Published in Mol Cell Biol on June 01, 1999
Human telomerase and its regulation. Microbiol Mol Biol Rev (2002) 3.11
Telomere length homeostasis requires that telomerase levels are limiting. EMBO J (2006) 2.81
Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature (2010) 2.36
Telomerase RNA level limits telomere maintenance in X-linked dyskeratosis congenita. Genes Dev (2006) 2.20
Telomerase RNA accumulates in Cajal bodies in human cancer cells. Mol Biol Cell (2003) 2.14
Mouse dyskerin mutations affect accumulation of telomerase RNA and small nucleolar RNA, telomerase activity, and ribosomal RNA processing. Proc Natl Acad Sci U S A (2004) 2.01
Natural and pharmacological regulation of telomerase. Nucleic Acids Res (2002) 1.92
Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells. Nucleic Acids Res (2001) 1.73
Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation. Carcinogenesis (2009) 1.73
Physiological assembly and activity of human telomerase complexes. Mech Ageing Dev (2007) 1.56
An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity. Neoplasia (2001) 1.48
Biogenesis of telomerase ribonucleoproteins. RNA (2012) 1.47
A transposable element within the Non-canonical telomerase RNA of Arabidopsis thaliana modulates telomerase in response to DNA damage [corrected]. PLoS Genet (2015) 1.41
Attenuated, flow-induced ATP release contributes to absence of flow-sensitive, purinergic Cai2+ signaling in human ADPKD cyst epithelial cells. Am J Physiol Renal Physiol (2009) 1.28
Telomerase reverse transcriptase is required for the localization of telomerase RNA to cajal bodies and telomeres in human cancer cells. Mol Biol Cell (2008) 1.22
The Telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle. J Cell Biol (2001) 1.15
Mapping of the gene for the human telomerase reverse transcriptase, hTERT, to chromosome 5p15.33 by fluorescence in situ hybridization. Neoplasia (2000) 1.10
Activation of telomerase rna gene promoter activity by NF-Y, Sp1, and the retinoblastoma protein and repression by Sp3. Neoplasia (2001) 1.05
Effects of short-term exposure to inhalable particulate matter on telomere length, telomerase expression, and telomerase methylation in steel workers. Environ Health Perspect (2010) 1.04
Telomerase regulation. Mutat Res (2011) 0.98
Disease-associated human telomerase RNA variants show loss of function for telomere synthesis without dominant-negative interference. Mol Cell Biol (2008) 0.98
UVB and proinflammatory cytokines synergistically activate TNF-alpha production in keratinocytes through enhanced gene transcription. J Invest Dermatol (2008) 0.95
Efficient and specific knockdown of small non-coding RNAs in mammalian cells and in mice. Nucleic Acids Res (2010) 0.93
Translation-dependent mechanisms lead to PML upregulation and mediate oncogenic K-RAS-induced cellular senescence. EMBO Mol Med (2012) 0.89
Genetic Variations in Telomere Maintenance, with Implications on Tissue Renewal Capacity and Chronic Disease Pathologies. Curr Pharmacogenomics Person Med (2010) 0.87
Reactivation of telomerase in cancer. Cell Mol Life Sci (2016) 0.87
Prognostic significance of telomere maintenance mechanisms in pediatric high-grade gliomas. J Neurooncol (2014) 0.86
Evidence of extra-telomeric effects of hTERT and its regulation involving a feedback loop. Exp Cell Res (2006) 0.86
The role of telomeres and telomerase reverse transcriptase isoforms in pluripotency induction and maintenance. RNA Biol (2016) 0.84
The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres. PLoS Genet (2015) 0.82
Exclusion of exon 2 is a common mRNA splice variant of primate telomerase reverse transcriptases. PLoS One (2012) 0.82
Involvement of the oncoprotein c-Myc in viral telomerase RNA gene regulation during Marek's disease virus-induced lymphomagenesis. J Virol (2007) 0.82
The regulation of telomerase in oncogenesis. Acta Naturae (2009) 0.81
Dynamics of Human Telomerase Holoenzyme Assembly and Subunit Exchange across the Cell Cycle. J Biol Chem (2015) 0.80
Combined effects of Cantide and chemotherapeutic drugs on inhibition of tumor cells' growth in vitro and in vivo. World J Gastroenterol (2005) 0.79
Telomerase gene expression in the chicken: Telomerase RNA (TR) and reverse transcriptase (TERT) transcript profiles are tissue-specific and correlate with telomerase activity. Age (Dordr) (2006) 0.79
The tamoxifen-induced suppression of telomerase activity in the human hepatoblastoma cell line HepG2: a result of post-translational regulation. J Cancer Res Clin Oncol (2004) 0.78
