Published in J Biol Chem on June 13, 1997
Visualization of phosphoinositides that bind pleckstrin homology domains: calcium- and agonist-induced dynamic changes and relationship to myo-[3H]inositol-labeled phosphoinositide pools. J Cell Biol (1998) 6.70
Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. J Cell Biol (2000) 3.63
Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting. EMBO J (1998) 3.09
A comprehensive map of the toll-like receptor signaling network. Mol Syst Biol (2006) 2.89
Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals. EMBO J (1998) 2.29
Molecular mechanisms of cell proliferation induced by low power laser irradiation. J Biomed Sci (2009) 2.13
The LAT story: a tale of cooperativity, coordination, and choreography. Cold Spring Harb Perspect Biol (2010) 1.77
Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT. Mol Cell Biol (2001) 1.69
Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes. Biochem J (2000) 1.53
Intracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate. J Cell Biol (2000) 1.52
Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell line. Mol Cell Biol (2000) 1.51
Revealing the role of phospholipase Cβ3 in the regulation of VEGF-induced vascular permeability. Blood (2012) 1.51
Cutting edge: CD4 is the receptor for the tick saliva immunosuppressor, Salp15. J Immunol (2006) 1.39
Genetic alteration of phospholipase C beta3 expression modulates behavioral and cellular responses to mu opioids. Proc Natl Acad Sci U S A (1999) 1.39
Cdc42 and Rac stimulate exocytosis of secretory granules by activating the IP(3)/calcium pathway in RBL-2H3 mast cells. J Cell Biol (2000) 1.38
Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation. J Exp Med (2002) 1.30
Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization. J Exp Med (1997) 1.25
Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1. Mol Biol Cell (2005) 1.23
Phospholipase cbeta is critical for T cell chemotaxis. J Immunol (2007) 1.22
Regulated disruption of inositol 1,4,5-trisphosphate signaling in Caenorhabditis elegans reveals new functions in feeding and embryogenesis. Mol Biol Cell (2002) 1.21
Phospholipase Cgamma2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinase. Mol Cell Biol (2008) 1.21
A novel Gbetagamma-subunit inhibitor selectively modulates mu-opioid-dependent antinociception and attenuates acute morphine-induced antinociceptive tolerance and dependence. J Neurosci (2008) 1.20
Interactions of G(h)/transglutaminase with phospholipase Cdelta1 and with GTP. Proc Natl Acad Sci U S A (1999) 1.18
Mammalian diacylglycerol kinases: molecular interactions and biological functions of selected isoforms. Biochim Biophys Acta (2009) 1.17
Stimulation of phospholipase C-beta2 by the Rho GTPases Cdc42Hs and Rac1. EMBO J (1998) 1.14
Potentially functional variants of PLCE1 identified by GWASs contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population. PLoS One (2012) 1.12
Synergistic activation of phospholipases Cgamma and Cbeta: a novel mechanism for PI3K-independent enhancement of FcepsilonRI-induced mast cell mediator release. Cell Signal (2008) 1.12
The relative role of PLCbeta and PI3Kgamma in platelet activation. Blood (2005) 1.09
Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice. J Clin Invest (2008) 1.09
Molecular modeling of the membrane targeting of phospholipase C pleckstrin homology domains. Protein Sci (2003) 1.08
G protein-coupled receptor-promoted trafficking of Gbeta1gamma2 leads to AKT activation at endosomes via a mechanism mediated by Gbeta1gamma2-Rab11a interaction. Mol Biol Cell (2008) 1.08
HIV-1 Nef interacts with inositol trisphosphate receptor to activate calcium signaling in T cells. J Exp Med (2002) 1.08
Distinct role of PLCbeta3 in VEGF-mediated directional migration and vascular sprouting. J Cell Sci (2009) 1.07
A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation. Blood (2009) 1.07
