Published in Hum Mol Genet on June 01, 1997
A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3' end. Mol Cell Biol (1999) 4.51
Purification of proteins associated with specific genomic Loci. Cell (2009) 3.53
Telomeres, stem cells, senescence, and cancer. J Clin Invest (2004) 2.87
Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. J Cell Biol (1999) 2.70
Chromosome break-induced DNA replication leads to nonreciprocal translocations and telomere capture. Genetics (1998) 2.55
Telomerase RNA level limits telomere maintenance in X-linked dyskeratosis congenita. Genes Dev (2006) 2.20
N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo. Mol Cell Biol (2001) 2.16
Telomerase RNA accumulates in Cajal bodies in human cancer cells. Mol Biol Cell (2003) 2.14
Telomere length assessment in human archival tissues: combined telomere fluorescence in situ hybridization and immunostaining. Am J Pathol (2002) 1.95
Functional multimerization of the human telomerase reverse transcriptase. Mol Cell Biol (2001) 1.90
Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax. Proc Natl Acad Sci U S A (1998) 1.74
Modification of subtelomeric DNA. Mol Cell Biol (2004) 1.60
The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activity. Neoplasia (2001) 1.60
Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding. Mol Biol Cell (2000) 1.60
Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels. Mol Cell Biol (1999) 1.55
Telomere elongation (Tel), a new mutation in Drosophila melanogaster that produces long telomeres. Genetics (2002) 1.48
Attachment of HeT-A sequences to chromosomal termini in Drosophila melanogaster may occur by different mechanisms. Mol Cell Biol (2000) 1.46
Telomere maintenance in telomerase-deficient mouse embryonic stem cells: characterization of an amplified telomeric DNA. Mol Cell Biol (2000) 1.42
Impaired germinal center reaction in mice with short telomeres. EMBO J (2000) 1.39
Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability. Mol Cell Biol (1997) 1.38
trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase. PLoS Genet (2006) 1.23
Telomerase reverse transcriptase is required for the localization of telomerase RNA to cajal bodies and telomeres in human cancer cells. Mol Biol Cell (2008) 1.22
Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo. Mol Cell Biol (2010) 1.22
Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT. Nucleic Acids Res (2014) 1.18
Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase. Nucleic Acids Res (2005) 1.18
Investigation of human telomerase holoenzyme assembly, activity, and processivity using disease-linked subunit variants. J Biol Chem (2009) 1.17
Enhancer of terminal gene conversion, a new mutation in Drosophila melanogaster that induces telomere elongation by gene conversion. Genetics (2002) 1.12
Tetrahymena telomerase is active as a monomer. Mol Biol Cell (2003) 1.10
hnRNP A2, a potential ssDNA/RNA molecular adapter at the telomere. Nucleic Acids Res (2005) 1.06
Telomeres in evolution and evolution of telomeres. Chromosome Res (2005) 1.06
Many disease-associated variants of hTERT retain high telomerase enzymatic activity. Nucleic Acids Res (2013) 1.04
The major reverse transcriptase-incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis. Cancer Res (2013) 1.04
Direct involvement of the TEN domain at the active site of human telomerase. Nucleic Acids Res (2010) 0.98
Sumoylation of the BLM ortholog, Sgs1, promotes telomere-telomere recombination in budding yeast. Nucleic Acids Res (2009) 0.98
Assessing telomeric DNA content in pediatric cancers using whole-genome sequencing data. Genome Biol (2012) 0.95
A common variant in the telomerase RNA component is associated with short telomere length. PLoS One (2010) 0.95
Pilocytic astrocytomas have telomere-associated promyelocytic leukemia bodies without alternatively lengthened telomeres. Am J Pathol (2010) 0.93
Artificial human telomeres from DNA nanocircle templates. Proc Natl Acad Sci U S A (2002) 0.91