The catalytic and the RNA subunits of human telomerase are required to immortalize equid primary fibroblasts. Chromosoma (2012) 0.76
Immortalization of Human Fetal Hepatocyte by Ectopic Expression of Human Telomerase Reverse Transcriptase, Human Papilloma Virus (E7) and Simian Virus 40 Large T (SV40 T) Antigen Towards Bioartificial Liver Support. J Clin Exp Hepatol (2014) 0.75
Current Insights to Regulation and Role of Telomerase in Human Diseases. Antioxidants (Basel) (2017) 0.75
Novel therapeutic approaches for various cancer types using a modified sleeping beauty-based gene delivery system. PLoS One (2014) 0.75
An Mtr4/ZFC3H1 complex facilitates turnover of unstable nuclear RNAs to prevent their cytoplasmic transport and global translational repression. Genes Dev (2017) 0.75
Quantification of Pseudouridine Levels in Cellular RNA Pools with a Modified HPLC-UV Assay. Genes (Basel) (2017) 0.75
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem (1987) 281.19
Specific association of human telomerase activity with immortal cells and cancer. Science (1994) 28.20
Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature (1984) 24.45
Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell (1985) 24.17
Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res (1990) 20.53
Extension of life-span by introduction of telomerase into normal human cells. Science (1998) 20.48
Improved retroviral vectors for gene transfer and expression. Biotechniques (1989) 19.48
Quantitation of mRNA by the polymerase chain reaction. Proc Natl Acad Sci U S A (1989) 15.69
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell (1997) 13.34
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature (1989) 13.18
Telomerase catalytic subunit homologs from fission yeast and human. Science (1997) 12.35
Reverse transcriptase motifs in the catalytic subunit of telomerase. Science (1997) 10.10
The RNA component of human telomerase. Science (1995) 9.86
Origin of concatemeric T7 DNA. Nat New Biol (1972) 9.08
TLC1: template RNA component of Saccharomyces cerevisiae telomerase. Science (1994) 9.08
mRNA stability in mammalian cells. Microbiol Rev (1995) 8.78
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell (1997) 8.74
A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J Theor Biol (1973) 7.28
Quantitative RT-PCR: limits and accuracy. Biotechniques (1996) 6.88
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Genet (1997) 6.69
Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA. Nucleic Acids Res (1984) 6.56
Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr Biol (1998) 4.59
A conserved secondary structure for telomerase RNA. Cell (1991) 4.52
Runaway telomere elongation caused by telomerase RNA gene mutations. Nature (1995) 4.34
Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nat Genet (1999) 4.22
Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts. Mol Cell Biol (1989) 3.89
Telomerase RNAs of different ciliates have a common secondary structure and a permuted template. Genes Dev (1994) 3.60
Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. Hum Mol Genet (1997) 3.56
Reconstitution of human telomerase activity in vitro. Curr Biol (1998) 3.51
Human telomerase contains evolutionarily conserved catalytic and structural subunits. Genes Dev (1997) 3.47
Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat Genet (1999) 3.47
Rapid switching of plant gene expression induced by fungal elicitor. Science (1985) 3.40
Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase. Oncogene (1998) 2.56
Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. Cancer Res (1998) 2.54
Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation. Oncogene (1998) 2.49
The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complex. Proc Natl Acad Sci U S A (1998) 2.43
Expression of mouse telomerase catalytic subunit in embryos and adult tissues. Proc Natl Acad Sci U S A (1998) 2.27
The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit. Hum Mol Genet (1997) 1.97
Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues. Cancer Res (1996) 1.87
Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax. Proc Natl Acad Sci U S A (1998) 1.74
Telomerase and chromosome end maintenance. Curr Opin Genet Dev (1998) 1.44
Essential factors in the kinetic analysis of RNA synthesis in HeLa cells. J Cell Physiol (1977) 1.42
A comparison of apparent mRNA half-life using kinetic labeling techniques vs decay following administration of transcriptional inhibitors. Anal Biochem (1991) 1.40