Bradykinin acutely inhibits activity of the epithelial Na+ channel in mammalian aldosterone-sensitive distal nephron. Am J Physiol Renal Physiol (2011) 1.06
Epidermal growth factor signaling and mitogenesis in Plcg1 null mouse embryonic fibroblasts. Mol Biol Cell (1998) 1.04
Molecular cloning and characterization of a novel phospholipase C, PLC-eta. Biochem J (2005) 1.02
Heterotrimeric G proteins, focal adhesion kinase, and endothelial barrier function. Microvasc Res (2011) 1.02
Phospholipase Cdelta1 is required for skin stem cell lineage commitment. EMBO J (2003) 1.02
Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis. Mol Cell Biol (2006) 1.01
Adenosine A1 receptors mediate mobilization of calcium in human bronchial smooth muscle cells. Am J Respir Cell Mol Biol (2006) 1.01
Functional independence and interdependence of the Src homology domains of phospholipase C-gamma1 in B-cell receptor signal transduction. Mol Cell Biol (1999) 1.00
A signal transduction pathway model prototype I: From agonist to cellular endpoint. Biophys J (2004) 1.00
Diacylglycerol kinases as sources of phosphatidic acid. Biochim Biophys Acta (2009) 0.99
Involvement of phospholipase Cgamma1 in mouse egg activation induced by a truncated form of the C-kit tyrosine kinase present in spermatozoa. J Cell Biol (1998) 0.99
Selective interaction of the C2 domains of phospholipase C-beta1 and -beta2 with activated Galphaq subunits: an alternative function for C2-signaling modules. Proc Natl Acad Sci U S A (1999) 0.99
Targeting of protein kinase C-epsilon during Fcgamma receptor-dependent phagocytosis requires the epsilonC1B domain and phospholipase C-gamma1. Mol Biol Cell (2005) 0.99
Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development. Mol Cell Biol (2005) 0.99
A specific role of phosphatidylinositol 3-kinase gamma. A regulation of autonomic Ca(2)+ oscillations in cardiac cells. J Cell Biol (2001) 0.98
Neuropeptide Y (NPY) potentiates phenylephrine-induced mitogen-activated protein kinase activation in primary cardiomyocytes via NPY Y5 receptors. Proc Natl Acad Sci U S A (2000) 0.98
Membrane raft-dependent regulation of phospholipase Cgamma-1 activation in T lymphocytes. Mol Cell Biol (2001) 0.98
Selection of gbeta subunits with point mutations that fail to activate specific signaling pathways in vivo: dissecting cellular responses mediated by a heterotrimeric G protein in Dictyostelium discoideum. Mol Biol Cell (1998) 0.97
Role of phospholipase C-L2, a novel phospholipase C-like protein that lacks lipase activity, in B-cell receptor signaling. Mol Cell Biol (2003) 0.96
Activation of host phospholipases C and D in macrophages after infection with Listeria monocytogenes. Infect Immun (2000) 0.96
SERPINA3K prevents oxidative stress induced necrotic cell death by inhibiting calcium overload. PLoS One (2008) 0.96
Hydrogen peroxide increases GABAergic mIPSC through presynaptic release of calcium from IP3 receptor-sensitive stores in spinal cord substantia gelatinosa neurons. Eur J Neurosci (2007) 0.96
A unified model for signal transduction reactions in cellular membranes. Biophys J (2002) 0.96
Glutamate regulation of calcium and IP3 oscillating and pulsating dynamics in astrocytes. J Biol Phys (2009) 0.96
rac regulates its effector phospholipase Cgamma2 through interaction with a split pleckstrin homology domain. J Biol Chem (2008) 0.94
Two distinct phases of calcium signalling under flow. Cardiovasc Res (2011) 0.94
Reorganization of actin cytoskeleton by the phosphoinositide metabolite glycerophosphoinositol 4-phosphate. Mol Biol Cell (2003) 0.94
Epigallocatechin-3-gallate increases intracellular [Ca2+] in U87 cells mainly by influx of extracellular Ca2+ and partly by release of intracellular stores. Naunyn Schmiedebergs Arch Pharmacol (2003) 0.93
