sci U S A (1999) 3.15

Autoimmune disease: why and where it occurs. Nat Med (2001) 3.04

The repertoire of T cells shaped by a single MHC/peptide ligand. Cell (1996) 3.04

Concanavalin A-inducible, interleukin-2-producing T cell hybridoma. J Exp Med (1980) 3.02

Production of soluble MHC class II proteins with covalently bound single peptides. Nature (1994) 2.98

Primary structure of human T-cell receptor alpha-chain. Nature (1985) 2.93

A maternally inherited superantigen encoded by a mammary tumour virus. Nature (1991) 2.92

Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen. Nature (1987) 2.89

Reactive oxygen species regulate activation-induced T cell apoptosis. Immunity (1999) 2.84

Two better cell lines for making hybridomas expressing specific T cell receptors. J Immunol (1989) 2.78

Immunological adjuvants promote activated T cell survival via induction of Bcl-3. Nat Immunol (2001) 2.76

Cytokine-induced survival of activated T cells in vitro and in vivo. Proc Natl Acad Sci U S A (1998) 2.71

Selective expansion of T cells expressing V beta 2 in toxic shock syndrome. J Exp Med (1990) 2.71

Molecular basis of different forms of metachromatic leukodystrophy. N Engl J Med (1991) 2.69

The major histocompatibility complex-restricted antigen receptor on T cells: distribution on thymus and peripheral T cells. Cell (1984) 2.64

Residues of the variable region of the T-cell-receptor beta-chain that interact with S. aureus toxin superantigens. Nature (1990) 2.60

The mouse T cell receptor: comparison of MHC-restricted receptors on two T cell hybridomas. Cell (1983) 2.58

Structures of an MHC class II molecule with covalently bound single peptides. Science (1996) 2.58

Evidence for two distinct classes of murine B cell growth factors with activities in different functional assays. J Exp Med (1983) 2.56

The effect of thymus environment on T cell development and tolerance. Cell (1988) 2.45

HLA-DR alleles differ in their ability to present staphylococcal enterotoxins to T cells. J Exp Med (1990) 2.30

Homeostasis of alpha beta TCR+ T cells. Nat Immunol (2000) 2.29

Antigen-specific. I region-restricted interactions in vitro between tumor cell lines and T cell hybridomas. J Immunol (1982) 2.26

T cells can distinguish between allogeneic major histocompatibility complex products on different cell types. Nature (1988) 2.21

Use of I region-restricted, antigen-specific T cell hybridomas to produce idiotypically specific anti-receptor antibodies. J Immunol (1983) 2.19

Interleukin 4 (IL-4) or IL-7 prevents the death of resting T cells: stat6 is probably not required for the effect of IL-4. J Exp Med (1997) 2.15

Rearrangement of T-cell receptor beta-chain genes during T-cell development. Proc Natl Acad Sci U S A (1985) 2.13

The role of L3T4 in recognition of Ia by a cytotoxic, H-2Dd-specific T cell hybridoma. J Exp Med (1984) 2.13

Gene transfer of H-2 class II genes: antigen presentation by mouse fibroblast and hamster B-cell lines. Cell (1984) 2.12

Compartmentalization of MHC class II gene expression in transgenic mice. Cell (1988) 2.08

CD4+ T cell division in irradiated mice requires peptides distinct from those responsible for thymic selection. J Exp Med (1999) 2.04

The major histocompatibility complex-restricted antigen receptor on T cells in mouse and man: identification of constant and variable peptides. Cell (1983) 2.04

The major histocompatibility complex-restricted antigen receptor on T cells. IV. An antiidiotypic antibody predicts both antigen and I-specificity. J Exp Med (1983) 2.03

The T cell receptor: the alpha and beta chains define idiotype, and antigen and MHC specificity. Cell (1985) 1.96

Characterization of the two heavy chains of the T3 complex on the surface of human T lymphocytes. J Biol Chem (1984) 1.93

Activation changes the spectrum but not the diversity of genes expressed by T cells. Proc Natl Acad Sci U S A (1999) 1.84

The antigen-specific, major histocompatibility complex-restricted receptor on T cells. Adv Immunol (1986) 1.73

Characterization of the gamma-interferon-mediated induction of antigen-presenting ability in P388D1 cells. J Immunol (1983) 1.69

Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers. Proc Natl Acad Sci U S A (2000) 1.61

Profound deletion of mature T cells in vivo by chronic exposure to exogenous superantigen. J Immunol (1993) 1.58

Expression of antigen-specific, major histocompatibility complex-restricted receptors by cortical and medullary thymocytes in situ. Cell (1985) 1.57