Evidence for post-transcriptional regulation of cyclin B1 mRNA in the cell cycle and following irradiation in HeLa cells. EMBO J (1995) 1.31
Incorporation of 6-thioguanosine and 4-thiouridine into RNA. Application to isolation of newly synthesised RNA by affinity chromatography. Eur J Biochem (1978) 1.28
Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction. Cancer Res (1992) 1.27
Selective isolation of newly synthesized mammalian mRNA after in vivo labeling with 4-thiouridine or 6-thioguanosine. Anal Biochem (1988) 1.18
Cloning and characterization of human and mouse telomerase RNA gene promoter sequences. Oncogene (1998) 1.16
Telomerase expression in respiratory epithelium during the multistage pathogenesis of lung carcinomas. Cancer Res (1997) 1.15
In situ hybridization for the detection of telomerase RNA in the progression from Barrett's esophagus to esophageal adenocarcinoma. Cancer (1998) 1.15
Newly synthesized RNA: simultaneous measurement in intact cells of transcription rates and RNA stability of insulin-like growth factor I, actin, and albumin in growth hormone-stimulated hepatocytes. Proc Natl Acad Sci U S A (1991) 1.05
Tissue distribution and regulation of rat prolactin receptor gene expression. Quantitative analysis by polymerase chain reaction. J Biol Chem (1994) 1.04
Re-expression of senescent markers in deinduced reversibly immortalized cells. Exp Gerontol (1992) 0.93
Telomerase activity and in situ telomerase RNA expression in malignant and non-malignant lymph nodes. J Clin Pathol (1997) 0.92
Protein synthesis in collagen lattice-cultured fibroblasts is controlled at the ribosomal level. FEBS Lett (1995) 0.89
In situ hybridization for telomerase RNA in routine cytologic brushings for the diagnosis of pancreaticobiliary malignancies. Gastrointest Endosc (1998) 0.85
Copy number, epigenetic state and expression of the rRNA genes in young and senescent rat embryo fibroblasts. Eur J Cell Biol (1997) 0.84
Specific association of human telomerase activity with immortal cells and cancer. Science (1994) 28.20
Extension of life-span by introduction of telomerase into normal human cells. Science (1998) 20.48
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Genet (1997) 6.69
A transcriptionally active DNA-binding site for human p53 protein complexes. Mol Cell Biol (1992) 6.56
Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo. Cell (1991) 6.48
Telomerase activity in human germline and embryonic tissues and cells. Dev Genet (1996) 5.00
Positive autoregulation of the myogenic determination gene MyoD1. Cell (1989) 4.28
Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nat Genet (1999) 4.22
A role for both RB and p53 in the regulation of human cellular senescence. Exp Cell Res (1991) 4.07
Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products. Nature (2000) 3.96
Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts. Mol Cell Biol (1989) 3.89
Correlating telomerase activity levels with human neuroblastoma outcomes. Nat Med (1995) 3.74
Defining the molecular mechanisms of human cell immortalization. Biochim Biophys Acta (1991) 3.73
Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis. Nature (1989) 3.73
Normal human chromosomes have long G-rich telomeric overhangs at one end. Genes Dev (1997) 3.42
Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J Immunol (1995) 3.20
Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev (1999) 3.19
Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity. Nucleic Acids Res (1995) 3.16
Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes Dev (2001) 3.16
Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer. Int J Cancer (1998) 3.12
Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology. Nat Med (2000) 2.81
Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier. Cancer Res (1998) 2.72
Telomere position effect in human cells. Science (2001) 2.61
Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc Natl Acad Sci U S A (1999) 2.36
Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb. Cancer Res (1994) 2.28
Telomerase and cancer. Hum Mol Genet (2001) 2.28
Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals. Hum Genet (1998) 2.27
E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts. Oncogene (1993) 2.25
Telomerase activity in small-cell and non-small-cell lung cancers. J Natl Cancer Inst (1995) 2.18
Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression. Oncogene (1994) 2.18