IgA Fc receptor (FcalphaR) cross-linking recruits tyrosine kinases, phosphoinositide kinases and serine/threonine kinases to glycolipid rafts. Biochem J (2002) 0.92
Differential expression of phospholipase C epsilon 1 is associated with chronic atrophic gastritis and gastric cancer. PLoS One (2012) 0.92
Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing. Mol Cell Biol (2007) 0.92
Genetic dissection of theta rhythm heterogeneity in mice. Proc Natl Acad Sci U S A (2005) 0.92
Phospholipase Cγ1 connects the cell membrane pathway to the nuclear receptor pathway in insect steroid hormone signaling. J Biol Chem (2014) 0.92
Leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) is a modulator of FGFR1. FEBS Lett (2012) 0.91
Phospholipase C-gamma1 is required for cell survival in oxidative stress by protein kinase C. Biochem J (2002) 0.90
Immunohistochemical expressions of mGluR5, P2Y2 receptor, PLC-beta1, and IP3R-I and -II in Merkel cells in rat sinus hair follicles. Histochem Cell Biol (2003) 0.90
An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion. EMBO J (2004) 0.90
G-protein signaling modulator-3 regulates heterotrimeric G-protein dynamics through dual association with Gβ and Gαi protein subunits. J Biol Chem (2011) 0.89
Regulation of oxidative stress-induced calcium release by phosphatidylinositol 3-kinase and Bruton's tyrosine kinase in B cells. Proc Natl Acad Sci U S A (2000) 0.89
Trophoblast adhesion of the peri-implantation mouse blastocyst is regulated by integrin signaling that targets phospholipase C. Dev Biol (2006) 0.89
An overview of brain-derived neurotrophic factor and implications for excitotoxic vulnerability in the hippocampus. Int J Pept (2011) 0.88
Mechanism of activation and inactivation of Gq/phospholipase C-β signaling nodes. Chem Rev (2011) 0.87
Tumor necrosis factor-alpha promotes survival of opossum kidney cells via Cdc42-induced phospholipase C-gamma1 activation and actin filament redistribution. Mol Biol Cell (2003) 0.87
Calcium signaling in mammalian egg activation and embryo development: the influence of subcellular localization. Mol Reprod Dev (2012) 0.87
House dust mite allergen Der f 2-induced phospholipase D1 activation is critical for the production of interleukin-13 through activating transcription factor-2 activation in human bronchial epithelial cells. J Biol Chem (2009) 0.87
Regulation of phospholipase Cgamma in the mesolimbic dopamine system by chronic morphine administration. J Neurochem (1999) 0.87
Structural basis for recognition of the T cell adaptor protein SLP-76 by the SH3 domain of phospholipase Cgamma1. J Mol Biol (2005) 0.87
Regulation of platelet plug formation by phosphoinositide metabolism. Blood (2013) 0.87
Novel bimodal effects of the G-protein tissue transglutaminase on adrenoreceptor signalling. Biochem J (1999) 0.86
Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis. J Biol Chem (2008) 0.86
Brain-derived neurotrophic factor and its clinical implications. Arch Med Sci (2015) 0.86
Calmodulin potentiates G beta gamma activation of phospholipase C-beta3. Biochem Pharmacol (2006) 0.85
Tumor progression locus 2 mediates signal-induced increases in cytoplasmic calcium and cell migration. Sci Signal (2011) 0.85
Diacylglycerol kinase β knockout mice exhibit attention-deficit behavior and an abnormal response on methylphenidate-induced hyperactivity. PLoS One (2012) 0.85
Direct activation of human phospholipase C by its well known inhibitor u73122. J Biol Chem (2011) 0.85
Custom distinctions in the interaction of G-protein beta subunits with N-type (CaV2.2) versus P/Q-type (CaV2.1) calcium channels. J Gen Physiol (2003) 0.85
Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling. Proc Natl Acad Sci U S A (2002) 0.85
Role of inositol phospholipid signaling in natural killer cell biology. Front Immunol (2013) 0.85
Kinetic analysis of phospholipase C from catharanthus roseus transformed roots using different assays Plant Physiol (1999) 0.84