A G-quadruplex stabilizer induces M-phase cell cycle arrest. J Biol Chem (2009) 0.87
Telomerase activity in melanoma and non-melanoma skin cancer. Br J Cancer (1999) 0.87
Telomerase-dependent and independent telomere maintenance and its clinical implications in medullary thyroid carcinoma. J Clin Endocrinol Metab (2014) 0.86
Prognostic significance of telomere maintenance mechanisms in pediatric high-grade gliomas. J Neurooncol (2014) 0.86
The role of dicentric chromosome formation and secondary centromere deletion in the evolution of myeloid malignancy. Genet Res Int (2011) 0.85
Telomeric circles are abundant in the stn1-M1 mutant that maintains its telomeres through recombination. Nucleic Acids Res (2009) 0.81
Contributions of differential p53 expression in the spontaneous immortalization of a chicken embryo fibroblast cell line. BMC Cell Biol (2006) 0.79
Telomeres in Cancer Therapy. J Biomed Biotechnol (2001) 0.78
A single-cell assay for telomere DNA content shows increasing telomere length heterogeneity, as well as increasing mean telomere length in human spermatozoa with advancing age. J Assist Reprod Genet (2015) 0.78
Activation of p53 protein by telomeric (TTAGGG)n repeats. Nucleic Acids Res (2001) 0.78
Absence of telomerase activity in malignant bone tumors and soft-tissue sarcomas. Sarcoma (2002) 0.75
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J (1992) 10.97
A survey of telomerase activity in human cancer. Eur J Cancer (1997) 10.84
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell (1997) 8.74
Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat Med (1997) 6.55
Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J (1995) 6.03
Telomere maintenance by recombination in human cells. Nat Genet (2000) 5.14
Transfer of the gene for thymidine kinase to thymidine kinase-deficient human cells by purified herpes simplex viral DNA. Proc Natl Acad Sci U S A (1977) 4.35
Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body. Cancer Res (1999) 4.24
Telomerase activity in human ovarian carcinoma. Proc Natl Acad Sci U S A (1994) 3.86
A rapid and efficient procedure for the purification of DNA from agarose gels. Anal Biochem (1980) 3.77
Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. Hum Mol Genet (1997) 3.56
Protection against lethal challenge of BALB/c mice by passive transfer of monoclonal antibodies to five glycoproteins of herpes simplex virus type 2. Infect Immun (1982) 3.02
Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J Immunol (1996) 2.80
Telomerase, cell immortality, and cancer. Cold Spring Harb Symp Quant Biol (1994) 2.76
Telomerase activity in normal leukocytes and in hematologic malignancies. Blood (1995) 2.71
Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production. Eur J Immunol (1996) 2.67
Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. J Virol (1994) 2.57
The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter. Hum Mol Genet (1999) 2.52
Cells that constitutively express the herpes simplex virus immediate-early protein ICP4 allow efficient activation of viral delayed-early genes in trans. J Virol (1985) 2.40
Alternative lengthening of telomeres and survival in patients with glioblastoma multiforme. Lancet (2003) 2.26
Glycoproteins of herpes simplex virus type 2 as defined by monoclonal antibodies. J Virol (1982) 2.24
Selective assay for herpes simplex viruses expressing thymidine kinase. J Virol (1979) 2.03
Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells. Mol Cell Biol (2001) 1.99
Monoclonal antibodies to two glycoproteins of herpes simplex virus type 2. J Virol (1981) 1.94
Establishment and characterization of SV40 T-antigen immortalized human esophageal epithelial cells. Cancer Res (1991) 1.88
Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues. Cancer Res (1996) 1.87
Telomere dynamics and telomerase activity in in vitro immortalised human cells. Eur J Cancer (1997) 1.87
Herpes simplex virus thymidine kinase transcripts are absent from both nucleus and cytoplasm during infection in the presence of cycloheximide. J Virol (1980) 1.86
Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts. Mol Cell Biol (1995) 1.85
Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen. EMBO J (1994) 1.84
Rapid detection of herpes simplex virus in clinical specimens by use of a capture biotin-streptavidin enzyme-linked immunosorbent assay. J Clin Microbiol (1984) 1.82
Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res (2000) 1.70
Telomerase activity associated with acquisition of malignancy in human colorectal cancer. Cancer Res (1995) 1.69
Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells. Virology (1991) 1.66
Human bronchial epithelial cells with integrated SV40 virus T antigen genes retain the ability to undergo squamous differentiation. Differentiation (1988) 1.64
Mapping of a 14,000-dalton antigen to early region 4 of the human adenovirus 5 genome. J Virol (1983) 1.64
A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines. Biochem Biophys Res Commun (2000) 1.62
Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells. Mol Cell Biol (2000) 1.60
The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activity. Neoplasia (2001) 1.60
Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-alpha and angiotensin II. Circulation (1998) 1.57
Development of retinoblastoma in the absence of telomerase activity. J Natl Cancer Inst (1996) 1.57
Comparison of standard tissue culture, tissue culture plus staining, and direct staining for detection of genital herpes simplex virus infection. J Clin Microbiol (1984) 1.56
Partial purification and characterization of the ribonucleotide reductase induced by herpes simplex virus infection of mammalian cells. J Virol (1981) 1.55
Establishment and some biological characteristics of human hepatoma cell lines. Gan (1975) 1.52
SV40-induced immortalization of human cells. Crit Rev Oncog (1994) 1.51
Establishment of a human in vitro mesothelial cell model system for investigating mechanisms of asbestos-induced mesothelioma. Am J Pathol (1989) 1.51
Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice. J Exp Med (1997) 1.51
Tamoxifen induces accumulation of MCF 7 human mammary carcinoma cells in the G0/G1 phase of the cell cycle. Eur J Cancer Clin Oncol (1983) 1.49
Histone deacetylation is involved in the transcriptional repression of hTERT in normal human cells. J Biol Chem (2000) 1.49
Telomere maintenance by telomerase and by recombination can coexist in human cells. Hum Mol Genet (2001) 1.48
Telomere length dynamics in telomerase-positive immortal human cell populations. Exp Cell Res (1998) 1.47
Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells. Cancer Res (1998) 1.45
Telomere maintenance mechanisms and cellular immortalization. Curr Opin Genet Dev (1999) 1.43
Inactivation of tumor suppressor p53 by mot-2, a hsp70 family member. J Biol Chem (1998) 1.43
Identification of candidate alternative lengthening of telomeres genes by methionine restriction and RNA interference. Oncogene (2007) 1.42
Tn5 mutagenesis of the transforming genes of human adenovirus type 5. Gene (1983) 1.41
Hepatocyte growth factor induces differentiation of adult rat bone marrow cells into a hepatocyte lineage in vitro. Biochem Biophys Res Commun (2000) 1.40
Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation. Oncogene (1992) 1.40
Strontium phosphate transfection of human cells in primary culture: stable expression of the simian virus 40 large-T-antigen gene in primary human bronchial epithelial cells. Mol Cell Biol (1987) 1.39
Multi-centre phase II clinical trial of yttrium-90 resin microspheres alone in unresectable, chemotherapy refractory colorectal liver metastases. Br J Cancer (2010) 1.39
Screening the p53 status of human cell lines using a yeast functional assay. Mol Carcinog (1997) 1.38
Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability. Mol Cell Biol (1997) 1.38
Presenile dementia combined with amyotrophy: a review of 34 Japanese cases. Arch Gerontol Geriatr (1987) 1.38