B cell helper factors. II. Synergy among three helper factors in the response of T cell- and macrophage-depleted B cells. J Immunol (1982) 1.57

The T-cell repertoire for antigen and MHC. Immunol Today (1988) 1.55

The T cell repertoire may be biased in favor of MHC recognition. Cell (1986) 1.55

Subversion of the immune system by pathogens. Cell (1994) 1.53

Structural and functional consequences of altering a peptide MHC anchor residue. J Immunol (2001) 1.51

The staphylococcal enterotoxins and their relatives. Science (1990) 1.50

Use of soluble peptide-DR4 tetramers to detect synovial T cells specific for cartilage antigens in patients with rheumatoid arthritis. Proc Natl Acad Sci U S A (2000) 1.46

Bystander virus infection prolongs activated T cell survival. J Immunol (1999) 1.43

Multiple binding sites for bacterial superantigens on soluble class II MHC molecules. Immunity (1995) 1.41

Peptide sequences of T-cell receptor delta and gamma chains are identical to predicted X and gamma proteins. Nature (1988) 1.41

T-cell survival. Immunol Rev (1998) 1.35

Influence of the major histocompatibility complex on positive thymic selection of V beta 17a+ T cells. Science (1989) 1.34

Crystal structure of mouse H2-M. Immunity (1998) 1.34

The growth of the very large CD8+ T cell clones in older mice is controlled by cytokines. J Immunol (2001) 1.33

Rearrangement of IgH genes in normal thymocyte development. J Immunol (1988) 1.32

TCR-induced transmembrane signaling by peptide/MHC class II via associated Ig-alpha/beta dimers. Science (2001) 1.31

T cell receptor (TCR)-mediated repertoire selection and loss of TCR vbeta diversity during the initiation of a CD4(+) T cell response in vivo. J Exp Med (2000) 1.30

The open reading frames in the 3' long terminal repeats of several mouse mammary tumor virus integrants encode V beta 3-specific superantigens. J Exp Med (1992) 1.30

The effects of chronic infection with a superantigen-producing virus. J Exp Med (1992) 1.24

T cells can be activated by peptides that are unrelated in sequence to their selecting peptide. Immunity (1997) 1.24

CD40 stimulation accelerates deletion of tumor-specific CD8(+) T cells in the absence of tumor-antigen vaccination. Proc Natl Acad Sci U S A (2001) 1.22

CD8+ T-cell clones in old mice. Immunol Rev (1997) 1.21

Surprisingly uneven distribution of the T cell receptor V beta repertoire in wild mice. J Exp Med (1990) 1.14

Use of somatic cell genetics to study chromosomes contributing to antigen plus I recognition by T cell hybridomas. J Exp Med (1983) 1.14

The major histocompatibility complex-restricted antigen receptor on T cells. Annu Rev Immunol (1984) 1.13

The use of mammary tumor virus (Mtv)-negative and single-Mtv mice to evaluate the effects of endogenous viral superantigens on the T cell repertoire. J Exp Med (1995) 1.13

T cell positive selection by a high density, low affinity ligand. Proc Natl Acad Sci U S A (1998) 1.12

A method for production of antibodies to human T-cell receptor beta-chain variable regions. Proc Natl Acad Sci U S A (1991) 1.11

The structure of V alpha and J alpha segments in the mouse. Nucleic Acids Res (1988) 1.11

Expression and role of the T cell receptor in early thymocyte differentiation in vitro. J Immunol (1987) 1.11

The major histocompatibility complex-restricted antigen receptor on T cells. IX. Role of accessory molecules in recognition of antigen plus isolated IA. J Immunol (1986) 1.07

Three T cell hybridomas do not contain detectable heavy chain variable gene transcripts. J Exp Med (1983) 1.06

Genomic-scale analysis of gene expression in resting and activated T cells. Curr Opin Immunol (2000) 1.05

Genetic markers of the antigen-specific T cell receptor locus. J Exp Med (1985) 1.05

Death and T cells. Immunol Rev (1993) 1.05

Functional and inducible expression of a transfected murine class II major histocompatibility complex gene. Proc Natl Acad Sci U S A (1984) 1.05

Altered antigen receptor signaling in anergic T cells from self-tolerant T-cell receptor beta-chain transgenic mice. Proc Natl Acad Sci U S A (1991) 1.04

The role of the T-cell receptor in thymocyte maturation: effects in vivo of anti-receptor antibody. Proc Natl Acad Sci U S A (1986) 1.04

Selection of antigen-specific T cells by a single IEk peptide combination. J Exp Med (1997) 1.04

Soluble class I MHC with beta2-microglobulin covalently linked peptides: specific binding to a T cell hybridoma. J Immunol (1999) 1.04