Molecular mechanisms of the antagonistic action between AT1 and AT2 receptors. Biochem Biophys Res Commun (2009) 0.83
Dissecting Arabidopsis Gβ signal transduction on the protein surface. Plant Physiol (2012) 0.83
Roles of PLC-gamma2 and PKCalpha in TPA-induced apoptosis of gastric cancer cells. World J Gastroenterol (2003) 0.83
Phospholipase Cdelta regulates germination of Dictyostelium spores. BMC Cell Biol (2001) 0.82
Phospholipase Cgamma activation and phosphoinositide hydrolysis are essential for embryonal development. Proc Natl Acad Sci U S A (1997) 0.81
The biological significance of phospholipase C beta 1 gene mutation in mouse sperm in the acrosome reaction, fertilization, and embryo development. J Assist Reprod Genet (2001) 0.81
Distinct roles of phosphoinositide-3 kinase and phospholipase Cgamma2 in B-cell receptor-mediated signal transduction. Mol Cell Biol (2006) 0.81
Hydrogen peroxide: a key messenger that modulates protein phosphorylation through cysteine oxidation. Sci STKE (2000) 3.45
Role of auxin-induced reactive oxygen species in root gravitropism. Plant Physiol (2001) 2.45
Casein kinase II phosphorylates p34cdc2 kinase in G1 phase of the HeLa cell division cycle. J Biol Chem (1992) 1.38
Influence of a Fungus-Feeding Nematode on Growth and Biocontrol Efficacy of Trichoderma harzianum. Phytopathology (2001) 1.29
Requirement of hydrogen peroxide generation in TGF-beta 1 signal transduction in human lung fibroblast cells: involvement of hydrogen peroxide and Ca2+ in TGF-beta 1-induced IL-6 expression. J Immunol (2000) 1.18
Immunocytochemical localization of casein kinase II during interphase and mitosis. J Cell Biol (1991) 1.15
Decreased expression of phospholipase C-beta 2 isozyme in human platelets with impaired function. Blood (1996) 1.13
Activation of phospholipase C-gamma by the concerted action of tau proteins and arachidonic acid. J Biol Chem (1996) 1.10
Truncated form of importin alpha identified in breast cancer cell inhibits nuclear import of p53. J Biol Chem (2000) 1.08
Synaptojanin inhibition of phospholipase D activity by hydrolysis of phosphatidylinositol 4,5-bisphosphate. J Biol Chem (1997) 1.02
Characterization of synthetic peptide substrates for p34cdc2 protein kinase. J Cell Biochem (1991) 1.00
AHNAK, a protein that binds and activates phospholipase C-gamma1 in the presence of arachidonic acid. J Biol Chem (1999) 0.99
Regulation of phospholipase C isozymes: activation of phospholipase C-gamma in the absence of tyrosine-phosphorylation. Chem Phys Lipids (1999) 0.91
Phosphorylation of the leucocyte NADPH oxidase subunit p47(phox) by casein kinase 2: conformation-dependent phosphorylation and modulation of oxidase activity. Biochem J (2001) 0.90
Homologous recombination of monkey alpha-satellite repeats in an in vitro simian virus 40 replication system: possible association of recombination with DNA replication. Mol Cell Biol (1994) 0.88
Regulation of megakaryocytic differentiation of K562 cells by FosB, a member of the Fos family of AP-1 transcription factors. Cell Mol Life Sci (2009) 0.86
An apparent deletion of an oligonucleotide detected by RNA fingerprint in the nondiabetogenic B variant of encephalomyocarditis virus is caused by a point mutation. J Virol (1988) 0.85
Creatine kinase B is a target molecule of reactive oxygen species in cervical cancer. Mol Cells (2001) 0.85
Amino acid differences in capsid protein, VP1, between diabetogenic and nondiabetogenic variants of encephalomyocarditis virus. Virology (1988) 0.85
Inhibition of phospholipase D by clathrin assembly protein 3 (AP3). J Biol Chem (1997) 0.84
Stimulation of human DNA topoisomerase II activity by its direct association with the beta subunit of protein kinase CKII. Mol Cells (2001) 0.84