Ototoxicity in patients receiving cisplatin: importance of dose and method of drug administration. Cancer Treat Rep (1982) 1.37
Differential sensitivity of human breast cancer cell lines to the growth-inhibitory effects of tamoxifen. Cancer Res (1985) 1.37
Mammalian stanniocalcins and cancer. Endocr Relat Cancer (2003) 1.35
Repression of an alternative mechanism for lengthening of telomeres in somatic cell hybrids. Oncogene (1999) 1.34
Telomerase activity in normal and malignant murine tissues. Oncogene (1995) 1.34
Prognostic factors affecting long term outcome after liver resection for hepatocellular carcinoma: results in a series of 100 Italian patients. Cancer (1998) 1.34
High quality RNA isolation from tumours with low cellularity and high extracellular matrix component for cDNA microarrays: application to chondrosarcoma. J Clin Pathol (2001) 1.33
Reduced expression of REIC/Dkk-3 gene in non-small cell lung cancer. Int J Oncol (2001) 1.32
Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability. Oncogene (2001) 1.31
Methylation of the human telomerase gene CpG island. Cancer Res (2000) 1.31
A novel human cDNA highly homologous to the fish hormone stanniocalcin. Mol Cell Endocrinol (1995) 1.30
Comparison of production of transforming growth factor-beta and platelet-derived growth factor by normal human mesothelial cells and mesothelioma cell lines. Cancer Res (1987) 1.30
Herpes simplex virus-induced ribonucleotide reductase: development of antibodies specific for the enzyme. J Gen Virol (1983) 1.29
A UV-specific endonucleolytic activity present in human cell extracts. Biochem Biophys Res Commun (1972) 1.29
Neoplastic transformation of human diploid fibroblasts (KMST-6) by treatment with 60Co gamma rays. Int J Cancer (1985) 1.28
Glucagonostatic and insulinotropic action of glucagonlike peptide I-(7-36)-amide. Diabetes (1989) 1.28
Antiproliferative activity of REIC/Dkk-3 and its significant down-regulation in non-small-cell lung carcinomas. Biochem Biophys Res Commun (2001) 1.27
Is ribonucleotide reductase the transforming function of herpes simplex virus 2? Nature (1983) 1.26
Characteristics of tumor cell bioactivity in oncogenic osteomalacia. Mol Cell Endocrinol (1996) 1.25
Immunological characterization of herpes simplex virus type 1 and 2 polypeptide(s) involved in viral ribonucleotide reductase activity. J Virol (1984) 1.24
Gene transfer of dominant-negative mutants of extracellular signal-regulated kinase and c-Jun NH2-terminal kinase prevents neointimal formation in balloon-injured rat artery. Circ Res (2001) 1.23
Idiopathic Parkinsonism with Lewy-type inclusions in cerebral cortex. A case report. Acta Neuropathol (1978) 1.23
Cloning of the herpes simplex virus ICP4 gene in an adenovirus vector: effects on adenovirus gene expression and replication. Virology (1989) 1.23
Production of hybrid cell lines secreting antibodies to herpes simplex virus type 2. J Virol Methods (1981) 1.22
Integration and expression of viral DNA in cells transformed by host range mutants of adenovirus type 5. J Virol (1982) 1.20
Identification and separation of the two subunits of the herpes simplex virus ribonucleotide reductase. J Virol (1986) 1.18
Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1. Mol Cell Biol (1993) 1.18
A new human chondrosarcoma cell line (OUMS-27) that maintains chondrocytic differentiation. Int J Cancer (1998) 1.18
Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells. J Biol Chem (1997) 1.18
Covalently closed circles of adenovirus 5 DNA. Nature (1983) 1.17
Genetic interactions between error-prone and error-free postreplication repair pathways in Saccharomyces cerevisiae. Mutat Res (1999) 1.16
Class II major histocompatibility antigen expression on coronary arterial endothelium in a patient with Kawasaki disease. Hum Pathol (1990) 1.16
Two human myeloma cell lines, amylase-producing KMS-12-PE and amylase-non-producing KMS-12-BM, were established from a patient, having the same chromosome marker, t(11;14)(q13;q32). Br J Haematol (1989) 1.15