Hayflick, his limit, and cellular ageing. Nat Rev Mol Cell Biol (2000) 2.15
Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase. J Biol Chem (2000) 2.14
Telomerase activity in human cancer. Curr Opin Oncol (1996) 2.13
Telomere shortening is associated with cell division in vitro and in vivo. Exp Cell Res (1995) 2.11
Telomerase activity in gastric cancer. Cancer Res (1995) 2.02
Preferred sequences for DNA recognition by the TAL1 helix-loop-helix proteins. Mol Cell Biol (1994) 2.00
The two-stage mechanism controlling cellular senescence and immortalization. Exp Gerontol (1993) 1.98
Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen. Exp Cell Res (1989) 1.96
Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro. Mol Cell Biol (1999) 1.96
The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes. Hum Mol Genet (2000) 1.93
Telomere positional effects and the regulation of cellular senescence. Trends Genet (1992) 1.90
Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4. Cancer Res (1994) 1.88
Telomerase activity: a prevalent marker of malignant human prostate tissue. Cancer Res (1996) 1.87
Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues. Cancer Res (1996) 1.87
Regulation of telomerase activity in immortal cell lines. Mol Cell Biol (1996) 1.82
Cellular senescence as a tumor-protection mechanism: the essential role of counting. Curr Opin Genet Dev (2001) 1.78
Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells. Nucleic Acids Res (2001) 1.73
Telomerase activity in human breast tumors. J Natl Cancer Inst (1996) 1.73
Telomere shortening is proportional to the size of the G-rich telomeric 3'-overhang. J Biol Chem (2000) 1.73
Identification of skeletal muscle precursor cells in vivo by use of MyoD1 and myogenin probes. Cell Tissue Res (1992) 1.67
Telomerase activity in human brain tumours. Lancet (1995) 1.64
Biliary excretion of cephalosporins in rats: influence of molecular weight. Antimicrob Agents Chemother (1980) 1.63
Telomerase activity in human liver tissues: comparison between chronic liver disease and hepatocellular carcinomas. Cancer Res (1995) 1.60
Heterogeneity of transcriptional activity of mutant p53 proteins and p53 DNA target sequences. Oncogene (1993) 1.59
Normal human telomeres are not late replicating. Exp Cell Res (1999) 1.57
Urea extraction of Z bands, intercalated disks, and desmosomes. J Ultrastruct Res (1968) 1.54
Transient expression of human telomerase extends the life span of normal human fibroblasts. Biochem Biophys Res Commun (2000) 1.54
Detection of benzo[a]pyrene diol epoxide-DNA adducts in peripheral blood lymphocytes and antibodies to the adducts in serum from coke oven workers. Proc Natl Acad Sci U S A (1985) 1.54
Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis. Cancer Genet Cytogenet (1997) 1.52
A temperature-sensitive mutant of human p53. EMBO J (1994) 1.51
Formation of anucleate and multinucleate cells in normal and SV 40 transformed WI-38 by cytochalasin B. Exp Cell Res (1972) 1.50
An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity. Neoplasia (2001) 1.48
Telomerase immortalization of human myometrial cells. Biol Reprod (2002) 1.48
Role of telomerase in cellular proliferation and cancer. J Cell Physiol (1999) 1.47
Detection of telomerase activity in malignant and nonmalignant skin conditions. J Invest Dermatol (1996) 1.46
Increasing trends in the use of breast-conserving surgery in California. Am J Public Health (2000) 1.44
Leukaemia in workers exposed to electrical and magnetic fields. Lancet (1982) 1.43
Telomeres and telomerase: a simple picture becomes complex. Cell (1996) 1.41
Cyclic amplification and selection of targets for multicomponent complexes: myogenin interacts with factors recognizing binding sites for basic helix-loop-helix, nuclear factor 1, myocyte-specific enhancer-binding factor 2, and COMP1 factor. Proc Natl Acad Sci U S A (1992) 1.41
Pulmonary effects of exposures in silicon carbide manufacturing. Br J Ind Med (1984) 1.39
Multiple myeloma in cosmetologists. Am J Ind Med (1982) 1.38
Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism? Trends Cell Biol (1995) 1.36
High telomerase activity is an independent prognostic indicator of poor outcome in colorectal cancer. Clin Cancer Res (2000) 1.36
Induction of muscle genes in neural cells. J Cell Biol (1984) 1.36
Cilia in cardiac differentiation. J Ultrastruct Res (1969) 1.35
Telomeres and telomerase: implications for cancer and aging. Radiat Res (2001) 1.34