Interleukin-10 up-regulates tumour-necrosis-factor-alpha-related apoptosis-inducing ligand (TRAIL) gene expression in mammary epithelial cells at the involution stage. Biochem J (2001) 0.83
Trp-Lys-Tyr-Met-Val-Met activates mitogen-activated protein kinase via a PI-3 kinase-mediated pathway independent of PKC. Life Sci (1999) 0.82
PLC gamma 1 Src homology domain induces mitogenesis in quiescent NIH 3T3 fibroblasts. Biochem Biophys Res Commun (1996) 0.81
Pioglitazone, a synthetic ligand for PPARgamma, induces apoptosis in RB-deficient human colorectal cancer cells. Apoptosis (2006) 0.81
Role of phospholipase C-gamma1 in insulin-like growth factor I-induced muscle differentiation of H9c2 cardiac myoblasts. Biochem Biophys Res Commun (2001) 0.80
Phosphorylation of ribosomal protein L5 by protein kinase CKII decreases its 5S rRNA binding activity. Biochem Biophys Res Commun (1999) 0.80
Prevention of encephalomyocarditis virus-induced diabetes by live recombinant Mycobacterium bovis bacillus Calmette-Guérin in susceptible mice. Diabetes (2000) 0.79
In vitro binding analysis of hepatitis B virus preS-derived putative helper T-cell epitopes to MHC class II molecules using stable HLA-DRB1*0405/DRA*0101 transfected cells. IUBMB Life (2000) 0.79
ATP-induced mitogenesis is modulated by phospholipase D2 through extracellular signal regulated protein kinase dephosphorylation in rat pheochromocytoma PC12 cells. Neurosci Lett (2001) 0.79
Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins. Mol Cells (2001) 0.78
Multiple forms of phospholipase D inhibitor from rat brain cytosol. Purification and characterization of heat-labile form. J Biol Chem (1996) 0.78
Characterization of protein interaction among subunits of protein kinase CKII in vivo and in vitro. Mol Cells (1998) 0.77
Distribution of the receptor for a novel peptide stimulating phosphoinositide hydrolysis in human leukocytes. Clin Biochem (1998) 0.77
The synthetic peptide, His-Phe-Tyr-Leu-Pro-Met, is a chemoattractant for Jukat T cells. Exp Mol Med (2001) 0.77
Interaction of the beta subunit of casein kinase II with the ribosomal protein L5. Biochem Biophys Res Commun (1996) 0.77
A new type of insertion mutation in monkey cells: insertion accompanied by long target site duplication. Mol Gen Genet (1991) 0.76
The highly basic ribosomal protein L41 interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase IIalpha by CKII. Biochem Biophys Res Commun (1997) 0.76
Protein kinase CKII interacts with and phosphorylates the SAG protein containing ring-H2 finger motif. Biochem Biophys Res Commun (1999) 0.76
Molecular cloning and characterization of cDNAs for anionic and neutral peroxidases from suspension-cultured-cells of sweet potato and their differential expression in response to stress. Mol Gen Genet (1997) 0.75
Development of a plasma generator for a long pulse ion source for neutral beam injectors. Rev Sci Instrum (2011) 0.75
Rotational resonance of nonaxisymmetric magnetic braking in the KSTAR tokamak. Phys Rev Lett (2013) 0.75
An efficient and site-specific gene trimming method. Biotechniques (1989) 0.75
Identification of antigenic differences between the diabetogenic and non-diabetogenic variants of encephalomyocarditis virus using monoclonal antibodies. J Gen Virol (1988) 0.75
Improving holographic data storage by use of an optimized phase mask. Appl Opt (1999) 0.75
First neutral beam injection experiments on KSTAR tokamak. Rev Sci Instrum (2012) 0.75
Effects of a water-soluble antitumor ether phosphonoinositide, D-myo-inositol 4-(hexadecyloxy)-3(S)-methoxybutanephosphonate (C4-PI), on inositol lipid metabolism in breast epithelial cancer cell lines. Biochem Pharmacol (1999) 0.75
Regulation of protein kinase CKII by direct interaction with the C-terminal region of p47(phox). Biochem Biophys Res Commun (2001) 0.75
Appearance and dynamics of helical flux tubes under electron cyclotron resonance heating in the core of KSTAR plasmas. Phys Rev Lett (2012) 0.75